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Browse the failure-mode index

12,248 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Longitudinal study of visual function in patients with relapsing-remitting multiple sclerosis with and without a history of optic neuritis

A. G. Gómez, A. García-Ben, A. S. García et al. · 2019 · Neurología (English Edition)

Abstract Introduction The contrast sensitivity test determines the quality of visual function in patients with multiple sclerosis (MS). The purpose of this study is to analyse changes in visual function in patients with relapsing-remitting…

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Negative / Null Result ReportMedicine

Validation of a freely distributable software for the analysis of electrophysiological signals: Smart Tools for Evoked Potentials (STEP)

Kelly Cristina Lira de Andrade, Aline Tenório Lins Carnaúba, C. Batista et al. · 2025 · International Symposium on Cooperative Database Systems for Advanced Applications

ABSTRACT Purpose This study aimed to validate the STEP, an application developed for the analysis of various auditory and vestibular electrophysiological signals. The STEP was designed to enhance the accuracy and efficiency of latency and…

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Negative / Null Result ReportOpen accessMedicine

Comparative effects of cilazapril, carvedilol and their combination in preventing from left ventricular remodelling after acute myocardial infarction in rats.

Yuejin Yang, Yida Tang, Y. Ruan et al. · 2002 · Journal of the Renin-Angiotensin-Aldosterone System

OBJECTIVES To compare the effects of cilazapril, carvedilol and their combination in preventing left ventricular remodelling (LVRM) after acute myocardial infarction (AMI) in rats. METHODS Twenty-four hours after left coronary artery…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of Pharyngeal Space in Different Combinations of Class II Skeletal Malocclusion

J. Soni, T. Shyagali, D. Bhayya et al. · 2015 · Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH

Objectives: The study was aimed to evaluate the pharyngeal airway linear measurements of untreated skeletal class II subjects with normal facial vertical pattern in prognathic maxilla with orthognathic mandible and orthognathic maxilla…

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Negative / Null Result ReportOpen accessMedicine

P1103A RANDOMIZED CONTROLLED STUDY ON THE DIALYZERS WITH CELLULOSE TRIACETATE MEMBRANE AND WITH POLYSULFONE MEMBRANE FOR MAINTENANCE HEMODIALYSIS PATIENTS

Zhangliu Chen, Yang Yun, N. Liu et al. · 2020 · Nephrology, Dialysis and Transplantation

With the continuous development and optimization of dialysis membrane materials, polysulfone (PS) as the third generation of dialysis membrane has replaced cellulose triacetate (CTA) and dominated the market because of its better…

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Negative / Null Result ReportOpen accessMedicine

Pulp Fibroblast Cell Apoptosis After Application of Hema Dentine Bonding Material with Ethanol and Water Solvent.

Ratih Elisa Nandarani, Ira Widjiastuti, Latief Mooduto · 2019 · Brazilian Dental Journal

The most common main materials for dentin bonding for composite resin restoration is 2-hydroxyethyl methacrylate (HEMA). HEMA has beneficial physical and chemical properties, and stable, yet toxic. The addition of ethanol or water, may…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Retinal Nerve Fiber Layer Thickness Measurements in Healthy Subjects Using Fourier and Time Domain Optical Coherence Tomography

I. Pinilla, E. Garcia-Martin, M. Idoipe et al. · 2012 · Journal of Ophthalmology

Purpose. To compare the retinal nerve fiber layer (RNFL) measurements using two different ocular coherence tomography (OCT) devices: Cirrus Fourier domain OCT and Stratus time domain OCT. To analyze reproducibility of Fourier domain…

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Negative / Null Result ReportMedicine

Reverse Shoulder Arthroplasty for Patients with Cuff Tear Arthropathy: Do Clinical Outcomes Differ by Inlay versus Onlay Design?

Prashant Meshram, Piotr Łukasiewicz, Laurence Okeke et al. · 2024 · Journal of shoulder and elbow surgery

BACKGROUND The influence of position of the humeral tray (inlay or onlay) on clinical outcomes in reverse shoulder arthroplasty (RSA) is a topic of debate. The purpose of this study was to compare clinical and radiographic outcomes of…

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Negative / Null Result ReportOpen accessMedicine

Retrospective Analysis of Chinese Patients with Hepatocellular Carcinoma (HCC) undergoing Transcatheter Arterial Chemoembolization (TACE) with or without Prophylactic Antibiotic Therapy.

Jiu Chen, Guolin Wu · 2018 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

OBJECTIVE To assess the necessity of prophylactic antibiotic therapy in HCC patients undergoing transcatheter arterial chemoembolization (TACE). STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY The First Affliated Hospital,…

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Negative / Null Result ReportOpen accessMedicine

Creatine Enhances the Effects of Cluster-Set Resistance Training on Lower-Limb Body Composition and Strength in Resistance-Trained Men: A Pilot Study

D. Bonilla, R. Kreider, J. Petro et al. · 2021 · Nutrients

Creatine monohydrate (CrM) supplementation has been shown to improve body composition and muscle strength when combined with resistance training (RT); however, no study has evaluated the combination of this nutritional strategy with…

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Negative / Null Result ReportOpen accessMedicine

Effect of subconjunctival injection with conbercept as an adjuvant to filtration surgery for open angle glaucoma: a prospective randomized interventional 6-month follow-up study.

Jing Zhang, Vikash Vikash, Ping Wang et al. · 2019 · International Journal of Ophthalmology

AIM To compare the safety and efficacy of subconjunctival injection with conbercept and 5-fluorouracil (5-FU) for open angle glaucoma (OAG) patients after filtration surgery. METHODS As a prospective randomized interventional trial, 36…

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Negative / Null Result ReportOpen accessMedicine

Efficacy of a multiple-component and multifactorial personalized fall prevention program in community-dwelling older adults at moderate-to-high fall risk: The PRE.C.I.S.A. Randomized Controlled Trial

Fabio La Porta, S. Caselli, G. Lullini et al. · 2022 · medRxiv

Background: The fall risk in the elderly is a major public health issue due to the immediate injury-related consequences and the risk of associated long-term disability. However, the delivery of effective interventions for fall prevention…

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Negative / Null Result ReportMedicine

Low-intensity versus high-intensity home-based treadmill training and walking attainment in young children with spastic diplegic cerebral palsy.

K. Mattern-Baxter, J. Looper, Chuan Zhou et al. · 2020 · Archives of Physical Medicine and Rehabilitation

OBJECTIVE To compare the effect of low-intensity (LI) versus high-intensity (HI) TT on walking attainment and overall walking activity in children with cerebral palsy (CP). DESIGN Prospective, multi-site, randomized controlled trial…

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Negative / Null Result ReportOpen accessMedicine

Hypoparathyroidism: what is the best calcium carbonate supplementation intake form?

Loraine Gollino, M. Biagioni, Nathalia Regina Sabatini et al. · 2017 · Brazilian Journal of Otorhinolaryngology

Introduction In hypoparathyroidism, calcium supplementation using calcium carbonate is necessary for the hypocalcemia control. The best calcium carbonate intake form is unknown, be it associated with feeding, juice or in fasting. Objective…

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Negative / Null Result ReportMedicine

How does variation of the bag volume in inert gas rebreathing cardiac output measurements influence the reproducibility in patients with pulmonary diseases?

F. Trinkmann, F. Kraus, M. Borggrefe et al. · 2011 · European Respiratory Journal

Background: Cardiac output (CO) is an important hemodynamic parameter, however its determination is difficult in daily clinical routine. Non-invasive inert gas rebreathing (IGR) showed promising results in recent investigations with the…

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Negative / Null Result ReportOpen accessMedicine

Assessment of proprioceptive exercises in the treatment of rotator cuff disorders in nursing professionals: a randomized controlled clinical trial.

L. V. Martins, M. Marziale · 2012 · Brazilian Journal of Physical Therapy

BACKGROUND Shoulder pain in nursing professionals may lead to limitations in occupational and daily activities and consequently interfere with quality of life. OBJECTIVE To compare the effects of two physical therapy programs which…

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Negative / Null Result ReportOpen accessMedicine

Lateral Pterygoid Muscle Biometric Modifications in Pterygoid Process Fractures Associated With Mandibular Fractures.

R. Nicot, Thomas Roland-Billecart, Alexandre Srouji et al. · 2020 · Journal of oral and maxillofacial surgery

PURPOSE Pterygoid process fractures (PPFs) are classically associated with Lefort fractures but can also be encountered in association with other facial fractures such as mandibular fractures. The aim of this study was to estimate the…

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Negative / Null Result ReportOpen accessMedicine

Multiple-dose versus single-dose gonadotropin-releasing hormone agonist after first in vitro fertilization failure associated with luteal phase deficiency: A randomized controlled trial

Danni Qu, Yuan Li · 2020 · Journal of International Medical Research

Objective To evaluate the efficacy and safety of multiple- versus single-dose gonadotropin-releasing hormone agonist (GnRH-a) addition to luteal phase support (LPS), in patients with a first in vitro fertilization (IVF) failure associated…

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Negative / Null Result ReportOpen accessMedicine

Postprandial changes in cardiometabolic disease risk in young Chinese men following isocaloric high or low protein diets, stratified by either high or low meal frequency - a randomized controlled crossover trial

A. Mok, S. Haldar, J. C. Lee et al. · 2015 · Nutrix Journal

BackgroundCardio-Metabolic Disease (CMD) is the leading cause of death globally and particularly in Asia. Postprandial elevation of glycaemia, insulinaemia, triglyceridaemia are associated with an increased risk of CMD. While studies have…

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Negative / Null Result ReportOpen accessMedicine

EFFICACY OF SILODOSIN VS TAMSULOSIN IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL

S. T. C. Ariwicaksono, R. B. Prasetyo, Nindra Prasadja et al. · 2019 · International Journal of Applied Pharmaceutics

Objective: Benign prostatic hyperplasia (BPH) is a nonmalignant enlargement of the prostate associated with aging. BPH can cause lower urinary tract syndrome (LUTS). Medical therapy for patients with moderate and severe LUTS symptoms…

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Negative / Null Result ReportOpen accessMedicine

Влияние экзогенных сурфактантов на показатели газового состава крови у новорождённых с респираторным дистресс-синдромом

A. A. Перепелица, Array М Голубев, Array В. Мороз · 2007

Objective: to study the effects of the surfactants Surfactant-BL and Curosurf on pulmonary oxygenizing properties in preterm neonatal infants with respiratory distress syndrome (RDS). The studies were performed in 81 preterm neonates with…

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Negative / Null Result ReportMedicine

Concepts of care for people with dementia

N. Rieckmann, C. Schwarzbach, M. Nocon et al. · 2009 · GMS Health Technology Assessment

Introduction Today there are approximately one million people with dementia in Germany. If current demographic trends continue, this number is likely to rise substantially in the coming years. In the older population, dementia is the most…

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