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WASTE Journal

Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of dual trigger on pregnancy outcomes in women with diminished ovarian reserve: A single-blind randomized clinical trial.

Zamaniyan, Abbasi, Habibpour et al. · 2026 · International journal of reproductive biomedicine

Diminished ovarian reserve is one of the most important issues in in vitro fertilization cycles. Some authors have reported beneficial effects of dual triggering in women with poor ovarian response, whereas other investigators have…

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Negative / Null Result ReportMedicine

Vaginal Microbiota and Cytokines Among Pregnant and Breastfeeding Women in Clinical Trials of the Dapivirine Vaginal Ring and Oral Tenofovir Disoproxil Fumarate/Emtricitabine.

Petrina, Dong, Beamer et al. · 2026 · Open forum infectious diseases

Vaginal dysbiosis is associated with HIV acquisition and preterm delivery. Our objective was to evaluate prevalent vaginal infections, and changes in microbiota and cytokines among pregnant and breastfeeding women from 4 African countries…

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Negative / Null Result ReportMedicine

Effects of Topical Lidocaine and Benzocaine on Pain Level and Injection Satisfaction in Arteriovenous Fistula Catheter Applications.

Güler, Kaplan, Şahan et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses

Pain during arteriovenous fistula (AVF) catheterization is a common discomfort faced by hemodialysis patients and can negatively affect treatment adherence, satisfaction, and overall quality of life. Effective pain management strategies…

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Negative / Null Result ReportMedicine

Adjunctive GLP1 Receptor Agonists in Patients with Inflammatory Bowel Diseases and Obesity and/or Diabetes: A Target Trial Emulation.

Yeh, Ahuja, Patel et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

We conducted a target trial emulation study to examine the effect of two glucagon-like peptide-1 receptor agonists (GLP1RAs) (semaglutide and tirzepatide) on clinical outcomes in patients with inflammatory bowel diseases (IBD) with obesity…

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Negative / Null Result ReportMedicine

Decoding marginal adaptation and microleakage: A field emission scanning electron microscopy and stereomicroscopic evaluation of cavity liners under class II composite restorations.

Mann, Sharma, Jhamb et al. · 2026 · Journal of conservative dentistry and endodontics

Esthetics are in high demand in modern dentistry; conservative dentistry offers tooth-colored restorative materials; however, drawbacks such as polymerization shrinkage can lead to microleakage. To minimize this problem, cavity liners are…

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Negative / Null Result ReportMedicine

Periodontal status, oral inflammatory biomarker, and relative expression of red complex bacteria in periodontitis-rheumatoid arthritis: a cross-sectional preliminary study.

Mahardika, Rakhmawati, Sulijaya et al. · 2026 · Frontiers in cellular and infection microbiology

To determine the differences in periodontal status-Probing Depth (PD), Clinical Attachment Loss (CAL), Bleeding on Probing (BOP); oral inflammatory biomarkers-Tumor Necrosis Factor Alpha (TNF-α), Interleukin 1 Beta (IL-1β),…

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Negative / Null Result ReportMedicine

Artificial Intelligence for Molecular Subtyping in Unresectable Gallbladder Cancer: A Proof-of-Concept Study for CT-based HER2 Status Prediction.

Gupta, Madan, Dutta et al. · 2026 · Journal of clinical and experimental hepatology

Human epidermal growth factor receptor 2 (HER2) overexpression is a critical therapeutic target in gallbladder cancer (GBC), but detection requires invasive sampling. We developed a fully automated computed tomography (CT)-based framework…

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Negative / Null Result ReportMedicine

Impact of language concordant care on comprehension and adherence to infection prevention protocols among hospitalized patients: A multicentre survey.

Reason, Rizvi, Chawla et al. · 2026 · Canada communicable disease report = Releve des maladies transmissibles au Canada

Language concordant care can influence patient outcomes. The level of language concordant care and its impact on adherence to infection prevention protocols has not been well described. To assess whether patients' preferred language…

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Negative / Null Result ReportMedicine

Screening criteria for drainage-free patients after retroperitoneal laparoscopic adrenal tumor resection and their prospective validation study value.

Zhao, He, Li et al. · 2026 · Experimental and therapeutic medicine

Retroperitoneal laparoscopic resection is the preferred minimally invasive surgery for adrenal tumors. Patients vary greatly in postoperative drain output, but no clear criteria exist to select candidates for a drainage-free strategy. The…

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Negative / Null Result ReportMedicine

Relationship Between Position, Shape, and Deformation of Papillary Muscles and Mitral Regurgitation After Transcatheter Aortic Valve Replacement.

Li, Chen, Zhou et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Moderate/severe mitral regurgitation (MR) can affect the prognosis of patients with transcatheter aortic valve replacement (TAVR). However, few studies have focused on the role played by papillary muscles (PMs). We intend to explore the…

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Negative / Null Result ReportMedicine

The effect of different access cavity designs and different irrigaton solutions on the removal of calcium hydroxi̇de from root canals: in vitro study.

Bodur, Küçükekenci̇ · 2026 · BMC oral health

This study investigated how different access cavity designs and irrigation solutions influence the removal of calcium hydroxide from root canals. Eighty-four mandibular molars were divided into three groups according to their access…

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Negative / Null Result ReportMedicine

Evaluation of Critical Risk Factors and Development of a Predictive Model for Surgical Site Infection in Type 2 Diabetic Patients Undergoing Oral and Maxillofacial Surgery.

Sun, Gong, Zhu et al. · 2026 · Annali italiani di chirurgia

This study aims to explore the critical risk factors associated with surgical site infection (SSI) in patients with type 2 diabetes mellitus (T2DM) undergoing oral and maxillofacial surgery, and to develop a predictive model to support…

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Negative / Null Result ReportMedicine

Preperitoneal analgesia under direct visualization: laparoscopic-guided deep rectus sheath block improves postoperative pain control after laparoscopic cholecystectomy: a randomized controlled trial.

Kavakli, Bozkurt, Diri et al. · 2026 · Surgical endoscopy

Conventional abdominal wall blocks primarily target somatic afferent nerves and may therefore provide limited relief for the peritoneal component of postoperative pain. This study aimed to investigate whether a laparoscopic-guided deep…

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Negative / Null Result ReportMedicine

Diagnostic Value of Quantitative Lung Perfusion Single-photon Emission CT/CT for Chronic Lung Allograft Dysfunction in Patients After Bilateral Lung Transplantation.

Nakashima, Iguchi, Sugimoto et al. · 2026 · Clinical nuclear medicine

Chronic lung allograft dysfunction (CLAD) is a major cause of late morbidity after lung transplantation, and spirometry lacks the ability to detect regional lung changes. Thus, in this study, we investigated whether quantitative perfusion…

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