12,248 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
de Zeeuw D · 2020 · Journal of nephrology
Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will…
View details →Georgiadis AG, Schavee PE, Koester TM et al. · 2025 · JB & JS open access
Background Cast removal may produce pain or anxiety in children. Virtual reality (VR) has been studied in other pediatric settings, but little evidence exists for its use during pediatric cast removal. Methods A randomized controlled trial…
View details →Bromberg JEC, Issa S, van der Holt B et al. · 2024 · Neuro-oncology
Background Studies on the efficacy of rituximab in primary CNS lymphoma (PCNSL) reported conflicting results. Our international randomized phase 3 study showed that the addition of rituximab to high-dose methotrexate, BCNU, teniposide, and…
View details →Pellesi L, Onan D, Martelletti P · 2024 · Toxins
Post-traumatic headache (PTH) is a common and debilitating consequence of traumatic brain injury (TBI), often resembling migraine and tension-type headaches. Despite its prevalence, the optimal treatment for PTH remains unclear, with…
View details →Zhou Q, Gao B, Hu J et al. · 2026 · BMJ oncology
Background Many patients with non-small cell lung cancer (NSCLC) have tumours that are either refractory or develop resistance following an initial response to anti-programmed cell death protein (ligand)-1 (PD-(L)1)-based treatment,…
View details →Kasperkiewicz M, van Beek N, Schmidt E · 2026 · Drugs
Autoimmune blistering diseases (AIBDs) are a heterogeneous group of at least a dozen disorders characterized by autoantibodies against structural proteins of desmosomes in the skin and surface-close epithelia in pemphigus and of the…
View details →Baugher B, Walter E, Hennigs E et al. · 2025 · Cureus
Freezing of gait (FoG) is a disabling symptom of Parkinson's disease (PD) characterized by involuntary cessation/reduction. While deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) effectively treats common PD symptoms…
View details →Gomeni R, Hopkins S, Bressolle-Gomeni F et al. · 2023 · Translational psychiatry
The objective of this study was to evaluate the performances of the propensity score weighted (PSW) methodology in a post-hoc re-analysis of a failed and a negative RCTs in depressive disorders. The conventional study designs,…
View details →Park L, Furey M, Nugent A et al. · 2018 · Biological psychiatry
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This conference abstract has been retracted at the request of author Maura Furey,…
View details →Autler AS, Darling AM, Skow RJ et al. · 2025 · Autonomic neuroscience : basic & clinical
Young women, who suffer from major depressive disorder (MDD) at twice the rate as young men, are particularly vulnerable to cardiovascular events triggered by emotional stress, an association that may be partially explained by excessive…
View details →Molto A, López-Medina C, Van den Bosch FE et al. · 2021 · Annals of the rheumatic diseases
Objectives To compare the benefits of a tight-control/treat-to-target strategy (TC/T2T) in axial spondyloarthritis (axSpA) with those of usual care (UC). Methods Pragmatic, prospective, cluster-randomised, controlled, open, 1-year trial…
View details →Denton CP, Del Galdo F, Khanna D et al. · 2022 · Rheumatology (Oxford, England)
Objectives The cytokine oncostatin M (OSM) is implicated in the pathology of SSc. Inhibiting OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc has the potential to slow or stop the disease process.…
View details →Khan A, Khan H, Hughes GK et al. · 2024 · Cancer medicine
Objective This study aims to evaluate published clinical trials of ramucirumab to assess the risk/benefit profile and burden over time for patients. Background The burden of oncologic drug development on patients paired with increasing…
View details →Kendall C, Swaminathan A, Borichevsky GM et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology
Background Fecal calprotectin (fCal) and fecal myeloperoxidase (fMPO) have been proposed as biomarkers for monitoring inflammatory bowel disease (IBD); however, their reliability is not fully established. This study investigated clinical…
View details →Zeiger E, Mitchell CA, Pfuhler S et al. · 2024 · Environmental and molecular mutagenesis
The Ames test is required by regulatory agencies worldwide for assessing the mutagenic and carcinogenic potential of chemical compounds. This test uses several strains of bacteria to evaluate mutation induction: positive results in the…
View details →Ferguson I, George G, Wu C et al. · 2025 · Cognitive therapy and research
Background The tendency to negatively interpret ambiguous situations (i.e., interpretation bias) is associated with the development and maintenance of emotional disorders. Reliable measures of this transdiagnostic construct are critical…
View details →van der Meulen C, van de Stadt LA, Kroon FPB et al. · 2025 · Rheumatology (Oxford, England)
Objective Pain in hand osteoarthritis (OA) is evaluated with repeated pain questionnaires. It is unclear whether these questionnaires adequately capture changes in pain recalled by patients. This study investigated whether changes on pain…
View details →Laviolle B, Locher C, Allain JS et al. · 2025 · Clinical pharmacology and therapeutics
Studies with negative results are less likely to be published than others, potentially leading to publication bias. Introduced in 2000, trial registration could have participated in decreasing the proportion of unpublished studies. We…
View details →Arter ZL, Nagasaka M · 2024 · Lung Cancer (Auckland, N.Z.)
Targeted therapies, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), have revolutionized the treatment landscape for EGFR-mutant non-small cell lung cancer (NSCLC). However, the emergence of resistance to…
View details →Ter Bruggen FFJA, Redekop WK, Stronks DL et al. · 2021 · Journal of pain research
Objective The success of neurostimulation depends partly on the amount of coverage of the neurostimulation-induced paresthesia of the painful area. This is often achieved by asking feedback from patients intraoperatively. If sedation…
View details →Agostinho M, Shani A, Canaipa R et al. · 2024 · Pain reports
Introduction Within-subject variability (WSV) of pain intensity reports has been shown to predict the placebo response. The focused analgesia selection test (FAST), which allows to experimentally assess WSV of pain reports, has been used…
View details →Dijk SW, Wollny C, Barkhausen J et al. · 2025 · JAMA
Importance Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective To assess the effects of…
View details →Correll CU, Durgam S, Kozauer SG et al. · 2026 · International clinical psychopharmacology
This Phase 3, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of lumateperone to treat bipolar depression. Patients (18-75 years) with bipolar I or bipolar II disorder experiencing a major depressive…
View details →Seybold U · 2018 · Deutsche medizinische Wochenschrift (1946)
Vaccination practices in Germany are driven by scientific developments and a complex regulatory environment. Some important developments in 2018 are described here: Starting in 2018 only quadrivalent influenza vaccines will be used for the…
View details →Bremhorst A, Mills DS, Stolzlechner L et al. · 2021 · Frontiers in psychology
The inner brow raiser is a muscle movement that increases the size of the orbital cavity, leading to the appearance of so-called 'puppy dog eyes'. In domestic dogs, this expression was suggested to be enhanced by artificial selection and…
View details →Mutale W, Freeborn K, Graybill LA et al. · 2021 · The Lancet. Global health
Background Testing men for HIV during their partner's pregnancy can guide couples-based HIV prevention and treatment, but testing rates remain low. We investigated a combination approach, using evidence-based strategies, to increase HIV…
View details →Chen H, Colasurdo M, Matsukawa H et al. · 2025 · European stroke journal
Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…
View details →Nickel JC, Moldwin R, Hanno P et al. · 2019 · The Journal of urology
Purpose In this 12-week, randomized, double-blind, placebo controlled, multicenter, 3-arm, parallel group, phase 3 trial we assessed the effects of a novel SHIP1 activator on bladder pain and urinary symptoms in patients with interstitial…
View details →Terpstra JA, van Beugen S, van der Vaart R et al. · 2026 · Internet interventions
Background Rheumatic and musculoskeletal diseases have a high burden. We aimed to evaluate the effectiveness of a therapist-guided internet-based cognitive-behavioral therapy (iCBT) on pain coping and secondary physical, psychological, and…
View details →Wilkie DJ, Yao Y, Ezenwa MO et al. · 2020 · Journal of pain and symptom management
Context Unrelieved cancer pain at the end of life interferes with achieving patient-centered goals. Objective To compare effects of usual hospice care and PAINRelieveIt® on pain outcomes in patients and their lay caregivers. Methods In a…
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