e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

12,250 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.

McGranahan MJ, Sabino-Carvalho JL, Zanuzzi MG et al. · 2026 · American journal of physiology. Regulatory, integrative and comparative physiology

Individuals with posttraumatic stress disorder (PTSD) are at elevated risk for cardiovascular disease (CVD). Emerging research suggests that increased blood pressure variability (BPV) reflects abnormalities in autonomic regulation and may…

View details →
Negative / Null Result ReportMedicine

Risk Factors for Recurrence and Complications Following Cytoreductive Surgery in Platinum-Resistant Ovarian Cancer: A Retrospective Cohort Study.

Wang L, Yao L, Wan J et al. · 2026 · Annali italiani di chirurgia

Aim This study aims to identify independent risk factors for tumor recurrence and postoperative complications in platinum-resistant ovarian cancer patients undergoing cytoreductive surgery. Methods This study retrospectively included 96…

View details →
Negative / Null Result ReportOpen accessMedicine

Associations of circulating resistin with Alzheimer's disease biomarkers and cognitive function in the preclinical stage of Alzheimer's disease.

Eruysal E, Ravdin L, Iadecola C et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundResistin is a circulating protein linked to systemic metabolic disorders and inflammation, both of which can contribute to the pathogenesis of Alzheimer's disease (AD). However, the role of resistin during the preclinical stage…

View details →
Negative / Null Result ReportMedicine

The relationship between pre-incarceration related social determinants and glycaemic control in African Americans with criminal legal involvement and type 2 diabetes.

Akinboboye O, Walker RJ, Campbell JA et al. · 2026 · Diabetic medicine : a journal of the British Diabetic Association

Aims To evaluate the relationship between pre-incarceration social determinants, demographic and clinical factors, and glycaemic control in African Americans with a history of criminal legal involvement and type 2 diabetes mellitus.…

View details →
Negative / Null Result ReportMedicine

Surgical Helmet Systems Were Not Associated With Lower Operative Infection Rates After Total Ankle Arthroplasty: A Retrospective Cohort Study.

McCahon JAS, Thomas GM, Hsu A et al. · 2026 · Foot & ankle international

BackgroundConflicting evidence exists regarding the ability of surgical helmet systems (SHSs) to reduce rates of infection after joint replacement. The purpose of this study was to investigate the use of SHS in total ankle arthroplasty…

View details →
Replication FailureMedicine

Quality over quantity: association between autistic traits and daily-life social interactions in adolescents and young adults from the TwinssCan cohort.

Fusar-Poli L, Prachason T, Brondino N et al. · 2026 · CNS spectrums

Objective Autistic traits (ATs) are associated with difficulties in social functioning, but their impact on the quantity and the quality of daily-life social interactions is not yet fully understood. Hereby, we examined the relationship…

View details →
Negative / Null Result ReportMedicine

The Efficacy of 5% Propolis Gel in the Treatment of Primary Herpetic Gingivostomatitis in Children and Its Effect on Salivary IFN-γ Levels: A Parallel Randomized Controlled Pilot Trial.

Shalaby R, Sadek GEM, Gamil Y et al. · 2026 · European journal of dentistry

Objectives This pilot trial was designed to investigate the efficacy of propolis-based gel in the treatment of primary herpetic gingivostomatitis in children and assessed salivary IFN-γ levels before and after treatment to reflect the…

View details →
Negative / Null Result ReportMedicine

Comparison of Knee Extensor Mechanism, Function, and Flexion Range of Motion Between Obese and Nonobese Patients After Simultaneous Bilateral Total Knee Arthroplasty: A Retrospective Follow-up Study.

Bakırhan S, Şahinoğlu E, Ünver B et al. · 2026 · The journal of knee surgery

Abstract Conflicting findings exist regarding the association between obesity and functionality after total knee arthroplasty (TKA). We aimed to compare knee extensor mechanism function, knee function, and knee flexion range of motion…

View details →
Negative / Null Result ReportOpen accessMedicine

Health Storylines Mobile Application and Self-management among Chronically Ill Patients: A Quasi-experimental Research Design.

Moreno-Lacalle RC, Agbayani KPG, Alog JR et al. · 2026 · Acta medica Philippina

Background Self-management is crucial for individuals with chronic illnesses. While mobile applications (mAPPs) have emerged to support diverse health needs, evidence regarding their efficacy for self-management among chronically ill…

View details →
Negative / Null Result ReportOpen accessMedicine

Impact of Post-Curing Exposure Time on the Dimensional Fidelity of 3D-Printed Provisional Crowns: A Root Mean Square (RMS) Evaluation.

Anghel MA, Mitruț I, Ionescu M et al. · 2026 · Journal of functional biomaterials

Background Dimensional stability during post-curing exposure time is critical for the clinical success of 3D-printed restorations. This study evaluates how different post-curing protocols affect the accuracy of provisional crowns. Methods…

View details →
Negative / Null Result ReportOpen accessMedicine

Impact of a structured case report on self-reported responses to simulated emergency scenarios: a randomized survey-based study.

Porschen C, Hellenthal KEM, Zarbock A et al. · 2026 · Scientific reports

Case reports are a long-standing component of medical research, but their association with self-reported responses to simulated clinical scenarios remains underexplored. This study investigated whether exposure to a structured case report…

View details →
Negative / Null Result ReportOpen accessMedicine

Subcutaneous Tranexamic Acid Achieves Comparable Serum Concentrations to Intramuscular Administration During Haemorrhagic Shock in a Swine Model.

Lynghaug T, Fuskevåg OM, Storm BS et al. · 2026 · Acta anaesthesiologica Scandinavica

Background Tranexamic acid is an antifibrinolytic agent reducing mortality when administered to trauma patients with haemorrhagic shock. This mortality reduction is time sensitive. Increased intramuscular dose administration has proven an…

View details →
Negative / Null Result ReportOpen accessMedicine

Impact of tumor budding on recurrence risk prediction in stage I-III colorectal cancer: a Swedish cohort study.

Barot S, Andersson-Franko M, Ghazi S et al. · 2026 · American journal of clinical pathology

Objectives Tumor budding is an emerging micromorphologic predictor of recurrence in localized colorectal cancer (CRC). Whether its addition to established CRC recurrence risk factors routinely assessed in clinical practice improves…

View details →
Negative / Null Result ReportMedicine

Feasibility of Individualized Homoeopathic Treatment in Temporomandibular Joint Dysfunction: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial.

Bhattacharjee B, Ghosh S, Basu N et al. · 2026 · Journal of integrative and complementary medicine

Objectives To assess the feasibility of conducting a randomized controlled trial and to explore preliminary effects of individualized homoeopathic medicines (IHMs) compared with placebo in patients with temporomandibular joint dysfunction…

View details →
Negative / Null Result ReportMedicine

Association between short-term air pollution exposure and the risk of fatal recurrence within 1 year in patients with first-episode acute hemorrhagic stroke: a time-stratified case-crossover study.

Gu X, Liu J, Wang H et al. · 2026 · Frontiers in public health

Objective To analyze the association between short-term exposure to air pollutants and the risk of fatal recurrence within 1 year in patients with first-episode acute hemorrhagic stroke, to provide scientific basis for health management…

View details →