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Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Nurse Practitioner Opioid Prescribing Authority: A Comparative Policy Analysis of New Zealand, United States, and Australia.

Kyei EF, Kyei GK, Forson MM et al. · 2026 · Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing

Aim To examine nurse practitioner opioid prescribing authority across three countries, analyzing safety outcomes, workforce distribution patterns, access equity, and service to vulnerable populations using integrated nursing policy and…

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Negative / Null Result ReportOpen accessMedicine

Sport Participation and Nutrition in Students: A Scoping Review of Neuroendocrine and Autonomic Mechanisms Linking Lifestyle Behaviors to Cognitive and Academic Outcomes.

Tafuri MG, Monda V, La Marra M et al. · 2026 · Nutrients

Background/Objectives: Sport participation and nutrition are increasingly recognized as key determinants of cognitive function and academic achievement in student populations. However, the biological mechanisms underpinning these…

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Negative / Null Result ReportMedicine

From Framework to Practice: Evaluating the Uptake of Sensitivity Analyses in The National Institute for Health and Care Excellence Real-World External Control Arm Evidence.

Leahy TP, Keenan C, Robertshaw E et al. · 2026 · Value in health regional issues

Objectives Growing reliance on single-arm trials (SATs) is driving increased real-world external control arm (RW-ECA) use in health technology assessment submissions. However, concerns over residual confounding and unmeasured bias often…

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Methods Dead-EndMedicine

Mapping gaps in CBCT-based evidence of external apical root resorption following orthognathic surgery: a scoping review.

Kanpittaya P, Nantanee R, Fakhruddin KS et al. · 2026 · International journal of oral and maxillofacial surgery

External apical root resorption (EARR) is a recognized adverse outcome of orthodontic treatment that may also be influenced by orthognathic surgery. However, the body of evidence on this combined effect is nascent and has not been mapped.…

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Negative / Null Result ReportMedicine

Phytotherapies and complementary therapies for erectile dysfunction: A focused secondary synthesis and critical clinical interpretation of the AFU/SFMS evidence base.

Lebâcle C, Kassab D, Faix A et al. · 2026 · The French journal of urology

Objectives To provide a focused secondary synthesis and critical clinical interpretation of the AFU/SFMS evidence base on phytotherapies and complementary therapies for erectile dysfunction (ED). Evidence acquisition The parent AFU/SFMS…

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Failed Experiment ReportMedicine

H3K27M-mutant diffuse midline glioma pharmacotherapy: Clinical evidence and practice implications of dordaviprone.

Nuss ZJ, DeYoung C, Gross D · 2026 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

ObjectiveTo evaluate current pharmacotherapeutic strategies for H3 K27M-mutant diffuse midline glioma (DMG), with emphasis on the clinical evidence for dordaviprone, its place in therapy, and its implications for oncology practice.Study…

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Failed Experiment ReportMedicine

Internet Promotion of Orthobiologics by the American Association of Hip and Knee Surgeons Members: Claims Versus Evidence in Patient-Facing Websites.

Bellissimo J, Hall B, Hali K et al. · 2026 · The Journal of arthroplasty

Background Orthobiologic therapies such as platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and hyaluronic acid (HA) are increasingly offered for orthopaedic conditions, but their online promotion may not accurately…

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Negative / Null Result ReportMedicine

EFFECTS OF GLP-1 RECEPTOR AGONISTS ON PERIODONTAL TISSUE: AN INTERDISCIPLINARY EVIDENCE MAPPING - SCOPING REVIEW.

Henriques JP, Weckwerth AVB, Santana ACP et al. · 2026 · Annales pharmaceutiques francaises

Objectives Diabetes mellitus and periodontal disease are highly prevalent chronic disorders linked by bidirectional inflammatory and oxidative pathways. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are emerging pharmacologic agents…

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Negative / Null Result ReportOpen accessMedicine

Association of ischaemic stroke/TIA with subsequent oral anticoagulant adherence in patients with atrial fibrillation: a scoping review.

Shukkoor AA, Turgeon RD, De Vera MA et al. · 2026 · BMJ open

Objectives This study aimed to investigate the association and potential causal relationship between ischaemic stroke/transient ischaemic attack (TIA) and oral anticoagulant (OAC) adherence using Bradford Hill's criteria and to determine…

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Negative / Null Result ReportOpen accessMedicine

Initiatives to support nursing workforce sustainability: A rapid umbrella review.

Tomblin Murphy G, Sampalli T, Elliott Rose A et al. · 2026 · International journal of nursing studies advances

Introduction Despite the global shortage of nurses, there is limited literature that comprehensively maps interventions to support, stabilize, and enhance the nursing workforce. Purpose This umbrella review aimed to identify structures,…

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Negative / Null Result ReportMedicine

Topical immunosuppressants for blepharitis in adults.

Kam KW, Mehraban Far P, Yim TW et al. · 2026 · The Cochrane database of systematic reviews

Rationale Blepharitis is a common ocular condition characterized by inflammation of the eyelid margins, which can cause irritating symptoms and ocular surface damage. Conventional treatment of blepharitis consists of eyelid hygiene and…

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Negative / Null Result ReportMedicine

Advanced sperm selection techniques for assisted reproduction.

Garg A, Nakhla O, Steeper M et al. · 2026 · The Cochrane database of systematic reviews

Rationale Assisted reproductive technologies (ART), including in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), combine an egg and sperm outside the body to enhance the probability of fertilisation and pregnancy.…

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Failed Experiment ReportMedicine

Value-based decision-making and behavioral economic constructs that distinguish people with and without cannabis use history.

Taylor AJ, Miller BP, Copeland A · 2026 · Journal of the experimental analysis of behavior

Behavioral economic accounts posit that distorted valuation processes underlie cannabis decisions; however, less is known about the moment-to-moment dynamics through which value influences observable choice behavior. This study explored…

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Replication FailureMedicine

Clinical practice recommendations for the management of Alport syndrome: a joint statement of the Korean Society of Nephrology and the Korean Society of Pediatric Nephrology.

Kim JH, Hwang YH, Kang E et al. · 2026 · Kidney research and clinical practice

Background Alport syndrome (AS) is a hereditary kidney disorder characterized by progressive hematuria, proteinuria, and kidney failure, frequently accompanied by hearing loss and ocular abnormalities. Although blockade of the…

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Replication FailureMedicine

Botulinum toxin type A for subacute/chronic neck pain.

Gross AR, Lee H, Chacko N et al. · 2026 · The Cochrane database of systematic reviews

Rationale Botulinum toxin type A (BoNT-A) intramuscular injections are commonly administered for neck pain unresponsive to other therapies, but the benefit-harm profile remains uncertain. Objectives To assess the benefits and harms of…

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