12,250 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Wen CP, Tsai MK, Wen C et al. · 2026 · Gut and liver
Background/aims Colorectal cancer (CRC) risk is approximately 0.1% according to registry data, and fecal immunochemical tests (FITs) identify approximately 5% of screened individuals as positive. We evaluated whether a negative FIT result…
View details →Ibrahim AM, Saleem A, Faisal MS et al. · 2025 · Digestive diseases and sciences
Background and aims Multitarget stool DNA (mt-sDNA) testing is a non-invasive colorectal cancer (CRC) screening tool, but false-negative results may delay diagnosis. Understanding which patients are more likely to have advanced lesions…
View details →Kundu A, Majumder D, Das D et al. · 2026 · Cureus
Introduction Latent tuberculosis infection (LTBI) is still neglected and acts as a barrier to the tuberculosis (TB) elimination goal of the National Tuberculosis Elimination Programme (NTEP) by 2025 sustaining TB transmission, particularly…
View details →López-Morales A, Benito D, Gerrikagoitia X et al. · 2026 · Canadian journal of microbiology
Influenza A infection is frequently detected in marine mammals causing mortality events of different magnitude. In recent years, the highly pathogenic avian influenza (HPAI) H5N1 virus (clade 2.3.4.4b) has been rapidly expanding and…
View details →Corma-Gómez A, Santos M, Martín-Carmona J et al. · 2026 · AIDS patient care and STDs
To evaluate the proportion of gay, bisexual, and other men who have sex with men (GBMSM) with ongoing high-risk sexual practices not engaged in care, and to assess linkage to and retention in care following a community-based intervention.…
View details →Stewart SF, Enne VI, Pandolfo AM et al. · 2026 · Antimicrobial resistance and infection control
Background Rapid molecular diagnostics such as the BioFire FilmArray Pneumonia Panel (the Pneumonia Panel) can improve antibiotic stewardship by supporting doctors to make more targeted antibiotic prescribing decisions faster compared to…
View details →Sheng D, Wang S, Xiao Z et al. · 2026 · European archives of psychiatry and clinical neuroscience
BACKGROUND: Observational studies have reported associations between retinal thickness and Alzheimer’s disease (AD); however, the causal relationship remains uncertain. OBJECTIVE: To investigate the potential causal relationships between…
View details →Schwartz A, Mikati S, Knipper F et al. · 2025 · Applied biosafety : journal of the American Biological Safety Association
Background The COVID-19 pandemic highlighted critical shortages in personal protective equipment (PPE), particularly respirators, which limited healthcare workers' safety worldwide. Decontamination and reuse of PPE, including powered-air…
View details →Ahogni I, Avanon H, Hueha C et al. · 2026 · Malaria journal
Background Accurate interpretation and recording of malaria rapid diagnostic tests (RDTs) are critical for case management and surveillance in malaria-endemic settings. In Benin, where over 90% of malaria diagnoses rely on RDTs, concerns…
View details →Bulut C, Arslan Z, Aydoğdu M et al. · 2026 · Forensic science international
Rising global alcohol consumption is a major public health and safety concern. Over the last decade, undeclared alcohol consumption has increasingly come into focus due to high inflation that has led many individuals to resort to unhealthy…
View details →Kavunga-Membo H, Chi HF, Emperador DM et al. · 2026 · The Lancet. Infectious diseases
Background Mpox has spread to 36 countries in Africa, yet many face challenges achieving nationwide PCR-based testing due to cost and limited access in remote and rural areas. Point-of-care antigen-based rapid diagnostic tests (RDTs) might…
View details →Watanabe T, Hirano T · 2026 · Clinical medicine insights. Pediatrics
Objective The importance and effectiveness of Newborn hearing screening (NHS) have been widely recognized. However, there are a few cases of false-negative NHS results. Hearing loss in children causes various disorders. Therefore,…
View details →Mangiaterra T, Chabay P, Bellan C et al. · 2026 · Frontiers in immunology
Epstein-Barr virus (EBV) infects more than 90% of the global population and is etiologically linked to a wide spectrum of lymphoid and epithelial malignancies. Although its role as an oncogenic virus is well established, the mechanisms…
View details →Wang X, Albayda J, Paik JJ et al. · 2025 · Rheumatology (Oxford, England)
Objective This study aims to evaluate the diagnostic accuracy of CA-125 and PET/CT in detecting cancer among adult patients with idiopathic inflammatory myopathy (IIM). Methods We conducted a retrospective study of a single-centre cohort…
View details →Kimura K, Kuwata T, Hiraoka Y et al. · 2026 · Journal of human genetics
Multigene panel testing (MGPT) is increasingly used for diagnosing hereditary cancers; however, its application in cascade testing remains limited, and the psychological impact on unaffected relatives is not well understood. This…
View details →Blasich NP, Adelekan AM · 2026 · Health science reports
Background Point-of-care rapid diagnostic testing plays a critical role in HIV detection and timely linkage to care, particularly in decentralized healthcare settings. To support testing reliability, the National Health Laboratory Service…
View details →Tong M, Ding W, Wu H et al. · 2025 · Infection and drug resistance
Background Abdominal tuberculosis (TB) in pediatric patients is a rare but serious condition that can often be misdiagnosed as malignancy or other abdominal disorders. Intestinal perforation is a rare and life-threatening complication that…
View details →Mogyoróssy S, Nagy G, Griger Z et al. · 2026 · Biomolecules
Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibodies are critical biomarkers in myositis, associated with distinct clinical features and prognosis. This study aimed to evaluate the proportion of anti-MDA5 positivity and…
View details →Thongmeesee K, Aung A, Bui TTH et al. · 2026 · Veterinary medicine and science
Background Haemoplasma (haemotropic Mycoplasma sp.) is an aetiological agent of infectious anaemia in several mammals, including cats and pigs. Blood cytology lacks sensitivity for detecting this infection, and information regarding its…
View details →Cao Y, Wang L, Wang R et al. · 2025 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Objective To assess the diagnostic value of whole exome sequencing (WES) for fetuses undergone induced abortion due to structural abnormalities. Methods A retrospective analysis was carried out on 43 aborted fetuses with negative results…
View details →Ceacero-Marín D, Puig-Pey Comas I, Nieto-Moragas J et al. · 2026 · Scandinavian journal of clinical and laboratory investigation
Background The direct antiglobulin test (DAT) is a key diagnostic tool in evaluating autoimmune haemolytic anaemia. However, indiscriminately ordering this test, together with certain methodological limitations, can compromise the…
View details →Toorop MMA, Kraakman MEM, Claas ECJ et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
This study investigates a diagnostic challenge in detecting Streptococcus pneumoniae using a Spn9802-targeted PCR assay. Four S. pneumoniae isolates tested lytA-positive but Spn9802-negative due to an insertion sequence (IS1515) within…
View details →Wear MP, Kim D, Roy R et al. · 2025 · The Journal of infectious diseases
The detection and quantification of cryptococcal capsular PS antigen in body fluids is useful for the diagnosis of cryptococcosis. We compared the sensitivity of four assays for measuring amount of cryptococcal PS and two clinical assays…
View details →Hunkár A, Prinz G, Pongrácz J et al. · 2026 · Journal of orthopaedic case reports
Introduction Periprosthetic joint infection (PJI) is a serious complication following total joint arthroplasty. It can be potentially limb- or life-threatening, often necessitating complex surgical intervention and prolonged antimicrobial…
View details →Baggio L, Gianni S, De Carlis R et al. · 2026 · World journal of transplantation
We read with interest the study by Cigrowsky et al published in the World Journal of Transplantation . Obesity is a common and serious health issue worldwide. Its incidence has been rapidly and continuously increasing. Obesity causes…
View details →Bandelow B · 2026 · Dialogues in clinical neuroscience
The present review summarises recommendations for the management of posttraumatic stress disorder (PTSD) based on a consensus among international experts in the field.Cognitive-behavioural therapy (CBT) has the best evidence base as a…
View details →Uyanık G, Yüksel M, Abay M et al. · 2026 · Veterinary journal (London, England : 1997)
The present study aimed to determine the diagnostic accuracy of the commercial Alertys OnFarm Pregnancy Test (AOPT) based on pregnancy-associated glycoprotein (PAG) for early pregnancy diagnosis in ewes. A total of 100 multiparous Awassi…
View details →Zhang J, Hu Y, Dong P et al. · 2025 · Diagnostics (Basel, Switzerland)
Sarcoidosis is a rare multisystem inflammatory disease characterized by non-necrotizing granulomas, typically affecting the lungs, lymph nodes, skin, and bones. Due to its extreme clinical heterogeneity, diagnosis remains challenging.…
View details →Pandey P, Bir R, Chatterjee K et al. · 2026 · Iranian journal of microbiology
Background and objectives Sepsis is a life threatening condition caused by a dysregulated host response to infection and is associated with high morbidity and mortality worldwide. Early bacterial detection and therapy with antibiotics…
View details →Samkange A, Chitanga S, Mbiri P et al. · 2025 · The Onderstepoort journal of veterinary research
Neosporosis is a leading cause of bovine abortions worldwide, with a substantial economic impact because of reproductive losses, costing the cattle industry billions of dollars annually. Despite the global significance of Neospora caninum,…
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