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WASTE Journal

Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Dietary Iron Intake and Risk of Gastric Cancer.

Pham YT, Nguyen BN, Nguyen TG et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Iron is one of the essential elements for human life. Prior studies provided inconclusive results about the association between dietary iron intake and gastric cancer risk. We determined the association between dietary iron…

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Negative / Null Result ReportOpen accessMedicine

Rare Occurrence of Myxoma in Heart Transplant Recipient: A Case Report.

Gutowska A, Bohdan M, Radtke-Łysek A et al. · 2026 · The American journal of case reports

BACKGROUND Cardiac myxomas are the most common primary cardiac tumors in the general population but are exceedingly rare in orthotopic heart transplant recipients. Fewer than 5 cases have been reported. Their pathogenesis in the setting of…

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Negative / Null Result ReportOpen accessMedicine

T174M-M235T <i>AGT</i> Gene Haplotypes in Women with Pre-Eclampsia from Northwest Mexico: A Pilot Case-Control Study.

Portillo-Gallo JH, Sánchez-González JM, Saldaña-Cruz AM et al. · 2026 · Current issues in molecular biology

Pre-eclampsia is a Hypertensive Disorder of Pregnancy (HDP) characterized by hypertension and proteinuria, affecting 2-8% of pregnancies worldwide and constituting a major public health concern. Genes of the renin-angiotensin system have…

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Negative / Null Result ReportOpen accessMedicine

Infectious potential and circulation of SARS-CoV-2 in wild rats.

Beissat K, Lattard V, Picard-Meyer E et al. · 2025 · PloS one

Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, a wide range of animal species (pets, mink…) have been naturally infected with this betacoronavirus. The emergence of new variants has…

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Negative / Null Result ReportOpen accessMedicine

Hierarchical Classification of Factors Associated With Noninvasive Prenatal Testing Failures and Its Impact on Pregnancy Outcomes.

Xie J, Jiang Y, Zhou Y et al. · 2024 · Maternal-fetal medicine (Wolters Kluwer Health, Inc.)

Objective To conduct a hierarchical classification analysis of the nonreportable results of noninvasive prenatal testing in an attempt to reduce failure rates and provide pregnant women with accurate information to alleviate their anxiety.…

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Negative / Null Result ReportMedicine

Frailty, Physical Function Impairment, and Pulmonary Function in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study.

Abdo M, Kunisaki KM, Morris A et al. · 2026 · AIDS research and human retroviruses

People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairments.…

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Negative / Null Result ReportOpen accessMedicine

Challenges in Results Robustness of Trials with Missing Data for the Primary Endpoint: Insights from Coronary Balloon/Stent Trials.

Lang X, Zhao Y, Zhu Y et al. · 2025 · Risk management and healthcare policy

Background To assess the consequence of different degrees of missing primary endpoint data for randomized controlled trials and to find the influence factors. Methods PubMed, Cochrane Library, EMBASE and ClinicalTrials.gov were searched up…

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Negative / Null Result ReportMedicine

Polygene by environment interactions predicting depressive outcomes.

Grillo AR · 2025 · American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Depression is a major public health problem with a continued need to uncover its etiology. Current models of depression contend that gene-by-environment (G × E) interactions influence depression risk, and further, that depression is…

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Negative / Null Result ReportMedicine

Performance of SARS-CoV-2 nucleic acid amplification testing in Austria as measured by external quality assessment schemes during 3 years of the COVID-19 pandemic: an observational retrospective study.

Buchta C, Aberle SW, Allerberger F et al. · 2023 · The Lancet. Microbe

Background The aim of external quality assessment (EQA) schemes is to evaluate the analytical performance of laboratories and test systems in a near-to-real-life setting. This monitoring service provides feedback to participant…

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Negative / Null Result ReportOpen accessMedicine

External quality assessments for SARS-CoV-2 genome detection in Austria : A comparison of the first postpandemic round with results from the pandemic era.

Buchta C, Aberle SW, Görzer I et al. · 2024 · Wiener klinische Wochenschrift

Background External quality assessment (EQA) schemes provide objective feedback to participating laboratories about the performance of their analytical systems and information about overall regional analytical performance. The EQAs are…

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Negative / Null Result ReportMedicine

Efficacy and tolerability of valproate versus topiramate in migraine prevention, a randomized controlled multi-center trial.

Zeinhom MG, Elsayed Khalil MF, Omar Youssif TY et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Although topiramate and valproate are antiseizure medications that have many contraindications and could produce many side effects, they are still used as migraine preventive therapy in middle- and low-income countries. Several trials…

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Negative / Null Result ReportOpen accessMedicine

Original article: novelty of Canadian manufacture nasopharyngeal swabs for collection of samples being tested for SARS-CoV-2 in a pandemic setting.

Palomino-Padilla S, Caceres-Cardenas G, Calderon R et al. · 2024 · Frontiers in public health

Objectives The COVID-19 pandemic caused a global shortage of nasopharyngeal (NP) swabs, required for RT-PCR testing. Canadian manufacturers were contacted to share NP swab innovations. The primary objective was to determine whether novel…

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Negative / Null Result ReportMedicine

The association between changes in muscle mass and function and mortality in individuals receiving peritoneal dialysis.

Wang L, Xue C, Zhu B et al. · 2025 · Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Background/objective Data in terms of how dynamic changes of muscle mass and function affect mortality in end-stage kidney disease (ESKD) patients undergoing dialysis have led to inconclusive results. The main goal of this research was to…

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Negative / Null Result ReportOpen accessMedicine

Ultrasound-Guided Versus Freehand Fine Needle Aspiration: A Comparative Study in Diagnosing Non-Salivary, Non-Thyroidal Head, and Neck Masses.

Rajamanickam SK, Prades Morera E, Agarwal A et al. · 2025 · Cureus

Background Fine needle aspiration cytology (FNAC) is widely used to evaluate head and neck masses, with both ultrasound (US)-guided and freehand techniques being employed. While US-guided FNAC is thought to enhance accuracy, freehand FNAC…

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Negative / Null Result ReportMedicine

The effect of an intervention to reduce aflatoxin consumption from 6 to 18 mo of age on length-for-age z-scores in rural Tanzania: a cluster-randomized trial.

Phillips E, Ngure FM, Kassim N et al. · 2025 · The American journal of clinical nutrition

Background Linear growth faltering continues to negatively affect children in low- and middle-income countries and is associated with poor cognitive, developmental, and educational outcomes. Laboratory and observational data suggest that…

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Negative / Null Result ReportOpen accessMedicine

Prior Use of Renin-Angiotensin System Inhibitors and Risk of Renal Replacement Therapy in Critically Ill Elderly Patients With Sepsis: A Population-Based Cohort Study.

Otero Castro V, Scales DC, Angriman F · 2025 · Critical care explorations

Objectives We sought to estimate the association between chronic use of renin-angiotensin system inhibitors and acute kidney injury requiring renal replacement therapy in critically ill adult patients with sepsis. Design Population-based…

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Negative / Null Result ReportOpen accessMedicine

No evidence of BoHV-1 exposure and low levels of pestivirus exposure in sera from 116 opportunistically sampled wild deer in Northern Ireland.

Lyons M, Lahuerta-Marin A, Clarke J et al. · 2025 · Irish veterinary journal

Bovine Viral Diarrhoea Virus (BVDV), Border Disease Virus (BDV), and Bovine Herpesvirus-1 (BoHV-1, the cause of Infectious Bovine Rhinotracheitis, IBR), are economically important endemic viruses in ruminant livestock in the United Kingdom…

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Negative / Null Result ReportMedicine

Efficacy and safety of esketamine versus propofol in electroconvulsive therapy for treatment-resistant depression: A randomized, double-blind, controlled, non-inferiority trial.

Zeng QB, Zou DC, Huang XB et al. · 2025 · Journal of affective disorders

Background Electroconvulsive therapy (ECT) is a commonly used alternative for treatment-resistant depression (TRD). Although esketamine has a rapid pharmacological antidepressant action, it has not been studied as an ECT anesthetic. The…

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