12,380 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Oh MS, Park KY, Jeong HB et al. · 2026 · BMC neurology
Background We aimed to determine cut-off values of factors affecting early neurological improvement in patients after recombinant tissue plasminogen activator therapy for acute ischemic stroke. Methods A total of 135 patients with acute…
View details →Moreira A, Azevedo R, Costa JA et al. · 2026 · European journal of dentistry
Objective Drug addiction is a growing global health concern with significant oral health consequences. Cannabis and cocaine are among the most frequently used illicit drugs, contributing to a high burden of oral pathologies. This study…
View details →Helvich J, Machu V, Novak L et al. · 2026 · Archives of public health = Archives belges de sante publique
Background Problematic social media use (PSMU) has become a critical public health concern. However, little is known about how the associations between PSMU, mental health, and substance use differ depending on participation in distinct…
View details →Borgehammar J, McClenahan B, Miller E et al. · 2026 · The Journal of manual & manipulative therapy
Objective Developing psychomotor competence in orthopedic manual physical therapy (OMPT) techniques is fundamental to post-professional physical therapy education. Concerns persist about whether online instructional models and the rise of…
View details →Vu NTH, Quach DT, Miyauchi S et al. · 2026 · Digestion
Introduction A family history of chronic constipation (CC) is considered an important predisposing factor for developing CC. This study aimed to compare the associations of maternal and paternal histories of CC with constipation in…
View details →Sharma S, Aschner A, Kabir N et al. · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Rationale The ketogenic diet (KD) is a well-established therapeutic option for children with non-surgical drug-resistant epilepsy (DRE). The purpose of this study was to determine whether specific anti-seizure medications (ASM) are…
View details →Hamidi F, Muhler F, Skopp G et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society
Background Out-of-hospital cardiac arrest (OHCA) is associated with poor outcomes and presents a considerable treatment challenge. Here, we investigated the association of prior beta-blocker treatment with outcomes in patients with OHCA.…
View details →Tall S, Pettersson J, Härkönen T et al. · 2026 · Diabetes care
Objective We assessed whether 1) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is associated with the risk of type 1 diabetes and 2) SARS-CoV-2 vaccination or infection is associated with disease severity at type…
View details →Kobayashi T, Takahara M, Kikuchi S et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Objective A single segment great saphenous vein (GSV) with a diameter ≥ 3.0 mm is widely accepted as the standard conduit for tibial and pedal bypass in chronic limb threatening ischaemia (CLTI) based on studies in European and American…
View details →Nakamura K, Sakai N, Hirai H et al. · 2026 · British journal of clinical pharmacology
Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long-term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their…
View details →Hennigar SR, Miller KM, Murphy RD et al. · 2026 · The Journal of nutrition
Background Iron deficiency (ID) is associated with decreased appetite and altered mood, which can contribute to feelings of early satiety and reduced overall well-being. Few studies have examined differences in appetite, satiety, and mood…
View details →Keskimölö T, Kiviaho A, Karppinen J et al. · 2026 · Aerospace medicine and human performance
Introduction Fighter pilots are exposed to high +Gz forces, helmet-mounted equipment, and extreme head positions that potentially cause cervical spine degeneration and pain. This study aimed to investigate whether individual +Gz exposure,…
View details →Taymur BD, Toklucu G, Gunkaya OS et al. · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Objective To evaluate the association between Selenium (Se) and other micronutrients (iron, ferritin, copper, zinc, and vitamin B12) and the development of preeclampsia (PE), and to assess their predictive performance. Study design An…
View details →Szabóová S, Duraníková O, Örzsik B et al. · 2026 · Lipids in health and disease
Background Cardiometabolic factors may influence migraine biology through metabolic, inflammatory, and vascular mechanisms, but studies examining insulin resistance and dyslipidaemia in migraine have yielded inconsistent results, partly…
View details →Rivas-Nieto AC, Alver SK, Mooney SJ et al. · 2026 · Journal of physical activity & health
Background Physical activity (PA) may be a modifiable factor for chronic kidney disease (CKD) prevention, but evidence specific to Hispanic/Latino populations is limited. Our objective was to examine associations between PA type/volume…
View details →de Freitas JJA, Nardotto DDMP, Netto LC et al. · 2026 · Infection
Purpose Although advances in intensive care have improved survival of patients with severe leptospirosis, it remains with high mortality. We aimed to identify factors associated with in-hospital mortality among patients with severe…
View details →Demirci SC, Aşik UB, Menkü BE et al. · 2026 · BMC psychiatry
Background Symptoms of attention-deficit/hyperactivity disorder (ADHD) are commonly observed in individuals with substance use disorders (SUD) and may be associated with increased addiction severity. Time perspective is a potential…
View details →Gillikin AP, Rabinovich EP, Barajas-Gamboa JS et al. · 2026 · Surgical endoscopy
Background Post-discharge venous thromboembolism (VTE) chemoprophylaxis after metabolic and bariatric surgery is variably implemented in clinical practice, although the optimal pharmacologic agent and dosing regimen remain unclear. This…
View details →Montalva-Valenzuela F, Guzmán-Muñoz E, Castillo-Paredes A et al. · 2026 · Healthcare (Basel, Switzerland)
Background: The standing long jump (SLJ) is a field-based test of lower-limb muscular fitness in youth and a proposed indicator of health-related physical fitness. However, evidence on its relationship with psychological, sleep, dietary,…
View details →de Ruyter H, Aitokari L, Iqbal A et al. · 2026 · The Journal of pediatrics
Objective To investigate associations of perinatal and lifestyle factors with alanine aminotransferase (ALT) levels as an early indicator of metabolic dysfunction-associated steatotic liver disease (MASLD). Study design Data from the…
View details →Castillo F, Tafur M, Lin C et al. · 2026 · Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
Introduction Nondiagnostic results after thyroid fine-needle aspiration (FNA) are common and may delay diagnosis. Purpose To identify demographic and sonographic predictors of nondiagnostic cytology at repeat thyroid FNA and to report…
View details →Rotevatn AØ, Eagan TM, McCann A et al. · 2026 · BMC pulmonary medicine
Background and aim Short-chain fatty acids (SCFAs) are metabolites largely produced by the gut microbiota, except for formate, which is also produced by the host. SCFAs may influence COPD development by modulating the immune system. This…
View details →Kim BI, Cheng R, Grabov E et al. · 2026 · The Journal of arthroplasty
Background Larger femoral heads have been proposed to reduce dislocation risk following total hip arthroplasty (THA). While the benefit of increasing head size from 28 or 32 mm to ≥ 36 mm is well established, it remains unclear whether…
View details →Toptas GR, Firatligil FB, Ozdal BB et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Objective To investigate the association between systemic inflammatory indices, including the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI), and…
View details →Soler-Blasco R, Lozano M, González-Safont L et al. · 2026 · Environmental research
Prenatal cadmium (Cd) exposure may impair placental function and disrupt biological processes relevant to foetal neurodevelopment, including oxidative stress and metal homeostasis, but epidemiological evidence linking Cd to childhood…
View details →Wang Y, Islam RM, Hodge A et al. · 2026 · Fertility and sterility
Objective To determine the associations between the sex steroids and sexual function and difficulties in a national, community-based sample of women aged 40 to 69 years according to menopausal status. Design This was a prespecified…
View details →Jamieson A, Kwon J, Gao T et al. · 2026 · Gynecologic oncology
Background Race, ethnicity, and geography can impact cancer management, genomics and outcomes. We aimed to determine the ethnic and geographic diversity of endometrial carcinoma (EC) patients in our province and their impact on molecular…
View details →Chisompola D, Luwaya E, Chalwe JM et al. · 2026 · Scientific reports
Interleukin-17A (IL-17A) is a key cytokine in inflammation and autoimmunity. However, its systemic correlates, particularly in a high HIV burden population, are not fully elucidated. This study aimed to identify the sociodemographic,…
View details →Murakami K, Shinozaki N, Livingstone MBE et al. · 2026 · The British journal of nutrition
While chrono-nutrition behaviors are inter-related, few studies examined patterns of chrono-nutrition behaviors using a comprehensive set of these behaviors. This study aimed to identify chrono-nutrition behavior patterns and examine their…
View details →Kleckner AS, Zhou Y, Diaz-Mercado Y et al. · 2026 · Chronobiology international
Circadian rest-activity rhythms, or a person's consistency in their daily activity and rest patterns, can be quantified using various parametric and non-parametric methods. However, these methods are seldom applied to understand symptoms…
View details →