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Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Clinical Evaluation of a Real-Time Wearable System for Monitoring In-Hospital Ambulatory Patients With COVID-19: Retrospective Data Study.

Vollam S, Roman C, Santos M et al. · 2026 · JMIR medical informatics

Background Many studies have evaluated the use of wearable monitoring systems to improve patient safety in hospital. Although some have demonstrated effects on intensive care admissions, there remains little evidence of impact on patient…

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Negative / Null Result ReportMedicine

Relationships Between Estradiol Levels and Vaginal Lactobacillus Abundance Across the Menstrual Cycles in Women.

Koczur K, Blukacz M, Galbarczyk A et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Microbiota of the urogenital tract is crucial for women's reproductive and sexual health and is largely dominated by Lactobacillus strains. A reduction of these bacteria within the vaginal microbial community has been linked to…

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Negative / Null Result ReportMedicine

Acoustic Measures of Articulation and Vocal Quality in Transgender People Completing Vocal Feminization Therapy.

McKenna VS, Gustin RL, Novak VD et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objective Acoustic outcomes documented following gender-affirming voice and communication therapy (GAVT) for vocal feminization often include measures of vocal pitch and resonance; however, it is likely that other aspects of speech and…

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Negative / Null Result ReportOpen accessMedicine

Magnetocardiography Combined With the SYNTAX Score for Exploratory Modeling of Clinician-Selected Revascularization Category in Three-Vessel Coronary Artery Disease: A Single-Center Pilot Study.

An Z, Wang S, Zhang M et al. · 2026 · Cardiology research and practice

Background Three-vessel coronary artery disease (3V-CAD) often requires revascularization with either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The SYNTAX score is widely used for anatomical risk…

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Negative / Null Result ReportMedicine

Auxin response and PIN-mediated transport in chlorophyte algae.

Smoljan A, Koutnik-Abele S, Vladimirtsev D et al. · 2026 · Journal of integrative plant biology

Auxin, primarily indole-3-acetic acid (IAA), is a central regulator of growth and development in land plants, but its physiological role in chlorophyte algae remains unclear. Here, we show that exogenous IAA modulates growth in Chlorella…

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Negative / Null Result ReportMedicine

The effects of probiotics supplementation on serum markers of oxidative stress in relapsing-remitting multiple sclerosis: a randomised, double-blind, placebo-controlled clinical trial.

Mohy N, Sanaie S, Rahnemayan S et al. · 2026 · Beneficial microbes

Oxidative stress is a significant contributor to neuronal damage in multiple sclerosis (MS), marked by an imbalance in reactive oxygen species and antioxidant defences. Probiotics may modulate oxidative stress and improve antioxidant…

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Negative / Null Result ReportMedicine

Voxel-wise case-control analysis of dose, linear energy transfer and symptomatic brainstem necrosis in pediatric brain tumors treated with proton therapy.

Handeland AH, Indelicato DJ, Engeseth GM et al. · 2026 · International journal of radiation oncology, biology, physics

Introduction Brainstem necrosis is a rare but serious toxicity following radiotherapy for pediatric brain tumors. In proton therapy (PT), concerns have emerged around elevated linear energy transfer (LET) and the relative biological…

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Negative / Null Result ReportMedicine

Fragmentation as a population rate-changer: A field experiment.

Nichols JD, Hines JE, Hinz RL et al. · 2026 · Ecology

Experimental and observational studies of effects of fragmentation on biodiversity and population dynamics have produced mixed results, with some reviews concluding strong evidence of negative effects and others concluding small positive…

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Negative / Null Result ReportMedicine

Prevention or relief? Voters' support for disaster policies.

Kim HH, Cragun J, DeScioli P · 2026 · Disasters

Researchers have argued that preventing disasters is more efficient than providing relief. Yet, previous scholarship has found that voters in the United States reward politicians more for relief than for prevention policies. It is unclear,…

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Negative / Null Result ReportMedicine

Educational Interventions to Improve Student Pharmacists' Empathy and Attitudes Toward Older Adults or Aging: A Scoping Review.

Gray SL, Liberman M, Onukwufor E et al. · 2026 · American journal of pharmaceutical education

Objectives Ageism remains a pervasive barrier to delivering high-quality health care to older adults. The objective of this scoping review is to describe studies on educational interventions aimed at improving the empathy and attitudes of…

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Negative / Null Result ReportOpen accessMedicine

Public support of and attitudes toward decriminalization of possession of illegal drugs among the general population in British Columbia.

Imtiaz S, Russell C, Ali F et al. · 2025 · Substance abuse treatment, prevention, and policy

BACKGROUND: Decriminalization of possession of illegal drugs was implemented in British Columbia, Canada for a three-year period starting from January 31, 2023. As public sentiment played a large role in the outcome of a similar reform in…

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Negative / Null Result ReportMedicine

Exploring Dimensions of Posttraumatic Stress in Young Children.

Mulligan DJ, Grasso DJ, Greene CA et al. · 2026 · Research on child and adolescent psychopathology

The latent structure of posttraumatic stress symptoms (PTSS) in early childhood remains poorly understood. This study aimed to assess PTSS in young children, identify underlying latent constructs, and evaluate their construct validity.…

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Negative / Null Result ReportOpen accessMedicine

Validation of the Leuven Postprandial Distress Scale According to the Rome IV Criteria for Functional Dyspepsia.

Van de Bruaene C, Carbone F, Van den Houte K et al. · 2026 · Journal of neurogastroenterology and motility

Background/aims : The Leuven Postprandial Distress Scale (LPDS) is a validated patient reported outcome (PRO) measure for functional dyspepsia (FD)/postprandial distress syndrome (PDS) patients according to Rome III criteria. However,…

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