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WASTE Journal

Browse the failure-mode index

12,251 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Variations of sex-hormones in reproductive aged females do not impact the repeated bout effect following maximal unaccustomed eccentric exercise of the elbow flexors.

Rilling A, Power GA · 2025 · Biology of sport

Neuromuscular function is impaired following unaccustomed eccentric exercise, the repeated bout effect (RBE) however, protects from damage following a subsequent bout. Muscle damage may be mitigated in females due to protective effects of…

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Negative / Null Result ReportMedicine

Interaction between cold ischemia time and Kidney Donor Profile Index on postrenal transplant outcomes.

Cashion WT, Zhang X, Puttarajappa C et al. · 2024 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

We analyzed whether there is an interaction between the Kidney Donor Profile Index (KDPI) and cold ischemia time (CIT) in recipients of deceased donor kidney transplant (KTs). Adults who underwent KTs in the United States between 2014 and…

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Negative / Null Result ReportMedicine

Patients with chronic bipolar disorder show impairments in interpreting literary fiction - A preliminary explorative study with the short story task.

Herold M, Kovács GX, Herold R et al. · 2024 · Journal of psychiatric research

Introduction Theory of mind (ToM) is a crucial skill in navigating and functioning in the social world. Significant ToM impairment was consistently found in bipolar disorder; it can be both a state and trait marker of the disorder.…

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Negative / Null Result ReportOpen accessMedicine

Correlation of Physical Activity Level with Muscle Strength and Size During One Week of Knee Joint Immobilization.

Harmon KK, Pourhatami Z, Malinowski D et al. · 2025 · Journal of functional morphology and kinesiology

Background : Knee joint immobilization is common after surgery or injury. Whether remaining physically active during immobilization preserves muscle strength and size has not been studied. Objectives : This observational study examined…

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Negative / Null Result ReportMedicine

The impact of co-occurring mental health problems on referral to and initiation of treatment among youth under probation supervision: Findings from a cluster randomized trial.

Stanley JN, DeLucca SC, Perron L et al. · 2024 · Journal of substance use and addiction treatment

Introduction Many youth under community supervision have substance use and co-occurring mental health issues. Yet, access to treatment is limited, and many programs cannot address co-occurring disorders. This study examines how…

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Negative / Null Result ReportOpen accessMedicine

The impact of cognitive behavioral therapy for insomnia on cognitive performance and amyloid beta in older adults: A randomized controlled trial.

Siengsukon CF, Hand LK, Nelson E et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association

Introduction Insomnia is associated with increased risk for Alzheimer's disease (AD). It is unknown how cognitive behavioral therapy for insomnia (CBT-I) impacts two hallmarks of AD progression, cognitive performance and beta-amyloid (Aβ)…

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Negative / Null Result ReportMedicine

Posttraumatic growth and health-related quality of life in cancer survivors: Does fatigue moderate the link?

Onyedibe MC, Blickle P, Schmidt ME et al. · 2024 · Stress and health : journal of the International Society for the Investigation of Stress

Interest in post-traumatic growth (PTG) as a predictor of health-related quality of life (HRQoL) is currently gaining attention. However, current evidence is still inconclusive on the nature of this relationship. The first objective of…

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Negative / Null Result ReportOpen accessMedicine

Exploring the impact of virtual reality anatomy training on preparing biomedical illustrators for drawing anatomical structures.

Cheung HCK, Zhong LS, Wall SL et al. · 2026 · Anatomical sciences education

Three-dimensional visualization technologies (3DVTs) in anatomy education are popular as they offer a cost-effective and accessible alternative to cadaveric specimens. However, the literature presents conflicting results regarding the…

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Negative / Null Result ReportOpen accessMedicine

Instructing participants about the random assignment of patients to treated and non-treated conditions does not diminish causal illusions.

Barreiro A, Rodríguez-Ferreiro J, Barberia I · 2025 · Royal Society open science

People sometimes perceive causal relationships between non-contingent events. When having to assess the contingency between a putative cause and an outcome, it is vital to ensure that all other causal forces are held constant whether the…

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Negative / Null Result ReportOpen accessMedicine

Risk Factors for Endoscopic Gastric Mucosal Lesions: Analysis of Lifestyle, Dietary, and Clinical Determinants in 361 Patients.

Chiciudean PL, Filip AM, Munteanu SN et al. · 2025 · Life (Basel, Switzerland)

Background/objectives Gastric mucosal lesions represent a significant health burden, with Helicobacter pylori infection being the primary cause of chronic gastritis worldwide. However, the role of modifiable lifestyle factors in modulating…

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Negative / Null Result ReportOpen accessMedicine

Tipping the scale: Effects of physical activity and body composition on cardiac parameters in postmenopausal females.

Fischer M, Tamariz-Ellemann A, Egelund J et al. · 2024 · Physiological reports

The risk of cardiovascular disease increases significantly after menopause. We sought to assess the impact of different activity levels on cardiac structure and function in postmenopausal women. We grouped age-similar, postmenopausal women…

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Negative / Null Result ReportMedicine

The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral myeloid cells.

Caetano-Silva ME, Rund L, Vailati-Riboni M et al. · 2024 · Brain, behavior, and immunity

Gut inflammation can trigger neuroinflammation and is linked to mood disorders. Microbiota-derived short-chain fatty acids (SCFAs) can modulate microglia, yet the mechanism remains elusive. Since microglia do not express free-fatty acid…

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Negative / Null Result ReportMedicine

Chronic estrogen supplementation in the aging castrated male rat is not associated with renal injury or activation of the renin angiotensin system.

Mallette JH, Crudup BF, Oudomrath Speyrer A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

The biological effects of chronic estrogen supplementation on renal function and injury with aging in men are unknown. Using an experimental model of feminizing hormone therapy (FHT) induced by 17β-estradiol (E2) (5 mg/kg sc)…

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Negative / Null Result ReportOpen accessMedicine

Participants with restricted dominant shoulder internal rotation range of motion demonstrate no side-to-side difference in humeral head translation; and no difference before and after joint mobilization: a pilot study.

Hoops JF, Hooper TL, Sobczak S et al. · 2024 · Journal of physical therapy science

[Purpose] To compare humeral head translation (HHT) during shoulder elevation between dominant and non-dominant shoulders in participants with limited dominant shoulder internal rotation range of motion (ROM). To determine if joint…

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Negative / Null Result ReportOpen accessMedicine

Error-related potentials during multitasking involving sensorimotor control: an ERP and offline decoding study for brain-computer interface.

Yasuhara M, Nambu I · 2025 · Frontiers in human neuroscience

Humans achieve efficient behaviors by perceiving and responding to errors. Error-related potentials (ErrPs) are electrophysiological responses that occur upon perceiving errors. Leveraging ErrPs to improve the accuracy of brain-computer…

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Negative / Null Result ReportMedicine

The liver-heart axis in patients with severe obesity: The association between liver fibrosis and chronic myocardial injury may be explained by shared risk factors of cardiovascular disease.

Young J, Seeberg KA, Aakre KM et al. · 2024 · Clinical biochemistry

Background Severe obesity is associated with increased risk of non-alcoholic fatty liver disease and cardiovascular disease. We hypothesized that liver fibrosis as quantified by the Enhanced Liver Fibrosis (ELF) test would be predictive of…

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Negative / Null Result ReportOpen accessMedicine

Re-evaluating heart rate variability biomarkers for glucose sensing: the impact of age normalisation and subject-independent validation.

Azam MB, Singh SI · 2026 · BMC medical informatics and decision making

Background Heart rate variability (HRV) derived from electrocardiogram (ECG) signals offers a promising non-invasive window into glycemic status; however, existing studies frequently combine distinct glucose measurements and employ…

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Negative / Null Result ReportMedicine

Salsalate negatively impacts microvascular function in women with endometriosis.

Williams AC, Content VG, Alexander LM · 2025 · American journal of physiology. Heart and circulatory physiology

Women with endometriosis, an inflammatory disease, are at increased risk of cardiovascular disease and demonstrate impaired microvascular endothelial function, characterized by reduced nitric oxide (NO)-mediated vasodilation. In some…

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Negative / Null Result ReportOpen accessMedicine

Relationship between survival outcomes in patients with colorectal liver metastasis undergoing hepatectomy and significance of fibrotic markers for liver injury assessment.

Nanashima A, Hiyoshi M, Imamura N et al. · 2025 · Translational cancer research

Background Progression of chronic liver dysfunction influenced by long-term chemotherapy or repeated hepatectomy might be related to patient overall survival as well as tumor factors in colorectal liver metastasis (CLM) patients. Our aim…

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