12,250 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Chopra AA, MacLeod JS, Compton TM et al. · 2026 · Clinical spine surgery
Study design Break-even cost analysis. Objectives This study uses a break-even cost-effectiveness model to assess whether enoxaparin is cost-effective for venous thromboembolism (VTE) prophylaxis in patients undergoing posterior lumbar…
View details →Fabbri F, Albusaidi I, Ntani G et al. · 2026 · Occupational medicine (Oxford, England)
Background Hand dermatitis is a common occupational skin disease and is particularly prevalent among healthcare workers. Aims To identify which digital skin surveillance methods are effective for detecting hand dermatitis. Methods A…
View details →Nduka IJ, Okafor CE, Ekwunife OI · 2026 · PloS one
Mammography still remains the gold standard for breast cancer screening, considering its impact on breast cancer mortality. However, it has a relatively low utilization rate in Nigeria. Although the National Strategic Cancer Control Plan…
View details →Rotter JM, Seifert R · 2026 · European journal of clinical pharmacology
Purpose Drug supply shortages are a recurring issue in developed countries, with consequences for patients even before the COVID-19 pandemic. Questions arise regarding the effectiveness and tolerability of alternative treatments chosen by…
View details →Jin L, Han L, Zeng J · 2026 · Frontiers in public health
Background For patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC) who progress after first-line therapy, effective subsequent options are urgently needed. From the perspective of China's healthcare system, this study…
View details →Renard K, Sung HD, Griffis C · 2026 · AANA journal
Gabapentin is widely used in perioperative analgesic protocols. Many clinical studies supporting the safety and analgesic efficacy of gabapentin for postoperative pain have been published over the last two decades. Several studies, many…
View details →Demnitz-King H, Cooper C, Poppe M et al. · 2026 · Age and ageing
Background Previous studies have modelled long-term cost-effectiveness of dementia prevention but seldom within trials. APPLE-Tree (Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build…
View details →Winstén AK, Langén V, Airaksinen KEJ et al. · 2026 · JAMA network open
Importance Anticoagulation for stroke prevention in subclinical, device-detected atrial fibrillation (AF) remains an area of clinical equipoise, and its cost-effectiveness is unknown. Objective To evaluate the cost-effectiveness of direct…
View details →Bigirimana D, Hu N, Soo J et al. · 2026 · Ophthalmology. Glaucoma
Purpose To assess the cost-effectiveness of Xen45 Gel Stent (XGS) compared with trabeculectomy for the surgical management of open angle glaucoma in the United States Medicare system. Design Cost-utility analysis using safety and efficacy…
View details →Thomas CA, Blau S, Neuhalfen H et al. · 2026 · JCO oncology practice
Purpose Biomarker testing, including immunohistochemistry (IHC) and next-generation sequencing, is the standard of care in advanced non-small cell lung cancer (NSCLC) for identifying actionable mutations such as EGFR , ALK , and KRAS .…
View details →Bedoya JU, Wagner M, Malézieux E et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver
Background & aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before…
View details →Ni X, Zhou S, He X et al. · 2026 · Toxicology in vitro : an international journal published in association with BIBRA
Background In HT-22 cells, 500 μM NMDA was used as a high-concentration oxidative stressor rather than a classical NMDA receptor-mediated excitotoxic stimulus. Because HT-22 cells lack functional ionotropic NMDA receptors, this model…
View details →Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology
Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…
View details →Lu J, Huang S, Wei S et al. · 2026 · Genes
Objective: TNFSF13B , which encodes B-cell-activating factor ( BAFF ) and peptidylarginine deiminase 4 ( PADI4 ), plays crucial roles in the pathogenesis of ANCA-associated vasculitis (AAV). This study investigated the associations of…
View details →Zhang G, Zhang L, Jiang M et al. · 2026 · Clinical rheumatology
Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) have an increased risk of developing lung cancer (LC).This study investigated whether non-receipt of immunosuppressive therapy is associated with LC…
View details →Chavatza K, Gialouri CG, Drougkas K et al. · 2026 · RMD open
Objective To examine the role of low-dose glucocorticoids (GCs) in major relapse, hospitalisation and damage accumulation risk during maintenance therapy in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAVs). Methods…
View details →Halliwell C, Courish M, Moyer R et al. · 2026 · Clinical rheumatology
Background Individuals with knee osteoarthritis are at an increased risk of poor metabolic health. We tested if cross-sectionally replacing stationary time with light or moderate-to-vigorous physical activity would be associated with lower…
View details →Hendrixson DT, Tiwari R, James P et al. · 2026 · Maternal & child nutrition
Upstream pathways influencing child growth are complex. Weight-for-age z-score (WAZ) reflects both ponderal and linear growth and can identify children at high mortality risk. Using data from a prospective cohort of 326 mother-child pairs…
View details →Suzuki Y, Misaka T, Okochi S et al. · 2026 · Fukushima journal of medical science
Background Heart-liver metabolic crosstalk contributes to heart failure pathophysiology. Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new disease entity based on positive metabolic criteria. However,…
View details →Bruno MT, Pagana A, Aiello T et al. · 2026 · BMC cancer
Background Active surveillance of cervical intraepithelial neoplasia grade 2 (CIN2) is increasingly adopted to reduce the risk of overtreatment, particularly in young women. However, the appropriateness of this approach remains debated,…
View details →Guzman JM, Hardi FA, Peckins MK et al. · 2026 · Psychoneuroendocrinology
The hypothalamic-pituitary-adrenal (HPA) axis maintains homeostasis and responds to stressors in the environment, shaping responsivity and behavior at least partly through its effects on the brain. For example, increased cortisol levels…
View details →Frijmersum ZZ, Van Der Meij E, Huirne JA et al. · 2026 · Occupational and environmental medicine
Objectives Women's labour force participation often declines after childbirth, but the role of sick leave during pregnancy and after childbirth in sustained employment remains unclear. This study examined: (1) the association between sick…
View details →Yang L, Xu L · 2026 · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Background Postpartum falls threaten maternal and infant safety, yet evidence on postpartum women's fall-prevention knowledge, attitude, and behaviour (KAB) and their sociodemographic correlates remains limited. This study examined…
View details →Campello E, Zanetto A, Ferdinande K et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver
Background and aims Cirrhosis is characterized by progressive immune dysregulation, endothelial dysfunction, and haemostatic imbalance. Circulating extracellular vesicles (EVs) have emerged as potential biomarkers reflecting these…
View details →Yamao S, Chiba Y, Kuniyoshi K et al. · 2026 · Ophthalmology. Retina
Purpose To evaluate surgical outcomes and identify key prognostic factors in retinal detachment associated with morning glory syndrome (MGS-RD). Design Retrospective consecutive case series. Subjects Fifteen consecutive eyes of 15 patients…
View details →Augustin M, Pollak TA, Morrin H · 2026 · NPP - digital psychiatry and neuroscience
AI-associated delusions represent an emerging phenomenon requiring mechanistic understanding. This review, after summarizing key contributions on AI-associated delusions, proposes the "amplification spiral" framework, wherein three…
View details →David P, Oliphant K, Zhou C et al. · 2026 · Pediatric research
Background Fentanyl, an opioid medication commonly given to hospitalized preterm infants, may alter gut microbiome development and subsequent neurodevelopmental outcomes. Methods We compare a cohort of preterm infants with and without…
View details →Merzaei Z, Kazemian H, Bamzadeh Z et al. · 2026 · BMC research notes
Objective Irritable bowel syndrome (IBS) presents with symptoms of pain, abdominal discomfort, and altered bowel habits. Changes in the intestinal microbiota, including an increase in Enterobacteriaceae like E. coli, have been associated…
View details →Siddique S, Wang R, Berardi D et al. · 2026 · Cancer
Background The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before the age of 50 years, has been increasing. The relationship between demographic, birth, and parental characteristics and risk…
View details →Gallaccio G, Müller A, Wang M et al. · 2026 · Neurology(R) neuroimmunology & neuroinflammation
Background and objectives Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder that overlaps clinically with multiple sclerosis (MS) but immunopathologically distinct. Although…
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