12,246 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Sirchia F, Kalantari S, Carli D et al. · 2026 · Pediatric neurology
Background Many patients with rare genetic diseases remain undiagnosed or receive a molecular diagnosis only after years. In this study, we want to evaluate the usefulness of clinical genome sequencing (cGS) in a cohort of complex…
View details →Jo HC, Park JE, Baek JC et al. · 2025 · Taiwanese journal of obstetrics & gynecology
Objective To report a case of mosaic trisomy 17 with inconsistent findings between noninvasive prenatal testing (NIPT) and genetic amniocentesis. Case report A 34-year-old primigravid woman presented for antenatal care at 9 weeks of…
View details →Kataria P, Upadhyay MK, Arya K et al. · 2025 · Journal of family medicine and primary care
Background Antenatal care (ANC) can be defined as the care provided by skilled health-care professionals to pregnant women in order to ensure the best health outcomes. Good quality routine antenatal care forms the foundation of positive…
View details →O'Leary C, Yoong E, Matsika A et al. · 2025 · Asia-Pacific journal of clinical oncology
Aims Castrate-resistant prostate cancer (CRPC) is a common malignancy with poor prognostic outcomes. Breast cancer (BRCA) genes 1 and 2 mutations occur in prostate cancers and confer poorer prognoses. Somatic BRCA testing can lead to…
View details →Makgoka TR, De Villiers M, Van Zyl DG · 2025 · South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Background Tuberculosis (TB) is a major contributor to mortality among patients affected by HIV. TB diagnosis can be challenging, especially in those who are severely ill and unable to produce sputum. Urine lipoarabinomannan (LAM) is a…
View details →Wang T, Park B, Anderson G et al. · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Early diagnosis of invasive fungal disease is essential for optimizing management. Although the clinical utility of fungal polymerase chain reaction (PCR) testing on plasma and bronchoalveolar lavage (BAL) has been established,…
View details →May J, Waturangi DE, Tan WA et al. · 2026 · Scientific reports
Biofilm-forming bacteria, such as Bacillus cereus and Vibrio harveyi are major contributors to food contamination and problems in aquaculture. This study aimed to evaluate the antibiofilm compounds of the phyllosphere bacterial…
View details →Zheng J, Guo Q, Yue G et al. · 2025 · World journal of urology
Objective There is ongoing debate regarding whether patients with a positive urine culture (UC) need to wait for the culture to turn negative following antimicrobial treatment before undergoing percutaneous nephrolithotomy (PCNL). This…
View details →Leech J, Sauer BM, Baduashvili A et al. · 2025 · Neurology. Clinical practice
Background and objectives The presence of oligoclonal bands (OCBs) indicates an augmented immune response within the CNS and is integral to the diagnosis of multiple sclerosis (MS). Expert consensus panels recommend OCB testing for…
View details →Wezenberg BN, Koster M, van Wingen G et al. · 2025 · Schizophrenia research
Objective Sleep disturbances and brain alterations are common in psychotic disorders and individuals at clinical high risk for psychosis (CHR-P). It remains unclear whether gray matter volume changes are inherent to psychosis or partly…
View details →Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Malaria journal
Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers' (HCWs) concerns…
View details →Ebner R, Braach J, Rübenthaler J et al. · 2025 · Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The aim of this retrospective study was to evaluate the correlation between findings from somatostatin receptor (SSTR) PET/CT and histopathology in patients with suspected intracranial meningiomas. Methods: We conducted a retrospective…
View details →Horn EJ, Menefee B, Schotthoefer AM et al. · 2026 · Journal of clinical microbiology
Current laboratory testing for Lyme disease (LD) relies on serology. We evaluated the performance of standard two-tiered testing (STTT) and modified two-tiered testing (MTTT) algorithms using samples obtained from well-characterized…
View details →Lisha W, Jiao Q, Mengyuan C et al. · 2025 · Microbiology spectrum
Regarding metagenomics next-generation sequencing (mNGS) negative literature, there have been much discussions about methodology; thus, we collected clinical and laboratory information for retrospective evidence-based research. We…
View details →Marland V, Nisbet L, Nic Daéid N · 2025 · Harm reduction journal
Background The detection of nitazene compounds in the United Kingdom has raised concerns among healthcare professionals, public health authorities, and law enforcement due to the increased risk of fatal overdose, particularly among opioid…
View details →Baumgarten J, Stephan E, Ohlwärther TEN et al. · 2026 · Forensic science, medicine, and pathology
Estimation of the postmortem interval (PMI) of found bones is an important and challenging part of forensic osteology assessments. This study examined human long bones that had been taken from cemeteries and hoarded by a "bone collector".…
View details →Sheybani L · 2026 · The European journal of neuroscience
A recent study by Hausdorf et al. reported that combining closed-loop acoustic stimulation with transcranial direct current stimulation during sleep does not improve memory consolidation. This contrasts with past studies that reported a…
View details →Pruss A, Skierska A, Kwiatkowski P et al. · 2025 · PloS one
Klebsiella pneumoniae is a typical opportunistic pathogen that exhibits multiple virulence factors and antibiotic resistance conditioning mechanisms. Carbapenemases are enzymes that help bacteria to exhibit the strongest resistance against…
View details →Vega-Gonzalez J, Toro JAC, García EL et al. · 2025 · Genes, chromosomes & cancer
According to the 5th edition of the WHO Classification of Soft Tissue and Bone Tumors, the diagnosis of synovial sarcoma relies on morphology, immunohistochemistry, and the detection of a specific fusion involving the SS18 gene with a…
View details →Taechikantaphat M, Kongchareon A, Julapanthong P et al. · 2026 · Veterinary and animal science
This prospective, randomized clinical trial compared the therapeutic efficacy and rate of platelet recovery of doxycycline 10 mg/kg once daily (SID) (Group A, n=17) versus 5 mg/kg twice daily (BID) (Group B, n=12) in 29 dogs naturally…
View details →Pimentel V, Becker J · 2025 · Arquivos de neuro-psiquiatria
Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune demyelinating disease characterized by a high risk of relapse and disability. In cases positive for aquaporin 4-immunoglobulin G (AQP4-IgG), long-term immunosuppression…
View details →Mazzotta E, Natale A, Bellinati L et al. · 2025 · Animals : an open access journal from MDPI
Equid milk (donkey or mare) has traditionally been consumed raw or fermented due to its distinctive chemical composition, which closely resembles human milk, and its nutritional benefits. Nowadays, interest in it is increasing, despite…
View details →Bai M, Li Y, Gao Q et al. · 2025 · Virology journal
Purpose Present study aimed to compare the boiling and magnetic bead nucleic acid extraction method for HPV genotypes detection. Methods By mixing hemoglobin with HPV positive quality control products, the anti-interference ability of two…
View details →Limaye AP, Crespo M, Kamar N et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background QuantiFERON-cytomegalovirus (QFT-CMV) is a standardized assay for the evaluation of cytomegalovirus-specific cell-mediated immunity (CMV-CMI). Objectives The purpose of this study was to assess the evolution of CMV-CMI…
View details →Wang X, Fan Z, Huo L et al. · 2025 · Breast care (Basel, Switzerland)
Background In sentinel node biopsy (SNB) procedure for breast cancer patient, whether the abnormal node was excised is uncertain. The impact of abnormal node on the accuracy of SNB results is unknown. Methods In this prospective study,…
View details →Russo F, Chatterjee D, DeMaria N et al. · 2024 · Journal of community genetics
DNA-based population screening for adult-onset diseases holds promise for advancing personalized medicine and improving public health. Yet as most individuals pursuing such screening receive negative results, the return of results process…
View details →Roman TS, Gray SM, Sneddon TP et al. · 2026 · HGG advances
The impact of clinical exome and genome sequencing (ES/GS) depends on the clinical setting. In the sequencing arm of a multifactor randomized clinical trial to evaluate broadening access, we assessed the diagnostic and inconclusive…
View details →Bölük S, Bölük S · 2025 · Cureus
Background In breast cancer surgery, sentinel lymph node biopsy (SLNB) is routinely utilized for axillary assessment. Frozen section examination of the sentinel lymph node (SLN) is used to guide the decision for axillary dissection.…
View details →Triantafyllidou O, Panagodimou E, Chasiakou S et al. · 2026 · Cureus
Objective To evaluate whether the addition of clomiphene citrate (CC) to a low-dose recombinant follicle-stimulating hormone (FSH) (r-FSH) gonadotropin-releasing hormone (GnRH)-antagonist protocol improves clinical outcomes in women with…
View details →Buteau JP, Moon D, Fahey MT et al. · 2026 · The Lancet. Oncology
Background MRI is recommended for men with clinical suspicion of significant prostate cancer. Those with high clinical risk but non-suspicious or equivocal MRI often undergo prostate biopsy, but have a low likelihood of clinically…
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