12,218 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Scott A. Asher, Hilliary N. White, Alexandra E. Kejner et al. · 2013 · Otolaryngology
OBJECTIVE: An increasing number of head and neck surgeons have begun using transoral robotic-assisted surgery. Our objective was to examine the postoperative bleeding complications we have encountered to determine risk factors and to…
View details →Lauren A. Wise, Edward Ruiz-Narváez, Julie R. Palmer et al. · 2012 · American Journal of Epidemiology
Rates of uterine leiomyomata (UL) are 2-3 times higher in African Americans than in European Americans. It is unclear whether inherited factors explain the ethnic disparity. To investigate the presence of risk alleles for UL that are…
View details →Katherine D. LaClair, Kebreten F. Manaye, Dexter L. Lee et al. · 2013 · Molecular Neurodegeneration
BACKGROUND: Though the precise cause(s) of Alzheimer's disease (AD) remain unknown, there is strong evidence that decreased clearance of β-amyloid (Aβ) from the brain can contribute to the disease. Therapeutic strategies to promote natural Aβ clearance mechanisms, such as the protein apolipoprotein-E (APOE), hold promise for the treatment of AD. The amount of APOE in the brain is regulated by nuclear receptors including retinoid X receptors (RXRs). Drugs that activate RXRs, including bexarotene, can increase APOE and ABCA1 production, and have been shown to decrease the Aβ burden and improve c
View details →Felice Nava, Irene Tramacere, Veronica Andrea Fittipaldo et al. · 2014 · Neuro-Oncology
BACKGROUND: Prospective follow-up studies of large cohorts of patients with glioblastoma (GBM) are needed to assess the effectiveness of conventional treatments in clinical practice. We report GBM survival data from the Brain Cancer…
View details →Abha A. Gupta, James R. Anderson, Alberto S. Pappo et al. · 2011 · Cancer
BACKGROUND: Patients aged >10 years with rhabdomyosarcoma have an inferior outcome compared with patients ages 1 to 9 years, which may be explained by toxicities (adverse events [AEs]) that result in chemotherapy dose reductions. METHODS:…
View details →Young-Hyo Ryu, Yong-Hee Kim, Jin‐Young Lee et al. · 2013 · PLoS ONE
Non-thermal plasma at atmospheric pressure has been actively applied to sterilization. However, its efficiency for inactivating microorganisms often varies depending on microbial species and environments surrounding the microorganisms. We investigated the influence of environmental factors (surrounding media) on the efficiency of microbial inactivation by plasma using an eukaryotic model microbe, Saccharomyces cerevisiae, to elucidate the mechanisms for differential efficiency of sterilization by plasma. Yeast cells treated with plasma in water showed the most severe damage in viability and ce
View details →Mirko S. Gilardino, Mihiran Karunanayake, Taghreed Alhumsi et al. · 2015 · Journal of Craniofacial Surgery
BACKGROUND: Cranioplasty can be performed either with gold-standard, autologous bone grafts and osteotomies or alloplastic materials in skeletally mature patients. Recently, custom computer-generated implants (CCGIs) have gained popularity…
View details →Bahaa Aba Alkhail · 2015 · Medical Teacher
INTRODUCTION: A near-peer-assisted learning term (NPAL) is "a trainee one or more years senior to another trainee". The current study is aiming to determine the pattern of NPAL activities, to compare its effect on student's course…
View details →Yasin Çınar, Abdullah Kürşat Cingü, Fatih Mehmet Türkçü et al. · 2013 · Cutaneous and Ocular Toxicology
PURPOSE: To compare outcomes of accelerated and conventional corneal cross-linking (CXL) for progressive keratoconus (KC). MATERIALS AND METHODS: Patients were divided into two groups as the accelerated CXL group and the conventional CXL…
View details →Selma Kronsteiner-Gicevic, Audrey J. Gaskins, Teresa T. Fung et al. · 2018 · PLoS ONE
BACKGROUND: Dietary diversity scores (DDS) are considered as metrics for monitoring the implementation of the UN's Sustainable Development Goals, but they need to be rigorously evaluated. OBJECTIVE: To examine two DDS, the Food Groups Index (FGI), and the Minimum Dietary Diversity-Women (MDD-W), alongside two dietary quality scores, the Alternate Healthy Eating Index (AHEI-2010) and the Prime Diet Quality Score (PDQS), with risks of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDPs). DESIGN: The analysis included 21,312 (GDM) and 19,917 (HDPs) singleton births r
View details →Maya Williams, Sandra V. Mayer, William L. Johnson et al. · 2014 · American Journal of Tropical Medicine and Hygiene
During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years.…
View details →Yoshimi Kubota, Hiroyasu Iso, Chigusa Date et al. · 2011 · Stroke
BACKGROUND AND PURPOSE: Only a few reports have dealt with the association of antioxidant vitamin intakes with mortality or morbidity from cardiovascular disease in Asia. We investigated the relation of dietary vitamins A, E, and C intake…
View details →Catherine Townsend, Julie Laffy, Bryan Wu et al. · 2016 · Frontiers in Immunology
Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 light chain variable region sequences from IgM-transcribing, newly f
View details →Davide Castagno, Mark C. Petrie, Brian Claggett et al. · 2012 · European Heart Journal
AIMS: The importance of heart rate in the pathophysiology of heart failure with reduced LVEF has recently attracted attention. In particular, the findings of the Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial…
View details →Marcos Hortes Nisihara Chagas, José Alexandre S. Crippa, Antônio Waldo Zuardi et al. · 2013 · Journal of Psychopharmacology
UNLABELLED: Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle. OBJECTIVE: The objective of this paper is to assess the effects on sleep of acute…
View details →Katherine Andrinopoulos, Gretchen Clum, Debra A. Murphy et al. · 2011 · AIDS Education and Prevention
In this study HIV health-related quality of life (HIV-HRQOL) is examined among 179 behaviorally infected adolescent and young adult women. Modifiable psychosocial variables including depression, stigma, social support, and illness…
View details →Eric Lim, Liz Darlison, John Edwards et al. · 2020 · BMJ Open
INTRODUCTION: Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and a platinum drug remains the only licensed standard of care. As the median survival for patients with mesothelioma is 12.1 months, surgery is an important consideration to improve survival and/or quality of life. Currently, only two surgical trials have been performed which found that neither extensive (extra-pleural pneumonectomy) or limited (partial pleurectomy) surgery improved survival (although there was some evidence of improved quality of life). Therefore, clinicians are now looking to evalu
View details →Murat Gedikoğlu, Levent Oğuzkurt, Serkan Gür et al. · 2013 · Catheterization and Cardiovascular Interventions
OBJECTIVES: To compare the success and complication rates of ultrasound-guided or palpation-guided punctures of the common femoral artery in a prospective randomized study. BACKGROUND: Percutaneous femoral arterial access is sometimes…
View details →Oded Zmora, Khaled Madbouly, Hagit Tulchinsky et al. · 2010 · Diseases of the Colon & Rectum
PURPOSE: Urinary bladder drainage for several days after pelvic surgery is a common surgical practice, despite insufficient evidence supporting its routine use. The aim of this study was to prospectively evaluate the utility of urinary…
View details →Sushmita Pamidi, Isabelle Marc, Gabrielle Simoneau et al. · 2016 · Thorax
OBJECTIVE: It is unclear whether objectively measured maternal sleep-disordered breathing (SDB) leads to poor fetal outcomes. In this study, we prospectively assessed whether polysomnography-based diagnosis of SDB in the third trimester is…
View details →Michael A. Castello, John D. Jeppson, Salvador Soriano · 2014 · BMC Neurology
BACKGROUND: High-profile Phase 3 clinical trials of bapineuzumab and solanezumab, antibodies targeted at amyloid-beta (Aβ) removal, have failed to meet their primary endpoints. Neither drug improves clinical outcomes in patients with late onset AD, joining a long list of unsuccessful attempts to treat AD with anti-amyloid therapies. DISCUSSION: These therapies are based on the assumption that Aβ accumulation is the primary pathogenic trigger of AD. Current evidence suggests that Aβ may actually accumulate as part of an adaptive response to long-term chronic brain stress stimuli that would make
View details →Jan Krhút, Vladimír Borovička, Karolína Bílková et al. · 2018 · Neurourology and Urodynamics
AIMS: To assess the efficacy and safety of mirabegron in the treatment of neurogenic detrusor overactivity. METHODS: This prospective, multicenter, randomized, double-blind, placebo-controlled study was conducted in three tertiary centers,…
View details →Mary Carmelle Philogene, Serena M. Bagnasco, Edward S. Kraus et al. · 2016 · Transplantation
BACKGROUND: This is a cross-sectional study designed to evaluate the histologic characteristics of graft injury in the presence of anti-angiotensin II type 1 receptor antibody (AT1R-Ab) and anti-endothelial cell antibody (AECA). METHODS:…
View details →Konstantinos A. Toulis, Brian H Willis, Tom Marshall et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
Context: Empagliflozin was found to decrease mortality in patients with type 2 diabetes mellitus (T2DM) and a prior cardiovascular disease (CVD) event. Objectives: To establish whether these benefits can be replicated in a real-world…
View details →Christopher M. Jackson, Christina M. Kochel, Christopher J. Nirschl et al. · 2015 · Clinical Cancer Research
PURPOSE: Immune responses to antigens originating in the central nervous system (CNS) are generally attenuated, as collateral damage can have devastating consequences. The significance of this finding for the efficacy of tumor-targeted…
View details →Daqing Hong, Jeong Jin Min, Jeongwon Kim et al. · 2010 · Anaesthesia and Intensive Care
In several recent clinical trials on cardiac surgery patients, remote ischaemic preconditioning (RIPC) showed a powerful myocardial protective effect. However the effect of RIPC has not been studied in patients undergoing off-pump coronary…
View details →John‐Stuart Brittain, Hayriye Cagnan, Arpan R. Mehta et al. · 2015 · Journal of Neuroscience
Parkinson's disease (PD) and essential tremor (ET) are the two most common movement disorders. Both have been associated with similar patterns of network activation leading to the suggestion that they may result from similar network dysfunction, specifically involving the cerebellum. Here, we demonstrate that parkinsonian tremors and ETs result from distinct patterns of interactions between neural oscillators. These patterns are reflected in the tremors' derived frequency tolerance, a novel measure readily attainable from bedside accelerometry. Frequency tolerance characterizes the temporal ev
View details →Helena Brodská, J Valenta, Květa Pelinková et al. · 2017 · Clinical Chemistry and Laboratory Medicine (CCLM)
BACKGROUND: Inflammatory biomarkers may aid to distinguish between systemic inflammatory response syndrome (SIRS) vs. sepsis. We tested the hypotheses that (1) presepsin, a novel biomarker, can distinguish between SIRS and sepsis, and (2)…
View details →Boulos Nassar, Mary Vaughan‐Sarrazin, Lan Jiang et al. · 2014 · JAMA Internal Medicine
IMPORTANCE: Intensive care unit (ICU) telemedicine (TM) programs have been promoted as improving access to intensive care specialists and ultimately improving patient outcomes, but data on effectiveness are limited and conflicting.…
View details →Richard H. White, Ann Brunson, Patrick S. Romano et al. · 2016 · Circulation
BACKGROUND: Evidence that vena cava filters (VCFs) are beneficial is limited. METHODS AND RESULTS: We retrospectively analyzed all noncancer patients admitted to nonfederal California hospitals for acute venous thromboembolism from 2005 to…
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