12,380 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Ruiz Hispán E, Pedregal M, Cristobal I et al. · 2021 · Journal of clinical medicine
Peritoneal metastases from gastric cancer play a key role in the fatal prognosis of the disease. The lack of efficacy of actual therapeutic approaches together with the outcomes achieved with checkpoint inhibitors in gastric cancer compel…
View details →Rabbia M, Guridi Ormazabal M, Staunton H et al. · 2024 · Journal of neuromuscular diseases
Background Stride Velocity 95th Centile (SV95C) is the first wearable device-derived clinical outcome assessment (COA) to receive European Medicines Agency (EMA) qualification as a primary endpoint in ambulant patients with Duchenne…
View details →Chase DM, Huang HQ, Deng W et al. · 2025 · Gynecologic oncology
Objective To prospectively evaluate the impact of adjuvant chemoradiation (RT + CIS) versus radiation (RT) on quality of life (QOL) and patient-reported outcomes (PROs) among patients with intermediate-risk, stage I-IIA cervical cancer…
View details →Floreani ED, Orlandi S, Chau T · 2022 · Frontiers in human neuroscience
Brain-computer interfaces (BCIs) are being investigated as an access pathway to communication for individuals with physical disabilities, as the technology obviates the need for voluntary motor control. However, to date, minimal research…
View details →Corpening B, Bürgler A, Tamási B et al. · 2025 · Environmental epidemiology (Philadelphia, Pa.)
Background Prior research suggests pollen allergies may be associated with cognitive function, although the effect sizes and specific cognitive outcomes varied across studies. With pollen seasons starting earlier and intensifying due to…
View details →Shkreli L, Woud ML, Bergunde L et al. · 2025 · European journal of psychotraumatology
Background: Steroid hormone dysregulations have frequently been implicated in posttraumatic stress disorder (PTSD) pathogenesis. However, the translation into naturalistic clinical settings as markers of symptomatology and treatment…
View details →Nicolaou L, Reuland CJ, Yang M et al. · 2026 · Lancet regional health. Americas
Background Household air pollution (HAP) is a major global health risk. Observational studies link HAP exposure to impaired child growth, but randomized controlled trial (RCT) evidence is inconsistent. Methods We followed children born…
View details →Willems YE, Raffington L, Ligthart L et al. · 2024 · Frontiers in psychiatry
Background Difficulty with self-control, or the ability to alter impulses and behavior in a goal-directed way, predicts interpersonal conflict, lower socioeconomic attainments, and more adverse health outcomes. Etiological understanding,…
View details →Madrigano J, Yan D, Liu T et al. · 2024 · GeoHealth
Indonesia faces significant air quality issues due to multiple emissions sources, including rapid urbanization and peatland fires associated with agricultural land management. Limited prior research has estimated the episodic shock of…
View details →Wachowicz A, Galbarczyk A, Marcinkowska UM et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council
Objectives Duration and quality of sleep are influenced by many factors, including hormonal changes. The aim of this study was to investigate the differences between the phases of the menstrual cycle in total sleep duration and sleep stage…
View details →Jennings EA, Roberts-Toler C, Harriman NW et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives Social isolation is a concern among aging populations, and household composition may play an important role in its impact on mental health. We use data from an aging cohort in rural South Africa to investigate the moderating…
View details →Abdul Jafar NK, Tham EKH, Fok D et al. · 2026 · Nutrients
Background: Maternal chronotype, maternal sleep, and breastfeeding practices are separately associated with maternal mood. However, it is not known if maternal mood mediates the associations between maternal chronotype or maternal sleep…
View details →Barendse MEA, Bilder RM, Snijders AL et al. · 2026 · Biological psychiatry global open science
Background Function of the striatal reward system has been implicated in both psychotic and bipolar disorders. We aimed to test whether ventral striatum (VS) activation during reward anticipation meets criteria of an endophenotype of these…
View details →Torkan A, Zoghi M, Foroughimehr N et al. · 2025 · Brain sciences
Background Research on the impact of 5G mobile phone electromagnetic exposure on corticospinal excitability and intracortical mechanisms is still poorly understood. Objective This randomized controlled pilot study explored the effects of…
View details →Millington O, Sharma A, Montanaro S et al. · 2023 · Chemical science
In molecular dimers that undergo intramolecular singlet fission (iSF), efficient iSF is typically accompanied by triplet pair annihilation at rates which prohibit effective triplet harvesting. Collisional triplet pair separation and…
View details →Galang CM, Obhi SS · 2023 · Experimental brain research
Previous research has shown that empathic pain observation can lead to motor facilitation in the form of faster reaction times. However, it is unclear whether participants are focusing on the others' pain or simply focusing on their own…
View details →Rosenheck R, Kurtz SG, Anand ST et al. · 2023 · Psychiatry research
Multi-site randomized effectiveness trials evaluate treatments under real-world conditions. Whether results change practice is under-studied. A 6-month 26-site Veterans Health Administration (VHA) cooperative study published in 2011…
View details →Das S, Freedland SJ · 2023 · Cancer prevention research (Philadelphia, Pa.)
Statins are widely prescribed medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase and therefore reduce cholesterol synthesis. Given the key role of cholesterol in cancer, statins may therefore have…
View details →Costa CL, Araujo-Menendez CEE, Lawrence A et al. · 2026 · Frontiers in aging neuroscience
Background High blood pressure (BP) is a known risk factor for dementia, but the relationships between BP and gross brain volumes are mixed and are understudied in groups who are at particularly high risk for dementia, such as…
View details →Chang MJ, Liu MT, Chen MR et al. · 2023 · Journal of medical virology
Systemic lupus erythematosus (SLE) characterized by immune dysfunction is possibly more vulnerable to herpes simplex virus (HSV) infection. The infection has been intensively considered a common onset and exacerbation of SLE. This study is…
View details →Martineau AR · 2023 · The Proceedings of the Nutrition Society
This review summarises evidence relating to a potential role for vitamin D supplementation in the prevention or treatment of coronavirus disease 2019 (COVID-19). Laboratory studies show that the active vitamin D metabolite…
View details →Palepu K, Sadeghi K, Kleinschmidt DF et al. · 2023 · BMC neurology
Background Sleep spindle activity is commonly estimated by measuring sigma power during stage 2 non-rapid eye movement (NREM2) sleep. However, spindles account for little of the total NREM2 interval and therefore sigma power over the…
View details →Trombetta AB, Hanney WJ, Anderson AW et al. · 2026 · Muscles (Basel, Switzerland)
Background Tensiomyography (TMG) offers a noninvasive means of evaluating skeletal muscle contractile properties, including muscle displacement (Dm), delay time (Td), contraction time (Tc), half-relaxation time (Tr), and sustain time (Ts).…
View details →Errington TM, Mathur M, Soderberg CK et al. · 2021 · eLife
Replicability is an important feature of scientific research, but aspects of contemporary research culture, such as an emphasis on novelty, can make replicability seem less important than it should be. The Reproducibility Project: Cancer…
View details →Gass JC, Tonkin S, Maguin E et al. · 2024 · Translational behavioral medicine
Ecological Momentary Assessment (EMA) methods are increasingly used by translational scientists to study real-world behavior and experience. The ability to draw meaningful conclusions from EMA research depends upon participant compliance…
View details →Giesen CG, Eder AB · 2022 · Cognition & emotion
The adaptation-by-binding account and the arousal-biased competition model suggest that emotional arousal increases binding effects for transient links between stimuli and responses. Two highly-powered, pre-registered experiments tested…
View details →Ianni KM, Chernew ME, McWilliams JM · 2026 · Health services research
Objective To examine the effects of offering non-emergency medical transportation (NEMT) on care utilization among low-income and disabled beneficiaries in Medicare Advantage (MA). Study setting and design We leveraged the 2019 expansion…
View details →Mauricio AM, Cioffi CC, Sanders AM et al. · 2025 · Psychological services
This explanatory sequential mixed methods hybrid Type 1 study examined the efficacy and implementation of Connect2Test, a brief motivational enhancement intervention to increase SARS-CoV-2 testing among people experiencing houselessness…
View details →Jaeger B, Jones AL, Satchell L et al. · 2026 · International review of social psychology
The role of perceiver differences in impression formation remains relatively poorly understood. One line of research has tried to understand these differences by exploring the role of perceivers' needs and motivations, reasoning that…
View details →Kumar AR, Sanford NN · 2025 · Seminars in radiation oncology
Based on available Level 1 evidence, standard dose conventional chemoradiation does not improve survival in patients with locally advanced pancreas cancer (LAPC), thus chemotherapy remains the only widely accepted therapy. Yet prognosis…
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