Failed Experiment ReportMedicine
Sabino-Carvalho JL, Guerrero RV, Teixeira AL et al. · 2025 · Autonomic neuroscience : basic & clinical
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by non-motor symptoms and marked altered sympathetic and parasympathetic activity. However, it is currently unclear if inappropriate autonomic adjustments are…
View details →Negative / Null Result ReportMedicine
Parsowith EJ, Herring E, Cohen B et al. · 2025 · Experimental gerontology
Background Over 25% of U.S. older adults experience chronic knee pain, which worsens with inactivity, creating a cycle of pain, disability, and sedentary behavior. However, a limited understanding of the underlying mechanisms hinders the…
View details →Negative / Null Result ReportMedicine
Rubino M, Fan R', Kulesz PA et al. · 2026 · The Laryngoscope
Objectives Complete or relative voice rest is recommended following phonomicrosurgery. Primarily, adherence to rest has been measured using patient reports, but their validity is unknown. Instrumental measures of rest adherence are…
View details →Negative / Null Result ReportOpen accessMedicine
Bertram AM, Lalot F, van der Werff L et al. · 2025 · Frontiers in psychology
Introduction Many daily situations require rapid judgments about whether information is true or false based on limited information. Prior research has predominantly examined how statement and source characteristics influence these…
View details →Negative / Null Result ReportMedicine
Alharbi BM, Williams HE, Parr T et al. · 2025 · Mathematical biosciences
We propose a mathematical model based on coupled ordinary differential equations (ODEs) for metabolite concentrations with the aim of investigating how modifications to the rates affects outputs from a regulatory network. Our aim is to…
View details →Negative / Null Result ReportMedicine
Poller A, Jha S, Molander L et al. · 2025 · International journal of cardiology
Background It is incompletely understood why patients with takotsubo syndrome (TS) have milder symptoms and a better hemodynamic profile than patients with ST-elevation myocardial infarction (STEMI) despite similar or more extensive…
View details →Negative / Null Result ReportOpen accessMedicine
Sencan A, Dundar N, Gunel B et al. · 2025 · Medeniyet medical journal
Objective To compare mechanical power (MP) levels among flow-controlled ventilation (FCV), volume-controlled ventilation (VCV), and pressure-controlled volume-guaranteed ventilation (PCV-VG) during laparoscopic surgery and to test the…
View details →Negative / Null Result ReportMedicine
Wesolowski LT, DiSilvestro AN, Williams BD et al. · 2025 · Journal of equine veterinary science
Disruption of circadian rhythms contributes to a myriad of health issues. Rhythms can be strengthened using artificial light but whether optimal light patterns support health parameters in horses is unknown. To test the hypothesis that…
View details →Negative / Null Result ReportMedicine
Rau J, Joseph R, Weise L et al. · 2025 · Journal of neurotrauma
Previous studies have shown that administration of high doses of morphine in the acute phase of spinal cord injury (SCI) significantly undermines locomotor recovery and increases symptoms of chronic pain in a rat spinal contusion model.…
View details →Negative / Null Result ReportMedicine
Pleau J, Tanguay N, Courtemanche Y et al. · 2025 · Maternal and child health journal
Objectives The objectives of this study are to describe cannabis use during pregnancy, identify associated factors, examine the associations between prenatal cannabis use and the cognitive, motor and language development of 2-year-old…
View details →Negative / Null Result ReportMedicine
Quaedflieg CWEM, Ashton SM, Beckers T et al. · 2025 · Journal of behavior therapy and experimental psychiatry
Fear is a universal experience and fuels our response to cope with threat. Persistent fear, after the threat is no longer present, is a central symptom seen in a number of clinical conditions. Exposure therapy, the most common treatment to…
View details →Negative / Null Result ReportOpen accessMedicine
Hidding M, van der Stouwe E, Rosema BS et al. · 2025 · Psychological medicine
Background Low self-esteem is an important and potentially modifiable risk factor for the development and outcome of psychotic disorders. The factors involved in low self-esteem in psychotic disorders are not yet fully understood. The…
View details →Negative / Null Result ReportOpen accessMedicine
Nam J, Bellinger GC, Li J et al. · 2025 · JMIR cardio
Background Wearable activity monitors offer clinicians and researchers accessible, scalable, and cost-effective tools for continuous remote monitoring of functional status. These technologies can complement traditional clinical outcome…
View details →Negative / Null Result ReportOpen accessMedicine
Liu X, Zheng W, Hoon L et al. · 2026 · Npj mental health research
Smartphone-delivered interventions offer a scalable solution for university students experiencing depression, yet outcomes remain inconsistent. This study examined predictors of depression remission and response in the AI-enhanced Vibe Up…
View details →Negative / Null Result ReportOpen accessMedicine
Bakhshinejad JA, Watkins CM, Pelton LM et al. · 2026 · International journal of exercise science
The primary aim of this investigation was to examine the effects of three drop jumps (DJ) on mean velocity (m/s) of subsequent deadlifts at various percentages of 1 RM. A secondary exploratory aim was to evaluate whether protocol order,…
View details →Negative / Null Result ReportOpen accessMedicine
Lewandowski KE, Luo J, Yao B et al. · 2025 · Frontiers in psychiatry
Introduction Motivational impairments are a hallmark symptom of psychotic disorders. However, motivation is a multidimensional construct believed to be underpinned by different neural mechanisms and differentially impaired both between and…
View details →Negative / Null Result ReportMedicine
Cronin SK, Barnard AM, Dietz SJ et al. · 2023 · Journal of dairy science
It is possible that some of the systemic responses to subacute ruminal acidosis (SARA) may be caused by increased intestinal starch fermentation. The objective of this experiment was to evaluate the effect of abomasal infusion of up to 3 g…
View details →Negative / Null Result ReportMedicine
He JD, Parker JD · 2023 · British journal of clinical pharmacology
Aims To mediate its pharmacodynamic effects, glyceryl trinitrate (GTN) requires bioactivation, by which it releases nitric oxide or a nitric oxide moiety. The exact mechanism of GTN bioactivation remains uncertain. Mitochondrial aldehyde…
View details →Negative / Null Result ReportOpen accessMedicine
Alizo Vera V, Childs JE, Kim J et al. · 2025 · eNeuro
Histone deacetylase 3 (HDAC3) is one of the most highly expressed HDACs in the brain shown to be a negative regulator of long-term memory formation. HDAC3 has also been shown to be involved in cocaine-associated behaviors, demonstrated by…
View details →Negative / Null Result ReportMedicine
Sabino-Carvalho JL, Li S, Mekonnen E et al. · 2025 · Medicine and science in sports and exercise
Purpose Parasympathetic reactivation is essential for the rapid decrease in heart rate following exercise and delayed heart rate recovery (HRR) post-exercise is linked to poor clinical outcomes. Chronic kidney disease (CKD) is associated…
View details →Negative / Null Result ReportMedicine
Volpe LJ, Zugelder M, Kotarinos R et al. · 2023 · Urogynecology (Philadelphia, Pa.)
Importance Although pelvic floor physical therapy (PFPT) is effective in treating high-tone pelvic floor dysfunction (HTPFD), data on the mechanism of improvement are limited. Objectives This study aimed to compare squeeze intravaginal…
View details →Negative / Null Result ReportOpen accessMedicine
Domin M, Lindenberg R, Lotze M · 2025 · Scientific reports
Evaluating the integrity of the corticospinal tract at the height of the posterior limb of the internal capsule with a lateralization index has been applied to predict upper limb motor recovery after stroke in numerous diffusion tensor…
View details →Negative / Null Result ReportMedicine
Lind CM, Agugliaro J, Ortega J et al. · 2024 · The Journal of experimental biology
Disease may be both a cause and a consequence of stress, and physiological responses to infectious disease may involve stress coping mechanisms that have important fitness consequences. For example, glucocorticoid and glycemic responses…
View details →Negative / Null Result ReportMedicine
Bogon J, Jagorska C, Steinecker I et al. · 2024 · Acta psychologica
The perception of time is subject to various environmental influences and exhibits changes across the lifespan. Studies on time perception have often been conducted using abstract stimuli and artificial scenarios, and recent claims for…
View details →Negative / Null Result ReportOpen accessMedicine
Smith A, Lin PD, Rifas-Shiman SL et al. · 2026 · Environmental epidemiology (Philadelphia, Pa.)
Background Per- and polyfluoroalkyl substances (PFAS) and nonessential metals impair immune responses, while essential metals promote immune maintenance. We evaluated associations of childhood PFAS and metal mixtures with measles, mumps,…
View details →Negative / Null Result ReportMedicine
Porto IM, do Amaral JV, Pacheco JPG et al. · 2025 · European child & adolescent psychiatry
Many countries implement double-shift schooling systems, offering morning or afternoon shifts. Given attention-deficit/hyperactivity disorder (ADHD) is associated with circadian preference for eveningness, this study hypothesised that…
View details →Negative / Null Result ReportOpen accessMedicine
Vervaecke AJ, Thery C, Housset V et al. · 2026 · JSES international
Background Glenoid concavity plays a critical role in shoulder stability via the concavity-compression mechanism. While the bony glenoid concavity, quantified by the bony shoulder stability ratio (BSSR), is a known determinant of…
View details →Negative / Null Result ReportMedicine
LaRosa S, Moore K, Harshaw N et al. · 2024 · The Journal of surgical research
Introduction Trauma bay and emergency department (ED) length of stay (LOS) are important time measures in patient care. The data on this subject are inconclusive or specific to one condition. Our goal was to determine the relationship…
View details →Negative / Null Result ReportOpen accessMedicine
Jacob J, Hesling-Fox J, Yamada M et al. · 2026 · Clinical neurophysiology practice
Objective Stroke survivors often show slower, uncoordinated bimanual performance. This study examined the effects of a single session of bimanual task practice on performance, coordination, motor corticospinal excitability (CSE), and…
View details →Negative / Null Result ReportOpen accessMedicine
Liu HZ, Khanna V, Ayeni OR et al. · 2025 · Cureus
Background Adipose-derived stem cells (ADSCs) hold therapeutic potential for the treatment of orthopedic conditions. However, no surveys to date have evaluated physicians' awareness and receptiveness toward these therapies - an essential…
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