12,218 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Ali A. Farooqui, Bradley Hiser, Stephen L. Barnes et al. · 2013 · Journal of neurosurgery
OBJECT: Patients with traumatic brain injury (TBI) are at risk for development of thromboembolic disease. The use of chemoprophylaxis in this patient group has not fully been characterized. The authors hypothesize that early…
View details →Edward S. Brewer, B. I. Reznikov, Rebecca F. Liberman et al. · 2010 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: The yield of head computed tomography (CT) for patients who suffered head trauma with a presenting Glasgow Coma Scale (GCS) score of 15 has been reported to be low, even in patients who are anticoagulated or on antiplatelet…
View details →Sung‐Wan Kim, Joon‐An Yoo, S. Y. Lee et al. · 2010 · Human Psychopharmacology Clinical and Experimental
OBJECTIVE: This study compared the effectiveness of risperidone and olanzapine in the treatment of delirium. METHODS: This was a 7-day, randomized, comparative clinical trial of risperidone and olanzapine in patients with delirium. The…
View details →Patricia Baxter, Jack M. Su, Arzu Onar‐Thomas et al. · 2020 · Neuro-Oncology
BACKGROUND: A Pediatric Brain Tumor Consortium (PBTC) phase I/II trial of veliparib and radiation followed by veliparib and temozolomide (TMZ) was conducted in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). The…
View details →Mark A. Hyde, Michael L. Hadley, Payam Tristani‐Firouzi et al. · 2012 · Archives of Dermatology
OBJECTIVE: To determine if the complete response rates of lentigo maligna (LM) to imiquimod, 5%, cream can be improved by the addition of a topical retinoid. DESIGN: Prospective randomized study of patients treated with imiquimod alone vs…
View details →Allon N. Friedman, Mary Chambers, Lisa M. Kamendulis et al. · 2013 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Obesity precedes and is strongly linked to the development of type 2 diabetic nephropathy in most patients, yet little is known about the effects of weight reduction on this disease. This study aimed to establish…
View details →William W. Ho, Igor L. Gomes‐Santos, Shuichi Aoki et al. · 2021 · Proceedings of the National Academy of Sciences
Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC). Mismatch repair-proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are unresponsive to immune checkpoint blockade (ICB) therapy. Here…
View details →Syed Khalid, Ravi S. Nunna, Samantha Maasarani et al. · 2020 · Neurosurgical FOCUS
OBJECTIVE: Patients with osteopenia or osteoporosis who require surgery for symptomatic degenerative spondylolisthesis may have higher rates of postoperative pseudarthrosis and need for revision surgery than patients with normal bone…
View details →Elisa Maria Stroppa, Ilaria Toscani, Chiara Citterio et al. · 2020 · Future Oncology
Background: We describe cancer patients with coronavirus disease-2019 (COVID-19) infection treated at the Piacenza’s general hospital (north Italy). Materials & methods: 25 cancer patients infected by COVID-19 admitted at the Piacenza’s…
View details →Caner Süsal, Dániel Wettstein, Bernd Döhler et al. · 2015 · Transplantation
BACKGROUND: The association of donor-specific HLA antibodies (DSA) with kidney graft failure has been addressed previously; however, the majority of studies were based on small numbers of patients with graft failure. METHODS: We…
View details →Martin D. Hoffman, Julie L. Ingwerson, Ian R. Rogers et al. · 2012 · Wilderness and Environmental Medicine
OBJECTIVE: Very high blood creatine kinase (CK) concentrations have been observed among recent finishers of the 161-km Western States Endurance Run (WSER), and it has been suggested that there is a link between rhabdomyolysis and…
View details →David Hodgson, Richard Pebody, Jasmina Panovska‐Griffiths et al. · 2020 · BMC Medicine
BACKGROUND: With a suite of promising new RSV prophylactics on the horizon, including long-acting monoclonal antibodies and new vaccines, it is likely that one or more of these will replace the current monoclonal Palivizumab programme. However, choosing the optimal intervention programme will require balancing the costs of the programmes with the health benefits accrued. METHODS: To compare the next generation of RSV prophylactics, we integrated a novel transmission model with an economic analysis. We estimated key epidemiological parameters by calibrating the model to 7 years of historical ep
View details →Xuling Lin, M. Lee, Olivia Buck et al. · 2016 · American Journal of Neuroradiology
BACKGROUND AND PURPOSE: Glioblastoma and primary CNS lymphoma dictate different neurosurgical strategies; it is critical to distinguish them preoperatively. However, current imaging modalities do not effectively differentiate them. We aimed to examine the use of DWI and T1-weighted dynamic contrast-enhanced–MR imaging as potential discriminative tools. MATERIALS AND METHODS: We retrospectively reviewed 18 patients with primary CNS lymphoma and 36 matched patients with glioblastoma with pretreatment DWI and dynamic contrast-enhanced–MR imaging. VOIs were drawn around the tumor on contrast-enhan
View details →Karolina Partheen, Björg Kristjánsdóttir, Karin Sundfeldt · 2011 · Journal of Gynecologic Oncology
OBJECTIVE: Women presenting with a large or complex ovarian cyst are referred to extensive surgical staging to ensure the correct diagnosis and treatment of a possible epithelial ovarian cancer. We hypothesized that measurement of the…
View details →Azra Fatima, Shao Kaifeng, Sven Dittmann et al. · 2013 · PLoS ONE
Long QT syndromes (LQTS) are heritable diseases characterized by prolongation of the QT interval on an electrocardiogram, which often leads to syncope and sudden cardiac death. Here we report the generation of induced pluripotent stems (iPS) cells from two patients with LQTS type 3 carrying a different point mutation in a sodium channel Nav1.5 (p.V240M and p.R535Q) and functional characterization of cardiomyocytes (CM) derived from them. The iPS cells exhibited all characteristic properties of pluripotent stem cells, maintained the disease-specific mutation and readily differentiated to CM. Th
View details →A. Sertaç Batıoğlu, Uğraş Şahin, Beril Gürlek et al. · 2011 · Gynecological Endocrinology
The aim of the study was to evaluate the efficacy of melatonin administration on oocyte quality in women underwent in vitro fertilization (IVF) cycles. Eighty-five women undergoing IVF cycles were randomized in two groups during IVF-embryo…
View details →Martin Michaelis, Bishr Agha, Florian Rothweiler et al. · 2015 · Scientific Reports
Flubendazole was shown to exert anti-leukaemia and anti-myeloma activity through inhibition of microtubule function. Here, flubendazole was tested for its effects on the viability of in total 461 cancer cell lines. Neuroblastoma was identified as highly flubendazole-sensitive cancer entity in a screen of 321 cell lines from 26 cancer entities. Flubendazole also reduced the viability of five primary neuroblastoma samples in nanomolar concentrations thought to be achievable in humans and inhibited vessel formation and neuroblastoma tumour growth in the chick chorioallantoic membrane assay. Resis
View details →Raffaele Garofalo, Brody A. Flanagin, Alessandro Castagna et al. · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Complex proximal humeral fractures are very difficult to treat particularly in patients older than 65 years with an osteoporotic bone and tuberosities compromised. The goal of this paper is to evaluate radiological outcomes at mid-term follow-up of proximal humerus fractures treated with reverse shoulder arthroplasty using a dedicated fracture stem. MATERIALS AND METHODS: The study population included 98 patients who underwent reverse shoulder with a dedicated fracture stem for an acute proximal humerus fracture; 87/98 patients were available for analysis. There were 62 female and
View details →Yan Xu, Sam Schulman, Dar Dowlatshahi et al. · 2017 · CHEST Journal
BackgroundDirect oral anticoagulants (DOACs) have expanded the armamentarium for antithrombotic therapy. Although DOAC-related major bleeding was associated with favorable outcomes compared with warfarin in clinical trials, warfarin…
View details →Elisa V. Bandera, Melony King, Urmila Chandran et al. · 2011 · BMC Women s Health
BACKGROUND: While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention. METHODS: We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial ovarian cancer risk. Cases were identified in six counties in New Jersey through the New Jersey State Cancer Registry. Controls were identified by random digit dialing, CMS (Centers for Medicare and Medicaid Service) lists, and area sampling. A total of 205 cases and 390 controls were
View details →Klaus Wirth, Hagen Hartmann, André Sander et al. · 2015 · The Journal of Strength and Conditioning Research
Strength training-induced increases in speed strength seem indisputable. For trainers and athletes, the most efficient exercise selection in the phase of preparation is of interest. Therefore, this study determined how the selection of…
View details →Jens Theysohn, Oliver Kraff, Stefan Maderwald et al. · 2011 · Journal of Magnetic Resonance Imaging
PURPOSE: To evaluate 7T MRI in the assessment of cerebrovascular alterations as seen in vascular dementia by means of detection of cerebral microbleeds (CMB) and depiction of white matter lesions (WML). 7T imaging was evaluated with…
View details →Junya Ako, Kiyoshi Hibi, Kenichi Tsujita et al. · 2019 · Circulation Journal
BACKGROUND: In patients with acute coronary syndrome (ACS), alirocumab reduced the risk of recurring ischemic events. ODYSSEY J-IVUS assessed the effect of alirocumab on coronary atheroma volume in Japanese patients recently hospitalized…
View details →Bill Hesselmar, Robert Saalman, Anna Rudin et al. · 2010 · Acta Paediatrica
OBJECTIVE: To investigate if the development of allergic diseases during the child's first 18 months of life is influenced by the time at which different food items were introduced into the child's diet. METHOD: A birth cohort of 184…
View details →Britt Clynick, Tamera J. Corte, Helen E. Jo et al. · 2021 · European Respiratory Journal
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease in which circulatory biomarkers have the potential for guiding management in clinical practice. We assessed the prognostic role of serum biomarkers in three…
View details →Jody Tversky, Andrew P. Lane, Antoine Azar · 2021 · Clinical & Experimental Allergy
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) can be a severe and debilitating disease associated with significant morbidity, loss of smell, sinus pressure and asthma exacerbations. Eosinophils play a role in the majority…
View details →James Holland, David Langton, Munawar Hashmi · 2012 · Journal of Bone and Joint Surgery - British Volume
We present the clinical results and survivorship of consecutive 100 Birmingham Hip Resurfacings in 90 patients at a minimum follow-up of ten years. All procedures were carried out by an independent surgeon who commenced a prospective study…
View details →Balaji Rangarathnam, Gary H. McCullough, Hylan Pickett et al. · 2015 · American Journal of Speech-Language Pathology
PURPOSE: The purpose of this study was to investigate the utility of telepractice for delivering flow phonation exercises to persons with primary muscle tension dysphonia (MTD). METHOD: Fourteen participants with a diagnosis of primary MTD…
View details →Hiroto Inaba, Yinmei Zhou, Oussama Abla et al. · 2015 · Blood
Comprehensive clinical studies of patients with acute megakaryoblastic leukemia (AMKL) are lacking. We performed an international retrospective study on 490 patients (age ≤18 years) with non-Down syndrome de novo AMKL diagnosed from 1989…
View details →Scott A. Asher, Hilliary N. White, Alexandra E. Kejner et al. · 2013 · Otolaryngology
OBJECTIVE: An increasing number of head and neck surgeons have begun using transoral robotic-assisted surgery. Our objective was to examine the postoperative bleeding complications we have encountered to determine risk factors and to…
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