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Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Are KLIC and CRIME-80 scores useful to assist decision-making initially or at the moment of repeat DAIR? - a retrospective study.

Contente J, Ferreira C, Silva M et al. · 2025 · Journal of bone and joint infection

Introduction : Debridement, antibiotics, and implant retention (DAIR) is recommended for early acute postoperative and late acute periprosthetic joint infections (PJIs). The KLIC and CRIME-80 scores have been proposed to predict DAIR…

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Negative / Null Result ReportMedicine

Elevational pattern of species range size of vascular plants in Changbai Mountain, China:A test of Rapo-port's rule.

Li MS, Wu XQ, Zhou YJ et al. · 2024 · Ying yong sheng tai xue bao = The journal of applied ecology

Species range size is closely related to its ability to migrate and adapt to environmental change. Rapoport's rule predicts that species range size would become larger with increasing latitude or elevation. Empirical evidence for…

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Negative / Null Result ReportMedicine

Self-Reported Inner Speech Reflects Improvement From Language Therapy.

Stark BC, Alexander JM, Stockrahm E et al. · 2026 · American journal of speech-language pathology

Purpose This study examined the role of inner speech-defined here as the subjective experience of covert lexical access-in naming recovery following semantic feature analysis (SFA) treatment in individuals with aphasia. Specifically, it…

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Negative / Null Result ReportMedicine

Focus on renal morphology, chronic kidney disease, and urinary system malignancies in acromegaly: report on data collected over a 40-year period.

Ercan P, Firlatan Yazgan B, Sendur SN et al. · 2026 · Pituitary

Purpose Long-term renal consequences of acromegaly remain poorly characterized. We assessed prevalence and independent predictors of renal cysts, chronic kidney disease (CKD), and the frequency of urinary-system malignancies, in a large…

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Negative / Null Result ReportMedicine

Rapid diagnosis and therapeutic mitigation in inflammatory bowel disease: utilizing the window of opportunity-findings from the UAE Epi-IBD study.

Swaid TK, Hamzeh LR, Bukasa LL et al. · 2026 · Intestinal research

Background/aims To determine time to diagnosis (TTD) and its impact on surgery and advanced therapy (AT) burden in inflammatory bowel disease (IBD) in a multi-ethnic United Arab Emirates (UAE) cohort, a region in the acceleration phase of…

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Negative / Null Result ReportOpen accessMedicine

Psoas muscle variables and adjuvant chemotherapy-related and survival outcomes following pancreaticoduodenectomy for periampullary malignancy.

Hajibandeh S, Hajibandeh S, Mckittrick H et al. · 2026 · World journal of gastrointestinal surgery

Background Early skeletal muscle wasting has been demonstrated to be associated with chemotherapy-related toxicity in patients with cancer. Hounsfield unit average calculation (HUAC) or psoas muscle index (PMI) can be used to diagnose…

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Negative / Null Result ReportMedicine

Variation in song structure does not predict associative learning performance in zebra finches (Taeniopygia castanotis) raised under controlled cultural conditions.

Derégnaucourt S, Le Maguer L, Geberzahn N · 2026 · Animal cognition

Vocal learning in songbirds requires the integration of auditory perception, sensorimotor learning, and performance monitoring, yet its relationship to general cognitive abilities remains unclear. We tested whether interindividual…

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Negative / Null Result ReportMedicine

Prenatal and adolescent exposure to metals/metalloids and telomere dynamics at 14 years: Evidence from the Chitwan birth cohort.

Wai KM, Parajuli RP, Umezaki M · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Telomeres are repetitive non-coding DNA sequences at chromosome ends that progressively shorten with each cell division, serving as markers of cellular aging. Recent studies have suggested that prenatal and postnatal exposure to…

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Replication FailureMedicine

Eating your emotions: Within-person relations of emotional overeating with lability/negativity and emotion regulation from childhood to young adulthood.

Parisi F, Steinsbekk S, Wichstrøm L et al. · 2026 · Child development

Emotional overeating theories posit that lability/negativity and poor emotion regulation increase emotional overeating risk, yet empirical evidence is limited. This longitudinal study followed 878 Norwegian participants (50.1% girls)…

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Negative / Null Result ReportMedicine

Loneliness and somatic complaints: An experience sampling method study.

Smeets M, Hutten E, Verboon P et al. · 2026 · Journal of psychosomatic research

Objective Previous studies have shown a positive relation between retrospectively measured loneliness and somatic complaints. This study investigated the relation between state loneliness and state somatic complaints as well as the…

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Negative / Null Result ReportMedicine

Impact of Septal Deviation and Sinonasal Variations on Nasolacrimal Duct Obstruction in PANDO and Chronic Dacryocystitis: A CT-Based Study.

Dikici O, Aslanci ME, Alkan İ · 2026 · Ear, nose, & throat journal

ObjectiveTo assess the relationship between nasal septal deviation characteristics, sinonasal variations, and nasolacrimal duct (NLD) obstruction in primary Acquired Nasolacrimal Duct Obstruction (PANDO) and chronic dacryocystitis.MethodsA…

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Negative / Null Result ReportMedicine

Associations Between Depression and Problematic Social Media Use: A Longitudinal Study and Daily Diary Study.

Yuan C, Zhou H, Wang A et al. · 2026 · International journal of psychology : Journal international de psychologie

Depression is frequently associated with problematic social media use (PSMU), yet evidence integrating day-to-day dynamics with longer-term temporal ordering remains limited. We conducted two studies to examine these associations. In Study…

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Negative / Null Result ReportMedicine

Posttraumatic cognitions and PTSD symptom change in massed prolonged exposure: The impact of treatment delivery on mechanisms of change.

Burton M, Haft S, Fiskeaux M et al. · 2026 · Journal of anxiety disorders

Background Prolonged Exposure (PE) is an effective treatment for PTSD and clarification of mechanisms of change can inform training and continued improvements. Posttraumatic cognitions have been shown to predict subsequent symptom change…

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