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WASTE Journal

Browse the failure-mode index

12,248 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Cross-sectional associations between lifecourse dementia risk factors, plasma neurodegenerative biomarkers, and cognition in older adults in India.

Gao S, Gross AL, Aksman LM et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundPlasma neurodegenerative biomarkers are a potential low-cost tool for studying Alzheimer's disease and dementia in population-based research, especially in low- and middle-income countries. However, their associations with…

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Negative / Null Result ReportOpen accessMedicine

Differences in surgical site infection rates by state according to state-mandated operating room air changes per hour.

Atkinson A, Marschall J, Burnham JP · 2025 · Antimicrobial resistance and infection control

Background Air changes per hour (ACH) in operating rooms (ORs) are energy intensive, and optimal air change settings are not known. Objectives We sought to explore whether there is a relationship between surgical site infections (SSIs)…

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Negative / Null Result ReportMedicine

Effects of docosahexaenoic acid supplementation on aggressive behavior among people with dementia: Secondary data analysis of a randomized clinical trial.

Perales-Puchalt J, Yang FM, Townley R · 2025 · Alzheimer disease and associated disorders

We tested the efficacy of docosahexaenoic acid (DHA) supplementation on aggressive behavior among people with dementia. We used secondary data from a randomized, double-blind, placebo-controlled trial. Analyses included 402 individuals…

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Negative / Null Result ReportOpen accessMedicine

Beta-blocker use and all-cause mortality in myocardial infarction survivors: A retrospective cohort study using propensity score methods in NHANES 1999 to 2018.

Sheng Y, Han Y, Xue Y · 2026 · Medicine

Beta-blockers are recommended for post-myocardial infarction (MI) care, but their long-term impact on all-cause mortality in real-world settings remains unclear. This study investigates the association using propensity score methods in a…

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Negative / Null Result ReportOpen accessMedicine

Exploring human-artificial intelligence interactions in a negative pragmatic trial of computer-aided polyp detection.

Watkins K, Ladabaum U, Olsen E et al. · 2024 · iGIE : innovation, investigation and insights

Background and aims The progress of artificial intelligence (AI) in endoscopy is at a crossroads. The positive results of randomized controlled trials of computer-aided detection (CADe) have not been replicated in multiple pragmatic CADe…

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Negative / Null Result ReportOpen accessMedicine

Lifting the veil: probing altered visual perception in derealization.

Kusztor A, Mulay N, Yamada M et al. · 2025 · Neuroscience of consciousness

During an acute episode of depersonalization/derealization (DP/DR), people report a complex and idiosyncratic change in their perceptual experience. Specifically, derealisation describes the experience of detachment from the external world…

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Negative / Null Result ReportMedicine

Peptides and primate personality: Central and peripheral oxytocin and vasopressin levels and social behavior in two baboon species (Papio hamadryas and Papio anubis).

Coppeto DJ, Martin JS, Ringen EJ et al. · 2024 · Peptides

The neurohormones oxytocin (OT) and arginine vasopressin (AVP) are involved in social behaviors and psychiatric conditions. However, more research on nonhuman primates with complex social behaviors is needed. We studied two closely-related…

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Negative / Null Result ReportOpen accessMedicine

Mendelian randomization analysis reveals no causal association between non-alcoholic fatty liver disease and hepatocellular carcinoma: implications for lipid metabolomics and shared pathophysiological mechanisms.

Wei Y, Li J · 2025 · Discover oncology

Background Non-alcoholic fatty liver disease (NAFLD) has been increasingly associated with hepatocellular carcinoma (HCC) risk in observational studies, yet the causal nature of this relationship and its impact on systemic lipid metabolism…

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Negative / Null Result ReportOpen accessMedicine

An evaluation of Massachusetts' flavored tobacco restriction one year after policy implementation: Is it promoting equity?

Singer JM, Wing JJ, Klein EG et al. · 2026 · Journal of public health policy

In the United States certain groups, such as African Americans (AA) and sexual minorities (SM) have disproportionately high rates of flavored tobacco use. Policies restricting flavored tobacco may especially benefit these groups and lead…

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Negative / Null Result ReportOpen accessMedicine

Housing Quality Improvement and Health Care Utilization: A Regression Discontinuity Study.

Dragan KL · 2026 · Journal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management]

Low-income housing is often of substandard quality. Health care payers like Medicaid and Medicare are piloting reimbursement for housing quality improvement with the rationale of reducing expenses from acute care use, but little is known…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness and implementation of a multi-faceted intervention to facilitate adoption of asthma self-management practices in Peruvian children and adolescents: a hybrid type 2 individually randomized controlled trial.

Zevallos-Morales A, Romani-Huacani E, Psoter KJ et al. · 2025 · Frontiers in public health

Background Peru has one of the highest burdens of asthma in the world, as well as large gaps in access to evidence-based treatments. Studies often overlook the ways in which the research context and data collection activities interact and…

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Negative / Null Result ReportMedicine

A challenge to the expected: Lack of longitudinal associations between the early caregiving environment, executive functions in toddlerhood, and self-regulation at 6 years.

Jónsdóttir LK, Forslund T, Frick MA et al. · 2024 · Developmental science

Previous research and theory indicate an importance of the quality of the early caregiving environment in the development of self-regulation. However, it is unclear how attachment security and maternal sensitivity, two related but distinct…

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Negative / Null Result ReportOpen accessMedicine

Examining the profile of couples attending a violence prevention intervention: A dyadic latent profile analysis.

Bhardwaj A, Musci RJ, Blackwell A et al. · 2025 · International health trends and perspectives

Objective Existing research points to how increasing male engagement in public health interventions without addressing gender inequities can perpetuate power imbalances in a relationship which may lead to increased stress and anxiety for…

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Negative / Null Result ReportOpen accessMedicine

No evidence that sociosexual orientation moderates effects of conception probability on women's preferences for male facial masculinity.

Lee AJ, Jones BC, Zietsch BP et al. · 2023 · Scientific reports

Although many researchers have proposed that women will show stronger preferences for male facial masculinity when conception probability is high, empirical tests of this hypothesis have produced mixed results. One possible explanation for…

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Negative / Null Result ReportMedicine

Gastrointestinal tract exposure to particles and DNA damage in animals: A review of studies before, during and after the peak of nanotoxicology.

Møller P, Roursgaard M · 2024 · Mutation research. Reviews in mutation research

Humans ingest particles and fibers on daily basis. Non-digestible carbohydrates are beneficial to health and food additives are considered safe. However, titanium dioxide (E171) has been banned in the European Union because the European…

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Negative / Null Result ReportOpen accessMedicine

Pro-inflammatory dietary patterns and their association with cardiovascular disease and pancreatic cancer in a hospital population: a cross-sectional study.

Jin Q, Liu Y, Tong Q et al. · 2025 · Frontiers in nutrition

Objective To examine whether a concise, clinic-feasible Patient Inflammatory Diet Score (PIDS) relates to prevalent pancreatic cancer and cardiovascular disease (CVD) in a hospital population, and to explore associations with systemic…

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Negative / Null Result ReportMedicine

Learning to draw parametric faces.

Davidenko N, Day J · 2025 · Memory & cognition

Humans' ability to draw faces accurately from memory is extremely rare. One source of difficulty is the drawing process itself, which requires converting a complex, three-dimensional mental representation to a two-dimensional drawing. To…

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