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WASTE Journal

Browse the failure-mode index

12,250 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Comparison of the Effects of Intranasal and Oral Midazolam Premedication on Sedation and Separation From Parents for Pediatric Patients.

Metin Yamac D, Erguven N, Ozenc E · 2026 · Anesthesiology research and practice

Aim The aim of this study is to compare the effect of intranasal and oral midazolam administered for premedication to children of preschool age on hemodynamic parameters, sedation, and separation from parents. Method A prospective,…

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Negative / Null Result ReportMedicine

Electromyographic and Handheld Dynamometry Assessment of Lumbo-Abdominal Function in Elite Acrobatic Military Parachutists: An Exploratory Cross-Sectional Study.

Reina Abellán J, Bonato F, Ángel García D · 2026 · Military medicine

Background Elite acrobatic military parachutists are exposed to extreme repetitive axial loads and high gravitational forces, and low back pain (LBP) is common; however, the relationship between LBP and trunk neuromuscular function in this…

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Negative / Null Result ReportMedicine

A randomised controlled trial comparing effectiveness of audio-visual aid and ai-personalised video self-modelling interventions to reduce dental fear and anxiety in paediatric patients.

Tasgaonkar A, Rathi N, Tasgaonkar M et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

Purpose Paediatric dental anxiety remains a significant challenge in clinical practice, often impacting co-operation and treatment outcomes. This randomised controlled trial compares the anxiety-reducing effects of AI-based self-modelling…

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Negative / Null Result ReportOpen accessMedicine

Translating Evidence into Obstetric Care: Developing a Best Practice-Informed Stepped-Care Clinical Algorithm for the Management of Gestational Insomnia.

Zhao FY, Yue LP, Ho YS et al. · 2026 · Nature and science of sleep

Background and aims Insomnia during pregnancy is potentially associated with adverse outcomes, including gestational diabetes mellitus, pre-eclampsia, cesarean delivery, preterm birth, and depression. This study aimed to synthesize…

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Negative / Null Result ReportMedicine

Electroacupuncture for essential hypertension: Mechanistic insights, current clinical evidence, and translational challenges.

Zhou Y, Qin S, Ma Y · 2026 · Clinical and experimental hypertension (New York, N.Y. : 1993)

Background Essential hypertension (EH) remains a leading modifiable risk factor for cardiovascular morbidity and mortality worldwide. Electroacupuncture (EA), combining traditional acupuncture with pulsed electrical stimulation at specific…

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Negative / Null Result ReportOpen accessMedicine

Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine-Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms.

Sun Y, Yang X, Zhu Q et al. · 2026 · Drug design, development and therapy

Autoimmune thyroiditis (AIT) is a chronic immune-mediated thyroid disorder characterized by lymphocytic infiltration, follicular epithelial injury, autoantibody production, and variable progression to thyroid dysfunction. Because current…

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Failed Experiment ReportMedicine

Automated tools for evidence quality assessment: a scoping review.

Huang J, Deng X, Zhou L et al. · 2026 · BMC medical research methodology

Background Evidence quality assessment is critical for informed public health decision-making, but manual approaches are time-consuming and subject to variability. Automated support tools have been proposed to improve efficiency and…

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Negative / Null Result ReportMedicine

Why evidence struggles to shape musculoskeletal health care and surgical practice in Australia: insights from an Australian clinician survey.

Yu J, Eyles JP, Moreti Cabral Silveira A et al. · 2026 · BMC health services research

Background Evidence based medicine is a critical cornerstone in contemporary medicine, yet uptake and adoption of evidence remain suboptimal. This is prominent in many fields of healthcare, including musculoskeletal health and surgery.…

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Abandoned HypothesisMedicine

Iridology: Biological plausibility, clinical evidence, and implications for ophthalmic practice : A position paper of the Associazione Pazienti Malattie Oculari (APMO).

Iuliano L, Veritti D, Lanzetta P · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Iridology is an alternative diagnostic practice that claims to identify systemic diseases and organ dysfunction through visual inspection of iris features, including pigmentation patterns, crypts, furrows, and discolorations. Despite its…

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Methods Dead-EndMedicine

Certainty of Evidence and Procedural Durability of Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: An Umbrella Review of Meta-Analyses.

Simão AC, de Oliveira MBG, Menezes Junior ADS · 2026 · Cardiology

Introduction This umbrella review aims to evaluate the certainty and consistency of the available evidence rather than to provide a new procedural comparison. We combined systematic reviews that looked at surgical septal myectomy (SM) and…

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Failed Experiment ReportMedicine

NICU Nurses' Attitudes Toward Adopting an Evidence-Based Practice Intervention to Improve Bone Mineralization in Preterm Infants.

Melendez Vassall I, Mannino JE, Watters P et al. · 2026 · Advances in neonatal care : official journal of the National Association of Neonatal Nurses

Metabolic bone disease (MBD) is a disorder affecting bone mineralization that leads to short and long-term consequences. A daily exercise regimen consisting of passive range of motion (ROM) and gentle compression of upper and lower…

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Failed Experiment ReportMedicine

Pharmacotherapy for post traumatic stress disorder (PTSD).

Williams T, Phillips NJ, Stein DJ et al. · 2026 · The Cochrane database of systematic reviews

Background Posttraumatic stress disorder (PTSD) is a prevalent and disabling disorder. Evidence that PTSD is characterised by specific psychobiological dysfunctions has contributed to a growing interest in the use of medication in its…

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Negative / Null Result ReportOpen accessMedicine

Evaluating the Innovator Training Program: Strengthening Evidence-Based Practice and Building Implementation Capability in the Australian Aged Care Workforce.

Champion S, Bilton R, Gordon S · 2026 · Australasian journal on ageing

Objectives This study evaluated the outcomes for individuals who completed an Innovator Training Program (ITP) funded by the Commonwealth Government of Australia and delivered by Aged Care Research & Industry Innovation Australia (ARIIA).…

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Failed Experiment ReportOpen accessMedicine

Joint Clinical Assessment in the EU HTA Regulation-Would Drugs Supported by Single-Arm Trials Fit Under Evaluation?

Kloc K, Toumi M, Łukomska E et al. · 2026 · Journal of market access & health policy

The Joint Clinical Assessment (JCA) evaluates the relative effectiveness (RE) of interventions over comparators. While randomised control trials (RCTs) are considered the gold standard, single-arm trials (SATs) require an external control…

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Methods Dead-EndOpen accessMedicine

The Six R's of Management Reasoning for Subintern Education.

Maldonado M, Boedeker P, Kusnoor AV · 2026 · The clinical teacher

Background Management reasoning (MR), the component of clinical reasoning concerned with treatment planning, patient preferences and resource considerations, develops later than diagnostic reasoning and remains underemphasised in medical…

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Abandoned HypothesisOpen accessMedicine

Intrawound vancomycin powder in orthopaedic surgery after the VPIP trial: a critical reappraisal of efficacy, dosing, application plane, and antimicrobial stewardship.

Werneburg F, Zeh A, Gutteck N et al. · 2026 · Journal of bone and joint infection

Topical intrawound vancomycin powder has been widely adopted in orthopaedic surgery as an adjunct for the prevention of surgical site infection (SSI) and periprosthetic joint infection (PJI). Retrospective cohorts and derived meta-analyses…

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Negative / Null Result ReportMedicine

Vitamin B12 supplementation for growth, development, and cognition in children.

Larvie DY, Güitrón Leal CE, Venkatramanan S et al. · 2026 · The Cochrane database of systematic reviews

Rationale Vitamin B 12 deficiency is an important public health problem in children, and has been associated with anaemia and impaired growth, cognition, and development. Vitamin B 12 deficiency may develop in children due to lower content…

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Negative / Null Result ReportMedicine

Assessing the foundations of forensic identification evidence: A critical examination of proficiency test design and results.

Scurich N, Albright TD · 2026 · Proceedings of the National Academy of Sciences of the United States of America

Proficiency testing is widely used to assess expertise in medicine, engineering, and other high-stakes fields. In forensic science, such tests are often cited in court as evidence that pattern-comparison methods are accurate and reliable.…

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