Negative / Null Result ReportMedicine
Yang YJ, Lee MR, Chung CL et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Despite the availability of rapid tuberculosis (TB) nucleic acid amplification (NAA) testing, prevention of TB transmission within healthcare facilities remains a challenge due to ongoing difficulties in promptly isolating…
View details →Negative / Null Result ReportMedicine
Wu M, Bukowski BR, Hickman JA et al. · 2026 · The Journal of arthroplasty
Background Accurate diagnosis of periprosthetic joint infection (PJI) remains suboptimal. Of the tests used, one is the alpha defensin lateral flow assay (ADLFA). This study assessed ADLFA for the diagnosis of PJI in total hip…
View details →Negative / Null Result ReportMedicine
Ismail A, Abunasser S, Salameh IM et al. · 2026 · Microorganisms
Fourth-generation immunoassays are widely used for HIV and syphilis screening; however, false-reactive results may increase confirmatory testing and operational burden in high-throughput laboratories. This study evaluated the comparative…
View details →Failed Experiment ReportMedicine
Kaya B, Can E, Karakurt Y et al. · 2026 · Advances in neonatal care : official journal of the National Association of Neonatal Nurses
Background Early-onset neonatal sepsis (EOS) remains a diagnostic challenge because clinical signs are nonspecific and blood cultures, although the diagnostic gold standard may yield false-negative results due to low blood volumes or…
View details →Replication FailureMedicine
Wang D, Huang D, Shen H et al. · 2026 · Nature human behaviour
Human-machine partnerships are increasingly used to address grand societal challenges, yet knowledge of the comparative strengths of humans and machines to innovate is nascent. Here we compare the ability of humans (N = 9,198) and large…
View details →Replication FailureOpen accessMedicine
Hajkowicz K, Woodford J, Pillai ES et al. · 2025 · Emerging infectious diseases
Using metatranscriptomics, we identified Trubanaman virus in cerebrospinal fluid from a severely immunocompromised man who died of encephalitis in Queensland, Australia. Virus sequences were related to orthobunyaviruses previously detected…
View details →Negative / Null Result ReportMedicine
Greenfield PT, Phillips BB, Throckmorton TW et al. · 2026 · Journal of surgical orthopaedic advances
Despite studies highlighting magnetic resonance imaging (MRI)/magnetic resonance angiogram (MRA) accuracy in diagnosing shoulder pathologies, there remains a paucity of data regarding false negative results of these tests. The authors…
View details →Negative / Null Result ReportMedicine
Burleigh-Flayer H, Canatsey R, Jean PA et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Cyclo-di-Badge (CdB) is a by-product of epoxy resin coatings applied to the inside of food cans. By-products are non-intentionally added substances (NIAS) with potential to migrate into food. Due to the lack of data on CdB, studies were…
View details →Failed Experiment ReportOpen accessMedicine
Rosiles T, Nguyen M, Calin-Jageman RJ et al. · 2026 · eNeuro
Forming a long-term memory requires changes in neuronal transcription. What happens, though, as the memory is forgotten? And how does the transcriptional state relate to the maintenance and recall of the long-term memory? To answer these…
View details →Negative / Null Result ReportOpen accessMedicine
Al Ayoubi O, Aldakak MA, Ibrahim B et al. · 2026 · Clinical case reports
Pleural tuberculosis is a common manifestation of extrapulmonary tuberculosis; however, its diagnosis remains challenging in paucibacillary disease, where clinical presentation may be atypical and microbiological tests frequently yield…
View details →Negative / Null Result ReportMedicine
Nielsen SM, Russell EM, Ellsworth RE et al. · 2025 · Journal of the National Comprehensive Cancer Network : JNCCN
Background The presence of variants of uncertain significance (VUS) should not influence clinical management; however, prior studies on breast cancer-related health care utilization in women with VUS versus negative germline genetic test…
View details →Failed Experiment ReportOpen accessMedicine
McGuier M, Bragg E, Holtzheimer P et al. · 2026 · eNeuro
There is a critical need for robust and reliable preclinical models for posttraumatic stress disorder (PTSD) to better understand pathophysiological mechanisms and support the development of novel treatments. The single prolonged stress…
View details →Negative / Null Result ReportMedicine
Salman E · 2026 · Indian journal of medical microbiology
Background The primary reason for increased lab use is inappropriate or needless test requests. Our study examined the benefits of repeated antinuclear antibody (ANA) testing and the reasons for ANA test requests in accordance with…
View details →Negative / Null Result ReportMedicine
Watanabe K, Takahashi H, Narumi R et al. · 2025 · The journal of obstetrics and gynaecology research
Non-invasive prenatal testing (NIPT) is a screening method that analyzes cell-free DNA (cfDNA) in maternal plasma to detect major aneuploidies. However, NIPT can fail to identify subtle chromosomal aberrations. We report a case in which…
View details →Failed Experiment ReportOpen accessMedicine
Hartady T, Sugandi SD, Viqih M · 2026 · Veterinary sciences
Poultry disease outbreaks are frequently multifactorial, involving complex interactions between infectious agents and environmental stressors. This report describes a case of avian influenza (AI) co-infection in a commercial broiler farm…
View details →Failed Experiment ReportOpen accessMedicine
İpek Demir K, Yılmaz D, Güvenir FA et al. · 2026 · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Background and objective Adverse drug reactions (ADRs) are a serious public health problem. This study aimed to evaluate reaction characteristics and diagnostic test results in pediatric patients in whom suspected drug allergy was…
View details →Failed Experiment ReportOpen accessMedicine
Yanagihara K, Nagata K, Yamakawa T et al. · 2025 · Cancers
Backgrounds : Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is a critical predictive biomarker for immune checkpoint inhibitor (ICI) therapy in triple-negative breast cancer (TNBC). However, prolonged storage of…
View details →Negative / Null Result ReportOpen accessMedicine
Sridapan T, Jaturapaktrarak C, Rujirawat T et al. · 2026 · Journal of fungi (Basel, Switzerland)
Pythiosis is an emerging infectious disease caused by the oomycete Pythium insidiosum , affecting humans and animals primarily in subtropical and tropical regions. The pathogen is commonly found in swampy environments, and exposure can…
View details →Negative / Null Result ReportOpen accessMedicine
Meng S, Zhao W, Zhang H et al. · 2026 · EJHaem
Objective To retrospectively analyze the early efficacy and safety of azacitidine plus lisaftoclax in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome with increased blasts (MDS-IB), providing a reliable clinical…
View details →Negative / Null Result ReportMedicine
Castle PE, Befano B, Hyer M et al. · 2026 · Journal of the National Cancer Institute
Background We demonstrated that cervical cancer risk following any screening result is lower if there is a known prior negative screening history vs an unknown screening history. We extended these findings to look at how screening performs…
View details →Negative / Null Result ReportMedicine
Çubuk F, Öksüz C, Öz M · 2026 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Objective A substantial proportion of urine cultures in patients with suspected urinary tract infections (UTIs) yield negative results. This study aimed to evaluate whether parameters from automated urinalysis could predict the likelihood…
View details →Negative / Null Result ReportOpen accessMedicine
Sato R, Takasaka N, Hosaka Y et al. · 2025 · BMC infectious diseases
Background The T-SPOT.TB assay is widely used for the adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative T-SPOT.TB results. The extent of TB spread may influence host immune functions, which can…
View details →Negative / Null Result ReportOpen accessMedicine
Sripa J, Suebsamran P, Pangjit K · 2026 · BMC infectious diseases
Background Opisthorchiasis remains an important public health problem in Southeast Asia and is strongly associated with cholangiocarcinoma. Although stool-based diagnosis is widely used, its sensitivity is limited in light infections,…
View details →Negative / Null Result ReportOpen accessMedicine
Unubol N, Ayaş M, Uyar NY et al. · 2025 · Microorganisms
In recent years, the World Health Organization has highlighted biofilm-derived multidrug-resistant bacteria as a critical threat to both global health and the environment. Although various testing methods are available, crystal violet and…
View details →Failed Experiment ReportMedicine
Witkin JM, Pandey KP, Smith JL · 2022 · Pharmacology, biochemistry, and behavior
Pharmacological modulation of glutamate has long been considered to be of immense therapeutic utility. The metabotropic glutamate receptors (mGluRs) are potential targets for safely altering glutamate-driven excitation. Data support the…
View details →Failed Experiment ReportMedicine
Abdelmalek MF, Sanyal AJ, Nakajima A et al. · 2024 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Pegbelfermin is a polyethylene glycol-conjugated analog of human fibroblast growth factor 21, a nonmitogenic hormone that regulates energy metabolism. This phase 2b study evaluated 48-week pegbelfermin treatment in…
View details →Negative / Null Result ReportOpen accessMedicine
Mukherjee S, Fujiwara Y, Fountzilas C et al. · 2025 · Cancer medicine
Background Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel…
View details →Negative / Null Result ReportMedicine
Fu Q, Chen Y, Huang D et al. · 2023 · Annals of surgical oncology
Background Folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) or modified FOLFIRINOX (mFFX) is the first-line standard of care for metastatic pancreatic adenocarcinoma; effective and safe treatment strategies are needed…
View details →Negative / Null Result ReportMedicine
Hiester A, Che Y, Lusch A et al. · 2023 · European urology
Background Primary retroperitoneal lymph node dissection (RPLND) for clinical stage (CS) IIA/B seminoma without adjuvant treatment is an experimental treatment to avoid radiotherapy- or chemotherapy-related toxicity from standard…
View details →Methods Dead-EndMedicine
Hamada S, Satomoto K, Goto K et al. · 2026 · Mutation research. Genetic toxicology and environmental mutagenesis
Objective The liver micronucleus (MN) assay is useful for detecting genotoxic hepatocarcinogens that may be missed by the erythrocyte MN assay. Because micronuclei form only in dividing cells, evaluating hepatocyte proliferation is…
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