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Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of Pharmacological Neuroprotection During Surgical Clipping of Anterior Circulation Intracranial Aneurysm on Neurological Outcome-A Randomized Controlled Study.

Gopalakrishna KN, Chakrabarti D, Bharadwaj S et al. · 2026 · Neurology India

Objective Patients with intracranial aneurysms while undergoing neurosurgical clipping frequently require the use of temporary clip, and this involves the risk of cerebral ischemia. The usual approaches for prevention of such an adverse…

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Negative / Null Result ReportMedicine

Long-term clinical outcomes of minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) compared with open TLIF(O-TLIF): A retrospective cohort study for at least 5 years.

Zhu F, Ning Y, Leng X et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

OBJECTIVE: The short-term outcomes of minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) and Open TLIF (O-TLIF) have been reported in previous studies. However, the long-term clinical outcomes of both procedures have been…

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Negative / Null Result ReportOpen accessMedicine

Does Inguinal TAPP Repair Increase the Rate of Midline Supraumbilical Trocar Site Hernia?-A Single-Center Retrospective Study.

Augustin G, Jeričević K, Bogdanić B · 2026 · Journal of clinical medicine

Background/Objectives : This study aimed to determine the inguinal hernia recurrence rate after transabdominal preperitoneal (TAPP) repair, particularly considering the effect of simultaneous umbilical hernia repair. The secondary aim was…

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Negative / Null Result ReportMedicine

Clinical characteristics and kidney outcomes in children with posterior urethral valve: a single-center experience.

Inceoğlu S, Uçkardeş D, Göknar N et al. · 2026 · International urology and nephrology

Introduction and aim Posterior urethral valve (PUV) represent a congenital obstructive uropathy, and despite advances in prenatal diagnosis and postnatal management, chronic kidney disease (CKD) develops in nearly 20% of affected patients.…

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Negative / Null Result ReportOpen accessMedicine

Depression, anxiety, and mental state in patients with early-stage dementia: comparison of reminiscence therapy and cognitive stimulation therapy.

Demir ZG, Doğan IA, Keskin R et al. · 2026 · Dementia & neuropsychologia

Psychosocial interventions may differentially target affective and cognitive symptoms in mild dementia, yet comparative evidence in long-term care is limited. Objective To compare the effects of Reminiscence Therapy (RT) and Cognitive…

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Negative / Null Result ReportOpen accessMedicine

Effects of Ropivacaine-Based Thoracic Paravertebral Block versus Erector Spinae Plane Block on Quality of Recovery in Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial.

Shi S, Liang Y, Liu T et al. · 2026 · Drug design, development and therapy

Background Colorectal cancer remains a leading cause of cancer-related mortality worldwide. Postoperative pain can impair recovery. Thoracic paravertebral block (TPVB) and erector spinae plane block (ESPB) are regional analgesic techniques…

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Negative / Null Result ReportMedicine

High Abdominal Fat Deposition was Regulated by Abdominal Fatty Acid Synthesis Related Genes and Reduced Reproduction in Late Stage of Chinese Indigenous Wannan Yellow Chicken.

Yu H, Wu L, Wang H et al. · 2026 · Animal bioscience

Objective Compared with commercial laying hens, indigenous chicken breeds generally exhibit lower reproductive performance. This study aims to elucidate the impact of abdominal fat deposition on the reproductive performance of indigenous…

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Negative / Null Result ReportMedicine

Healing Integrity Determines Meniscal Extrusion After Isolated Medial Meniscus Posterior Root Repair in Knees With No Lower Limb Malalignment.

Kim JS, Hwang UJ, Woo CW et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Purpose To investigate changes in meniscal extrusion and meniscal healing status following root repair, and the relationship between meniscal extrusion and healing conditions. Methods Patients who underwent isolated root repair between…

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Negative / Null Result ReportOpen accessMedicine

Evaluating poultry by-product meal, tomato pomace, and azolla with or without Natuzyme supplementation as sustainable alternatives to fish meal for Nile tilapia (Oreochromis niloticus).

Kamel AM, Mahmoud MM, Ibrahim MT et al. · 2026 · Tropical animal health and production

Several studies have predicted that developing countries will be unable to afford fish meal as a primary aquafeed protein source in the future. This experiment evaluated the effect of replacing fish meal (FM) with poultry by-product meal…

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Negative / Null Result ReportOpen accessMedicine

Monitoring the Adverse Implications of Coronavirus 2019-induced Pulmonary Complications on Patients' Respiratory Capacity and Physical Abilities with Moderate and Severe Signs during Interval Follow-up.

Aali F, Habibi Z, Aali F et al. · 2026 · Journal of medical signals and sensors

Background The respiratory system of individuals with coronavirus 2019 (COVID-19) experiences significant strain due to the body's immunological response and inflammation, leading to organ failure. Over time, patients have improvement in…

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Negative / Null Result ReportOpen accessMedicine

Endometrial HOXA-10, HOXA-11, ß-1 integrin, ECM-1, FAK, and CD44 immunohistochemical expressions in endometriosis-related recurrent IVF failure: a retrospective case-control study.

Toruk EŞ, Kaplan EA, Sarıbaş GS et al. · 2026 · Journal of ovarian research

BACKGROUND: Endometriosis is a common cause of infertility and is frequently associated with recurrent implantation failure in assisted reproductive technologies. Impaired endometrial receptivity, mediated by altered transcription factors,…

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Negative / Null Result ReportOpen accessMedicine

Efficacy of Normobaric High-Flow Oxygen Therapy Combined with Low Molecular Weight Heparin in the Management of Fetal Growth Restriction: A Prospective Cohort Study.

He M, Zhao K, Wei Q et al. · 2026 · International journal of women's health

Objective This study investigated the clinical efficacy of adding normobaric high-flow oxygen therapy (NHFOT) to low molecular weight heparin (LMWH) and standard supportive care for the management of the present FGR cohort, idiopathic…

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Negative / Null Result ReportMedicine

Single antiplatelet therapy vs oral anticoagulation monotherapy in patients with atrial fibrillation and coronary artery disease after successful catheter ablation: A target trial emulation.

Li F, Zhao Y, Peng X et al. · 2026 · Heart rhythm

Background The optimal long-term antithrombotic strategy in patients with atrial fibrillation (AF) and coronary artery disease (CAD) after successful catheter ablation (CA) remains uncertain. Objective This study aimed to compare the…

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Negative / Null Result ReportOpen accessMedicine

Evaluating the Effectiveness of Age Simulation Gloves.

Lüleci EH, Kedgley AE · 2026 · Human factors

ObjectiveThis study evaluated the effectiveness of age simulation gloves in replicating age-related declines in hand function.BackgroundCommercially available age simulation gloves are increasingly used. However, their ability to replicate…

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Negative / Null Result ReportOpen accessMedicine

A comparative analysis of the performance of leading large language models on the endodontics section of the dentistry specialization exam in Türkiye.

Başkan B, Başkan HK, Koç N · 2026 · PloS one

Objective This study aimed to evaluate and compare the performance of eight contemporary LLMs on the endodontics section of the DUS, assessing their accuracy in both theoretical knowledge and simulated clinical scenarios from historical…

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