12,248 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Sciscione AC, Booker WA, Clifton RG et al. · 2026 · Obstetrics and gynecology
Objective Activity restriction is commonly recommended in pregnancy despite lacking evidence of benefit. We sought to evaluate the amount of physical activity in patients at high risk for preterm birth and pregnancy latency and preterm…
View details →Aparajita, Barmon D, Baruah U et al. · 2025 · World journal of surgical oncology
Background Recent studies have found the presence of post- hysterectomy atypical glandular cells in upper vagina in ~ 30% patients of Endometrial Cancer (EC) with implications of causing isolated vaginal recurrence. The primary objective…
View details →Cai LY, Hoseinyazdi M, Lakhani DA et al. · 2025 · Stroke (Hoboken, N.J.)
Background Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging-based inclusion criteria, whereas many successful large vessel occlusion (LVO)…
View details →Mol F, Scheltinga M, Roumen R et al. · 2023 · Neuromodulation : journal of the International Neuromodulation Society
Objectives Approximately 10% of patients who undergo inguinal hernia repair or Pfannenstiel incision develop chronic (> three months) postsurgical inguinal pain (PSIP). If medication or peripheral nerve blocks fail, a neurectomy is the…
View details →Nathan SD, Lacasse V, Bell H et al. · 2024 · Pulmonary circulation
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative…
View details →Ghimouz A, Dureau S, Carton M et al. · 2026 · Scientific reports
The value of music (MUS) and virtual reality (VR) in reducing pain or anxiety during central venous port implantation (CVPI) is controversial. We conducted a randomised multicenter controlled trial in 127 patients who received either MUS…
View details →Janeway KA, Chou AJ, Buxton A et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…
View details →Savsani PK, Khan SH, Perkins AJ et al. · 2025 · Critical care medicine
Objectives To describe the performance of the Healthy Aging Brain Care Monitor Self Report (HABC-M SR) in assessment of post-intensive care syndrome (PICS) among Acute Respiratory Failure ICU survivors. Design Secondary data analysis of a…
View details →Chaudhari A, Almajali M, Khan N et al. · 2026 · Stroke (Hoboken, N.J.)
Background Endovascular thrombectomy (EVT) has transformed the management of acute ischemic stroke, but remains inaccessible to many patients due to anatomic, clinical, or logistical limitations. Treatment strategies for patients with…
View details →Andersson Y, Løvstakken E, Herud TM et al. · 2025 · Annals of surgical oncology
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and…
View details →Dubbelman MA, Vromen EM, Tijms BM et al. · 2024 · Alzheimer's & dementia (New York, N. Y.)
With the advent of the first generation of disease-modifying treatments for Alzheimer's disease, it is clearer now more than ever that the field needs to move toward personalized medicine. Pooling data from past trials may help identify…
View details →Scahill L, Shillingsburg MA, Ousley O et al. · 2022 · Journal of the American Academy of Child and Adolescent Psychiatry
Objective To compare Direct Instruction Language for Learning (DI) plus treatment as usual (TAU) with TAU alone in children with autism spectrum disorder and moderate language delay. Method In this study, 83 children (age range, 4 years to…
View details →Bremhorst A, Mills DS, Würbel H et al. · 2022 · Animal cognition
Facial expressions potentially serve as indicators of animal emotions if they are consistently present across situations that (likely) elicit the same emotional state. In a previous study, we used the Dog Facial Action Coding System…
View details →Desai R, Tan F, Wu M et al. · 2026 · Arthritis care & research
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been…
View details →Bedlack R, Barkhaus P, Carter G et al. · 2022 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit.…
View details →Aouad K, El-Zorkany B · 2022 · Mediterranean journal of rheumatology
The Treat-to-target (T2T) strategy in axial spondyloarthritis (axSpA) stipulates that treatment should reach a predefined target and if not reached, intensification of therapy is implemented aiming at best future outcomes. Clinical…
View details →Turvill J, Haritakis M, Pygall S et al. · 2026 · Endoscopy international open
Background and study aims During the COVID-19 pandemic the National Health Service introduced colon capsule endoscopy (CCE) as an alternative to colonoscopy in patients awaiting 3-year post-polypectomy surveillance. We determined the…
View details →Pepine CJ, Handberg E, Cooper-DeHoff R et al. · 2026 · Open heart
Importance Women with angina due to suspected ischaemia referred for coronary angiography often have no obstructive coronary artery disease (ANOCA/INOCA). Objective To determine if intensive medical treatment (IMT) reduces major ischaemic…
View details →Wessels AM, Edgar CJ, Nathan PJ et al. · 2021 · Drug discovery today
Go/No-Go decision making in early phase clinical trials is challenging for drug developers working in Alzheimer's disease. Recent negative trial results have been attributed to a lack of efficacy and important safety concerns. Furthermore,…
View details →Chalak LF, Kang S, Kota S et al. · 2023 · Early human development
Background There is a critical need for development of physiological biomarkers in infants with birth asphyxia to identify the physiologic response to therapies in real time. This is an ancillary single site study of the High-Dose…
View details →Mudugal D, Monteith TS · 2021 · Expert review of neurotherapeutics
Introduction : Cluster headache [CH] is a severely disabling trigeminal autonomic cephalalgia [TAC]. Approximately 1 in 1,000 adults are affected by CH. Calcitonin gene-related peptide [CGRP] is an important mediator in the pathophysiology…
View details →Figueroa-Parra G, Putman MS, Crowson CS et al. · 2024 · Lupus science & medicine
Objective We aimed to evaluate the robustness of phase III randomised controlled trials (RCTs) for SLE and lupus nephritis (LN) using the fragility index (FI), the reverse FI (RFI) and the fragility quotient (FQ). Methods We searched for…
View details →Li S, Mahr C, Kataria R et al. · 2026 · JACC. Advances
Background Landmark randomized controlled trials like DanGer Shock, IABP-SHOCK II, and ECLS-SHOCK guide infarct-related cardiogenic shock (CS) management with temporary mechanical circulatory support (tMCS), but strict enrollment criteria…
View details →Albers GW, Bernstein R, Brachmann J et al. · 2021 · Stroke
Occult atrial fibrillation (AF) is a leading cause of stroke of unclear cause. The optimal approach to secondary stroke prevention for these patients remains elusive. The term embolic stroke of undetermined source (ESUS) was coined to…
View details →Ishizuka K, Ono S · 2025 · Journal of clinical pharmacology
Despite the tremendous effort in the oncology community, the success rate of anticancer development remained low at 30% to 40% from the Phase 3 study to the regulatory approval. The factors associated with the regulatory approval for…
View details →Chen H, Colasurdo M, Matsukawa H et al. · 2026 · European stroke journal
Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…
View details →Cerbone L, Orecchia S, Bertino P et al. · 2023 · Cancers
Mesothelioma comprises a group of rare cancers arising from the mesothelium of the pleura, peritoneum, tunica vaginalis testis and pericardium. Mesothelioma is generally associated with asbestos exposure and has a dismal prognosis, with…
View details →Pope JE · 2020 · The Lancet. Rheumatology
Strides have been made in the treatment of pulmonary arterial hypertension and interstitial lung disease in patients with systemic sclerosis, with successful trials of combination therapies in pulmonary arterial hypertension and of new…
View details →Persu A, Stoenoiu MS, Maes F et al. · 2023 · Clinical kidney journal
Following second-generation randomized trials, there is evidence that renal denervation (RDN) decreases blood pressure (BP), although to a lesser extent than suggested in the initial controlled and observational studies. The recent…
View details →Azarbarzin A, Vena D, Esmaeili N et al. · 2026 · European heart journal
Background and aims Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular and…
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