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Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

N95 filtering facepiece respirator fit assessment outcomes by gender, age, race, and facial hair in a community population sample.

Bagheri Hosseinabadi M, Yu M, Petersen A et al. · 2026 · Annals of work exposures and health

The necessity for respiratory protection has increased due to global threats such as pandemics, industrial accidents, and extreme weather events. The effectiveness of N95 filtering facepiece respirators depends on how well they fit the…

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Negative / Null Result ReportOpen accessMedicine

Deficit irrigation and grafting effects on soil attributes, vegetative growth, yield components, and quality of 'Crimson Seedless' grapevines under a semiarid region.

Salama AM, Al-Obeed RS, Helmy A et al. · 2026 · Frontiers in plant science

This study evaluated the combined effects of grafting and deficit irrigation (DI) on soil attributes, vegetative growth, yield components, fruit quality, and water productivity of 'Crimson Seedless' grapevines under semiarid conditions. It…

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Negative / Null Result ReportMedicine

Comparison of the efficacy of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion in the treatment of double-level lumbar spondylolisthesis combined with spinal stenosis: a retrospective comparative study.

Ma Z, Luan H, Abulimiti K et al. · 2026 · BMC surgery

Objective To compare the clinical and radiographic outcomes of posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) in the treatment of double-level lumbar spondylolisthesis combined with spinal…

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Negative / Null Result ReportMedicine

The Effect of Preoperative Tranexamic Acid on Blood Transfusions in Geriatric Hip Fracture Surgery: A Randomized Controlled Trial.

Sullivan M, Perea LL, Bradburn E et al. · 2026 · Journal of orthopaedic trauma

Objectives To evaluate whether preoperative intravenous tranexamic acid (TXA) reduces postoperative blood transfusion rates in geriatric patients undergoing operative treatment for hip fracture. Methods Design Prospective, double-blinded,…

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Negative / Null Result ReportOpen accessMedicine

A comparative study of clinical efficacy, electrophysiological outcomes, and perioperative parameters between endoscopic carpal tunnel release and open carpal tunnel release for carpal tunnel syndrome.

Zhang Z, Liu Y, Yang H et al. · 2026 · Frontiers in cellular neuroscience

Purpose To compare the clinical efficacy of endoscopic (ECTR) and open (OCTR) carpal tunnel release for carpal tunnel syndrome (CTS) and provide evidence-based surgical guidance. Methods A retrospective cohort study was conducted including…

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Negative / Null Result ReportOpen accessMedicine

Comparison of the Bond Strength of Silane-Treated Glass Fiber Posts at Different Solvent Evaporation Times: An In Vitro Study.

Ramos-Ramos V, Dextre-Herrera S, Ramírez-Vargas G et al. · 2026 · Journal of clinical and experimental dentistry

Background Silane is used as a coupling agent on glass fiber posts to enhance chemical interaction at the post-resin cement interface. This in vitro study evaluated the bond strength of silane-treated glass fiber posts at different solvent…

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Negative / Null Result ReportMedicine

Capsular management in posterolateral total hip arthroplasty: impact on proprioception, balance, functional outcomes, and complications.

Guven S, Veizi E, Nazligul AS et al. · 2026 · Journal of orthopaedic surgery and research

Background The role of capsular management in total hip arthroplasty (THA) performed via the posterolateral approach remains debated, particularly regarding its effects on proprioception, balance, and postoperative stability. While…

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Negative / Null Result ReportMedicine

Effect of Verbal Working Memory Training on Auditory Processing Abilities, Working Memory, and Listening Effort in Children With Central Auditory Processing Disorders.

Spandita HL, Jain C · 2026 · Language, speech, and hearing services in schools

Purpose The study aimed to assess the effect of verbal working memory (WM) training on auditory processing abilities, WM, and listening effort (LE) in children with central auditory processing disorders ((C)APD). Method The study involved…

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Negative / Null Result ReportOpen accessMedicine

Carotid Plaque Characteristics Evaluation on DUS and MDCTA: Interobserver and Intermodality Agreement in a Single-Center Study.

Mutavdzic P, Kokovic T, Gakovic B et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Carotid artery stenosis has traditionally guided therapeutic decision-making; however, plaque morphology and composition are increasingly recognized as more reliable indicators of cerebrovascular risk than…

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Negative / Null Result ReportMedicine

[Comparison between methods to estimate total body fat mass in triathletes: dual X-ray absorptiometry, bioelectrical impedance and anthropometric equations].

Herrera-Torres OA, Flores-Zapata J, Ferreyro-Bravo F · 2026 · Nutricion hospitalaria

Introduction Introduction: the estimation of body fat mass (FM) can be performed using different methods. Although Dual-Energy X-ray Absorptiometry (DXA) is considered the reference technique due to its precision and reproducibility, its…

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Negative / Null Result ReportOpen accessMedicine

Correlations between inflammatory biomarkers and clinicopathological features in surgically resected thymic epithelial tumors: implications for preoperative diagnosis.

Fu J, Han P, Xu J et al. · 2026 · PeerJ

Objective This study aimed to analyze the correlations between pathological characteristics, risk factors, and inflammatory biomarkers in patients with thymic epithelial tumors (TETs) undergoing surgical resection. Methods A retrospective…

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Negative / Null Result ReportMedicine

The association between a sepsis diagnosis, demographic factors, and health-related quality of life in survivors at 180 days following critical illness.

De Silva S, Charles-Nelson A, McQuilten Z et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background Survivors of critical illness often have poor health-related quality of life (HRQoL). However, it is unclear what factors are associated with changes in HRQoL after critical illness. Objectives The aim of this study was to…

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Negative / Null Result ReportMedicine

Anti-inflammatory agents for the management of COPD - Quo Vadis?

Bakakos A, Sotiropoulou Z, Anagnostopoulos N et al. · 2025 · Respiratory medicine

Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality around the globe. Its main characteristics are persistent respiratory symptoms and progressive airflow limitation, both of which are driven by…

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Negative / Null Result ReportOpen accessMedicine

A Retrospective Study of a Postoperative Inflammation-Based Score for Predicting Disease-Free Survival in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy.

Yang Q, Li J, Ding L et al. · 2026 · Cancer management and research

Background Growing research findings highlight the potential of inflammatory markers measured after surgery as prognostic indicators for survival outcomes in rectal carcinoma patients. However, their precise clinical significance remains…

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Negative / Null Result ReportOpen accessMedicine

The fluid paradox: dissociation between clinical and ultrasound parameters of fluid overload - results of the INCIVEX exploratory study.

Wong A, Cheah K, Papathanakos G et al. · 2026 · Anaesthesiology intensive therapy

Introduction Fluid management in critically ill patients relies on clinical assessment, fluid balance calculations and, increasingly, point-of-care ultrasound. However, the rela-tionships between these assessment modalities remain poorly…

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Negative / Null Result ReportMedicine

Survival outcomes of the use of adjuvant chemotherapy in resected esophagus cancer after neoadjuvant chemoradiotherapy.

Ke TM, Lin T, Chow WH et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for esophageal cancer, but the role of adjuvant chemotherapy remains unclear. This study investigates the survival benefits of adjuvant…

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Negative / Null Result ReportMedicine

Does the Timing of Lysis of Adhesions After Anterior Cruciate Ligament Reconstruction Affect Final Range of Motion?

Schneble CA, Miltenberg B, Jurgensmeier K et al. · 2025 · The American journal of sports medicine

Background Arthrofibrosis is seen in 1.7% to 38% of patients after anterior cruciate ligament reconstruction (ACLR) and has been associated with worse postoperative patient-reported outcomes. There are limited data regarding the optimal…

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Negative / Null Result ReportMedicine

Collaborative Navigation Improves Spatial Learning Across Symmetric and Asymmetric Locomotion in Virtual Reality.

Chakraborty S, Gagnon H, McNamara TP et al. · 2026 · IEEE transactions on visualization and computer graphics

Multi-user virtual reality (VR) systems support multiple locomotion methods, but coordination may be challenging when partners use different methods. We studied dyads navigating a shared virtual maze using symmetric (same) or asymmetric…

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