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Browse the failure-mode index

12,248 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Ivermectin treatment of demodicosis in 56 hamsters.

K. Tani, T. Iwanaga, K. Sonoda et al. · 2001 · Journal of Veterinary Medical Science

Fifty-six hamsters with demodicosis were treated with daily oral administration of ivermectin (0.3 mg/kg). Thirty-three cases (58.9%) were cured and 6 cases (10.7%) had improved clinically but needed to continue treatment. Of 5 cases…

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Negative / Null Result ReportOpen accessMedicine

Dose escalation in radical radio(chemo)therapy for cervical and upper thoracic esophageal cancer with 3DCRT/IMRT (ChC&UES): a multicenter retrospective study

Xiao-han Zhao, Wencheng Zhang, Xin Wang et al. · 2024 · Radiation Oncology

Cervical and upper thoracic esophageal cancer (ESCA) presents treatment challenges due to limited clinical evidence. This multi-center study (ChC&UES) explores radical radio(chemo)therapy efficacy and safety, especially focusing on…

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Negative / Null Result ReportOpen accessMedicine

Three-year follow-up of changes of cortical bone thickness after implantation of Endo-Exo-Prosthesis (EEP) for transfemoral amputees

M. Örgel, E. Liodakis, Pratya Jaratjitwilai et al. · 2020 · Journal of Orthopaedic Surgery and Research

Introduction Transcutaneous Osseointegrated Prosthetic Systems (TOPS) offer a good alternative for patients who cannot be satisfactorily rehabilitated by conventional suspension sockets. The Endo-Exo-Prothesis (EEP, ESKA Orthopaedic…

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Negative / Null Result ReportMedicine

Interplay Among Reward Processing, Schizotypal Traits, and Psychosocial Stress in a Large Chinese Young Adult Sample: A Cross‐Sectional Network Analysis

Donghao Tuo, Yi-hang Huang, Simon S. Y. Liu et al. · 2026 · PsyCh Journal

ABSTRACT Reward processing comprises reward sensitivity, motivation, and pleasure experience, but how these components jointly relate to schizotypal traits and psychosocial stress in young adult samples remains unclear. Using network…

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Negative / Null Result ReportMedicine

Glutathione S-transferase expression in benign and malignant eyelid tumors

Efe Saygın, R. Karadag, S. Ozkanlı et al. · 2021 · Biotechnic & Histochemistry

ABSTRACT Eyelid tumors commonly originate from the skin and its appendages. Environmental toxins and oxidants affect eyelid carcinogenesis. Glutathione S-transferases (GST) are antioxidants that participate in pathogenesis. We investigated…

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Negative / Null Result ReportOpen accessMedicine

Vaccination counseling with and without excipient skin testing in patients with suspected allergic reactions to mRNA COVID-19 vaccines and patients with atopy

Dilawar Khokhar, K. O’Shea, C. Akin et al. · 2022 · Journal of Allergy and Clinical Immunology: Global

Background Allergic reactions have been reported with mRNA vaccines for COVID-19 prevention. Patients perceived to be at higher risk for a reaction may be referred to an allergist, although evaluation strategies may differ between…

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Negative / Null Result ReportMedicine

Exploratory safety investigations in normal, freely moving Göttingen minipigs using telemetry: Pharmacological validation.

Julie Jacobsen, Berit Ø. Christoffersen · 2025 · Journal of pharmacological and toxicological methods

INTRODUCTION Adverse cardiovascular (CV) effects is a major cause of drug attrition. Early assessment of CV risk for new drug candidates may be warranted for early de-risking of the further development. Predictive animal models and a…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of Health Literacy and Associated Factors Among Adults Living in Saudi Arabia: A Cross-Sectional Study

Yaser M. Alahmadi · 2023 · Inquiry : a journal of medical care organization, provision and financing

In this westernized culture, maintaining a healthy lifestyle has become a major health concern internationally. Health literacy is an emerging concept and requires effective measures and reform to improve the health status and health of…

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Negative / Null Result ReportMedicine

PP27 Pre-hospital lactate monitoring: a worthy adjunct to systolic blood pressure and shock index in triggering blood product administration in patients with suspected traumatic haemorrhage?

J. Griggs, M. Sherriff, J. Leung et al. · 2019 · Emergency Medicine Journal

Introduction Pre-hospital identification of patients with suspected occult traumatic haemorrhage is problematic. Physiological parameters and clinical gestalt are inadequate surrogates for ongoing haemorrhage. Lactate monitoring may hold…

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Negative / Null Result ReportMedicine

AAV2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two Year Interim Results of an Ongoing Phase I/II Gene Therapy Trial.

T. Aleman, Rachel M. Huckfeldt, Leona W. Serrano et al. · 2022 · Ophthalmology (Rochester, Minn.)

PURPOSE To assess the safety of the subretinal delivery of a recombinant adeno-associated virus serotype 2 (AAV2) vector carrying a human CHM-encoding cDNA in choroideremia (CHM). DESIGN Prospective, open-label, non-randomized,…

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Negative / Null Result ReportOpen accessMedicine

Assessing the Safety of Craniotomy for Resection of Primary Central Nervous System Lymphoma: A Nationwide Inpatient Sample Analysis

Jonathan Yun, Jingyan Yang, Michael Cloney et al. · 2017 · Frontiers in Neurology

Background Unlike many other central nervous system (CNS) tumors, the surgical management of primary central nervous system lymphomas (PCNSL) is traditionally limited by diagnostic biopsy. Studies that predate the use of modern…

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Negative / Null Result ReportOpen accessMedicine

Is the use of BITA vs SITA grafting safe and beneficial in octogenarians?

D. Pevni, T. Ziv-Baran, A. Kramer et al. · 2020 · Annals of Thoracic Surgery

BACKGROUND Bilateral internal thoracic artery grafts (BITA) is questionable in octogenarians because of shorter life expectancy and increased risk of perioperative complications. The aim of this study was to examine the safety and…

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Negative / Null Result ReportOpen accessMedicine

Atlantooccipital overlapping and its effect on outcomes after ventral fixation in dogs with atlantoaxial instability

F. Takahashi, Takaharu Hakozaki, Shigenori Kouno et al. · 2018 · Journal of Veterinary Medical Science

We compared clinical outcomes after ventral fixation in dogs with atlantoaxial instability (AAI) on the basis of the presence or absence of atlantooccipital overlapping (AOO). Of 41 dogs diagnosed with AAI and treated ventral fixation, 12…

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Negative / Null Result ReportMedicine

Is There Postoperative Fluid Accumulation After the Unilateral Biportal Endoscopic Technique as Minimally Invasive Spine Surgery: In Vivo Study.

Omer Bozduman, Kadri Yıldız, Bilal Aykaç et al. · 2025 · Turkish Neurosurgery

AIM To establish the presence and amount of fluid accumulation in UBE procedure, and the relationship of fluid management with other variables. MATERIAL AND METHODS All patients underwent UBE spinal surgery with one level between September…

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Negative / Null Result ReportOpen accessMedicine

The effectiveness of generic emails versus a remote knowledge broker to integrate mood management into a smoking cessation programme in team-based primary care: a cluster randomised trial

N. Minian, Sheleza Ahad, Anna Ivanova et al. · 2021 · Implementation Science

Background Knowledge brokering is a knowledge translation approach that has been gaining popularity in Canada although the effectiveness is unknown. This study evaluated the effectiveness of generalised, exclusively email-based prompts…

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Negative / Null Result ReportOpen accessMedicine

Effect of isolated and combined ingestion of caffeine and citrulline malate on resistance exercise and jumping performance: a randomized double-blind placebo-controlled crossover study

M. Haugen, F. T. Vårvik, J. Grgic et al. · 2023 · European Journal of Nutrition

The aim of this study was to explore the isolated and combined effects of caffeine and citrulline malate (CitMal) on jumping performance, muscular strength, muscular endurance, and pain perception in resistance-trained participants. Using…

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