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WASTE Journal

Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

An evaluation of Massachusetts' flavored tobacco restriction one year after policy implementation: Is it promoting equity?

Singer JM, Wing JJ, Klein EG et al. · 2026 · Journal of public health policy

In the United States certain groups, such as African Americans (AA) and sexual minorities (SM) have disproportionately high rates of flavored tobacco use. Policies restricting flavored tobacco may especially benefit these groups and lead…

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Negative / Null Result ReportOpen accessMedicine

Housing Quality Improvement and Health Care Utilization: A Regression Discontinuity Study.

Dragan KL · 2026 · Journal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management]

Low-income housing is often of substandard quality. Health care payers like Medicaid and Medicare are piloting reimbursement for housing quality improvement with the rationale of reducing expenses from acute care use, but little is known…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness and implementation of a multi-faceted intervention to facilitate adoption of asthma self-management practices in Peruvian children and adolescents: a hybrid type 2 individually randomized controlled trial.

Zevallos-Morales A, Romani-Huacani E, Psoter KJ et al. · 2025 · Frontiers in public health

Background Peru has one of the highest burdens of asthma in the world, as well as large gaps in access to evidence-based treatments. Studies often overlook the ways in which the research context and data collection activities interact and…

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Negative / Null Result ReportMedicine

A challenge to the expected: Lack of longitudinal associations between the early caregiving environment, executive functions in toddlerhood, and self-regulation at 6 years.

Jónsdóttir LK, Forslund T, Frick MA et al. · 2024 · Developmental science

Previous research and theory indicate an importance of the quality of the early caregiving environment in the development of self-regulation. However, it is unclear how attachment security and maternal sensitivity, two related but distinct…

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Negative / Null Result ReportOpen accessMedicine

Examining the profile of couples attending a violence prevention intervention: A dyadic latent profile analysis.

Bhardwaj A, Musci RJ, Blackwell A et al. · 2025 · International health trends and perspectives

Objective Existing research points to how increasing male engagement in public health interventions without addressing gender inequities can perpetuate power imbalances in a relationship which may lead to increased stress and anxiety for…

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Negative / Null Result ReportOpen accessMedicine

No evidence that sociosexual orientation moderates effects of conception probability on women's preferences for male facial masculinity.

Lee AJ, Jones BC, Zietsch BP et al. · 2023 · Scientific reports

Although many researchers have proposed that women will show stronger preferences for male facial masculinity when conception probability is high, empirical tests of this hypothesis have produced mixed results. One possible explanation for…

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Negative / Null Result ReportMedicine

Gastrointestinal tract exposure to particles and DNA damage in animals: A review of studies before, during and after the peak of nanotoxicology.

Møller P, Roursgaard M · 2024 · Mutation research. Reviews in mutation research

Humans ingest particles and fibers on daily basis. Non-digestible carbohydrates are beneficial to health and food additives are considered safe. However, titanium dioxide (E171) has been banned in the European Union because the European…

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Negative / Null Result ReportOpen accessMedicine

Pro-inflammatory dietary patterns and their association with cardiovascular disease and pancreatic cancer in a hospital population: a cross-sectional study.

Jin Q, Liu Y, Tong Q et al. · 2025 · Frontiers in nutrition

Objective To examine whether a concise, clinic-feasible Patient Inflammatory Diet Score (PIDS) relates to prevalent pancreatic cancer and cardiovascular disease (CVD) in a hospital population, and to explore associations with systemic…

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Negative / Null Result ReportMedicine

Learning to draw parametric faces.

Davidenko N, Day J · 2025 · Memory & cognition

Humans' ability to draw faces accurately from memory is extremely rare. One source of difficulty is the drawing process itself, which requires converting a complex, three-dimensional mental representation to a two-dimensional drawing. To…

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Negative / Null Result ReportOpen accessMedicine

No Genetic Causal Relationship Between HIV Infection and Insulin Resistance, Diabetes: A Bidirectional Mendelian Randomization Analysis.

Liu P, Zeng Q · 2025 · Journal of multidisciplinary healthcare

Background The causal relationship between HIV infection and insulin resistance, as well as diabetes mellitus, remains uncertain. This study explores these associations using genome-wide association study data and Mendelian randomization…

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Negative / Null Result ReportOpen accessMedicine

In the eastern Mediterranean, the rat lungworm Angiostrongylus cantonensis is absent or extremely rare according to recent surveys.

Anettová L, Šipková A, Cibulka P et al. · 2025 · Parasitology research

This study summarizes the findings of a comprehensive field investigation into the presence of Angiostrongylus cantonensis, a zoonotic nematode responsible for meningitis, in selected regions of the eastern Mediterranean. Samples were…

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Failed Experiment ReportMedicine

Is exergaming a viable exercise option for obese black women?

Hicks J, Dash C, Smith D et al. · 2025 · Contemporary clinical trials

Background Physical inactivity and obesity, which are disproportionately higher in Black women, are known risk factors of breast cancer. Novel methods to address this public health concern involve leveraging screen-viewing activities to…

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Negative / Null Result ReportMedicine

College Student Video Gaming: Risk or Resilience for Mental Health?

Vengurlekar IN, Thudi KR · 2025 · Psychological reports

Video gaming has become a popular method of entertainment for college students. Previous work indicates mixed results regarding the link between video gaming and mental health outcomes. However, little research has addressed how different…

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Negative / Null Result ReportMedicine

Post-occlusive reactive hyperemia in habituated caffeine users: Effects of abstaining versus consuming typical doses.

Chatlaong MA, Stanford DM, Miller WM et al. · 2024 · Clinical hemorheology and microcirculation

Background Post-occlusive reactive hyperemia (PORH) typically requires caffeine abstinence. For habitual users, it is unknown if abstinence affects PORH. Objective Compare PORH after habitual users consume or abstain from caffeine. Methods…

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Abandoned HypothesisOpen accessMedicine

Why doesn't neuroimaging work in psychiatry?

McCutcheon RA, Jauhar S, Pillinger T · 2026 · The British journal of psychiatry : the journal of mental science

Half a century of neuroimaging has transformed our understanding of psychiatric disorders but not our clinical practice. This piece examines why that promise remains unfulfilled and argues that the future lies not in ever newer tools but…

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Negative / Null Result ReportOpen accessMedicine

Intake of the Total, Classes, and Subclasses of (Poly)phenols and Breast Cancer Risk: A Prospective Analysis of the EPIC Study.

López-Padilla MF, Seoane-Miraz D, Guiñón-Fort D et al. · 2026 · Antioxidants (Basel, Switzerland)

Polyphenols represent the largest and most diverse class of dietary antioxidants. Epidemiological evidence linking specific (poly)phenol classes, such as flavonoids and lignans, to breast cancer (BC) risk remains limited and largely…

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Negative / Null Result ReportOpen accessMedicine

Early and later susceptibility to effects of parenting: Exploring Frankenhuis and Panchanathan's (2011) evolutionary commitment hypothesis.

Zhang X, Machlin L, McLaughlin K et al. · 2025 · Developmental psychology

This study tests Frankenhuis and Panchanathan's (2011) evolutionary commitment hypothesis by examining individual differences in susceptibility to the effects of parenting during early and late childhood. Drawing from the Future of…

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Negative / Null Result ReportOpen accessMedicine

Musical groove listening does not enhance primary motor cortex activation.

O'Connell SR, Wilson GE, Berkowitz DH et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Groove is the pleasurable urge to move to the beat of music, a universally experienced human phenomenon. Because listeners are often inspired to move to music with groove, we asked whether high-groove music would promote greater motor…

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