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Browse the failure-mode index

12,248 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Restricting facial mimicry does not impair emotion recognition or influence the evaluation of human affect vocalizations and instrumental sounds.

Wołoszyn K, Hohol M, Winkielman P · 2026 · Scientific reports

The embodied simulation approach predicts that restricting facial movements disrupts emotion recognition. Such effects have been reported for facial and whole-body emotional expressions, but findings remain inconsistent, and it is unclear…

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Negative / Null Result ReportOpen accessMedicine

Object relations are processed with, but not without, awareness.

Palgi S, Bester-Arest T, Faivre N et al. · 2025 · Neuroscience of consciousness

The scope of unconscious integration is widely debated. Here, we examined this question, focusing specifically on deciphering the relations between two associatively related objects, in a set of five behavioral and electrophysiological…

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Negative / Null Result ReportMedicine

Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning.

Lupien SJ, Roy DC, Raymond C et al. · 2020 · Development and psychopathology

Stress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with…

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Negative / Null Result ReportOpen accessMedicine

The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial.

Jackson E, Riley T, Overton PG · 2026 · PloS one

Background Although several effective therapies exist for Attention Deficit Hyperactivity Disorder (ADHD), current pharmaceutical treatment carries a high risk of misuse and high levels of discontinuation, evidencing a need for…

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Negative / Null Result ReportOpen accessMedicine

Acceptance of mixed gambles is sensitive to the range of gains and losses experienced, and estimates of lambda (λ) are not a reliable measure of loss aversion: Reply to André and de Langhe (2020).

Walasek L, Mullett TL, Stewart N · 2021 · Journal of experimental psychology. General

Walasek and Stewart (2015) demonstrated that loss aversion estimated from fitting accept-reject choice data from a set of 50-50 gambles can be made to disappear or even reverse by manipulating the range of gains and losses experienced in…

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Negative / Null Result ReportOpen accessMedicine

A Matched Design for Causal Inference With Survey Data: Evaluation of Medical Marijuana Legalization in Kentucky and Tennessee.

Benedetti MH, Lu B, Zhu M · 2024 · Biometrical journal. Biometrische Zeitschrift

A concern surrounding marijuana legalization is that driving after marijuana use may become more prevalent. Survey data are valuable for estimating policy effects, however their observational nature and unequal sampling probabilities…

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Negative / Null Result ReportOpen accessMedicine

Does Conflictual Dialogue Improve a Story?

Berks JW, Williams MN · 2026 · Europe's journal of psychology

According to creative writing experts, adding conflict to dialogue improves story quality and audience reaction to that story. This idea draws from the widely held theory that conflict is vital for dramatic stories. Yet despite conflict's…

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Replication FailureOpen accessMedicine

Liposomal Bupivacaine versus Ropivacaine with Dexamethasone in Rectus Sheath Block for Laparoscopic Gastrectomy: A Randomized Controlled Trial.

Yi K, Zhan Y, Wei A et al. · 2026 · Drug design, development and therapy

Background The optimal analgesia regimen for patients undergoing laparoscopic gastrectomy is still unclear. This study evaluated the efficacy of ultrasound-guided rectus sheath block (RSB) with liposomal bupivacaine in providing sustained…

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Negative / Null Result ReportOpen accessMedicine

Preschoolers' Early Sentence Comprehension: Comparing Bilingual and Monolingual Children and the Role of Executive Function and Vocabulary Development.

Rodenhurst N, Messenger K · 2026 · Developmental science

Previous research into children's comprehension of syntactic structures has investigated early awareness of transitive and intransitive structures amongst monolingual children but research into bilingual children's understanding of the…

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Negative / Null Result ReportOpen accessMedicine

Mortality risks associated with short-term exposure to ultrafine particles in London and the West Midlands.

Nenon D, Fuller G, Masselot P et al. · 2026 · Environmental epidemiology (Philadelphia, Pa.)

Background Some research has suggested that ultrafine particles (UFP), with an aerodynamic diameter less than 100 nm, might be the most harmful component of ambient particulate matter air pollution on human health. In the United Kingdom,…

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