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WASTE Journal

Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Association between different onset types and clinical outcomes in patients with large ischemic stroke following endovascular therapy.

Cheng, Zhu, Xie et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

This study aimed to explore the association between different stroke onset types [unwitnessed stroke (UWS) vs. witnessed stroke (WS)] and clinical outcomes in patients with large ischemic stroke treated with endovascular therapy (EVT).…

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Negative / Null Result ReportMedicine

The effect of clinical bibliotherapy on self-esteem, hope and depressive symptoms among adolescents living with sickle cell disorder in Ibadan, Nigeria: a non-randomized controlled pilot study.

Adeoye, Ani, Egbokhare et al. · 2026 · Psychology, health & medicine

Sickle Cell Disorder (SCD) is a complex, multi-system blood condition affecting 7.78 million people, with 80% of global cases in sub-Saharan Africa, especially Nigeria. The condition is associated with physical health complications and…

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Negative / Null Result ReportMedicine

Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice.

Kaewmanee, Ganesan, Choochana et al. · 2026 · PloS one

Phy-Blica-O (PBO) is a traditional Thai polyherbal formulation historically regarded as a brain tonic and memory enhancer. Despite its long-standing ethnomedicinal use, its neuroprotective mechanisms have not been scientifically validated.…

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Negative / Null Result ReportMedicine

A Quantitative in Vitro Framework Reveals State-Dependent Pharmacological Responses to Repeated Inflammatory Stimulation in Synovial Fibroblasts.

Yamada, Hosokawa, Mitoma et al. · 2026 · Biological & pharmaceutical bulletin

Rheumatoid arthritis is characterized by chronic synovial inflammation and recurrent flares, which are thought to involve joint-specific inflammatory memory. Synovial fibroblasts (SFs) contribute to this process through altered responses…

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Negative / Null Result ReportMedicine

Cardioprotective role of antihypertensive treatment in chemotherapy-induced cardiotoxicity: umbrella review of meta-analyses of randomised controlled trials.

Rostami, Ashraf, Hosseininasab · 2026 · Open heart

Chemotherapy-induced cardiotoxicity is a major contributor to long-term cardiovascular morbidity among cancer survivors. ACE inhibitors (ACEIs), angiotensin receptor blockers and beta blockers have been proposed as prophylactic therapies;…

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Negative / Null Result ReportMedicine

β-Blockers after myocardial infarction with preserved or mildly reduced left ventricular ejection fraction: Fragility of contemporary evidence.

Zuin, Chopard, Drachman et al. · 2026 · American heart journal plus : cardiology research and practice

β-Blockers have been traditionally prescribed after acute myocardial infarction (MI), but contemporary evidence in patients with preserved or mildly reduced left ventricular ejection fraction (LVEF ≥40%) have not provided…

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Negative / Null Result ReportMedicine

Cerebellar cognitive-affective syndrome in Friedreich Ataxia.

Petit, Sayah, Indelicato et al. · 2026 · Journal of neurology

Increasing evidence suggests that cognition and affect may be affected in Friedreich Ataxia (FA). To investigate the Cerebellar Cognitive Affective Syndrome (CCAS) in patients with FA and evaluate its correlations with speech and clinical…

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Negative / Null Result ReportMedicine

Anti-complement and anticoagulant activities from the salivary glands and gut of Ctenocephalides felis felis (Siphonaptera: Pulicidae) in wild and domestic Carnivora hosts.

Rodrigues, Filho, Alves et al. · 2026 · Insect biochemistry and molecular biology

Ctenocephalides felis felis is an ectoparasite of global relevance, causing impacts at the One Health interface. The process of hematophagy depends on evolutionary adaptations, in which arthropods have evolved inhibitors of host hemostatic…

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Negative / Null Result ReportMedicine

High-Frequency Gastric Electrical Stimulation Selectively Remodels Nitrergic Neurons in the Gastric Antrum of Healthy Beagles.

Huang, Fu, Yang et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

The study aimed to investigate the effects and mechanisms of high-frequency short-pulse gastric electrical stimulation (GES) on gastric emptying and specific myenteric neurons of the gastric antrum in healthy beagle dogs. Four healthy…

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Negative / Null Result ReportMedicine

Associations Between Social Determinants of Health and Cardiovascular Complications After Hand Surgery: Examining the Role of Income, Unemployment, Insurance, and Education.

Sabet, Young, Lowder et al. · 2026 · Journal of surgical orthopaedic advances

This study examines the impact of social determinants of health (SDoH) on cardiovascular complications after hand surgery, focusing on income, unemployment, insurance, and education. Using PearlDiver data (2011 - 2022), adult patients with…

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Negative / Null Result ReportMedicine

Unilateral Ankle Exoskeleton Assistance Reshapes Gait: Temporal Parameters, Load Distribution, and Inter-Limb Symmetry.

Wang, Ding, Jing et al. · 2026 · IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

Wearable exoskeletons have shown efficacy in gait rehabilitation and locomotor enhancement. Despite much work on the physiological and biomechanical aspects of human-exoskeleton interaction, systematic investigations into how exoskeleton…

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Negative / Null Result ReportMedicine

Evaluation of the Effects of Diabetes Mellitus and Periodontitis on Alveolar Bone Radiodensity Using Hounsfield Unit Measurement and Fractal Analysis.

Acipinar, Deveci, Balel · 2026 · Journal of imaging informatics in medicine

This retrospective study aimed to evaluate the effects of diabetes mellitus and periodontitis on alveolar bone density and trabecular bone quality using cone-beam computed tomography (CBCT) and to compare fractal analysis with Hounsfield…

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Negative / Null Result ReportMedicine

Associations between thoracolumbar fascia deformation, erector spinae activity, and deadlift performance: a matched pairs study.

Brandl, Schmidt, Schleip et al. · 2026 · Journal of bodywork and movement therapies

Recent research has pointed to a crucial role of intra- and extramuscular fascial tissue in force transmission. The paraspinal fascia has been shown to contribute to the maintenance of spinal stability and paraspinal muscle activity. This…

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Negative / Null Result ReportMedicine

Effects of Nd:YAG Capsulotomy on the IC-8 Lens.

Tay, Mehta · 2026 · Journal of refractive surgery (Thorofare, N.J. : 1995)

To investigate the safety and efficacy of Nd:YAG capsulotomy to treat posterior capsule opacification in eyes implanted with the IC-8 Apthera intraocular lens (IOL) (Bausch Surgical). This was a retrospective, non-randomized,…

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