12,246 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Kacar, Ayaz-Alkaya · 2026 · Journal of pediatric nursing
Internet addiction is a growing problem among children and adolescents. Pathological internet use may lead to psychological and social issues. More effective and innovative interventions are needed to promote the mental health of children.…
View details →Lopes, Costa, Nociti Junior et al. · 2026 · Brazilian oral research
This study investigated the effects of incorporating 3wt% titanium dioxide nanotubes (nTiO2) into calcium hydroxide [Ca(OH)2]-based intracanal medicament (ICM) formulations on the proliferation, viability, and mitochondrial metabolic…
View details →Linke, Mayer, Suttkus et al. · 2026 · Pediatric research
This study examined parental stress indicators during outpatient pediatric surgery and whether intraoperative text messaging could alleviate stress. This randomized trial assigned parents of children aged 6 months to 6 years undergoing…
View details →Melnikova · 2025 · Bulletin of experimental biology and medicine
Using in vivo microscopy, changes in the diameter of pial arterial microvessels were studied in rats with modeled moderate acute blood loss followed by whole-body cooling against the background of a single administration of tranexamic acid…
View details →Nazki, Tennakoon, Reddy et al. · 2026 · The Journal of general virology
Infectious bursal disease virus (IBDV) causes an endemic immunosuppressive disease in chickens. Prior exposure to IBDV influences the pathogenesis and shedding of chicken strains of influenza A virus (IAV), but its effect on waterfowl…
View details →Tuncekin, Toprak · 2026 · Iranian journal of immunology : IJI
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic autoimmune inflammatory disorders in which TNF-α plays a key role. Anti-TNF agents are widely used in the management of these diseases. Since TNF-α is also…
View details →Xu, Hu, Zhao et al. · 2026 · Obesity (Silver Spring, Md.)
HDM1002, a small-molecule agonist of glucagon-like peptide-1 receptors, was evaluated for safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD). Chinese participants (18-60 years) with…
View details →Shen, Yan, Yan et al. · 2026 · Journal of environmental sciences (China)
Diazotrophs play a crucial role within the rhizosphere by fixing atmospheric nitrogen and promoting plant growth. However, the diversity of diazotrophic communities and the influences of human activity are largely unclear. This study…
View details →Uludag, Uludag · 2026 · Current medicinal chemistry
Recently, there has been growing interest in the roles of vitamin D and certain platelet characteristics, such as mean platelet volume (MPV). However, the influence of vitamin D levels on these platelet traits is still under discussion.…
View details →Estaji, Ahmadizadeh · 2026 · Journal of psychiatric research
Based on neurocognitive models, the development and maintenance of post-traumatic stress disorder (PTSD) are correlated with cognitive biases, including attention and memory biases, which are associated with imbalanced activation of…
View details →Cazalis-Henry, Seuront, Spilmont · 2026 · Biology letters
Brown macroalgae like Fucus serratus are key ecosystem engineers in intertidal environments and are increasingly threatened by anthropogenic pollution and global change. This study examined how the combined effects of conventional and…
View details →Grub, Naab · 2026 · Digital health
To examine user perceptions of human advisors versus chatbots in mental health apps and assess the impact of algorithm literacy interventions. In an online experiment, participants engaged in simulated chats about digital stress. A…
View details →Maureen, Budiardjo, Wahono · 2026 · Journal of the Indian Society of Pedodontics and Preventive Dentistry
Down syndrome is a genetic condition caused by trisomy 21, often accompanied by orofacial hypotonia and anomalies in stomatognathic development. A hypotonic tongue may alter oral cavity morphology, particularly palatal depth, anterior…
View details →Goh, Sud, Chau et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Renin-angiotensin system inhibitors (RASIs) are recommended to preserve residual kidney function (RKF) in patients on peritoneal dialysis (PD); however, evidence of benefit is inconsistent. This study evaluated…
View details →Ptáček, Musil, Guarnieri et al. · 2026 · International journal of molecular sciences
Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disorder; to date, there is no long-term effective treatment. Recently, a relationship has been discovered between the human intestinal microbiome and the pathogenesis of…
View details →Deng, Xiang, Li et al. · 2026 · Animals : an open access journal from MDPI
Due to the lack of corn and soybean meal in animal feeding, rice bran meal (RBM) has been proposed as a beneficial substitute for these feedstocks' ingredients. Its fermentation by using diverse microbes has been adopted as a beneficial…
View details →Hazell, Khazova, O'Mahoney · 2026 · Antioxidants (Basel, Switzerland)
Conflicting evidence exists on whether blue or red light modulates nitric oxide (NO) release within skin cells. Using environmentally relevant doses, irradiances and spectral distribution akin to low-level sunlight, we provide evidence…
View details →Tas, Erturk · 2026 · Indian journal of surgical oncology
Due to controversial results, the clinical impact of sex in pancreatic cancer has not been fully clarified. We aimed to investigate the clinical significance of sex in patients with pancreatic cancer in this study. A total of 334…
View details →Elgayar · 2026 · Scientific reports
This trial aimed to explore the effect of supervised breathing exercises (BEs) on depression, sexual function, and exercise capacity in postmenopausal women. Sixty-four depressed postmenopausal women with associated sexual dysfunction were…
View details →Chen, Liu, Xue et al. · 2026 · Molecular pain
The insular cortex (IC), a critical hub for nociception, emotion, and cognition processing, has emerged as a key role in the descending modulation of spinal cord excitability. Although previous studies have suggested that IC may influence…
View details →Balducci, Haxhi, Vitale et al. · 2026 · Acta diabetologica
To assess the effect of a 1-year supervised exercise training program on long-term mortality in people with type 2 diabetes. This is a post hoc analysis of the Italian Diabetes and Exercise Study randomized clinical trial, which enrolled…
View details →Zhang, Song, Ji et al. · 2026 · Ecotoxicology and environmental safety
The rise in electronic waste from the electronics industry has increased environmental and health risks. Pollutants like tris(2-chloroethyl) phosphate (TCEP) and lead (Pb) are particularly concerning for their harmful effects on…
View details →Rezaeinejad, Sepidarkish, Moini et al. · 2026 · Pregnancy hypertension
While cigarette smoking has been paradoxically associated with a reduced risk of preeclampsia, the effect of waterpipe (WP) smoking, an increasingly prevalent form of tobacco use remains poorly understood. This study aimed to investigate…
View details →Ehne, Kastensson, Wedin et al. · 2026 · Journal of bone oncology
The use of postoperative radiotherapy (PORT) as an adjunct to orthopaedic surgery of the long bones is widely recommended. Evidence of the benefits is however sparse. The primary research question of this study was whether PORT reduces the…
View details →Karunayawong, Sukmanee, Butchon et al. · 2026 · BMJ open
Since 1985, the international healthcare community has recommended the ideal rate of caesarean section (CS) to be 10%-15% at the national level. The literature has reported that overused CS without necessary medical indications can be…
View details →Li, Hou, Li et al. · 2026 · Chemistry & biodiversity
Two new pyrrole alkaloids, asiaticain A (1) and asiaticain B (2), two aromatic compounds 3-4, and one steroid 5 were isolated from Lanmaoa asiatica. The structural elucidation of the isolated compounds was determined by using NMR, MS, IR,…
View details →Rodrigues, Macedo, de Paulo et al. · 2026 · Oral surgery, oral medicine, oral pathology and oral radiology
To evaluate the effects of sticky bone a biomaterial composed of Solid-PRF (S-PRF), a variant of platelet-rich fibrin (PRF), and deproteinized bovine bone-on bone formation after tooth extraction performed prior to radiotherapy, with…
View details →Olivieri, Amatori, Battocchio et al. · 2026 · Nanomaterials (Basel, Switzerland)
Gold nanorods (AuNRs) were synthesized and optimized with the aim of obtaining strongly hydrophilic nanomaterials, suitable as a drug delivery system (DDS) for copper-based drugs. After careful purification, AuNRs were characterized by…
View details →Expósito-Díaz, Medina, Moral · 2026 · Environmental microbiology reports
Olive anthracnose, the most critical disease affecting fruit and oil quality, is caused by Colletotrichum species, with C. godetiae dominant in Italian and Spanish orchards. Climate change could exacerbate its impact, particularly through…
View details →Balcerac, Cuzzubbo, Bompaire et al. · 2026 · Revue neurologique
Since 2005, the standard treatment for newly diagnosed glioblastoma involves radiotherapy combined with concomitant and adjuvant temozolomide (TMZ), as per the Stupp protocol. A known long-term complication of radiotherapy is…
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