12,251 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Puli L, Kooijman L, Kanij T et al. · 2026 · Journal of medical Internet research
Background Routine financial activities are now conducted primarily through digital channels. Many such systems remain inaccessible to more than 2.2 billion people globally living with vision impairment, limiting independent financial…
View details →Sheldrick RC, Hooker JL, Davignon M et al. · 2026 · Academic pediatrics
Objectives We used real-world evidence to estimate the accuracy of autism screening questionnaires, including sensitivity, specificity, and predictive probabilities for positive results and for individual screening scores. Study design…
View details →Zaher F, Ahrens J, Raucher-Chéné D et al. · 2026 · Bipolar disorders
Clinicians aspire to predict the emergence of Bipolar Disorder (BD) in a timely manner. To accomplish this, markers reflecting mental states that can be gathered non-invasively and at large scale are needed. Here, we systematically…
View details →Nuss ZJ, DeYoung C, Gross D · 2026 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
ObjectiveTo evaluate current pharmacotherapeutic strategies for H3 K27M-mutant diffuse midline glioma (DMG), with emphasis on the clinical evidence for dordaviprone, its place in therapy, and its implications for oncology practice.Study…
View details →Bellissimo J, Hall B, Hali K et al. · 2026 · The Journal of arthroplasty
Background Orthobiologic therapies such as platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and hyaluronic acid (HA) are increasingly offered for orthopaedic conditions, but their online promotion may not accurately…
View details →La Vignera S, Condorelli RA · 2026 · International journal of molecular sciences
Incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1 RAs), have emerged as potentially promising therapeutic agents for improving ovarian function, especially in women with polycystic ovary syndrome…
View details →Luo X, Wang B, Liu H et al. · 2026 · Integrative medicine research
Background Atopic dermatitis (AD) is a common chronic inflammatory skin disorder with substantial global burden. In some regions, Chinese medicine (CM) and integrated Chinese-Western medicine (ICWM) are widely used, but the overall…
View details →Henriques JP, Weckwerth AVB, Santana ACP et al. · 2026 · Annales pharmaceutiques francaises
Objectives Diabetes mellitus and periodontal disease are highly prevalent chronic disorders linked by bidirectional inflammatory and oxidative pathways. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are emerging pharmacologic agents…
View details →Shukkoor AA, Turgeon RD, De Vera MA et al. · 2026 · BMJ open
Objectives This study aimed to investigate the association and potential causal relationship between ischaemic stroke/transient ischaemic attack (TIA) and oral anticoagulant (OAC) adherence using Bradford Hill's criteria and to determine…
View details →Mohamed D, Ramadan AA, Mabrok HB et al. · 2026 · World journal of biological chemistry
Phytosterols are plant-derived sterols structurally similar to cholesterol and present in vegetable oils, seeds, legumes, and whole grains. Their best-established health effect is lowering circulating low-density lipoprotein cholesterol,…
View details →Lande-Brenner A, Ecker UKH, Mayo R · 2026 · Scientific reports
This research demonstrates that citing scientific sources to correct disinformation can be ineffective or even counterproductive, and offers a potential remedy. Three experiments simulated a WhatsApp conversation about COVID-19 vaccine…
View details →Gallardo LM · 2026 · The American journal of clinical hypnosis
Age regression represents a foundational technique in clinical hypnosis, yet its therapeutic mechanisms, clinical applications, and evidence base remain incompletely understood and subject to ongoing controversy. This integrative critical…
View details →Tomblin Murphy G, Sampalli T, Elliott Rose A et al. · 2026 · International journal of nursing studies advances
Introduction Despite the global shortage of nurses, there is limited literature that comprehensively maps interventions to support, stabilize, and enhance the nursing workforce. Purpose This umbrella review aimed to identify structures,…
View details →Kam KW, Mehraban Far P, Yim TW et al. · 2026 · The Cochrane database of systematic reviews
Rationale Blepharitis is a common ocular condition characterized by inflammation of the eyelid margins, which can cause irritating symptoms and ocular surface damage. Conventional treatment of blepharitis consists of eyelid hygiene and…
View details →Garg A, Nakhla O, Steeper M et al. · 2026 · The Cochrane database of systematic reviews
Rationale Assisted reproductive technologies (ART), including in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), combine an egg and sperm outside the body to enhance the probability of fertilisation and pregnancy.…
View details →Weber I, Whelan BM, Bruce JM et al. · 2026 · Sports health
Context There is significant interest in jugular venous compression (JVC) devices from multiple parties, including sports physicians, athletic trainers, athletes, and parents. Objective To examine the effects of JVC on repetitive head…
View details →· 2026 · Journal of cellular and molecular medicine
Retraction Z. Li and B. M. Pützer, "Spliceosomal Protein E Regulates Neoplastic Cell Growth by Modulating Expression of Cyclin E/CDK2 and G2/M Checkpoint Proteins," Journal of Cellular and Molecular Medicine 12, no. 6a (2008): 2427-2438.…
View details →Taylor AJ, Miller BP, Copeland A · 2026 · Journal of the experimental analysis of behavior
Behavioral economic accounts posit that distorted valuation processes underlie cannabis decisions; however, less is known about the moment-to-moment dynamics through which value influences observable choice behavior. This study explored…
View details →Kim JH, Hwang YH, Kang E et al. · 2026 · Kidney research and clinical practice
Background Alport syndrome (AS) is a hereditary kidney disorder characterized by progressive hematuria, proteinuria, and kidney failure, frequently accompanied by hearing loss and ocular abnormalities. Although blockade of the…
View details →Gross AR, Lee H, Chacko N et al. · 2026 · The Cochrane database of systematic reviews
Rationale Botulinum toxin type A (BoNT-A) intramuscular injections are commonly administered for neck pain unresponsive to other therapies, but the benefit-harm profile remains uncertain. Objectives To assess the benefits and harms of…
View details →Mehta V, Galletti C, Mathur A et al. · 2026 · Systematic reviews
Background Oral candidiasis (OC) is among the most prevalent oral infections, frequently associated with immunosuppression, denture wearing, advanced age, and excessive antibiotic use. Given the growing concerns about antifungal…
View details →Wu X, Zhang B, Yu M et al. · 2026 · Photodiagnosis and photodynamic therapy
Repeated low-level red-light therapy (RLRL) has emerged as a promising ocular photobiomodulation strategy for childhood myopia control. Published randomized trials have reported substantial reductions in axial elongation and refractive…
View details →Anarna K, Fiander M, Mitra S · 2026 · The Cochrane database of systematic reviews
Rationale Preterm and low-birthweight infants are at risk of anemia due to a variety of factors, including low levels of erythropoietin. They may therefore benefit from erythropoiesis-stimulating agents (ESAs). However, controversy remains…
View details →He Z, Yang L, Liang Z et al. · 2026 · NPJ digital medicine
Large language models (LLMs) are being deployed in clinical settings despite an underdeveloped evidence base regarding their real-world effectiveness. This study employed systematic evidence mapping to characterize outcome measures used in…
View details →Ordóñez-Riaño S, Jiménez-Leal W · 2026 · Acta psychologica
What motivates people to place trust in strangers-the sense that they ought to trust, or the feeling that they want to? Competing perspectives suggest that trust may be driven either by obligations or by desires. In two studies, we tested…
View details →De Laet H, Nijhof AD, Wiersema JR · 2026 · Autism : the international journal of research and practice
While prevailing theories suggest social interaction difficulties are inherent to autism, the theory of the double empathy problem (DEP) proposes these difficulties arise from a mismatch between different neurotypes. The theory predicts…
View details →Kiang M, Lepock JR, Mizrahi R et al. · 2026 · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
Objectives Patients at clinical high risk (CHR) for schizophrenia experience a wide range of clinical outcomes. Given this heterogeneity, long-term prognostic biomarkers are needed. The gamma-frequency EEG auditory steady-state response…
View details →Csigai P, Sparrow L, Maquet L et al. · 2026 · Scientific reports
Resting heart rate variability (HRV) is considered a marker of individuals' capacity to adapt to environmental demands, although direct empirical evidence remains limited. This study examined whether resting HRV predicts subjective and…
View details →Werle D, Sablottny L, Tuschen-Caffier B et al. · 2026 · Appetite
While the hierarchical model of approach-avoidance motivation suggests a heightened food-specific approach behavior for individuals with binge eating disorder (BED), empirical evidence does not confirm the postulated food approach bias.…
View details →Flint RW Jr, Morehouse J, Chown AE et al. · 2026 · Psychological reports
Long-term reactivated memories undergo a time-dependent reconsolidation process during which they are susceptible to modulation. We report the results of an experiment examining the effect of multiple reminder treatments on reconsolidation…
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