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WASTE Journal

Browse the failure-mode index

12,248 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Dehorning Does Not Alter the Stress Response in Southern White Rhinoceroses (Ceratotherium simum simum) during Transport: A Preliminary Investigation

Anita Metzinger, Leith C. R. Meyer, P. Buss et al. · 2024 · Journal of Wildlife Diseases

Abstract: Translocation and dehorning are common and important practices for rhinoceros management and conservation. It is not known if dehorning causes a stress response or negatively affects rhinoceroses during transport. Twenty-three…

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Negative / Null Result ReportOpen accessMedicine

Ventilation during continuous compressions or at 30:2 compression-to-ventilation ratio results in similar arterial oxygen and carbon dioxide levels in an experimental model of prolonged cardiac arrest

Jukka Kopra, E. Litonius, P. Pekkarinen et al. · 2023 · Intensive Care Medicine Experimental

Background In refractory out-of-hospital cardiac arrest, transportation to hospital with continuous chest compressions (CCC) from a chest compression device and ventilation with 100% oxygen through an advanced airway is common practice.…

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Negative / Null Result ReportMedicine

Effect of Volume on Postoperative Outcomes After Left Pancreatectomy: A Multicenter Prospective Snapshot Study (SPANDISPAN Project)

D. Aparicio-López, J. Ramia, C. Villodre et al. · 2025 · Journal of Clinical Medicine

Background/Objectives: Like many other countries, the management of pancreatic cancer in Spain has developed in a fragmented manner. This study analyzes clinical outcomes related to patient volume at different centers after left…

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Negative / Null Result ReportOpen accessMedicine

The Effect of Two Calcium Silicate Materials on the Fracture Strength of Simulated Immature Teeth during Regenerative Endodontic Treatment

H. Edrees, A. Y. Siddiqui, M. M. Almousa et al. · 2021 · Journal of Evolution of Medical and Dental Sciences

BACKGROUND Necrotic immature permanent teeth undergoing Regenerative Endodontic Treatment (RET) are subjected to functional forces that might lead to their fracture before achieving apical closure. This study compared the fracture strength…

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Negative / Null Result ReportMedicine

A Half-Century Review of Male and Female Resident Outcomes in Oral and Maxillofacial Surgery: A Single-Institution Report.

Susan Keefe, Carrie Baldwin, Elda Fisher et al. · 2025 · Journal of oral and maxillofacial surgery

BACKGROUND Limited comprehensive historical data exist comparing male and female residents in oral and maxillofacial surgery (OMS) residency programs. This gap underscores the need to examine sex-based differences to guide equitable…

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Negative / Null Result ReportMedicine

The Effect of the Lateral First Metatarsal Head Shape on Hallux Valgus in Forced Turnout in Pre-Pointe Female Ballet Dancers: A Pilot Study.

Paul H Doan, David M Handojo, Shivani Parihar et al. · 2024 · Journal of the American Podiatric Medical Association (Print)

BACKGROUND A rounded lateral first metatarsal head shape is associated with higher rates of hallux abducto valgus recurrence following corrective surgery; however, the effect of the lateral first metatarsal head shape on the hallux…

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Negative / Null Result ReportOpen accessMedicine

A Benchmark Side-by-Side Comparison of Two Well-Established Protocols for in vitro Hematopoietic Differentiation From Human Pluripotent Stem Cells

F. Gutiérrez-Agüera, Virginia C. Rodríguez-Cortez, P. Petazzi et al. · 2021 · Frontiers in Cell and Developmental Biology

The generation of transplantable hematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) remains challenging. Current differentiation protocols from hPSCs generate mostly hematopoietic progenitors of the primitive…

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Negative / Null Result ReportMedicine

Which clinical factors and biochemical parameters differentiate major depressive disorder with versus without lifetime psychotic symptoms?

C. M. Esposito, F. Legnani, J. Barkin et al. · 2026 · International journal of psychiatry in clinical practice

OBJECTIVE Major depressive disorder (MDD) is a prevalent disabling condition, with psychotic features complicating its course and management. Purpose of the study is to identify clinical and biochemical factors differentiating psychotic…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of the Effectiveness and Safety of a Multifaceted Computerized Antimicrobial Stewardship Intervention in Surgical Settings: A Single-center Cluster-randomized Controlled Trial.

Xin Yuan, Kai Chen, Jing Yuan et al. · 2023 · International Journal of Antimicrobial Agents

BACKGROUND Inappropriate antimicrobial use is common for patients undergoing surgery. Whether a multifaceted computerized antimicrobial stewardship program is effective and safe in reducing inappropriate antimicrobial use in surgical…

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Negative / Null Result ReportOpen accessMedicine

Medical management in locally advanced and metastatic prostate cancer: Does changes in treatment policy have any specific effect on PSA levels?

M. Bağcıoğlu, C. Surcel, S. Ozcan et al. · 2017 · Archivio Italiano di Urologia e Andrologia

OBJECTIVE Androgen deprivation therapy (ADT) is commonly used as a first-line treatment for locally advanced and metastatic prostatic cancer (Pca). There is no consensus about which alternative treatment should be used after the failure of…

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Negative / Null Result ReportOpen accessMedicine

No difference in anti-spike antibody and surrogate viral neutralization following SARS-CoV-2 booster vaccination in persons with HIV compared to controls (CO-HIV Study)

Kendall Kling, Patrick Janulis, A. Demonbreun et al. · 2023 · Frontiers in Immunology

Background Understanding the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination will enable accurate counseling and inform evolving vaccination strategies. Little is known about antibody response…

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Negative / Null Result ReportOpen accessMedicine

The Neonatal Congenital Anomalies: Incidence and Risk Factors Before and After the war at Al-Thawrah Hospital- Sana'a,Yemen.

F. M. Abol-Gaith, N. Ismail, A. Al-Mutawakel · 2019 · Assiut Scientific Nursing Journal

Background: Congenital anomalies (CAs) are structural or functional abnormalities that occur during intrauterine life and can be identified prenatally, at birth or may be detected in infancy later. Aim: To compare the incidence and risk…

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Negative / Null Result ReportOpen accessMedicine

“Customized Titanium Mesh versus Titanium Reinforced Membrane in localized Alveolar Ridge Augmentation with Simultaneously delayed implant placement” A randomized clinical study

Maha Shaikh, A. Gamal, Ahmed Amr · 2020

Aim: To compare two different alveolar ridge augmentation (ARA) approaches applied in conjunction with delayed dental implants regarding the enhancement of the buccolingual alveolar ridge width and the changes in alveolar crestal level…

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Negative / Null Result ReportOpen accessMedicine

Clinical outcomes of subcutaneous vs. transvenous implantable defibrillator therapy in a polymorbid patient cohort

B. Kattih, F. Operhalski, F. Boeckling et al. · 2022 · Frontiers in Cardiovascular Medicine

Background The subcutaneous implantable cardioverter-defibrillator (S-ICD) has been designed to overcome lead-related complications and device endocarditis. Lacking the ability for pacing or resynchronization therapy its usage is limited…

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Negative / Null Result ReportOpen accessMedicine

Polyomavirus BK Genome Comparison Shows High Genetic Diversity in Kidney Transplant Recipients Three Months after Transplantation

Olga Mineeva-Sangwo, Joan Martí-Carreras, E. Cleenders et al. · 2022 · Viruses

BK polyomavirus (BKPyV) is a human DNA virus generally divided into twelve subgroups based on the genetic diversity of Viral Protein 1 (VP1). BKPyV can cause polyomavirus-associated nephropathy (PVAN) after kidney transplantation.…

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Negative / Null Result ReportMedicine

Metabolic and Nutritional Outcomes After Sleeve Gastrostomy and Gastric Bypass in Adolescents: A Cohort Study with 1-Year Follow-Up

Faraneh Zolfaghari, M. Barzin, M. Mahdavi et al. · 2025 · Hormone and Metabolic Research

Abstract We conducted this study to compare the anthropometric and metabolic outcomes and nutritional status, after sleeve gastrostomy (SG) and gastric bypass (GB) in adolescents with severe obesity. We selected 219 adolescents with severe…

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Negative / Null Result ReportOpen accessMedicine

Open simple prostatectomy and robotic simple prostatectomy for large benign prostatic hyperplasia: Comparison of safety and efficacy

J. Cho, K. T. Moon, J. Lee et al. · 2021 · Prostate International

Background To compare the safety and efficacy of open simple prostatectomy (OSP) and robotic simple prostatectomy (RSP) for the treatment of large benign prostatic hyperplasia (BPH). Materials and methods We retrospectively reviewed the…

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Negative / Null Result ReportMedicine

An AI-Enabled Low-Cost Wearable to Support Musculoskeletal Rehabilitation: A Proof of Concept

I. Mumuni, Darren Player, R. Tehrany et al. · 2025 · Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Musculoskeletal (MSK) disorders remain one of the leading causes of disability worldwide. Although multi-modal physiotherapy, an approach that combines manual therapy, exercise therapy and education is the recommended core treatment, many…

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Negative / Null Result ReportOpen accessMedicine

Physical activity in women attending a dissonance-based intervention after Roux-en-Y Gastric Bypass: A 2-year follow-up of a randomized controlled trial

S. Possmark, F. Sellberg, A. Ghaderi et al. · 2021 · PLoS ONE

Background The majority of Roux-en-Y gastric bypass (RYGB) patients are not sufficiently physically active post-surgery, yet little support from the Swedish healthcare system is offered. We investigated if a dissonance-based group…

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