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Browse the failure-mode index

12,248 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Ultrasound-Guided Transperineal Versus Transrectal Prostate Aspiration Biopsy in Diagnosing Prostate Cancer: An Observational Comparison Study.

Cao Y, Zhu H, Wu J · 2026 · Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Background Ultrasound-guided prostate biopsy is the standard method for the diagnosis of prostate cancer. However, the effect of the optimal puncture approach on diagnostic yield and patient outcomes remains controversial. Objective To…

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Negative / Null Result ReportMedicine

Nirmatrelvir-Ritonavir Versus Short-Course Remdesivir for Mild COVID-19 in High-Risk Hospitalized Patients: A Propensity Score-Matched Study.

Steuber TD, Belk M, Thayer B et al. · 2026 · The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

Background: As coronavirus disease 2019 (COVID-19) has evolved, patients increasingly present with milder disease, raising questions about optimal management of those hospitalized for other conditions, but found to have COVID-19 with high…

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Negative / Null Result ReportOpen accessMedicine

First- Versus Second- or Subsequent-Line Use of Cyclin-Dependent Kinase 4/6 Inhibitors for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Metastatic or Recurrent Breast Cancer: A Multicenter, Retrospective Cohort Study.

Yao S, Imoto S, Tsuchiya A et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are recommended as first- or second-line treatment for hormone receptor (HR)-positive, human epidermal growth factor receptor 2…

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Negative / Null Result ReportMedicine

Performance of large language models and clinical decision support in perioperative management of oral anticoagulants.

Çalışkan MU, Sarıbaş H, Keskin G et al. · 2026 · International journal of medical informatics

Background Perioperative anticoagulant management is critical because of the competing risks of ischemia and bleeding. Large language models (LLMs) and clinical decision support (CDS) have shown substantial advances and are increasingly…

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Negative / Null Result ReportOpen accessMedicine

Platelet-rich plasma versus granulocyte colony-stimulating factor in addressing recurrent implantation failure: A randomized, double-blind clinical trial.

Tehrani HG, Mostajeran E, Dehghani-Mohammadabadi R et al. · 2026 · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Background The aim of the study is to evaluate the effect of platelet-rich plasma (PRP) versus granulocyte colony-stimulating factor in addressing recurrent implantation failure. Materials and methods Fifty patients were randomly assigned…

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Negative / Null Result ReportOpen accessMedicine

Outcome analysis of conservative treatment of a distal radius fracture with OPTIVOhand orthosis versus plaster cast: a randomized controlled trial.

Friederich M, Brunner J, Kirsch E et al. · 2026 · BMC musculoskeletal disorders

Background Distal radius fractures (DRF) are often immobilized using a conventional plaster cast although orthoses offer a time- and resource-saving alternative. This prospective randomized study compared the conservative DRF treatment…

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Negative / Null Result ReportOpen accessMedicine

Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus.

Lv N, Xiang J, Kuang J et al. · 2026 · Frontiers in endocrinology

Introduction 25-hydroxyvitamin D [25(OH)D] deficiency is highly prevalent in type 2 diabetes mellitus (T2DM) and may contribute to immune and metabolic dysfunction. This study aimed to investigate the clinical associations of serum 25(OH)D…

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Failed Experiment ReportOpen accessMedicine

Is biceps augmentation effective for scope-assisted lower trapezius tendon transfer in posterosuperior irreparable rotator cuff tears? A retrospective short-term clinical comparison.

Baek CH, Elhassan BT, Lim C et al. · 2026 · Archives of orthopaedic and trauma surgery

Introduction Although favorable clinical outcomes of scope-assisted lower trapezius tendon transfer (SALTT) have been reported in posterosuperior irreparable rotator cuff tears (PSIRCTs) patients, the limited restoring of static stability…

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Negative / Null Result ReportMedicine

Similar Strength and Hypertrophic Adaptations in Less Time? Myo-Reps vs. Traditional Straight-Sets in Resistance-Trained Men.

Bradshaw JT, Sanzo K, Barakat C et al. · 2026 · Journal of strength and conditioning research

Abstract Bradshaw, JT, Sanzo, K, Barakat, C, Barshun, A, Inglima, S, Gotla, T, Thompson, BK, De Souza, EO, and Walters, JA. Similar strength and hypertrophic adaptations in less time? Myo-reps vs. traditional straight-sets in…

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Negative / Null Result ReportOpen accessMedicine

Effect of output intensity of light curing unit on coronal tooth discoloration induced by silicate calcium-based materials: an ex vivo study.

Farshad F, Shokouhinejad N, Pedram P et al. · 2026 · Biomaterial investigations in dentistry

Objective Clinicians have various curing options due to new light-cure devices with different intensities. The present study aimed to evaluate the effect of two light-curing intensities (1,200 mW/cm² vs. 3,000 mW/cm²) on coronal…

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Negative / Null Result ReportMedicine

Effect of Pharmacological Neuroprotection During Surgical Clipping of Anterior Circulation Intracranial Aneurysm on Neurological Outcome-A Randomized Controlled Study.

Gopalakrishna KN, Chakrabarti D, Bharadwaj S et al. · 2026 · Neurology India

Objective Patients with intracranial aneurysms while undergoing neurosurgical clipping frequently require the use of temporary clip, and this involves the risk of cerebral ischemia. The usual approaches for prevention of such an adverse…

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Negative / Null Result ReportMedicine

Long-term clinical outcomes of minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) compared with open TLIF(O-TLIF): A retrospective cohort study for at least 5 years.

Zhu F, Ning Y, Leng X et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

OBJECTIVE: The short-term outcomes of minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) and Open TLIF (O-TLIF) have been reported in previous studies. However, the long-term clinical outcomes of both procedures have been…

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Negative / Null Result ReportOpen accessMedicine

Does Inguinal TAPP Repair Increase the Rate of Midline Supraumbilical Trocar Site Hernia?-A Single-Center Retrospective Study.

Augustin G, Jeričević K, Bogdanić B · 2026 · Journal of clinical medicine

Background/Objectives : This study aimed to determine the inguinal hernia recurrence rate after transabdominal preperitoneal (TAPP) repair, particularly considering the effect of simultaneous umbilical hernia repair. The secondary aim was…

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Negative / Null Result ReportMedicine

Clinical characteristics and kidney outcomes in children with posterior urethral valve: a single-center experience.

Inceoğlu S, Uçkardeş D, Göknar N et al. · 2026 · International urology and nephrology

Introduction and aim Posterior urethral valve (PUV) represent a congenital obstructive uropathy, and despite advances in prenatal diagnosis and postnatal management, chronic kidney disease (CKD) develops in nearly 20% of affected patients.…

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Negative / Null Result ReportOpen accessMedicine

Depression, anxiety, and mental state in patients with early-stage dementia: comparison of reminiscence therapy and cognitive stimulation therapy.

Demir ZG, Doğan IA, Keskin R et al. · 2026 · Dementia & neuropsychologia

Psychosocial interventions may differentially target affective and cognitive symptoms in mild dementia, yet comparative evidence in long-term care is limited. Objective To compare the effects of Reminiscence Therapy (RT) and Cognitive…

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