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Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Methods Dead-EndOpen accessMedicine

Comparison of Three Behavior Modification Techniques for Management of Anxious Pediatric Dental Patients Aged 4-6 Years during Cavity Preparation Using Airotor: A Randomized Controlled Trial.

Safoora AK, Vadakkepurayil K, Santhakumar M · 2026 · International journal of clinical pediatric dentistry

Background and objectives Dental anxiety is frequently observed in children and often poses a significant challenge to providing effective and high-quality dental care. Managing a child's anxiety in the clinical setting is a critical…

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Negative / Null Result ReportMedicine

Transanastomotic Tube Use and Anastomotic Stricture: A Multicenter Prospective Randomized Trial in Neonates Undergoing Repair of Type C Esophageal Atresia with Distal Tracheoesophageal Fistula.

Lee J, Russell KW, Smith C et al. · 2026 · Annals of surgery

Objective Anastomotic stricture (AS) is the most common complication following repair of type C esophageal atresia with distal tracheoesophageal fistula (EA/TEF). Retrospective studies suggest transanastomotic tube (TT) use may increase AS…

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Negative / Null Result ReportMedicine

Treatment Outcomes in Frail Patients with Advanced Pancreatic Ductal Adenocarcinoma: A Real-World Comparison of Gemcitabine, S-1, and Stereotactic Ablative Radiotherapy.

Kim CH, Kim EJ, Lee TS et al. · 2026 · Oncology

Background Elderly patients or those with poor performance status are underrepresented in clinical trials of pancreatic ductal adenocarcinoma (PDAC), and optimal treatment strategies for this frail population remain unclear. In real-world…

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Negative / Null Result ReportMedicine

The outcome of pulp revascularization of necrotic mature permanent teeth with periapical lesions using platelet-rich fibrin versus induced bleeding: a prospective preliminary randomized clinical trial.

Awawdeh L, Almesleh B, Hammouri H et al. · 2026 · Clinical oral investigations

Objectives The present study evaluated clinically and radiographically the effectiveness of Regenerative endodontic procedures (REPs) using platelet-rich fibrin (PRF) versus induced bleeding (IB) in treating mature necrotic teeth.…

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Negative / Null Result ReportOpen accessMedicine

Clinical Microbial Contamination of Multidose Brimonidine: A Prospective Comparison of Benzalkonium Chloride and Purite® Preservatives.

Karaca S, Yilmaz OF, Sarmis A et al. · 2026 · Journal of ophthalmology

Objective To compare microbial contamination between multidose brimonidine eye drops preserved with benzalkonium chloride (BAK-MDB) and multidose brimonidine eye drops preserved with Purite® (PUR-MDB) using a comparative approach on the…

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Negative / Null Result ReportMedicine

Ultrasound-Guided Transperineal Versus Transrectal Prostate Aspiration Biopsy in Diagnosing Prostate Cancer: An Observational Comparison Study.

Cao Y, Zhu H, Wu J · 2026 · Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Background Ultrasound-guided prostate biopsy is the standard method for the diagnosis of prostate cancer. However, the effect of the optimal puncture approach on diagnostic yield and patient outcomes remains controversial. Objective To…

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Negative / Null Result ReportMedicine

Nirmatrelvir-Ritonavir Versus Short-Course Remdesivir for Mild COVID-19 in High-Risk Hospitalized Patients: A Propensity Score-Matched Study.

Steuber TD, Belk M, Thayer B et al. · 2026 · The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

Background: As coronavirus disease 2019 (COVID-19) has evolved, patients increasingly present with milder disease, raising questions about optimal management of those hospitalized for other conditions, but found to have COVID-19 with high…

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Negative / Null Result ReportOpen accessMedicine

First- Versus Second- or Subsequent-Line Use of Cyclin-Dependent Kinase 4/6 Inhibitors for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Metastatic or Recurrent Breast Cancer: A Multicenter, Retrospective Cohort Study.

Yao S, Imoto S, Tsuchiya A et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are recommended as first- or second-line treatment for hormone receptor (HR)-positive, human epidermal growth factor receptor 2…

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Negative / Null Result ReportMedicine

Performance of large language models and clinical decision support in perioperative management of oral anticoagulants.

Çalışkan MU, Sarıbaş H, Keskin G et al. · 2026 · International journal of medical informatics

Background Perioperative anticoagulant management is critical because of the competing risks of ischemia and bleeding. Large language models (LLMs) and clinical decision support (CDS) have shown substantial advances and are increasingly…

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Negative / Null Result ReportOpen accessMedicine

Platelet-rich plasma versus granulocyte colony-stimulating factor in addressing recurrent implantation failure: A randomized, double-blind clinical trial.

Tehrani HG, Mostajeran E, Dehghani-Mohammadabadi R et al. · 2026 · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Background The aim of the study is to evaluate the effect of platelet-rich plasma (PRP) versus granulocyte colony-stimulating factor in addressing recurrent implantation failure. Materials and methods Fifty patients were randomly assigned…

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Negative / Null Result ReportOpen accessMedicine

Outcome analysis of conservative treatment of a distal radius fracture with OPTIVOhand orthosis versus plaster cast: a randomized controlled trial.

Friederich M, Brunner J, Kirsch E et al. · 2026 · BMC musculoskeletal disorders

Background Distal radius fractures (DRF) are often immobilized using a conventional plaster cast although orthoses offer a time- and resource-saving alternative. This prospective randomized study compared the conservative DRF treatment…

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Negative / Null Result ReportOpen accessMedicine

Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus.

Lv N, Xiang J, Kuang J et al. · 2026 · Frontiers in endocrinology

Introduction 25-hydroxyvitamin D [25(OH)D] deficiency is highly prevalent in type 2 diabetes mellitus (T2DM) and may contribute to immune and metabolic dysfunction. This study aimed to investigate the clinical associations of serum 25(OH)D…

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Failed Experiment ReportOpen accessMedicine

Is biceps augmentation effective for scope-assisted lower trapezius tendon transfer in posterosuperior irreparable rotator cuff tears? A retrospective short-term clinical comparison.

Baek CH, Elhassan BT, Lim C et al. · 2026 · Archives of orthopaedic and trauma surgery

Introduction Although favorable clinical outcomes of scope-assisted lower trapezius tendon transfer (SALTT) have been reported in posterosuperior irreparable rotator cuff tears (PSIRCTs) patients, the limited restoring of static stability…

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Negative / Null Result ReportMedicine

Similar Strength and Hypertrophic Adaptations in Less Time? Myo-Reps vs. Traditional Straight-Sets in Resistance-Trained Men.

Bradshaw JT, Sanzo K, Barakat C et al. · 2026 · Journal of strength and conditioning research

Abstract Bradshaw, JT, Sanzo, K, Barakat, C, Barshun, A, Inglima, S, Gotla, T, Thompson, BK, De Souza, EO, and Walters, JA. Similar strength and hypertrophic adaptations in less time? Myo-reps vs. traditional straight-sets in…

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Negative / Null Result ReportOpen accessMedicine

Effect of output intensity of light curing unit on coronal tooth discoloration induced by silicate calcium-based materials: an ex vivo study.

Farshad F, Shokouhinejad N, Pedram P et al. · 2026 · Biomaterial investigations in dentistry

Objective Clinicians have various curing options due to new light-cure devices with different intensities. The present study aimed to evaluate the effect of two light-curing intensities (1,200 mW/cm² vs. 3,000 mW/cm²) on coronal…

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