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Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

Severe COVID-19 in a patient with chronic graft-versus-host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib.

Saraceni F, Scortechini I, Mancini G et al. · 2021 · Transplant infectious disease : an official journal of the Transplantation Society

Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant, which is known to be mediated by cytotoxic T-cell effectors and dysregulated inflammatory cytokines. Similarly, the lung injury observed in…

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Replication FailureOpen accessMedicine

Regional nodal irradiation (RNI) in breast cancer patients with residual isolated tumor cells or micrometastatic nodal disease after neoadjuvant chemotherapy.

Kim JK, Karp JM, Gerber NK · 2023 · Clinical and translational radiation oncology

Background/purpose The optimal management of residual micrometastases and isolated tumor cells (ITC) in patients with invasive breast cancer who undergo neoadjuvant chemotherapy (NAC) followed by definitive surgery is not well-studied. We…

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Negative / Null Result ReportOpen accessMedicine

Feasibility of two levels of protein intake in patients with colorectal cancer: findings from the Protein Recommendation to Increase Muscle (PRIMe) randomized controlled pilot trial.

Ford KL, Sawyer MB, Ghosh S et al. · 2024 · ESMO open

Background Low muscle mass (MM) predicts unfavorable outcomes in cancer. Protein intake supports muscle health, but oncologic recommendations are not well characterized. The objectives of this study were to evaluate the feasibility of…

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Negative / Null Result ReportMedicine

Baclofen as add-on to standard psychosocial treatment for alcohol dependence: a randomized, double-blind, placebo-controlled trial with 1 year follow-up.

Ponizovsky AM, Rosca P, Aronovich E et al. · 2015 · Journal of substance abuse treatment

Background Limited clinical trials and case-reports yielded conflicting results regarding the efficacy of baclofen (a GABAB agonist) in the treatment of alcohol dependence. The aim of this study was to test the efficacy and tolerability of…

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Negative / Null Result ReportOpen accessMedicine

Neurophysiological Changes Associated with Antidepressant Response to Ketamine Not Observed in a Negative Trial of Scopolamine in Major Depressive Disorder.

Park L, Furey M, Nugent AC et al. · 2019 · The international journal of neuropsychopharmacology

Background This randomized, placebo-controlled, crossover trial examined the antidepressant efficacy of the muscarinic antagonist scopolamine in major depressive disorder subjects with more severe and refractory forms of major depressive…

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Negative / Null Result ReportMedicine

The Functional Visual Field(s) in simple visual search.

Wu CC, Wolfe JM · 2022 · Vision research

During a visual search for a target among distractors, observers do not fixate every location in the search array. Rather processing is thought to occur within a Functional Visual Field (FVF) surrounding each fixation. We argue that there…

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Failed Experiment ReportOpen accessMedicine

Timing of Exposure to ICU Diaries and Its Impact on Mental Health, Memories, and Quality of Life: A Double-Blind Randomized Control Trial.

Tripathy S, Acharya SP, Sahoo AK et al. · 2022 · Critical care explorations

Optimal time for ICU diary delivery and impact on mental health (MH), anxiety-depression, post-traumatic stress symptoms (PTSS), quality of life (QOL), and memories is unclear. We evaluated the effect of ICU diaries, dispatched at…

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Negative / Null Result ReportOpen accessMedicine

Oral cannabidiol (CBD) as add-on to paracetamol for painful chronic osteoarthritis of the knee: a randomized, double-blind, placebo-controlled clinical trial.

Pramhas S, Thalhammer T, Terner S et al. · 2023 · The Lancet regional health. Europe

Background Painful knee osteoarthritis (KOA) is common, pharmacological treatment, however, is often hampered by limited tolerability. Cannabidiol, which preclinically showed anti-inflammatory, analgesic activity, could supplement…

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Failed Experiment ReportOpen accessMedicine

Angina and left ventricular dysfunction: can we 'reduce' it?

Biscaglia S, Tebaldi M, Mele D et al. · 2019 · European heart journal supplements : journal of the European Society of Cardiology

Despite the evolution in pharmacology and devices, recurrent and persistent angina still represent a frequent issue in clinical practice. A 69-year-old Caucasian female patient has history of surgical aortic valve replacement with a…

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Negative / Null Result ReportOpen accessMedicine

Metabotropic Glutamate Receptor 4 (mGlu4) Positive Allosteric Modulators Lack Efficacy in Rat and Marmoset Models of L-DOPA-Induced Dyskinesia.

Finlay CJ, Jackson MJ, Fisher R et al. · 2024 · Journal of Parkinson's disease

Background Increased activity across corticostriatal glutamatergic synapses may contribute to L-DOPA-induced dyskinesia in Parkinson's disease. Given the weak efficacy and side-effect profile of amantadine, alternative strategies to reduce…

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Negative / Null Result ReportOpen accessMedicine

The effect of negative randomized trials and surgeon volume on the rates of arthroscopy for patients with knee OA.

Ghomrawi HMK, Marx RG, Pan TJ et al. · 2018 · Contemporary clinical trials communications

Publication of 2 (negative) randomized clinical trials (RCTs) in 2002 and 2008 demonstrating inefficacy of arthroscopic debridement of the knee (ADK) for osteoarthritis, and a 2004 national non-coverage Medicare determination, have…

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Negative / Null Result ReportOpen accessMedicine

Efficacy of Wharton Jelly Mesenchymal Stromal Cells infusions in moderate to severe SARS-Cov-2 related acute respiratory distress syndrome: a phase 2a double-blind randomized controlled trial.

Pochon C, Laroye C, Kimmoun A et al. · 2023 · Frontiers in medicine

Background The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal…

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Negative / Null Result ReportOpen accessMedicine

Exhaled-Breath Testing Using an Electronic Nose during Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome: An Experimental Pilot Study.

Goudman L, Jansen J, Vets N et al. · 2021 · Journal of clinical medicine

The increased awareness of discrepancies between self-reporting outcome measurements and objective outcome measurements within the field of neuromodulation has accelerated the search towards more objective measurements. The aim of this…

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Negative / Null Result ReportOpen accessMedicine

Radiation Therapy for Retroperitoneal Sarcomas: A Strass-Ful Situation.

Farooqi AS, Guadagnolo BA, Mitra D et al. · 2023 · Current oncology (Toronto, Ont.)

Locoregional recurrence (LRR) is the predominant pattern of relapse and often the cause of death in patients with retroperitoneal sarcomas (RPS). As a result, reducing LRR is a critical objective for RPS patients. However, unlike soft…

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Negative / Null Result ReportOpen accessMedicine

Pembrolizumab Plus Docetaxel Versus Docetaxel for Previously Treated Metastatic Castration-Resistant Prostate Cancer: The Randomized, Double-Blind, Phase III KEYNOTE-921 Trial.

Petrylak DP, Ratta R, Matsubara N et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose The standard of care for metastatic castration-resistant prostate cancer (mCRPC) after second-generation androgen receptor pathway inhibitor (ARPI) therapy is still docetaxel. The randomized, double-blind, phase III KEYNOTE-921…

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Negative / Null Result ReportMedicine

Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial.

Brustad N, Garland J, Thorsen J et al. · 2020 · JAMA pediatrics

Importance Studies suggest an association between maternal vitamin D status during pregnancy and offspring anthropometry and bone mineralization, but investigations are few and with mixed results. Objective To investigate the effect of a…

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Negative / Null Result ReportOpen accessMedicine

Cholesterol efflux capacity of high-density lipoprotein was not associated with cognitive decline and brain structures in older people with diabetes mellitus.

Wu Y, Tan KC, Shiu SW et al. · 2022 · Journal of diabetes investigation

Aims/introduction To examine the association between cholesterol efflux capacity (CEC) of serum high-density lipoprotein (HDL) and cognitive function and brain structures in older people with diabetes mellitus. Materials and methods…

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Failed Experiment ReportOpen accessMedicine

The Effect of Live-Virus Vaccines on Tests for Tuberculosis Infection During the US Immigration Medical Examination: Are Vaccines Causing False-Negative Results?

Regan JJ, Wang Z, Phares CR · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background It is not recommended to perform tuberculin skin tests (TSTs) or interferon-γ release assays (IGRAs) in the 4 weeks following live-virus vaccination because these vaccines are thought to increase the risk of false-negative…

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Failed Experiment ReportOpen accessMedicine

Four Consecutive False Negative Newborn Screens in a Patient with Classical Congenital Adrenal Hyperplasia: A Case Report

Rizzuto P, Gangat M, Khattab A et al. · 2026 · Journal of clinical research in pediatric endocrinology

21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH). Salt-wasting CAH can present with life-threatening salt-wasting crises, underscoring the importance of universal newborn screening. We present a…

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