12,380 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Midilli B, Nurten A, Gürtekin B et al. · 2025 · Behavioural brain research
Antimuscarinic administration and food intake cause convulsions in mice and rats after fasting for 48 h or less. Increased M 1 and M 2 muscarinic receptor expression in brain regions during fasting, and reversal of changes by refeeding may…
View details →Rothe J, Thiel T, Roessner V et al. · 2025 · BMC psychiatry
Background Autistic individuals often experience significant difficulties adapting to even slight changes in their routines. The COVID-19 pandemic created an uncertain situation marked by frequent changes in daily life, though some…
View details →Honkanen J, Molnár K, Karhumaa T et al. · 2025 · Journal of endocrinological investigation
Purpose Thyroid surgery is performed for various indications, including goiter, suspected or diagnosed malignancy, and hyperthyroidism. While previous studies have focused on postoperative quality of life (QoL) improvements, limited data…
View details →Borghoff KA, Ounda AE, Swee ML et al. · 2025 · Clinical nephrology
Background and objectives Chronic kidney disease (CKD) is associated with increased cardiovascular risk, which may be mediated by vascular calcification. Based on evidence that bisphosphonates inhibit vascular calcification, we…
View details →Kuan HY, Chang CH · 2024 · Journal of physiological investigation
Abstract Stress is an adaptive response crucial for survival. However, chronic stress can lead to maladaptive behaviors and health issues. Prolonged stress reduces the flexibility of defensive coping behaviors. Previous studies have shown…
View details →Nam J, Bellinger GC, Li J et al. · 2025 · JMIR cardio
Background Wearable activity monitors offer clinicians and researchers accessible, scalable, and cost-effective tools for continuous remote monitoring of functional status. These technologies can complement traditional clinical outcome…
View details →Liu X, Zheng W, Hoon L et al. · 2026 · Npj mental health research
Smartphone-delivered interventions offer a scalable solution for university students experiencing depression, yet outcomes remain inconsistent. This study examined predictors of depression remission and response in the AI-enhanced Vibe Up…
View details →Bakhshinejad JA, Watkins CM, Pelton LM et al. · 2026 · International journal of exercise science
The primary aim of this investigation was to examine the effects of three drop jumps (DJ) on mean velocity (m/s) of subsequent deadlifts at various percentages of 1 RM. A secondary exploratory aim was to evaluate whether protocol order,…
View details →Lewandowski KE, Luo J, Yao B et al. · 2025 · Frontiers in psychiatry
Introduction Motivational impairments are a hallmark symptom of psychotic disorders. However, motivation is a multidimensional construct believed to be underpinned by different neural mechanisms and differentially impaired both between and…
View details →Cronin SK, Barnard AM, Dietz SJ et al. · 2023 · Journal of dairy science
It is possible that some of the systemic responses to subacute ruminal acidosis (SARA) may be caused by increased intestinal starch fermentation. The objective of this experiment was to evaluate the effect of abomasal infusion of up to 3 g…
View details →He JD, Parker JD · 2023 · British journal of clinical pharmacology
Aims To mediate its pharmacodynamic effects, glyceryl trinitrate (GTN) requires bioactivation, by which it releases nitric oxide or a nitric oxide moiety. The exact mechanism of GTN bioactivation remains uncertain. Mitochondrial aldehyde…
View details →Alizo Vera V, Childs JE, Kim J et al. · 2025 · eNeuro
Histone deacetylase 3 (HDAC3) is one of the most highly expressed HDACs in the brain shown to be a negative regulator of long-term memory formation. HDAC3 has also been shown to be involved in cocaine-associated behaviors, demonstrated by…
View details →Sabino-Carvalho JL, Li S, Mekonnen E et al. · 2025 · Medicine and science in sports and exercise
Purpose Parasympathetic reactivation is essential for the rapid decrease in heart rate following exercise and delayed heart rate recovery (HRR) post-exercise is linked to poor clinical outcomes. Chronic kidney disease (CKD) is associated…
View details →Volpe LJ, Zugelder M, Kotarinos R et al. · 2023 · Urogynecology (Philadelphia, Pa.)
Importance Although pelvic floor physical therapy (PFPT) is effective in treating high-tone pelvic floor dysfunction (HTPFD), data on the mechanism of improvement are limited. Objectives This study aimed to compare squeeze intravaginal…
View details →Domin M, Lindenberg R, Lotze M · 2025 · Scientific reports
Evaluating the integrity of the corticospinal tract at the height of the posterior limb of the internal capsule with a lateralization index has been applied to predict upper limb motor recovery after stroke in numerous diffusion tensor…
View details →Lind CM, Agugliaro J, Ortega J et al. · 2024 · The Journal of experimental biology
Disease may be both a cause and a consequence of stress, and physiological responses to infectious disease may involve stress coping mechanisms that have important fitness consequences. For example, glucocorticoid and glycemic responses…
View details →Bogon J, Jagorska C, Steinecker I et al. · 2024 · Acta psychologica
The perception of time is subject to various environmental influences and exhibits changes across the lifespan. Studies on time perception have often been conducted using abstract stimuli and artificial scenarios, and recent claims for…
View details →Smith A, Lin PD, Rifas-Shiman SL et al. · 2026 · Environmental epidemiology (Philadelphia, Pa.)
Background Per- and polyfluoroalkyl substances (PFAS) and nonessential metals impair immune responses, while essential metals promote immune maintenance. We evaluated associations of childhood PFAS and metal mixtures with measles, mumps,…
View details →Porto IM, do Amaral JV, Pacheco JPG et al. · 2025 · European child & adolescent psychiatry
Many countries implement double-shift schooling systems, offering morning or afternoon shifts. Given attention-deficit/hyperactivity disorder (ADHD) is associated with circadian preference for eveningness, this study hypothesised that…
View details →Vervaecke AJ, Thery C, Housset V et al. · 2026 · JSES international
Background Glenoid concavity plays a critical role in shoulder stability via the concavity-compression mechanism. While the bony glenoid concavity, quantified by the bony shoulder stability ratio (BSSR), is a known determinant of…
View details →LaRosa S, Moore K, Harshaw N et al. · 2024 · The Journal of surgical research
Introduction Trauma bay and emergency department (ED) length of stay (LOS) are important time measures in patient care. The data on this subject are inconclusive or specific to one condition. Our goal was to determine the relationship…
View details →Jacob J, Hesling-Fox J, Yamada M et al. · 2026 · Clinical neurophysiology practice
Objective Stroke survivors often show slower, uncoordinated bimanual performance. This study examined the effects of a single session of bimanual task practice on performance, coordination, motor corticospinal excitability (CSE), and…
View details →Liu HZ, Khanna V, Ayeni OR et al. · 2025 · Cureus
Background Adipose-derived stem cells (ADSCs) hold therapeutic potential for the treatment of orthopedic conditions. However, no surveys to date have evaluated physicians' awareness and receptiveness toward these therapies - an essential…
View details →Hill E, Harleman M, Harris L et al. · 2024 · Environmental Research
Traffic-related air pollution (TRAP) poses a significant public health risk that is associated with adverse birth outcomes. Large roadway infrastructure projects present a natural experiment to examine how resulting congestion change is…
View details →Martin EA, Kim SB, Beckham GK et al. · 2025 · Journal of functional morphology and kinesiology
Objectives The objective of this study was to examine the neuromuscular fatigue response to playing in a singles pickleball tournament, as measured by performance on a countermovement jump test (CMJ). We hypothesized that players would…
View details →Goh R, Ng F, Bacchi S et al. · 2025 · Cerebrovascular diseases extra
Introduction We aimed to determine whether relative hypotension, defined as a systolic blood pressure (SBP) threshold of 0.318) during anterior circulation large-vessel occlusion (LVO) acute ischaemic stroke (AIS). Methods In a…
View details →O'Sullivan S, Bolland M, Cundy T · 2025 · JBMR plus
In a 2015 study of SQSTM1 mutation carriers who had initial negative bone scintigraphy, we found that the rate of development of Paget's disease of bone (PDB) over 5 yr was low. We report here an additional 8-yr follow-up of this cohort,…
View details →Fiala MA, Ji M, Slade M et al. · 2026 · JCO oncology practice
Purpose This study aimed to determine if high-deductible health plan (HDHP) enrollment contributes to financial burden and hinders access to care for patients with multiple myeloma (MM). Materials and methods Patients diagnosed with MM…
View details →Shoji T, Kogure K, Toda N et al. · 2025 · Geriatrics (Basel, Switzerland)
Background/Objectives : In Japan, the number of older patients with diabetes mellitus (DM) is rapidly increasing; however, the impact of DM on higher-level functional capacity in this population is unclear. In this study, we aimed to…
View details →Shariffi B, Harper JL, McMillan NJ et al. · 2025 · American journal of physiology. Heart and circulatory physiology
Insulin has important vasodilatory effects in the peripheral circulation, but less is known about insulin's role in cerebrovascular control. Herein, we hypothesized both systemic (intravenous) and local (intranasal) insulin administration…
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