Replication FailureMedicine
Fisayo T, Evans C, Mutasa K et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Cytomegalovirus (CMV) co-infection is associated with mortality in adults with HIV, but whether CMV is associated with mortality in children with HIV remains uncertain. Methods In 498 children (median age 6.3 years,…
View details →Negative / Null Result ReportMedicine
Mayo AK, Beaudoin JJ, Woodhead JL et al. · 2026 · Clinical pharmacology and therapeutics
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving…
View details →Negative / Null Result ReportOpen accessMedicine
Frey L, Grunwald S, Ruckes C et al. · 2026 · European urology open science
Background and objective Metastatic testicular germ cell tumors (mTGCTs) are treated with combination chemotherapy (Cx) containing bleomycin (BEP [bleomycin, etoposide, and cisplatin]). Bleomycin-induced pulmonary toxicity (BPT) is a…
View details →Negative / Null Result ReportMedicine
Liang D, Tong Y, Li F et al. · 2026 · Cerebrovascular diseases (Basel, Switzerland)
Introduction General anesthesia (GA) with endotracheal intubation is standard during endovascular treatment (EVT) for acute ischemic stroke (AIS), but the optimal timing for post-procedural extubation remains unclear. Methods In this…
View details →Failed Experiment ReportMedicine
Radha S, Arends M, Kislinger G et al. · 2026 · PLoS biology
Rapid information processing in complex organisms depends on myelin, which consists of a multilamellar membrane that tightly adheres to the axonal surface along the internode and at paranodal loops, where specialized adhesion proteins…
View details →Negative / Null Result ReportMedicine
Mirda D, Hao J, Dungan M et al. · 2026 · Cancers
Background : Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC), and colorectal surveillance has been shown to reduce death from CRC in this high-risk population. This study aimed to examine adherence to…
View details →Negative / Null Result ReportMedicine
Ito K, Fujii M, Oba Y et al. · 2026 · International orthopaedics
Purpose To determine changes in low back pain (LBP) after total hip arthroplasty (THA), identify preoperative factors associated with residual LBP and LBP improvement, and clarify the association between residual LBP and patient-reported…
View details →Negative / Null Result ReportMedicine
Cunningham PM, Hayes JE · 2026 · Appetite
Widespread nutrition advice instructs consumers to drink water with meals to increase fullness and reduce energy intake. However, recent data indicates greater water intake is associated with more food intake at a meal, not less. Switching…
View details →Negative / Null Result ReportMedicine
Charoenrat B, Sungkarat S, Phirawatthakul C et al. · 2026 · BMC geriatrics
Background Neck pain is associated with altered postural and gait performance in older adults. Smartphone use may further challenge postural and gait control due to additional cognitive and motor demands. This study aimed to investigate…
View details →Negative / Null Result ReportMedicine
Ediz E, Küçükdağ HN, Özel MA · 2026 · Scientific reports
Although high fructose consumption is known to be associated with metabolic disorders, specific intake thresholds and consumption patterns related to hepatic steatosis have not been fully defined. This study aimed to quantify daily…
View details →Negative / Null Result ReportMedicine
Millarch AS, Schøning J, Hjulmand VG et al. · 2026 · The journal of trauma and acute care surgery
Background Opioids have a well-known capacity to induce long-term dependency with related increased morbidity and mortality. Usage patterns following traumatic injury are, however, not well studied. We investigated long-term opioid usage…
View details →Negative / Null Result ReportMedicine
Melcer T, Robinson MI, Jurick S et al. · 2026 · The journal of trauma and acute care surgery
Background Limited longitudinal research has been conducted on health outcomes during the first 15 years after combat-related lower limb amputation. Methods This retrospective analysis of Departments of Defense and Veterans Affairs health…
View details →Negative / Null Result ReportMedicine
Jiang Y, Kong M, Feng T et al. · 2026 · Scientific reports
Emergency department overcrowding places sustained pressure on triage workflows and patient prioritization. Artificial intelligence (AI)-augmented triage systems have been introduced to support emergency decision-making, but frontline…
View details →Negative / Null Result ReportMedicine
Yang W, Tan M, Lin H et al. · 2026 · Food & function
Oyster-derived peptides have shown potential for bone protection; yet, the anti-osteoporotic activity of defined sequences remains insufficiently characterized in glucocorticoid-induced osteoporosis (GIOP). Here, DLAGRDLTDYLM (OP4),…
View details →Negative / Null Result ReportMedicine
Tegegne DT, Banaszkiewicz S, Bania J et al. · 2026 · Molecules (Basel, Switzerland)
Background: Enterococcus faecalis is one of the most frequent causes of catheter-associated urinary tract infections, largely due to its ability to form biofilms on indwelling urinary catheter surfaces, which enhance bacterial persistence…
View details →Negative / Null Result ReportOpen accessMedicine
Vilaseca A, Villagrán-García M, Farina A et al. · 2026 · Neurology(R) neuroimmunology & neuroinflammation
Objectives Ma/Ma2-associated neurologic autoimmunity is characterized by CNS involvement. However, isolated peripheral nervous system (PNS) presentations have been rarely reported. We aimed to describe the frequency and syndromes of…
View details →Negative / Null Result ReportOpen accessMedicine
Wu J, Liang P, He Y et al. · 2026 · Frontiers in cellular and infection microbiology
Background Bladder cancer is one of the most common malignancies worldwide, and only a subset of patients derives durable benefit from immune checkpoint blockade. An immune-cold tumor microenvironment, characterized by limited immune…
View details →Negative / Null Result ReportMedicine
Gysan MR, Kastrati K, Pochepnia S et al. · 2026 · Journal of clinical medicine
Background: Systemic autoimmune rheumatic diseases-associated interstitial lung disease (SARD-ILD) presents with varied disease courses, emphasizing the need for reliable predictors of progression. The prognostic utility of bronchoalveolar…
View details →Negative / Null Result ReportOpen accessMedicine
Jennings CJ, Marciniak SJ, Pinton G et al. · 2026 · Discover oncology
Aim To investigate the expression of succinate dehydrogenase B and its potential as a therapeutic target in pleural mesothelioma (PM). Methods The expression of succinate dehydrogenase B was examined in cell lines using PCR. The expression…
View details →Negative / Null Result ReportMedicine
Bertholdi Filho SU, Telles JP, Melo IM et al. · 2026 · Critical care science
Objective To evaluate the efficacy of monotherapy versus combination therapy in the treatment of carbapenem-resistant Acinetobacter baumannii infections. Methods A retrospective observational study was conducted in two tertiary hospitals…
View details →Negative / Null Result ReportMedicine
Tan Y, Cheng F, Li P et al. · 2026 · Epigenomics
Background Glioblastoma (GBM) is epigenetically heterogeneous, and previous long noncoding RNA (lncRNA) methylation studies have often begun from tumor-wide screens. We asked whether brain-enriched lncRNAs show promoter…
View details →Negative / Null Result ReportMedicine
Terrinoni M, Caputo V, Palisciano M et al. · 2026 · Genes
Background/Objectives: Cervical cancer is mainly driven by persistent infection with high-risk human papillomaviruses (HPV), particularly HPV16 and HPV18. Despite advances in cytology, HPV-DNA testing and vaccination, challenges remain in…
View details →Negative / Null Result ReportMedicine
Jameson AT, Hur WS · 2026 · Current opinion in hematology
Purpose of review Metabolic diseases, including obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and diabetes, are associated with increased thrombotic risks. Conversely, components of the hemostatic system…
View details →Negative / Null Result ReportMedicine
Holleman J, Kåreholt I, Kivipelto M et al. · 2026 · Gerontology
Introduction Physical and cognitive impairment constitute large burdens of disease in older adults, but may be preventable through reduction of modifiable risk factors. While chronic stress has been linked to cognitive and physical…
View details →Negative / Null Result ReportMedicine
Ahmadi T, Ghorbanzadeh V, Hosseinnejad E et al. · 2026 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Doxorubicin remains an indispensable component of many chemotherapy regimens; however, its clinical use is limited by dose-dependent cardiotoxicity that may progress to dilated cardiomyopathy and heart failure. In the present study, we…
View details →Negative / Null Result ReportMedicine
Mogoș RA, Carauleanu A, Vasilache IA et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Autoimmune thyroiditis (AIT) is often reported patients with PCOS, and may co-occur with altered metabolic risk markers. The aims of this study were to assess baseline differences according to thyroid…
View details →Negative / Null Result ReportMedicine
Han Y, Zhong C, Lu Z et al. · 2026 · Scientific reports
Abdominal massage (AM), a traditional Chinese medicine treatment, is gradually being recognized in clinical practice for its ability to improve the symptoms of obesity and type 2 diabetes mellitus (T2DM) in clinical practice. This study…
View details →Negative / Null Result ReportMedicine
Wang J, Soley BDS, Xiao Y et al. · 2026 · Cancer research communications
Cancer-associated fibroblasts (CAFs) display remarkable plasticity, enabling them to adapt to therapeutic and mechanical stress within the tumor microenvironment (TME). Here, we identify a shared mechanotransduction pathway by which BRAF…
View details →Negative / Null Result ReportMedicine
Chan SWY, Wang R, Liu J · 2026 · Psychological assessment
Adult-reported surveys are more cost-effective for measuring children's executive function (EF) skills than direct child assessments, which are often resource-intensive. This study examined the extent to which teacher and parent reports…
View details →Negative / Null Result ReportMedicine
Tang Z, Huang C, Qiu G et al. · 2026 · Clinical rheumatology
Objective Gout is directly associated with hyperuricemia. This study aims to investigate the adherence rate to urate-lowering therapy (ULT) and its influencing factors among patients with gout in Southwest China. Methods A cross-sectional…
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