12,251 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Stewart JJ, Allen BS, Polutchko SK et al. · 2026 · Journal of experimental botany
Refilling of xylem embolism during recovery from drought has been studied for decades, although the legitimacy of supporting evidence has been debated in recent years due to potentially widespread methodological artifacts associated with…
View details →van der Steege AE, Humuza J, Shyirambere C et al. · 2026 · BMJ global health
Introduction The WHO Model Lists of Essential Medicines (MLEM and MLEMc) guide national medicine selection, particularly in low-income and lower middle-income countries (LMICs). Concerns exist about the adequacy and transferability of…
View details →Ganguly A, Bhowmik S, Hajra A · 2026 · Therapeutic hypothermia and temperature management
Shivering is a common complication of targeted temperature management (TTM), which could undermine its neuroprotective benefits by increasing cerebral oxygen consumption and metabolic demand. Buspirone, a 5-HT1A receptor partial agonist,…
View details →Simone J, Cooke C, Lee S et al. · 2026 · Sexually transmitted infections
Congenital syphilis (CS) has been rapidly re-emerging as a public health crisis across North America. The present standard of care treatment for CS involves a 10-day hospitalisation for intravenous penicillin G, which is costly for…
View details →Jin X, Shen T, Wang Y et al. · 2026 · JBI evidence implementation
Introduction Auditory hallucinations, persistent and distressing symptoms in patients with schizophrenia, are often poorly controlled by antipsychotics. Structured non-pharmacological interventions remain limited in routine clinical…
View details →Black CFD, Phillips C, Sanders IA et al. · 2026 · Child maltreatment
It is unclear whether research has generated causal evidence about the impact of mandatory reporting (MR) policies on reporting outcomes. This scoping review applied concepts from the NIH Stage Model to map and organize five decades of…
View details →Gao Y, Liu M, Li L et al. · 2026 · The Cochrane database of systematic reviews
Background Triple-negative breast cancer (TNBC), an aggressive subtype lacking oestrogen and progesterone receptors and amplification of HER2 receptors, accounts for 12% to 17% of breast cancers. Adjuvant and neoadjuvant chemotherapy…
View details →Brock AS · 2026 · American journal of speech-language pathology
Purpose The objective of this review article is to examine and describe the literature on training speech-language pathology students on the principles of evidence-based practice (EBP). Method A scoping literature review was undertaken in…
View details →Yao S, Xu L · 2026 · Frontiers in medicine
Background Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast disease characterized by a prolonged clinical course with recurrent episodes, and the optimal treatment remains controversial. Multiple systematic…
View details →Riestra-Ayora J, Fernández-Navarro C, Martín-Sanz E et al. · 2026 · Diving and hyperbaric medicine
Introduction Fitness-to-dive after otologic surgery is often approached conservatively, with some procedures historically labelled as absolute contraindications despite limited empirical evidence. The available literature is heterogeneous…
View details →De Santis KK, Matthias K, Nikoyan K et al. · 2026 · Journal of prevention (2022)
Cochrane reviews provide high-quality evidence syntheses. To guide the production and dissemination of new Cochrane reviews, an evidence map based on the characteristics of existing reviews is necessary. This study is a scoping review that…
View details →Yang M, Lovrenert K, Thirumavalavan N et al. · 2026 · Basic and clinical andrology
Background Male infertility affects approximately 10% of men globally, yet approximately 70% of cases lack a definitive genetic diagnosis. Next-generation sequencing has identified numerous monogenic causes, many of which are linked to…
View details →Hu JX, Wen Q, Zhou H et al. · 2026 · Geriatric nursing (New York, N.Y.)
Objective To systematically synthesize the best available evidence on nonpharmacological interventions in traditional Chinese medicine (TCM) for cognitive impairment in patients with Alzheimer's disease (AD). Methods Guided by the "6S"…
View details →Belančić A, Rogoznica Pavlović M, Fajkić A et al. · 2026 · Rheumatology international
Obstructive sleep apnoea (OSA) and spondyloarthritis (SpA) are chronic inflammatory disorders associated with substantial cardiometabolic morbidity and impaired quality of life. Increasing evidence suggests that these conditions frequently…
View details →Gopinath D, On CY, Veettil SK et al. · 2026 · Oral diseases
Background The cumulative evidence from meta-analyses on interventions for oral submucous fibrosis (OSF) remains uncertain in terms of strength, precision, and quality. This umbrella review synthesizes the current evidence on available…
View details →Qiu F, Ling C, Wang S et al. · 2026 · Molecules (Basel, Switzerland)
Mulberrofuran A (MFA), a natural product originally isolated from the root bark of Morus alba L. (Sang-Bai-Pi), is a structurally distinctive mulberry-derived 2-arylbenzofuran bearing a prenyl-related side chain. Although MFA has attracted…
View details →Chauhan V, Goyal D, Thakur S et al. · 2026 · The western journal of emergency medicine
Introduction Organophosphate (OP) poisoning is a significant global health issue, particularly in tropical regions. Despite established treatments such as atropine and oximes, the effectiveness of other interventions remains uncertain.…
View details →Gazit N, Ben-Gal G, Eliashar R · 2026 · JMIR medical education
Background Assessment of technical aptitude, cognitive abilities, and personality characteristics is important in selecting candidates for surgical training. Currently, the selection of surgical training candidates does not systematically…
View details →Du Y, Xu Z, Wen T et al. · 2026 · Diabetes, metabolic syndrome and obesity : targets and therapy
Purpose The care of diabetic foot ulcers (DFU) continues to be a notable clinical challenge. The efficacy and safety of stem cell therapies versus conventional treatments for DFU are debated. Cross-sectional analyses of meta-analyses…
View details →Zhang Y, Wu Z · 2026 · Frontiers in public health
Background Digital technologies in oncology require patients and health workers to possess adequate electronic health literacy (eHealth literacy). Yet, the extent to which this literacy influences cancer-specific insights, ranging from…
View details →Hou YN, Gubili J, Mao JJ · 2026 · Seminars in radiation oncology
Studies show that patients with cancer use herbal products more often than the general population. Lowering the risk of disease recurrence, symptom control, and improving quality of life are often the reasons cited for such use. However, a…
View details →Kyei EF, Kyei GK, Forson MM et al. · 2026 · Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing
Aim To examine nurse practitioner opioid prescribing authority across three countries, analyzing safety outcomes, workforce distribution patterns, access equity, and service to vulnerable populations using integrated nursing policy and…
View details →Tafuri MG, Monda V, La Marra M et al. · 2026 · Nutrients
Background/Objectives: Sport participation and nutrition are increasingly recognized as key determinants of cognitive function and academic achievement in student populations. However, the biological mechanisms underpinning these…
View details →Leahy TP, Keenan C, Robertshaw E et al. · 2026 · Value in health regional issues
Objectives Growing reliance on single-arm trials (SATs) is driving increased real-world external control arm (RW-ECA) use in health technology assessment submissions. However, concerns over residual confounding and unmeasured bias often…
View details →Kanpittaya P, Nantanee R, Fakhruddin KS et al. · 2026 · International journal of oral and maxillofacial surgery
External apical root resorption (EARR) is a recognized adverse outcome of orthodontic treatment that may also be influenced by orthognathic surgery. However, the body of evidence on this combined effect is nascent and has not been mapped.…
View details →Lebâcle C, Kassab D, Faix A et al. · 2026 · The French journal of urology
Objectives To provide a focused secondary synthesis and critical clinical interpretation of the AFU/SFMS evidence base on phytotherapies and complementary therapies for erectile dysfunction (ED). Evidence acquisition The parent AFU/SFMS…
View details →Maisch P, Hamidi Madani M, Koziarz A et al. · 2026 · The Cochrane database of systematic reviews
Rationale Disease recurrence and progression remain major challenges in the treatment of non-muscle invasive bladder cancer (NMIBC). Blue light-enhanced transurethral resection of bladder cancer (TURBT) is an approach to improve staging…
View details →Shao F, Han Z, Su Q et al. · 2026 · JMIR serious games
Background Serious games (SGs) have emerged as a promising tool in nursing education, providing interactive learning environments for clinical simulation, skill development, and feedback. These games enhance knowledge, clinical reasoning,…
View details →Cai M, Lai W, Peng W et al. · 2026 · BMC oral health
Background Diabetes Mellitus (DM) is a global metabolic disorder affecting 537 million adults. Periodontitis stands as its sixth major complication and shares a bidirectional relationship with diabetes, whereby each condition exacerbates…
View details →Angelucci F, Cerman J, Amlerova J et al. · 2026 · Degenerative neurological and neuromuscular disease
Spermidine is a naturally occurring polyamine involved in multiple cellular processes, including growth regulation, protein translation, and autophagy. Increasing attention has been devoted to its potential neuroprotective effects,…
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