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Browse the failure-mode index

12,248 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The effect of self-reported knee instability on plantar pressure and postural sways in women with knee osteoarthritis

Liana Chaharmahali, F. Gandomi, A. Yalfani et al. · 2021 · Journal of Orthopaedic Surgery and Research

Background Giving way and knee instability are common problems in patients with knee osteoarthritis, disrupting the daily activities and balance of the affected individual. The present study aimed to evaluate the postural control status of…

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Negative / Null Result ReportOpen accessMedicine

Differing natural killer cell, T cell and antibody profiles in antiretroviral-naive HIV-1 viraemic controllers with and without protective HLA alleles

A. Moyano, Bongiwe Ndlovu, Msizi Mbele et al. · 2023 · PLoS ONE

Previous work suggests that HIV controllers with protective human leukocyte antigen class I alleles (VC+) possess a high breadth of Gag-specific CD8+ T cell responses, while controllers without protective alleles (VC-) have a different…

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Negative / Null Result ReportOpen accessMedicine

Minimally Invasive Approaches Versus Conventional Sternotomy for Aortic Valve Replacement: A Propensity Score Matching Study

J. Bang, Jong Wook Kim, J. Lee et al. · 2012 · The Korean journal of thoracic and cardiovascular surgery

Background The aim of this study is to evaluate our institutional results of the aortic valve replacement through minimally invasive approaches compared with conventional sternotomy. Materials and Methods From August 1997 to July 2010, 838…

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Negative / Null Result ReportMedicine

The Effect of Pomegranate Extract on Survival and Peritoneal Bacterial Load in Cecal Ligation and Perforation Model of Sepsis in Rats

S. Tavasoli, A. Zarnani, Mohamadreza Vafa et al. · 2014 · International Journal of Preventive Medicine

Background: Sepsis is one of the major causes of death in intensive care units. Oxidative stress and hyper-inflammation has been shown to be major cause of mortality and morbidity in septic cases. Pomegranate is a fruit considered for its…

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Negative / Null Result ReportOpen accessMedicine

Influence of Gold Nanoparticle Incorporation Into Glass Ionomer Cement on Fibroblast Metabolic Activity, Surface Roughness and Hardness.

Zia A, Baldwin A, Nlemorisa C et al. · 2026 · International journal of dentistry

Objective To assess the influence of gold nanoparticle (AuNP) liquid-phase modification of glass ionomer cement (GIC) on fibroblast metabolic activity, alongside its effects on surface hardness and roughness, in an exploratory pilot in…

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Negative / Null Result ReportOpen accessMedicine

Structure-Driven Bioactivity of Chitosan-Agarose-Gelatin Hydrogels Functionalized with Tannic Acid-Cu<sup>2+</sup>/Sr<sup>2+</sup> Complexes.

Wekwejt M, Chevallier P, Desgagne F et al. · 2026 · ACS applied materials & interfaces

Hydrogels represent a versatile platform for regenerative applications; nevertheless, their translation is often limited by insufficient biofunctionality and poorly defined structure-property relationships in multicomponent networks. In…

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Negative / Null Result ReportMedicine

A 2 year retrospective study of vegan patients and their pregnancy outcomes in a tertiary level Irish hospital.

Abdelrahman M, Maher S, Lindow SW et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective Recent previous studies have revealed outcomes of higher risk of low birth weight, small for gestational age, and pre-eclampsia for vegan pregnant women compared to other diets. This review examined if patients with vegan diet in…

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Negative / Null Result ReportOpen accessMedicine

Does Combined Intravenous and Topical Tranexamic Acid Offer Additional Benefit Compared With Intravenous or Topical Alone in Open Elbow Arthrolysis-A Pilot Randomized Controlled Trial.

Chen C, Zhang J, Hua K et al. · 2026 · Orthopaedic surgery

Purposes Open elbow arthrolysis (OEA) is a common method for treating post-traumatic elbow stiffness, which may lead to severe bleeding when resecting heterotopic ossification (HO) and fibrous scar tissue. The purpose of this study is to…

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Negative / Null Result ReportMedicine

The influence of lesion type and lesion location on the prediction of language laterality in patients with cerebral vascular malformations using functional MRI.

Rossmann J, Hense K, Knott M et al. · 2026 · Journal of neurosurgery

Objective Predicting language lateralization using functional MRI (fMRI) in patients with cerebral vascular malformations close to language areas is essential for treatment decision-making and patient outcomes. Functional MRI-based…

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Negative / Null Result ReportOpen accessMedicine

Comparable improvements in selective, but not sustained, attention in response to a multi-ingredient nootropic formulation when compared with caffeine.

Hearris MA, Langan-Evans C, Foo WL et al. · 2026 · European journal of nutrition

PURPOSE: The ergogenic effects of caffeine on cognitive performance are largely restricted to improved alertness and enhanced attention and do not typically extend to other cognitive domains. In contrast, plant extracts and phytochemicals…

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Negative / Null Result ReportMedicine

Retrospective Analysis of Dronedarone Versus Amiodarone on Outcomes Following Radiofrequency Ablation for Atrial Fibrillation.

Shi Y, Shi X, Li H et al. · 2026 · British journal of hospital medicine (London, England : 2005)

Aims/background Pharmacological therapy can enhance the therapeutic efficacy of radiofrequency ablation (RFA) for atrial fibrillation (AF) and reduce the risk of recurrence. Dronedarone and amiodarone are two commonly prescribed adjuvant…

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Negative / Null Result ReportMedicine

Similar water uptake depths in lianas and trees, but divergent functional trait coordination across organs in a seasonally dry tropical forest in Cambodia.

Hiiragi K, Sopheak T, Sophors C et al. · 2026 · Tree physiology

Although previous studies have suggested that lianas exhibit superior growth compared with trees during dry seasons, their strategies for acquiring water remain poorly understood. This study investigated the water uptake depth and…

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Negative / Null Result ReportOpen accessMedicine

Impact of Junior Physicians' Resignation on Palliative Sedation Practices: A Retrospective Single-Center Study in South Korea.

Hong M, Lee SW, Jung M · 2026 · Journal of hospice and palliative care

Purpose This study aimed to evaluate changes in the proportion of patients receiving palliative sedation (PS) before and after the mass resignation of junior physicians in South Korea. Methods This single-center retrospective chart review…

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Negative / Null Result ReportOpen accessMedicine

Mitigation of salinity stress in Mentha piperita L. through foliar application of chitosan-salicylic acid encapsulated ZnO nanoparticles.

Al-Obaidi MHR, Mehrabani LV, Hassanpouraghdam MB et al. · 2026 · Scientific reports

Salinity stress harms plant growth and physiological characteristics. To investigate the effect of NaCl salinity stress (without salinity stress and 100 mM salinity) and foliar spray with: control (distilled water), zinc oxide…

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Negative / Null Result ReportMedicine

Factors Associated With Surgical Outcomes in Medial Orbital Wall Fracture Reconstruction With Absorbable Plates.

Li B · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Preoperative imaging factors associated with absorbable plate reconstruction outcomes for medial orbital wall fractures are not well-established. The role of muscle cone integrity on computed tomography (CT) has not been…

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Negative / Null Result ReportOpen accessMedicine

The effect of <i>Lactiplantibacillus plantarum</i> probiotic supplement on rainbow trout challenged with <i>Aeromonas salmonicida</i>.

Mikulikova I, Lepkova Z, Bandouchova H et al. · 2026 · Veterinarni medicina

Two probiotic ( Lactiplantibacillus plantarum ) supplementation strategies (continuous and cyclic) were evaluated for their ability to enhance resistance of rainbow trout ( Oncorhynchus mykiss ) to Aeromonas salmonicida infection. Neither…

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