12,380 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Guzman JM, Hardi FA, Peckins MK et al. · 2026 · Psychoneuroendocrinology
The hypothalamic-pituitary-adrenal (HPA) axis maintains homeostasis and responds to stressors in the environment, shaping responsivity and behavior at least partly through its effects on the brain. For example, increased cortisol levels…
View details →Frijmersum ZZ, Van Der Meij E, Huirne JA et al. · 2026 · Occupational and environmental medicine
Objectives Women's labour force participation often declines after childbirth, but the role of sick leave during pregnancy and after childbirth in sustained employment remains unclear. This study examined: (1) the association between sick…
View details →Yang L, Xu L · 2026 · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Background Postpartum falls threaten maternal and infant safety, yet evidence on postpartum women's fall-prevention knowledge, attitude, and behaviour (KAB) and their sociodemographic correlates remains limited. This study examined…
View details →Campello E, Zanetto A, Ferdinande K et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver
Background and aims Cirrhosis is characterized by progressive immune dysregulation, endothelial dysfunction, and haemostatic imbalance. Circulating extracellular vesicles (EVs) have emerged as potential biomarkers reflecting these…
View details →Yamao S, Chiba Y, Kuniyoshi K et al. · 2026 · Ophthalmology. Retina
Purpose To evaluate surgical outcomes and identify key prognostic factors in retinal detachment associated with morning glory syndrome (MGS-RD). Design Retrospective consecutive case series. Subjects Fifteen consecutive eyes of 15 patients…
View details →Augustin M, Pollak TA, Morrin H · 2026 · NPP - digital psychiatry and neuroscience
AI-associated delusions represent an emerging phenomenon requiring mechanistic understanding. This review, after summarizing key contributions on AI-associated delusions, proposes the "amplification spiral" framework, wherein three…
View details →David P, Oliphant K, Zhou C et al. · 2026 · Pediatric research
Background Fentanyl, an opioid medication commonly given to hospitalized preterm infants, may alter gut microbiome development and subsequent neurodevelopmental outcomes. Methods We compare a cohort of preterm infants with and without…
View details →Merzaei Z, Kazemian H, Bamzadeh Z et al. · 2026 · BMC research notes
Objective Irritable bowel syndrome (IBS) presents with symptoms of pain, abdominal discomfort, and altered bowel habits. Changes in the intestinal microbiota, including an increase in Enterobacteriaceae like E. coli, have been associated…
View details →Siddique S, Wang R, Berardi D et al. · 2026 · Cancer
Background The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before the age of 50 years, has been increasing. The relationship between demographic, birth, and parental characteristics and risk…
View details →Gallaccio G, Müller A, Wang M et al. · 2026 · Neurology(R) neuroimmunology & neuroinflammation
Background and objectives Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder that overlaps clinically with multiple sclerosis (MS) but immunopathologically distinct. Although…
View details →Kumura Y, Maruta M, Yokota H et al. · 2026 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Background Post-operative delirium (POD) is a common complication in older patients with cancer undergoing surgery, leading to prolonged hospitalisation and cognitive decline. This study examined the relationship between pre-operative…
View details →Xu P, Zhong S, Peng X · 2026 · The Journal of international medical research
Barium-associated intestinal ischemia is a rare but life-threatening complication following upper gastrointestinal barium contrast examinations, with an incidence of less than 0.01%. Hepatic portal venous gas is a condition secondary to…
View details →Sochacka K, Kotowska A, Lachowicz-Wiśniewska S · 2026 · Nutrients
Background: This study aimed to compare a limited set of predefined diet-, lifestyle-, knowledge-, and psychosocial indicators across school youth, students, and adults in Poland, and to examine their associations with three predefined…
View details →Machado EM, Matthews M, Rathleff MS et al. · 2026 · Brazilian journal of physical therapy
Background Clinical functional tests for patellofemoral pain (PFP), such as step-up, step-down and squat, are commonly used in clinic practice, although the extent to which changes in these tests reflect changes in patient-reported outcome…
View details →Fusco S, Nesseler J, Minn L et al. · 2026 · Diagnostics (Basel, Switzerland)
Background : Crohn's disease-associated intestinal strictures represent a major source of morbidity and frequently require endoscopic or surgical intervention. However, patients with stricturing Crohn's disease demonstrate substantial…
View details →Sitter TM, Savinen S, Andiné P et al. · 2026 · BMJ mental health
Background Patients in forensic psychiatric care (FPC) are often treated with various psychotropic medications. However, evidence regarding their effectiveness in this setting is lacking. Objective The study aimed to estimate how different…
View details →Larkio J, Söderström M, Holmström J et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Objective The aim of this retrospective observational study was to analyse imaging and patient related parameters of splenic artery aneurysms (SAAs) and their impact on SAA growth and rupture. Methods The term "aneurysm" was systematically…
View details →Ganesh A, Smith EE, Mostert J et al. · 2026 · Neurology
Background and objectives The cost and complexity of phase 2 randomized-controlled trials (RCTs) hinder further development of promising treatment candidates for Alzheimer disease (AD). The Simon Two-Stage futility trial design, originally…
View details →Juárez Sarrión C, Armas IR, Torrano Guillamón A et al. · 2026 · Animals : an open access journal from MDPI
Objectives To describe the clinical, clinicopathological and ultrasonographic characteristics of dogs with an acute pancreatitis (AP) and to identify prognostic markers associated with short-term mortality in a referral population. Methods…
View details →Huang B, Mao C, Xu T et al. · 2026 · Animals : an open access journal from MDPI
Early-life microbial community assembly is important for gastrointestinal development, immune maturation, and feed utilization in young ruminants, but the maternal reservoirs associated with neonatal lamb gut microbial profiles remain…
View details →Choi JS, Kim KM · 2026 · Healthcare (Basel, Switzerland)
Background The number of long-term care hospitals (LTCHs) in Korea has been increasing. Because LTCHs primarily care for older adults who are vulnerable to infection, strict infection control (IC) practices are essential. This study aimed…
View details →Qu ZW, Zhang Y, Guo MY · 2026 · The Journal of international medical research
ObjectiveTo investigate the association of preoperative hypoalbuminemia (serum albumin <35 g/L) with clinicopathological characteristics and survival outcomes in patients with gastric cancer undergoing radical gastrectomy and to construct…
View details →Abdulridha GAO, Fadhel AS, Al-Kinany SQ et al. · 2026 · Journal of neuroimmunology
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by leukocyte infiltration, immune activation, demyelination, and axonal injury. This case-control observational study aimed to investigate…
View details →Baltu D, Taş N, Alıcı N et al. · 2026 · Pediatric nephrology (Berlin, Germany)
Background Although acetazolamide is the main medical treatment for idiopathic intracranial hypertension (IIH), data on acetazolamide-induced metabolic acidosis and its long-term outcomes are limited. This study aimed to investigate the…
View details →Rinaldi V, Ridolfi F, Finotello R et al. · 2026 · Veterinary medicine and science
Hypertrophic osteopathy (HO) is a paraneoplastic or parainflammatory syndrome characterised by painful periosteal new bone formation and soft tissue swelling, most commonly associated with thoracic neoplasia. The pathogenesis of HO remains…
View details →Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering
Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…
View details →Jaime-Jorge S, García-Ael C, Azanza G et al. · 2026 · European journal of investigation in health, psychology and education
This paper analyses associations between psychological health at work and life satisfaction among employees. Specifically, it investigates the association between work stress and emotional exhaustion and explores whether connectedness to…
View details →Lu B, Wang P, Hu J et al. · 2026 · Environmental pollution (Barking, Essex : 1987)
Wetland interfaces regulate greenhouse-gas exchange and carbon retention, yet contaminant exposure may disrupt the relationship between these two processes. Whether aqueous perfluorooctane sulfonate (PFOS), a persistent aquatic…
View details →Shioiri H, Takahashi T, Matsumoto T · 2026 · International orthopaedics
Purpose To investigate factors associated with achieving both postoperative knee flexion range of motion (ROM) ≥ 125° and Numerical Rating Scale (NRS) pain score ≤ 1 at one year after posterior cruciate-retaining total knee arthroplasty…
View details →Liu S, Tan Y, Zang L · 2026 · Healthcare (Basel, Switzerland)
Background/Objectives: Climate change worry is an emerging concern in youth mental health, but little is known about how it is associated with positive psychological functioning among university students. This study examined whether…
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