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Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Can trade and security alliance help reduce interstate war?

Choi SW · 2024 · PloS one

This study explains how the gap between theory and empirical research hinders scientific progress in the area of international political economy. To demonstrate this point, I use Chen's Extended Dependence Theory, which challenges liberal…

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Negative / Null Result ReportOpen accessMedicine

Comparison of oncological outcomes between wedge resection and segmentectomy for T1a/bN0M0 non-small-cell lung cancer: a population-based retrospective cohort study.

Zhang Z, Lian H, Huang L et al. · 2026 · International journal of surgery (London, England)

Background Sublobar resection, including wedge resection (WR) and segmental resection (SR) has been considered for early-stage non-small-cell lung cancer (NSCLC). However, the optimal sublobar approach continues to be a subject of…

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Negative / Null Result ReportOpen accessMedicine

No evidence that averaging voices influences attractiveness.

Ostrega J, Shiramizu V, Lee AJ et al. · 2024 · Scientific reports

Vocal attractiveness influences important social outcomes. While most research on the acoustic parameters that influence vocal attractiveness has focused on the possible roles of sexually dimorphic characteristics of voices, such as…

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Negative / Null Result ReportOpen accessMedicine

Parietal theta burst TMS does not modulate bistable perception.

Schauer G, Grassi PR, Gharabaghi A et al. · 2024 · Neuroscience of consciousness

The role of the parietal cortex in perceptual awareness and in resolving perceptual ambiguity is unsettled. Early influential transcranial magnetic stimulation studies have revealed differences in conscious perception following parietal…

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Negative / Null Result ReportOpen accessMedicine

The relationship between aging out of the special supplemental nutrition program for women, infants, and children assistance and weight status in kindergarten.

Lazic A, Thomsen MR, Brown CC et al. · 2025 · Preventive medicine reports

Objective The Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides access to nutritional resources to low-income children starting at birth through enrollment in kindergarten or turning five years old. The…

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Negative / Null Result ReportOpen accessMedicine

Biomechanical Factors Associated with Intraindividual Differences in Running Economy Across Advanced Footwear Technology Models in Long-Distance Runners.

Fohrmann D, Schaffarczyk M, Menge C et al. · 2026 · Sports medicine - open

Background Advanced footwear technology (AFT) can enhance long-distance running performance by improving running economy (RE). However, the range of the individual improvements is large. Different intra-individual responses in running…

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Negative / Null Result ReportOpen accessMedicine

PCSK9 and Breast Cancer Survival: A Mendelian Randomization Study.

Pott J, Mason AM, Salo V et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects lipid metabolism. A recent study identified an association between rs562556 within the PCSK9 gene and breast cancer survival (BCS), suggesting PCSK9 inhibition as an…

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Negative / Null Result ReportOpen accessMedicine

Vibration-Induced Nystagmus in Patients with Ménière's Disease: Is There a Correlation to Endolymphatic Hydrops?

Lorente-Piera J, Blanco M, Manrique-Huarte R et al. · 2025 · Audiology research

Background/Objectives : Skull vibration-induced nystagmus (SVIN) is a rapid bedside test that reveals vestibular asymmetry. Its clinical utility in Ménière's disease (MD) remains controversial, particularly regarding its association with…

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Negative / Null Result ReportOpen accessMedicine

Outcomes and experiences of music workshops for adolescents with depression and anxiety: An exploratory noncontrolled trial in Bogotá.

Gómez-Restrepo C, Roldan MC, Ariza-Salazar K et al. · 2024 · BMC research notes

Objective Adolescents frequently experience mental distress. However, there is little research on community activities that help adolescents recover from depression and anxiety. This study investigated the outcomes and experiences of music…

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Negative / Null Result ReportOpen accessMedicine

Alterations of brain network topology and structural-functional connectivity coupling in noise-induced hearing loss based on macroscopic scale.

Wang A, Bao X, Wang C et al. · 2025 · Frontiers in neuroscience

Objective To investigate the changes in the global attributes of structural connectivity (SC) and functional connectivity (FC) graph theory, as well as the coupling topological structure of the whole brain SC-FC in patients with…

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Negative / Null Result ReportOpen accessMedicine

Association of cardiovascular risk scores with coronary plaque and its progression among individuals with family history of coronary artery disease.

Soh CH, Nerlekar N, Whitmore K et al. · 2026 · American journal of preventive cardiology

Background Multiple cardiovascular (CV) risk assessment scores can predict CV events. The current trend towards assessing atheroma has led to these scores being used to identify patients who might benefit from coronary plaque imaging.…

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Negative / Null Result ReportOpen accessMedicine

<i>TNF-α</i> rs1800629 Polymorphism in Vietnamese COPD Patients: Exploratory Evidence for Recessive Protective Association and Clinical Correlates.

Nguyen HM, Le DHH, Ho TTH et al. · 2026 · The application of clinical genetics

Background Chronic obstructive pulmonary disease (COPD) poses a significant health burden in Vietnam. The TNF-α rs1800629 (-308G/A) polymorphism is an influential factor in disease pathogenesis. However, its association is inconsistent…

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Negative / Null Result ReportOpen accessMedicine

Kava consumption and the rise of sociopolitical complexity in Oceania.

Hrnčíř V, Sheehan O, Claessens S et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America

Humans have been using psychoactive substances for millennia, despite their potential negative health and social consequences. According to some scholars, our craving for mind-altering drugs is an evolutionary mistake-a hijacking of our…

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