Negative / Null Result ReportOpen accessMedicine
Zehner KM, Salib A, Sanchez JG et al. · 2026 · Journal of hand surgery global online
Purpose Carpal tunnel syndrome may be considered for carpal tunnel injection (CTI). Ultrasound (US) guidance has been proposed to improve CTI accuracy, but the trend across the years, factors associated with utilization, and outcomes are…
View details →Negative / Null Result ReportOpen accessMedicine
Almutairi M, Alalmaee R, Alamer E et al. · 2026 · Journal of clinical tuberculosis and other mycobacterial diseases
Background Tuberculosis (TB) is a major global health issue, particularly among HIV-positive individuals. In Saudi Arabia, the incidence has declined to 8.4 per 100,000 but remains a concern among high-risk groups. Extrapulmonary TB,…
View details →Negative / Null Result ReportMedicine
Zhang P, Guo Y, Xu Y et al. · 2025 · Talanta
The identification of natural active compounds is typically a cumbersome and time-intensive process due to the necessity for elaborate sample pretreatment, leading to inefficiencies. Although recent advancements have introduced methods for…
View details →Negative / Null Result ReportMedicine
Britnell JA, Palme R, Kerley GIH et al. · 2024 · Functional Ecology
Steroid hormones, especially glucocorticoids (GCs), are widely used to assess physiological responses to stressors. As steroid hormones are heavily metabolised prior to excretion, it is essential to validate enzyme immunoassays (EIAs) for…
View details →Negative / Null Result ReportMedicine
Anez SG, Flail DB, Burkhart EP et al. · 2025 · Journal of natural products
Monotropa uniflora L. ("ghost pipe"), is a North American traditional medicinal plant which has recently seen an increase in consumption nationwide. However, a single 1889 study reported the presence of grayanotoxin I in M. uniflora,…
View details →Methods Dead-EndMedicine
Psaltis PJ, Nguyen MT, Singh K et al. · 2025 · Cardiovascular research
Aims Low-dose colchicine reduces the risk of cardiovascular events after myocardial infarction (MI). The purpose of this study was to assess the effect of colchicine post-MI on coronary plaque morphology in non-culprit segments by optical…
View details →Methods Dead-EndOpen accessMedicine
Kardjadj M, Chang TW, Chavez R et al. · 2025 · Microorganisms
Clinical success in treating complicated urinary tract infections (cUTIs) depends on accurate pathogen detection, given the common occurrence of polymicrobial infections and antimicrobial resistance. This multicenter, randomized,…
View details →Failed Experiment ReportOpen accessMedicine
Sawada A, Yoneta K, Togashi E et al. · 2024 · Journal of physical therapy science
[Purpose] In gastric cancer patients, low muscle mass decreases overall survival and quality of life (QOL). Resistance exercise with leucine-enriched essential amino acid (LEAA) supplementation may prevent muscle mass loss. This study was…
View details →Negative / Null Result ReportMedicine
Strotzer QD, Nieberle F, Kupke LS et al. · 2024 · Radiology
Background Large language models have already demonstrated potential in medical text processing. GPT-4V, a large vision-language model from OpenAI, has shown potential for medical imaging, yet a quantitative analysis is lacking. Purpose To…
View details →Negative / Null Result ReportOpen accessMedicine
Bäumges H, Jelinek S, Lange H et al. · 2025 · Cells
Fucose-containing glycoproteins and glycolipids broadly occur in humans as well as in many other species and are essential for a wide range of physiological processes, such as cell adhesion, fertilization, and tumor development. In humans,…
View details →Negative / Null Result ReportOpen accessMedicine
Leslie WD, Zarzour F, Binkley N et al. · 2025 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Statins are among the most widely prescribed medications in older individuals. Inconsistent data in humans suggest that statin medications may be associated with greater BMD and lower risk for osteoporosis. We identified 22 393 individuals…
View details →Negative / Null Result ReportOpen accessMedicine
Sadiq DR, Mikhael EM · 2024 · Clinical ophthalmology (Auckland, N.Z.)
Background Glaucoma is a chronic progressive eye disorder. It is the primary cause of blindness. To prevent glaucomatous damage and blindness, the intra-ocular pressure (IOP) must be lowered to certain levels, this level is known as "IOP"…
View details →Negative / Null Result ReportOpen accessMedicine
Verdecchia P, Coiro S, Bartolini C et al. · 2025 · American journal of hypertension
Background Different definitions of white-coat hypertension (WCH) may explain its variable outcome across studies. Methods In an Italian study started in 1986, we followed 3,153 people with (office blood pressure (BP) >=140/90 mmHg) and…
View details →Negative / Null Result ReportMedicine
Falck RS, Cosco TD, Wister AV et al. · 2024 · Maturitas
Objectives To explore whether the association between physical activity (PA) and cognition is moderated by neighbourhood disadvantage, and whether this relationship varies with age. Study design A longitudinal analysis of the Canadian…
View details →Negative / Null Result ReportMedicine
Poyntz-Wright IP, Harrison XA, Pedersen S et al. · 2024 · The Science of the total environment
Environmental DNA (eDNA) is a technique increasingly used for monitoring organisms in the natural environment including riverine macroinvertebrates. However, the effectiveness of eDNA for monitoring riverine macroinvertebrates compared…
View details →Negative / Null Result ReportMedicine
Li SL, Lin HL, Mi HF et al. · 2024 · Practical laboratory medicine
Objectives To evaluate the diagnostic performance of different brands of immunochromatographic test (ICT) reagents for Chlamydia trachomatis using homogenized samples to provide a reference for reagent quality control. Methods Eight…
View details →Negative / Null Result ReportMedicine
Schilter KF, Kapoor S, Smith BA et al. · 2024 · Laboratory medicine
Objective The aim of this study was to compare the performance of direct amplification of viral nucleic acid from transport medium to extracted nucleic acid for polymerase chain reaction (PCR), sequencing, and genotyping applications.…
View details →Failed Experiment ReportOpen accessMedicine
Sakaki K, Murakami T, Fujimoto H et al. · 2025 · Frontiers in endocrinology
Background Insulinomas, the most common functional pancreatic neuroendocrine tumors, cause hypoglycemia due to excessive insulin production, leading to severe clinical symptoms like coma or death. Resection surgery is the major curative…
View details →Failed Experiment ReportOpen accessMedicine
Mac PA, Anderson KD, Dakul DA · 2026 · Scientific reports
Schistosomiasis and soil-transmitted helminthiasis elimination programmes depend heavily on microscopic diagnostics, yet these methods may fail to detect low-intensity infections that sustain transmission. Molecular techniques could reveal…
View details →Negative / Null Result ReportMedicine
Maestrini I, Viganò A, Di Stefano G et al. · 2024 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Background The association between paroxysmal hemicrania (PH) and trigeminal neuralgia-the so-called PH-tic syndrome-has rarely been described. However, a correct diagnosis is crucial since both disorders require specific treatments.…
View details →Negative / Null Result ReportMedicine
Craver R, Collier S, Anderson M · 2024 · Fetal and pediatric pathology
Background: We investigated the utilization of cell free microbial DNA (cfDNA) at a Children's Hospital. Materials and Methods: cfDNA results were assessed regarding the contribution to therapeutic decisions. Results: Of 80 tests on 59…
View details →Negative / Null Result ReportMedicine
Luda KM, Agerholm M, Sonne SB et al. · 2026 · Molecular metabolism
Background White adipose tissue (WAT) plays a central role in maintaining systemic metabolic homeostasis by buffering lipid flux throughout the body. Impairment of this lipid-buffering capacity is a hallmark of obesity and has also been…
View details →Negative / Null Result ReportMedicine
Wang H, Kang L, Mu Y et al. · 2026 · Archives of animal nutrition
Light weaning body weight (LWBW) piglets exhibit inferior growth performance, and their energy requirement vary dynamically with increasing body weight. Although high-energy diets improve growth, they risk impairing liver health.…
View details →Negative / Null Result ReportMedicine
Walsh RW, Meledeo MA, Nicolson SE et al. · 2026 · Transfusion
Background Hypocalcemia is correlated with poor outcomes in trauma patients and is considered the fourth component in the "diamond of death" alongside acidosis, coagulopathy, and hypothermia. Study design and methods We characterized the…
View details →Negative / Null Result ReportMedicine
Pelletier M, Yang J, Joshi M et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Background Transforming Growth Factor Beta (TGFβ) plays a dual role in cancer, acting as a tumor suppressor early in disease but promoting progression and immune evasion when dysregulated. In pancreatic ductal adenocarcinoma (PDAC),…
View details →Negative / Null Result ReportMedicine
De S Ferreira JM, Rodrigues HP, Alba HDR et al. · 2026 · Animal : an international journal of animal bioscience
High-concentrate diets supplemented with rumen-protected fats are widely used in feedlot lamb systems to improve energy supply and performance; however, the metabolic efficacy of these lipid sources may depend on the availability of…
View details →Negative / Null Result ReportMedicine
· 2025 · Nephron
In the article "Immunosuppressant Agents as Add-On Therapy Failed to Improve the Outcome of Immunoglobulin A Nephropathy with Crescent Score C1" [Nephron. 2024;148:587-600; https://doi.org/10.1159/000534788] by Bi et al., the funding grant…
View details →Replication FailureMedicine
August D, Marsh N, Hall S et al. · 2026 · The Journal of perinatal & neonatal nursing
Purpose Implement and evaluate near-infrared (NIR) huddles for neonatal peripheral intravenous catheter (PIVC) insertion. Methods An implementation project investigated PIVC insertion attempts, site, inserter designation, dwell, and…
View details →Negative / Null Result ReportMedicine
Huang JQ, Xiao HM, Ma CX et al. · 2026 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
To compare survival outcomes and safety between concurrent chemoradiotherapy (CCRT) and CCRT with concurrent immune checkpoint inhibitor (ICI) in patients with locally advanced esophageal squamous cell carcinoma. This multicenter cohort…
View details →Negative / Null Result ReportMedicine
Moura RP, Mwema A, Bottemanne P et al. · 2026 · Journal of controlled release : official journal of the Controlled Release Society
Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting over 2.5 million people worldwide. Despite available therapies, no current treatment halts disease progression or specifically targets remyelination. Here, we…
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