e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

A novel allele of B(A) blood group detected in a donor and a patient during a retrospective review of ABO group anomalies in a tertiary hospital.

Suksard K, Millard GM, Teravichitchainan U et al. · 2025 · Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

Background ABO discrepancies, inconclusive results between forward and reverse typing, are one of the significant challenges encountered in transfusion medicine. Their frequency and etiologies can vary among ethnicities. This study aimed…

View details →
Negative / Null Result ReportOpen accessMedicine

MRI findings of an incidental ectopic posterior pituitary gland in an adult: Case report and review of T1 hyperintense lesions in the literature.

Hashem S, Murhega RB, Migabo PA · 2026 · Radiology case reports

The ectopic posterior pituitary represents a rare congenital malformation attributable to aberrant embryogenesis of the neurohypophysis. Although it may occur as an isolated anomaly, it is frequently concomitant with other congenital…

View details →
Negative / Null Result ReportOpen accessMedicine

Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar.

Ramasindrazana B, Rahalison ZA, Gauthier P et al. · 2025 · PLoS neglected tropical diseases

Background The plague, caused by Yersinia pestis, remains a critical public health issue, particularly in endemic regions like Madagascar. Rapid and accurate detection of this pathogen is essential for effective outbreak management and…

View details →
Negative / Null Result ReportMedicine

Genetic counselling in the era of next generation sequencing.

Espada-Musitu D, Manero-Azua Á, Vado Y et al. · 2025 · Anales de pediatria

Advances in next-generation sequencing (NGS) technologies have made the detection of the molecular causes of paediatric diseases increasingly affordable, accessible and rapid. While exome sequencing and genome sequencing were until…

View details →
Negative / Null Result ReportOpen accessMedicine

Baseline radiological parameters associated with good neurological outcome following ventriculoperitoneal shunt in normal pressure hydrocephalus: A single-center study on 82 patients.

Paracino R, De Domenico P, Ricciuti RA et al. · 2025 · Surgical neurology international

Background Idiopathic normal pressure hydrocephalus (iNPH) is a benign neurologic condition with treatment response rates ranging only between 30 and 50%. Several studies have attempted to identify clinical or radiological predictive…

View details →
Negative / Null Result ReportMedicine

Cancer genetic profile and risk of thrombosis.

Pelegrín-Mateo FJ, Zambrano CB, Vázquez EB et al. · 2025 · European journal of internal medicine

Cancer-associated thrombosis (CAT) remains a leading cause of morbidity and mortality among oncology patients, with an incidence influenced by tumor type, stage, treatment, and molecular characteristics. This review explores the molecular…

View details →
Negative / Null Result ReportMedicine

Intraoperative electrophysiological balloon test occlusion (BTO): A novel Solution to an inconclusive conventional BTO.

Datta A, Katyayan I, Das KK et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Parent Artery Occlusion (PAO) is a valid treatment choice in giant internal carotid artery (ICA) aneurysms of the cavernous segment when the preoperative balloon test occlusion (BTO) demonstrates an adequate cross circulation from the…

View details →
Negative / Null Result ReportMedicine

Incidental Ovarian Uptake in Bone Scintigraphy.

Saber Tanha A, Hosseini S, Soltani E et al. · 2025 · Clinical nuclear medicine

Abstract A 47-year-old woman, recently diagnosed with breast cancer, underwent staging. A whole-body bone scan revealed an unexpected focal 99m Tc-MDP uptake in her right ovary. Extensive literature review suggested various malignant…

View details →
Negative / Null Result ReportOpen accessMedicine

A new multiplex molecular assay based on padlock probes and rolling circle amplification for MDR-TB detection in clinical specimens: a prospective diagnostic accuracy study.

Dudnyk A, Tytarenko N, Lytvyniuk O et al. · 2026 · Therapeutic advances in infectious disease

Background Patients with multidrug-resistant tuberculosis (MDR-TB) receive treatment that is at least 20% less effective than drug-susceptible cases globally. Objectives The study evaluated the diagnostic accuracy of mfloDx MDR-TB assay…

View details →
Negative / Null Result ReportMedicine

Assessment of blood serum stability with Raman spectroscopy and explanatory AI.

Mieites V, Fernández-Manteca MG, Santiuste Torcida I et al. · 2025 · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

This study explores the potential of conventional Raman spectroscopy and commonly used spectral analysis pipelines for rapid and straightforward assessment of degradation in serum samples resulting from storage delays. Serum samples from…

View details →
Negative / Null Result ReportOpen accessMedicine

Variations in transcranial doppler among pediatric patients with sickle cell disease in the Brazilian Northeast: a cross-sectional study.

de Oliveira Castro Marques TR, Vidal SA, da Costa HA et al. · 2026 · Hematology, transfusion and cell therapy

Background Stroke, the most severe neurological complication of sickle cell disease, can result in irreversible sequelae and death. Transcranial Doppler combined with periodic blood transfusions reduces the chances of stroke by 90 %. In…

View details →
Negative / Null Result ReportMedicine

The impact of a second embryo biopsy for preimplantation genetic testing for monogenic diseases (PGT-M) with inconclusive results on pregnancy potential: results from a matched case-control study.

Guarneri C, Reschini M, Pinna M et al. · 2024 · Journal of assisted reproduction and genetics

Purpose To evaluate whether a second biopsy, following a first diagnostic failure on blastocysts tested for preimplantation genetic testing for monogenic diseases (PGT-M), allows to obtain genetic diagnosis and to what extent this…

View details →
Failed Experiment ReportOpen accessMedicine

Persistent cognitive deficits in ACL-injured athletes despite of rehabilitation: an observational longitudinal study.

Jiménez-Martínez J, Alarcón-López F, Chirosa-Ríos LJ et al. · 2025 · Frontiers in sports and active living

Background Rehabilitation programs following an anterior cruciate ligament (ACL) injury tend to focus on improving conditional aspects such as biomechanics. Recently, some studies have analyzed the relationship between cognition and ACL…

View details →
Negative / Null Result ReportOpen accessMedicine

Pre-Analytical and Analytical Challenges in Whole-Exome Sequencing of Formalin-Fixed Paraffin-Embedded Breast and Prostate Cancer Tissue: A Real-World Multicenter Study.

Rosa ML, Bordignon C, Schuch JB et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Formalin-fixed paraffin-embedded tissue is widely used in pathology and molecular diagnostics, yet its variable quality can critically influence the accuracy of sequencing-based analyses. This study investigated…

View details →
Negative / Null Result ReportOpen accessMedicine

Comprehensive assessment of invalid and indeterminate results in Truenat MTB-RIF testing across sites under the national TB elimination program of India.

Gopalaswamy R, Kumar N, Vashistha H et al. · 2023 · Frontiers in public health

Introduction Truenat MTB-RIF assay (Truenat), a nucleic acid amplification test (NAAT), is a real-time polymerase chain reaction (RT-PCR) chip-based assay that can detect Mycobacterium tuberculosis ( Mtb ) and rifampicin (RIF) drug…

View details →
Failed Experiment ReportOpen accessMedicine

Cytogenomics and optical genome mapping approaches characterize a derivative interstitial monosomy 18p due to a maternal complex intrachromosomal rearrangement.

Graziani L, Genovese S, Genovesi ML et al. · 2025 · Molecular cytogenetics

Background Monosomy 18p (MIM: 146390) is a well-known chromosomal disorder associated with intellectual disability, short stature, and non-specific craniofacial features resulting from partial or total deletion of the short arm of…

View details →
Negative / Null Result ReportOpen accessMedicine

The Role of Inflammasomes in LPS and Gram-Negative Bacterial Sepsis.

Hernández-Cuellar E, Tsuchiya K, Medina-Contreras O et al. · 2025 · Journal of clinical medicine

Background/Objectives : Sepsis is a life-threatening condition characterized by an uncontrolled immune response due to systemic infections. It is responsible for millions of deaths worldwide. Although inflammasomes play an important role…

View details →
Negative / Null Result ReportMedicine

Ivermectin performance against equine strongylids: Efficacy, egg reappearance periods, and fecal egg counting method comparison.

Nielsen MK, Bartholdy ID, Kristensen KS et al. · 2025 · Veterinary parasitology

Equine strongylids are ubiquitous and can cause severe health issues. Anthelmintic resistance is widely common in cyathostomin parasites, and recent studies have documented increasing incidence of resistance to the macrocyclic lactone drug…

View details →
Negative / Null Result ReportMedicine

Clinical utility of comprehensive gene panel testing for common and rare causes of skeletal dysplasia and other skeletal disorders: Results from the largest cohort to date.

MacCarrick G, Aradhya S, Bailey M et al. · 2024 · American journal of medical genetics. Part A

Molecular genetics enables more precise diagnoses of skeletal dysplasia and other skeletal disorders (SDs). We investigated the clinical utility of multigene panel testing for 5011 unrelated individuals with SD in the United States…

View details →