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WASTE Journal

Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Preoperative Lateralization and Diagnostic Value of Selective Bilateral Internal Jugular Venous Sampling in Primary Hyperparathyroidism: Single-Center Experience.

Solodjankina A, Kratovska A, Ponomarjova S et al. · 2024 · Medicina (Kaunas, Lithuania)

Background and Objectives : Primary hyperparathyroidism (pHPT) is a common endocrine disorder caused by excessive production of parathyroid hormone (PTH) leading to elevated calcium levels. Diagnosis is primarily based on biochemical…

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Negative / Null Result ReportMedicine

The utility of disc space and vertebral body specimens cell count differential for the diagnosis of native vertebral osteomyelitis: a prospective cohort study.

Zein SE, Tande AJ, Carr CM et al. · 2024 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Background Diagnostic methods for native vertebral osteomyelitis (NVO) often yield inconclusive results. Image-guided spine biopsies for culture are specific but diagnose NVO in only 50% of cases. Pre-exposure to antimicrobials further…

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Negative / Null Result ReportMedicine

Sharpening the lens to evaluate interprofessional education and interprofessional collaboration by improving the conceptual framework: a critical discussion.

Neubauer FB, Wagner FL, Lörwald A et al. · 2024 · BMC medical education

It has been difficult to demonstrate that interprofessional education (IPE) and interprofessional collaboration (IPC) have positive effects on patient care quality, cost effectiveness of patient care, and healthcare provider satisfaction.…

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Negative / Null Result ReportMedicine

Lack of controlled studies on snakebite prevention: a rapid review.

Rodrigo C, Gnanathasan A · 2024 · Transactions of the Royal Society of Tropical Medicine and Hygiene

Globally, snakebites cause an estimated 80 000-140 000 deaths annually. While there are evidence-based recommendations for managing snakebite victims, recommendations on the prevention of snakebites are limited to expert opinions. We…

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Negative / Null Result ReportOpen accessMedicine

High rates of benzimidazole-resistance-associated alleles in Haemonchus contortus and detection of resistance against macrocyclic lactones in strongylids from German alpaca herds.

Hinney B, Wiedermann S, Vaneev X et al. · 2024 · Parasites & vectors

The population of South American camelids (SAC) has been steadily growing in Europe, where they are confronted with the regional endoparasite population of ruminants. As there are no anthelmintic drugs registered for use against nematode…

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Negative / Null Result ReportOpen accessMedicine

A prospective cohort study produces inconclusive results in linking dietary calcium intake to overall and specific causes of mortality.

Le NT, Nguyen TG, Huynh NYN et al. · 2025 · Scientific reports

Dietary calcium's role in human health and disease prevention is inconclusive. We examined the associations between dietary calcium intake and the risk of overall and specific causes of mortality. A prospective cohort study was performed…

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Negative / Null Result ReportOpen accessMedicine

Concomitant Autoimmune Liver Disease and Hepatic Actinomycosis: A Diagnostic Challenge-Brief Report and Review of the Literature.

Manni G, Pambianco M, Sicuro C et al. · 2025 · International journal of molecular sciences

Hepatic actinomycosis (HA) and IgG4-related inflammatory pseudotumors are rare and often overlooked causes of liver mass, which can easily be misdiagnosed as primary liver cancer or metastasis. Diagnosis is arduous due to unspecified…

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Negative / Null Result ReportMedicine

No detectable impact of ALPS-treated water discharge on tritium levels in terrestrial waters of the upper Ota River catchment, Fukushima, Japan.

Sakuma K, Yoshimura K · 2026 · Journal of environmental radioactivity

Tritium ( 3 H) is the principal radionuclide remaining in ALPS-treated water discharged from the Fukushima Dai-ichi Nuclear Power Plant (FDNPP), and its potential environmental impact has drawn considerable attention. To evaluate possible…

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Negative / Null Result ReportOpen accessMedicine

Evaluating the Impact of a Molecular Diagnostic Algorithm on Tuberculosis and Nontuberculous Mycobacterial Infections in Newfoundland and Labrador, Canada.

Needle R, Yu Y, Soualhine H et al. · 2025 · Biomedicines

Background/Objectives : The diagnosis of Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacterial (NTM) infections is accomplished by three main diagnostics methods: smear microscopy, culture, and molecular testing.…

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Negative / Null Result ReportOpen accessMedicine

A Study on the Visibility and Radiological Characteristics of a Normal Appendix in Patients Undergoing Non-contrast Computed Tomography at Teaching Hospital Jaffna, Sri Lanka.

Gobishangar S, Abiharan P, Jenil A et al. · 2026 · Cureus

Background The appendix is a vermiform structure with a variable position, length, and thickness. Imaging plays a critical role in diagnosing an inflamed appendix, with non-contrast computed tomography (NCCT) being an effective modality…

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Negative / Null Result ReportMedicine

Tooth wear and bruxism: A scoping review.

Bronkhorst H, Kalaykova S, Huysmans MC et al. · 2024 · Journal of dentistry

Objective This study presents a scoping review to determine the association between tooth wear and bruxism. Data A protocol was developed a priori (Open Science Framework (DOI 10.17605/OSF.IO/CS7JX)). Established scoping review methods…

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Negative / Null Result ReportMedicine

50 Hz magnetic field influences caspase-3 activity and cell cycle distribution in ionizing radiation exposed SH-SY5Y neuroblastoma cells.

Nieminen V, Martikainen MV, Kalliomäki S et al. · 2024 · International journal of radiation biology

Purpose Earlier evidence suggests that extremely low frequency magnetic fields (ELF MFs) can modify the effects of carcinogenic agents. However, the studies conducted so far with ionizing radiation as the co-exposure agent are sparse and…

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Negative / Null Result ReportMedicine

Quadrant-Specific Retinal Nerve Fiber Layer Thinning in Hydroxychloroquine Retinal Toxicity: A Controlled OCT-Based Structural and Exposure Analysis in Systemic Lupus Erythematosus.

Geamănu A, Pîrvulescu RA, Tricorache D et al. · 2026 · Diagnostics (Basel, Switzerland)

Background: Hydroxychloroquine (HCQ) is widely used in systemic lupus erythematosus (SLE), yet cumulative exposure may result in progressive retinal toxicity. Structural biomarkers capable of identifying subclinical damage remain…

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Negative / Null Result ReportMedicine

Satellite-Derived NDVI Trend Indicators for Adaptive Management of Trail-Penetrated Special Protection Areas: A Spatiotemporal Assessment with Markov-Chain Risk Projections.

Sung K · 2026 · Environmental management

Trail penetration within strictly designated protected areas is often treated as a conservation concern, yet its consequences for vegetation trends at national scales remain empirically unresolved. This study evaluated whether trail…

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Negative / Null Result ReportMedicine

Reliability of Hepatic Steatosis Quantification by Controlled Attenuation Parameter in Steatotic Liver Disease.

Simonis L, Marcour Y, Embacher J et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Background & aims Assessment of hepatic steatosis is key for diagnosis and monitoring of steatotic liver disease. Controlled attenuation parameter is widely used, but concerns regarding its measurement variability exist. We evaluated the…

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Negative / Null Result ReportOpen accessMedicine

The challenges of implementing less invasive surgical management for cervical cancer in a limited-resource setting in Botswana: A case series.

Corn E, Becht K, Adefres B et al. · 2026 · Gynecologic oncology reports

Purpose Cervical cancer is the number one cause of cancer-related mortality for women in Botswana, where care is complicated by the country's severe shortage of gynecologic oncologists. Recent data suggests that "low-risk" stage I cervical…

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Negative / Null Result ReportOpen accessMedicine

Neutralising antibody responses to emerging SARS-CoV-2 omicron sub-variants are enhanced in persons with hybrid immunity.

Walmsley SL, Nabipoor M, Qi F et al. · 2026 · Clinical & translational immunology

Objectives To assess neutralizing antibody responses to emerging SARS-CoV-2 variants. Methods We explored SARS-CoV-2 neutralizing antibodies in140 adults participating in a longitudinal study of antibody responses to COVID vaccines.…

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