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Browse the failure-mode index

12,248 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

No Genetic Causal Relationship Between HIV Infection and Insulin Resistance, Diabetes: A Bidirectional Mendelian Randomization Analysis.

Liu P, Zeng Q · 2025 · Journal of multidisciplinary healthcare

Background The causal relationship between HIV infection and insulin resistance, as well as diabetes mellitus, remains uncertain. This study explores these associations using genome-wide association study data and Mendelian randomization…

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Negative / Null Result ReportOpen accessMedicine

In the eastern Mediterranean, the rat lungworm Angiostrongylus cantonensis is absent or extremely rare according to recent surveys.

Anettová L, Šipková A, Cibulka P et al. · 2025 · Parasitology research

This study summarizes the findings of a comprehensive field investigation into the presence of Angiostrongylus cantonensis, a zoonotic nematode responsible for meningitis, in selected regions of the eastern Mediterranean. Samples were…

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Failed Experiment ReportMedicine

Is exergaming a viable exercise option for obese black women?

Hicks J, Dash C, Smith D et al. · 2025 · Contemporary clinical trials

Background Physical inactivity and obesity, which are disproportionately higher in Black women, are known risk factors of breast cancer. Novel methods to address this public health concern involve leveraging screen-viewing activities to…

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Negative / Null Result ReportMedicine

College Student Video Gaming: Risk or Resilience for Mental Health?

Vengurlekar IN, Thudi KR · 2025 · Psychological reports

Video gaming has become a popular method of entertainment for college students. Previous work indicates mixed results regarding the link between video gaming and mental health outcomes. However, little research has addressed how different…

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Negative / Null Result ReportMedicine

Post-occlusive reactive hyperemia in habituated caffeine users: Effects of abstaining versus consuming typical doses.

Chatlaong MA, Stanford DM, Miller WM et al. · 2024 · Clinical hemorheology and microcirculation

Background Post-occlusive reactive hyperemia (PORH) typically requires caffeine abstinence. For habitual users, it is unknown if abstinence affects PORH. Objective Compare PORH after habitual users consume or abstain from caffeine. Methods…

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Abandoned HypothesisOpen accessMedicine

Why doesn't neuroimaging work in psychiatry?

McCutcheon RA, Jauhar S, Pillinger T · 2026 · The British journal of psychiatry : the journal of mental science

Half a century of neuroimaging has transformed our understanding of psychiatric disorders but not our clinical practice. This piece examines why that promise remains unfulfilled and argues that the future lies not in ever newer tools but…

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Negative / Null Result ReportOpen accessMedicine

Intake of the Total, Classes, and Subclasses of (Poly)phenols and Breast Cancer Risk: A Prospective Analysis of the EPIC Study.

López-Padilla MF, Seoane-Miraz D, Guiñón-Fort D et al. · 2026 · Antioxidants (Basel, Switzerland)

Polyphenols represent the largest and most diverse class of dietary antioxidants. Epidemiological evidence linking specific (poly)phenol classes, such as flavonoids and lignans, to breast cancer (BC) risk remains limited and largely…

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Negative / Null Result ReportOpen accessMedicine

Early and later susceptibility to effects of parenting: Exploring Frankenhuis and Panchanathan's (2011) evolutionary commitment hypothesis.

Zhang X, Machlin L, McLaughlin K et al. · 2025 · Developmental psychology

This study tests Frankenhuis and Panchanathan's (2011) evolutionary commitment hypothesis by examining individual differences in susceptibility to the effects of parenting during early and late childhood. Drawing from the Future of…

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Negative / Null Result ReportOpen accessMedicine

Musical groove listening does not enhance primary motor cortex activation.

O'Connell SR, Wilson GE, Berkowitz DH et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Groove is the pleasurable urge to move to the beat of music, a universally experienced human phenomenon. Because listeners are often inspired to move to music with groove, we asked whether high-groove music would promote greater motor…

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Negative / Null Result ReportOpen accessMedicine

Psychobehavioral profiles of eating risk: schema-emotion regulation patterns differ in central adiposity with genotype (FTO rs9939609) as external validator-a pilot study.

Obara-Gołębiowska M · 2026 · Eating and weight disorders : EWD

Purpose To identify person-centered psychological profiles of eating-related risk based on early maladaptive schemas (EMS), emotion regulation difficulties, and eating behaviors, and to examine their external validation using…

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Negative / Null Result ReportOpen accessMedicine

Effect of a Pragmatic eHealth Behavioral Gestational Weight Gain Intervention on Household Chaos in Pregnant People of Lower Socioeconomic Status: Randomized Controlled Trial.

Kracht CL, Falkenhain K, Flanagan EW et al. · 2026 · JMIR mental health

Background Household chaos is an emerging risk factor for childhood obesity development, especially in families with lower socioeconomic status (SES). It is unclear if changes in household chaos, especially in pregnancy, may mediate the…

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Negative / Null Result ReportOpen accessMedicine

Fragile Mentalizing: Lack of Behavioral and Neural Markers of Social Cognition in an Established Social Perspective Taking Task when Combined with Stress Induction.

Cheema S, Augustin C, Göttlich M et al. · 2024 · eNeuro

The growing field of social neuroscience is reliant on the development of robust, ecologically valid paradigms for simulating social interaction and measuring social cognition in highly controlled laboratory settings. Perspective taking is…

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Negative / Null Result ReportOpen accessMedicine

Mirror exposure in adolescents with anorexia nervosa: a feasibility study on body image disturbance and attentional bias.

Pelzer M, Werthmann J, Svaldi J et al. · 2026 · Eating and weight disorders : EWD

Purpose Body image disturbances (BID) are central to anorexia nervosa (AN), influencing its development, maintenance and relapse. While mirror exposure (ME) has been shown to reduce BID in adults, research in adolescents is limited. This…

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Failed Experiment ReportOpen accessMedicine

Inhibition of p38α MAPK increases short-term astrocyte reactivity: the exploratory VIP trial in early Alzheimer's disease.

Gouilly D, Da-Costa A, Vrillon A et al. · 2025 · Journal of neuroinflammation

BACKGROUND: Neuro-inflammation is an early mechanistic target in Alzheimer’s disease (AD). However, the effect of anti-inflammatory drugs on biomarkers of neuro-inflammation has yet to be described. Biomarkers of neuro-inflammation showed…

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