12,246 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Lagström RMB, Bräuner KB, Frandsen MN et al. · 2026 · Endoscopy international open
Background and study aims Because most colorectal polyps are diminutive and carry minimal cancer risk, artificial intelligence (AI) might enable diagnostic strategies such as leave-in-situ and resect-and-discard, provided it meets…
View details →Javaugue V, Pascal V, Nasr SH et al. · 2025 · Kidney international
Introduction Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is classified within the spectrum of monoclonal gammopathy of renal significance (MGRS). However, PGNMID features an unexpected low rate of…
View details →Calabrese V, Metro D, Alibrandi A et al. · 2025 · Nefrologia
The Classification and Regression Tree (CART) is a supervised learning approach useful used to segment the space of and the predictors/features space into smaller homogeneous regions that are, represented in a decision tree. It computes…
View details →Costa TH, Bonet-Bub C, Kutner JM · 2024 · Hematology, transfusion and cell therapy
Background and objectives The identification of platelet antibodies is essential for diagnosing and managing conditions such as fetal and neonatal alloimmune thrombocytopenic purpura, post-transfusion purpura, and immune platelet…
View details →Epchtien RE, Temkin E, Masarwa S et al. · 2025 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
We evaluated whether skin sampling with E-swabs is an effective alternative to pre-moistened sponges for detecting carbapenem-resistant Acinetobacter baumannii (CRAB) carriage. Skin samples were collected by sponges with enrichment and…
View details →Cullinane A, Nelly M, Dayot L et al. · 2025 · Viruses
This study describes a comparison of the detection of rotavirus in clinical samples from foals using two commercially available rapid antigen detection (RAD) kits, with the detection of rotavirus nucleic acid via a laboratory-based,…
View details →Hellingman A, Göttle NL, Walz A et al. · 2026 · ACS infectious diseases
Malaria remains a major global health threat, and the emergence of partial artemisinin resistance challenges current treatment regimens. Reliable antimalarial screening assays are therefore essential for identifying new drug candidates.…
View details →Zhang C, Li J, Zhuang W · 2026 · Frontiers in oncology
Background Acute myeloid leukemia (AML) is an acute leukemia characterized by aberrant proliferation of myeloid blasts in the bone marrow. Auer bodies are identifiable in the blasts of certain AML subtypes, but their "faggot-like"…
View details →Hashimoto G, Tsukagoshi Y, Saito A et al. · 2026 · JACC. Case reports
Background Inferior sinus venosus (SV) atrial septal defect (ASD) is a rare interatrial communication, found near the inferior vena cava (IVC)-right atrial (RA) junction, that may be overlooked on transesophageal echocardiography (TEE).…
View details →Cutarelli A, De Falco F, Brunetti R et al. · 2024 · Frontiers in veterinary science
Virological evaluation was performed on equine semen to detect the presence of papillomaviruses (PVs) using droplet digital polymerase chain reaction (ddPCR) as the aim of this study was to investigate whether the sperm from asymptomatic…
View details →Thakur M, Mewara A, Lakshmi P et al. · 2025 · Diagnostic microbiology and infectious disease
Ascariasis, caused by Ascaris lumbricoides, is a widespread parasitic infection. Traditional diagnostic methods, such as microscopy, can miss infections with low worm burdens, leading to false negatives. This study compares four diagnostic…
View details →Wilk B, Lim H, Hicks J et al. · 2025 · JACC. Clinical electrophysiology
Background Atrial fibrillation is associated with abnormal synchronization of left atrial electrical activity and substantially increased risk of myocardial infarction, stroke and heart failure. Objectives This study sought to investigate,…
View details →Fukuta K, Shimada Y, Nagamatu Y et al. · 2025 · European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Objectives The advantages of preoperative three-dimensional (3D) image simulations, which require enhanced computed tomography (ECT), for anatomical lung resection are well documented. However, the necessity for contrast agent presents a…
View details →Hes C, Gui LT, Bay A et al. · 2025 · Molecular metabolism
Objective Growth differentiation factor 15 (GDF15) acts on the receptor dimer of GDNF family receptor alpha-like (GFRAL) and Rearranged during transfection (RET). While Gfral-expressing cells are known to be present in the area postrema…
View details →Janse van Vuuren R, Martel PO, Narbonne P · 2025 · microPublication biology
In C. elegans hermaphrodites, the distal tip cells (DTCs) capping the gonad arms provide a Notch ligand, the niche signal that maintains germline stem cell pools. Using fixed germlines, it was recently shown that the transcription of a…
View details →Clifton J, Woodward S, Hardcastle S et al. · 2025 · International journal of obstetric anesthesia
Background Disparities in labor epidural analgesia (LEA) management could reduce maternal satisfaction and increase risk. We compared times from the first administration of breakthrough pain medication (top-up) to LEA replacement to…
View details →Chen Z, Trivedi AN, Rahman M et al. · 2026 · JAMA internal medicine
Importance On May 12, 2023, the Medicare program reinstated the long-standing 3-day hospitalization rule for skilled nursing facility (SNF) care after it had been waived for more than 2 years during the COVID-19 pandemic. This abrupt…
View details →Hayden JE, Deane CS · 2026 · Current opinion in clinical nutrition and metabolic care
Purpose of review To critically review recent findings related to the effects of omega-3 fatty acid supplementation on skeletal muscle, with a particular focus on skeletal muscle protein turnover and mitochondrial function. Recent findings…
View details →Chei CL, Nakamura S, Watanabe K et al. · 2025 · International journal of cancer
Chest x-ray (CXR) is widely used for lung cancer screening in Japan. We evaluated the sensitivity and specificity of CXR in detecting early lung cancer and its histological types. We cross-referenced lung cancer municipality screening data…
View details →Shi Q, Bao J, Li J et al. · 2025 · Respirology case reports
Occult bronchial foreign bodies are extremely rare in adults. Affected patients typically lack a clear history of aspiration, exhibit no characteristic clinical signs and present with unremarkable chest imaging, often leading to…
View details →Liang S, Wang J, Fu W et al. · 2026 · Diagnostics (Basel, Switzerland)
Objective: The integration of artificial intelligence (AI) into computer-aided detection (CAD) is a major innovation in lung cancer diagnosis. However, its reliability in detecting the earliest radiographic sign-faint ground-glass…
View details →Asanoma K, Yahata H, Kodama K et al. · 2025 · Asian journal of endoscopic surgery
Introduction This study examined factors that affected sentinel lymph node (SLN) identification of patients with endometrial cancer having a preoperative estimation of low recurrent risk. Methods This study included 97 patients with…
View details →Zhang Z, He S, Li X et al. · 2024 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Objective To assess the value of optical genome mapping (OGM) for the detection of chromosomal structural abnormalities including ring chromosomes, balanced translocations, and insertional translocations. Methods Clinical data of four…
View details →Esmeraldo MA, Chambers S, Kravutske Y et al. · 2026 · Brain informatics
Purpose MELD Graph is a state-of-the-art artificial intelligence (AI) model for automated detection of focal cortical dysplasia (FCD), but its performance remains limited, highlighting the need to investigate which aspects of the pipeline…
View details →Allahham M, Rennert W, Miller KM et al. · 2025 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Background Rotavirus (RV) and Adenovirus (AdV) gastroenteritis affect children worldwide. The sensitivity and specificity of the AMP Rapid Test ROTA/ADENOVIRUS [AMP-RA] for the detection of RV and AdV were compared against qPCR Allplex™…
View details →Sarto F, Kalc M, Motanova ES et al. · 2025 · Journal of applied physiology (Bethesda, Md. : 1985)
Previous studies showed that properties of higher-threshold motor units (MUs) and neuromuscular junction (NMJ) function are preserved during short-term disuse. This study aimed to test how a longer disuse period affects MU properties, NMJ…
View details →Pires RHM, Simon S, Buzier R et al. · 2025 · Journal of hazardous materials
Excess of trace elements (TE) significantly alters the performances of anaerobic digestors (AD). Due to interactions with organic matter in particular, only a small fraction of TE can effectively interact with the biomass. However,…
View details →Bakhshaliyev S, Arslanoğlu E, Huseynov H et al. · 2026 · Diagnostics (Basel, Switzerland)
Background : This study evaluated the diagnostic efficacy of transthoracic echocardiography (TTE) and 128-slice multislice computed tomography (MSCT) angiography in congenital heart disease (CHD). Methods : Between January 2018 and August…
View details →Gaeta R, Giuffra V, Maixner F et al. · 2024 · International journal of paleopathology
Objective The aim of this study is to investigate potential evidence of tuberculosis in mummified remains. Materials The natural mummy of an anonymous friar from the mortuary chapel of the church of Santa Maria della Grazia in Comiso…
View details →Gonullu-Rotman D · 2024 · American journal of medical genetics. Part C, Seminars in medical genetics
This piece narrates the journey of Maria (name of the mother has been altered to protect the family's privacy), a new mother confronting her newborn's unexpected diagnosis of very long chain acyl-CoA dehydrogenase (VLCAD) deficiency,…
View details →