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Browse the failure-mode index

12,250 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

EXPRESS: Exaggerated Self-Referencing in Body Dysmorphic Disorder.

Richards-Brown M, Castiello de Obeso S, Dennison R et al. · 2026 · Quarterly journal of experimental psychology (2006)

The self-prioritisation effect demonstrates that people have a bias to learn and process self-relevant compared to other-relevant information. This tendency may provide a tool to understand how body image and perception become disrupted in…

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Negative / Null Result ReportMedicine

Predictors of Ageism among Social Work Students and Practitioners in Greece: The Role of Aging Anxiety and Experiential Factors.

Micheli K, Koutra K, Markakis G · 2026 · International journal of aging & human development

This study examines whether aging anxiety (based on terror management theory) or demographic and experiential factors better explain attitudes toward older adults among social work students and professionals. Cross-sectional data were…

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Negative / Null Result ReportMedicine

Genetically predicted gut bacteria, circulating bacteria-associated metabolites and liver cancer: A Mendelian randomisation study.

Daniel N, Papadimitriou N, Chatziioannou AC et al. · 2026 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Background and aims Recent data suggest a role for the gut microbiome in the development of hepatocellular carcinoma. We investigated associations of gut microbiome abundances and concentrations of circulating bacteria-associated…

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Negative / Null Result ReportMedicine

Ocular toxoplasmosis in Latin American and European patients: clinical characteristics, visual outcomes, and recurrence patterns.

Shamani-Aminian A, Adán A, Llorenç V · 2026 · Journal of ophthalmic inflammation and infection

Ocular toxoplasmosis is the most common cause of posterior uveitis worldwide and a major cause of visual impairment. Previous studies suggest that the disease may follow a more aggressive clinical course in patients from Latin America;…

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Negative / Null Result ReportMedicine

Thoracic radiographs in dogs with gastric dilatation-volvulus rarely affect the decision to proceed with surgery or survival to discharge: a 25-year retrospective study of 176 cases.

Lee J, DeGroot W · 2026 · Journal of the American Veterinary Medical Association

Objective To assess whether thoracic radiographs in dogs with gastric dilatation-volvulus (GDV) are associated with the decision to proceed with surgery and survival to discharge. Methods A retrospective cohort study of dogs with GDV…

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Negative / Null Result ReportMedicine

When coverage is high: rethinking the role of caregiver perceptions in childhood vaccination uptake in Uganda.

Gunderson AK, Kwon T, Kumarasinghe Y et al. · 2026 · Transactions of the Royal Society of Tropical Medicine and Hygiene

Background Beliefs of a child's primary caregiver are known to influence immunization uptake. As coverage increases, the characteristics of households with undervaccinated children may be shifting. Methods We conducted a cross-sectional…

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Negative / Null Result ReportMedicine

ESR1 as a candidate gene for adolescent idiopathic scoliosis pathogenesis in North-West Indian population.

Kowra S, Singh H, Singh V et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Introduction Estrogens are crucial in the development and growth of skeletal systems. Estrogen receptor alpha (ESRα) and beta (ESRβ) are crucial regulators of estrogen response. Estrogen receptor genes (ESR1 and ESR2) have been extensively…

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Negative / Null Result ReportMedicine

Mediterranean diet and MIND diet adherence in relation to biochemical markers in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A cross-sectional study.

Acar Ozer T, Arslan M, Şahin K · 2026 · Nutrition and health

BackgroundMetabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is one of the most prevalent chronic liver diseases worldwide and is strongly associated with metabolic dysfunction. Dietary patterns such as the Mediterranean and…

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Negative / Null Result ReportMedicine

Oral Manifestations in a Drug-Addicted Population Being Treated in Rehabilitation Clinics in Northern Portugal: A Cross-Sectional Observational Study.

Moreira A, Azevedo R, Costa JA et al. · 2026 · European journal of dentistry

Objective Drug addiction is a growing global health concern with significant oral health consequences. Cannabis and cocaine are among the most frequently used illicit drugs, contributing to a high burden of oral pathologies. This study…

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Negative / Null Result ReportMedicine

Problematic social media use, mental health, and substance use in Czech adolescents: the comparative role of extracurricular activities - findings from the 2022 HBSC study.

Helvich J, Machu V, Novak L et al. · 2026 · Archives of public health = Archives belges de sante publique

Background Problematic social media use (PSMU) has become a critical public health concern. However, little is known about how the associations between PSMU, mental health, and substance use differ depending on participation in distinct…

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Negative / Null Result ReportMedicine

Effect of Concurrent Anti-Seizure Medications on the Efficacy of the Ketogenic Diet in Children with Epilepsy.

Sharma S, Aschner A, Kabir N et al. · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Rationale The ketogenic diet (KD) is a well-established therapeutic option for children with non-surgical drug-resistant epilepsy (DRE). The purpose of this study was to determine whether specific anti-seizure medications (ASM) are…

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Failed Experiment ReportMedicine

Association of prior beta-blocker treatment and outcome in patients with out-of-hospital cardiac arrest.

Hamidi F, Muhler F, Skopp G et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society

Background Out-of-hospital cardiac arrest (OHCA) is associated with poor outcomes and presents a considerable treatment challenge. Here, we investigated the association of prior beta-blocker treatment with outcomes in patients with OHCA.…

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Negative / Null Result ReportMedicine

Clinical Outcomes in Japanese Patients with Chronic Limb Threatening Ischaemia Undergoing Tibial and Pedal Bypass with a Single Segment Great Saphenous Vein Graft.

Kobayashi T, Takahara M, Kikuchi S et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Objective A single segment great saphenous vein (GSV) with a diameter ≥ 3.0 mm is widely accepted as the standard conduit for tibial and pedal bypass in chronic limb threatening ischaemia (CLTI) based on studies in European and American…

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