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WASTE Journal

Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

IL-6 and TNFα are associated with depressive symptoms among men in a community-based cohort, with a tentative trend for IL-17A: Findings from the Shika Study in Japan.

Tsuboi H, Sakakibara H, Minamida-Urata Y et al. · 2026 · Neuro endocrinology letters

Objective Emerging evidence suggests that low-grade systemic inflammation contributes to depressive symptoms; however, population-based longitudinal evidence, particularly from community samples, remains limited. This study examined the…

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Negative / Null Result ReportMedicine

Outcomes of extremely preterm infants with neonatal hyperglycemia and hypernatremia: a retrospective cohort study.

Fursule A, Athalye-Jape G, Deepak D et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective To assess whether early hypernatremia (HN) and/or hyperglycemia (HG) in the first postnatal week are associated with adverse neurodevelopmental outcomes in extremely preterm (EP; Study design This was a single-center…

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Negative / Null Result ReportMedicine

Association between platelet indices and next-day bleeding and clotting in children and adults on extracorporeal membrane oxygenation: A retrospective study.

Chegondi M, Jawahar A, Badheka A et al. · 2026 · Perfusion

IntroductionBleeding and clotting phenotypes are common in patients supported with Extracorporeal Membrane Oxygenation (ECMO) and are associated with increased mortality. However, tools to distinguish bleeding from clotting phenotypes…

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Negative / Null Result ReportMedicine

Subclinical malaria in sickle cell disease in Northern Uganda: prevalence, predictors, and hematologic impact.

Matejak NJ, Ngolobe H, O'Connell CT et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Sickle Cell Disease (SCD), characterized by persistently low hemoglobin (Hb) and hematocrit levels, is among the leading causes of under-five mortality in high prevalence countries. Sub-Saharan Africa bears the highest burden of…

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Negative / Null Result ReportMedicine

Associations between attitudes and beliefs about the role of nutrition and diet quality with pain interference and physical function.

Fredhoff B, Bernstetter A, Fotiou H et al. · 2026 · Complementary therapies in clinical practice

Background and purpose Nutrition likely influences pain, but the role of patient beliefs remains understudied in musculoskeletal conditions. This study examined whether beliefs about the role of nutrition in pain, diet quality, and eating…

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Failed Experiment ReportMedicine

Effectiveness of chlorhexidine gluconate-impregnated dressings in preventing central line-associated bloodstream infection in a paediatric intensive care unit: A randomised controlled trial.

Portero-Prados FJ, Pabón-Carrasco M, Ponce-Blandón JA · 2026 · Intensive & critical care nursing

Objectives To compare the effectiveness and dermatological safety of chlorhexidine gluconate (CHG)-impregnated dressings versus conventional transparent dressings in preventing central line-associated bloodstream infection (CLABSI) in…

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Negative / Null Result ReportMedicine

Associations of preoperative patient mental health status, sociodemographic and clinical characteristics with baseline pain, function and satisfaction in patients undergoing revision rotator cuff repairs.

Streubel PN, Sahoo S, Zhang C et al. · 2026 · Journal of shoulder and elbow surgery

Background This study aimed to investigate the associations of general patient and disease-specific factors with baseline patient reported outcome measures (PROMs) in patients undergoing revision rotator cuff repair (RCR). Baseline…

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Negative / Null Result ReportMedicine

Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.

McGranahan MJ, Sabino-Carvalho JL, Zanuzzi MG et al. · 2026 · American journal of physiology. Regulatory, integrative and comparative physiology

Individuals with posttraumatic stress disorder (PTSD) are at elevated risk for cardiovascular disease (CVD). Emerging research suggests that increased blood pressure variability (BPV) reflects abnormalities in autonomic regulation and may…

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Negative / Null Result ReportMedicine

Risk Factors for Recurrence and Complications Following Cytoreductive Surgery in Platinum-Resistant Ovarian Cancer: A Retrospective Cohort Study.

Wang L, Yao L, Wan J et al. · 2026 · Annali italiani di chirurgia

Aim This study aims to identify independent risk factors for tumor recurrence and postoperative complications in platinum-resistant ovarian cancer patients undergoing cytoreductive surgery. Methods This study retrospectively included 96…

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Negative / Null Result ReportOpen accessMedicine

Associations of circulating resistin with Alzheimer's disease biomarkers and cognitive function in the preclinical stage of Alzheimer's disease.

Eruysal E, Ravdin L, Iadecola C et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundResistin is a circulating protein linked to systemic metabolic disorders and inflammation, both of which can contribute to the pathogenesis of Alzheimer's disease (AD). However, the role of resistin during the preclinical stage…

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Negative / Null Result ReportMedicine

The relationship between pre-incarceration related social determinants and glycaemic control in African Americans with criminal legal involvement and type 2 diabetes.

Akinboboye O, Walker RJ, Campbell JA et al. · 2026 · Diabetic medicine : a journal of the British Diabetic Association

Aims To evaluate the relationship between pre-incarceration social determinants, demographic and clinical factors, and glycaemic control in African Americans with a history of criminal legal involvement and type 2 diabetes mellitus.…

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Negative / Null Result ReportMedicine

Surgical Helmet Systems Were Not Associated With Lower Operative Infection Rates After Total Ankle Arthroplasty: A Retrospective Cohort Study.

McCahon JAS, Thomas GM, Hsu A et al. · 2026 · Foot & ankle international

BackgroundConflicting evidence exists regarding the ability of surgical helmet systems (SHSs) to reduce rates of infection after joint replacement. The purpose of this study was to investigate the use of SHS in total ankle arthroplasty…

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Replication FailureMedicine

Quality over quantity: association between autistic traits and daily-life social interactions in adolescents and young adults from the TwinssCan cohort.

Fusar-Poli L, Prachason T, Brondino N et al. · 2026 · CNS spectrums

Objective Autistic traits (ATs) are associated with difficulties in social functioning, but their impact on the quantity and the quality of daily-life social interactions is not yet fully understood. Hereby, we examined the relationship…

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Negative / Null Result ReportMedicine

The Efficacy of 5% Propolis Gel in the Treatment of Primary Herpetic Gingivostomatitis in Children and Its Effect on Salivary IFN-γ Levels: A Parallel Randomized Controlled Pilot Trial.

Shalaby R, Sadek GEM, Gamil Y et al. · 2026 · European journal of dentistry

Objectives This pilot trial was designed to investigate the efficacy of propolis-based gel in the treatment of primary herpetic gingivostomatitis in children and assessed salivary IFN-γ levels before and after treatment to reflect the…

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Negative / Null Result ReportMedicine

Comparison of Knee Extensor Mechanism, Function, and Flexion Range of Motion Between Obese and Nonobese Patients After Simultaneous Bilateral Total Knee Arthroplasty: A Retrospective Follow-up Study.

Bakırhan S, Şahinoğlu E, Ünver B et al. · 2026 · The journal of knee surgery

Abstract Conflicting findings exist regarding the association between obesity and functionality after total knee arthroplasty (TKA). We aimed to compare knee extensor mechanism function, knee function, and knee flexion range of motion…

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Negative / Null Result ReportOpen accessMedicine

Health Storylines Mobile Application and Self-management among Chronically Ill Patients: A Quasi-experimental Research Design.

Moreno-Lacalle RC, Agbayani KPG, Alog JR et al. · 2026 · Acta medica Philippina

Background Self-management is crucial for individuals with chronic illnesses. While mobile applications (mAPPs) have emerged to support diverse health needs, evidence regarding their efficacy for self-management among chronically ill…

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Negative / Null Result ReportOpen accessMedicine

Impact of Post-Curing Exposure Time on the Dimensional Fidelity of 3D-Printed Provisional Crowns: A Root Mean Square (RMS) Evaluation.

Anghel MA, Mitruț I, Ionescu M et al. · 2026 · Journal of functional biomaterials

Background Dimensional stability during post-curing exposure time is critical for the clinical success of 3D-printed restorations. This study evaluates how different post-curing protocols affect the accuracy of provisional crowns. Methods…

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Negative / Null Result ReportOpen accessMedicine

Impact of a structured case report on self-reported responses to simulated emergency scenarios: a randomized survey-based study.

Porschen C, Hellenthal KEM, Zarbock A et al. · 2026 · Scientific reports

Case reports are a long-standing component of medical research, but their association with self-reported responses to simulated clinical scenarios remains underexplored. This study investigated whether exposure to a structured case report…

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