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WASTE Journal

Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Evaluation of betaxolol in improving the glasgow outcome scale extended (GOSE) of the acute phase of patients with mild to moderate Traumatic Brain Injury: a double blinded randomized clinical trial.

Zeynodini Meimand H, Anbarloui MR, Eslamian M et al. · 2025 · Neurological research

Background Traumatic brain injury (TBI) is one of the most important causes of morbidity and mortality. It is important to have an effective treatment that can improve the quality of life and cognitive functions of these patients.…

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Negative / Null Result ReportMedicine

Dose-Response Relationships of Tea, Coffee, and Alcohol Consumption With Cognitive Function in Middle-Aged and Older Adults: Analysis Based on the China Health and Nutrition Survey (CHNS).

Zeng Z, Ye X, He H et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society

This study examined the associations of tea, coffee, and alcohol consumption with cognitive function in Chinese adults aged ≥45 years ( n = 1326), using data from the China Health and Nutrition Survey (1997-2006). Multiple linear…

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Negative / Null Result ReportMedicine

Prospective evaluation of nonporous wrap fails to minimize inadvertent perianesthetic hypothermia in healthy canine patients undergoing ovariohysterectomy.

Bartels CM, Ranganathan B, Spinner M · 2025 · Journal of the American Veterinary Medical Association

Objective To prospectively evaluate a nonporous wrap's ability to prevent inadvertent perianesthetic hypothermia (IPH) in canines undergoing ovariohysterectomy. Methods All client-owned canines and felines undergoing ovariohysterectomy…

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Replication FailureMedicine

Treatment of Melasma Using Low-Fluence QS Nd: YAG (1064 nm) Laser: A Blind, Randomized, Placebo-Controlled Trial.

Sadeghpour M, Laughter M, Rizzo SI et al. · 2026 · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Background Despite evidence supporting efficacy of low-fluence Q-switched (QS) neodymium-doped yttrium aluminum garnet (Nd:YAG) 1,064-nm lasers, treatment protocols are not standardized and limited to mostly retrospective, observational,…

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Negative / Null Result ReportMedicine

Growth Hormone's Impact on Oxidative Stress, Ovarian Response, and <i>In Vitro</i> Fertilization in Polycystic Ovary Syndrome Across Different Ages.

Zhao P, Wang X, Zhang Q et al. · 2025 · British journal of hospital medicine (London, England : 2005)

Aims/Background Growth hormone (GH) supplementation contributes to improved reproductive and pregnancy outcomes in in vitro fertilization (IVF)-embryo transfer (ET) in polycystic ovary syndrome (PCOS) women. This study aimed to explore the…

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Negative / Null Result ReportOpen accessMedicine

Preoperative 15 mg of melatonin for reducing anxiety and post-traumatic stress disorder symptoms in mandibular third molar surgery: A randomized double-blind placebo-controlled clinical trial.

Rosa HH, Ruppel C, Trappel ND et al. · 2026 · Medicina oral, patologia oral y cirugia bucal

Background This study evaluated the efficacy of a single 15 mg preoperative sublingual dose of melatonin in reducing anxiety as the primary outcome, and its effects on psychomotor performance, postoperative sleep quality, and early…

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Failed Experiment ReportOpen accessMedicine

Does the Fissure Last Technique Really Reduce Postoperative Airleak After Lung Resection? Results From a Prospective Randomized Controlled Trial.

Vaisitti F, Sobrero S, Rudella S et al. · 2026 · Interdisciplinary cardiovascular and thoracic surgery

Objectives The fissure last (FL) technique described in 1998 has the goal of minimizing postoperative airleak leaving the stapling of the fissure as the last step. The aim of this study was the reduction in airleak may be already evident…

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Failed Experiment ReportMedicine

Survival impact of adjuvant capecitabine in triple-negative breast cancer Latin American patients with residual disease: a real-world study.

Graciano N, López L, Rodriguez CA et al. · 2025 · Breast cancer research and treatment

Purpose Patients with triple-negative breast cancer (TNBC) who do not achieve pathological complete response (non-pCR) after neoadjuvant chemotherapy (NACT) have a high-risk of relapse. While adjuvant capecitabine (AdjCape) has…

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Negative / Null Result ReportMedicine

Quality of life effects of renal artery stenting versus medical therapy for atherosclerotic renal-artery stenosis: results from the randomized CORAL trial.

Arnold SV, Wang K, Kirtane AJ et al. · 2025 · European heart journal. Quality of care & clinical outcomes

Background Renal-artery stenosis can be associated with difficult to control hypertension, although renal-artery stenting has not been shown to improve clinical outcomes. Alternative antihypertensive medications could potentially result in…

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Negative / Null Result ReportMedicine

Comprehensive Analysis of a Single-Center Inpatient Posttransplant Physical Therapy Program in High-Acuity Patients: Is It Worth the Effort?

Ugarte R, Noguchi D, Jaeger C et al. · 2025 · Journal of the American College of Surgeons

Background High-acuity post-liver transplantation (LT) patients often have a prolonged hospital course. In response, we developed a novel, intensive inpatient group physical therapy (PT) program and sought to evaluate its impact on…

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Negative / Null Result ReportOpen accessMedicine

The combination of atezolizumab and BCG in high-risk non-muscle invasive bladder cancer: results of the phase Ib/II BladderGATE clinical trial.

Guerrero-Ramos F, Gómez-Cañizo C, Rodríguez-Izquierdo M et al. · 2026 · The oncologist

Background BladderGATE evaluated the safety, tolerability, and efficacy of intravenous (IV) atezolizumab combined with intravesical Bacillus Calmette-Guérin (BCG) in patients with BCG-naïve high-risk non-muscle invasive bladder cancer…

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Failed Experiment ReportMedicine

Editorial Commentary: Bone Marrow Stimulation Provides Little Benefit for Repair of Full-Thickness Rotator Cuff Tears.

Lapner P · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Rotator cuff retears remain the most frequently observed complication after arthroscopic cuff repair, with tendon nonhealing rates reported between 20% and 68%. Biological solutions to improve healing rates are needed, and bone marrow…

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Negative / Null Result ReportOpen accessMedicine

Platelet-rich fibrin matrix as treatment for complex anal fistulae: A 3-year experience at a tertiary centre.

Lusilla Lopez A, Fält UA, Buchwald P et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Aim Treatment of complex anal fistulae remains a significant challenge for physicians and patients. A sphincter-preserving technique with bioactive platelet-rich fibrin matrix is one option. This three-year study aimed to evaluate the…

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Negative / Null Result ReportOpen accessMedicine

The efficacy of nutritional phytochemical compounds in improving cognition.

Marsh A, Quelch D, Mackonochie M et al. · 2026 · The international journal of neuropsychopharmacology

The incidence of cognitive disorders is rising, and medications to address cognitive impairments are limited. Phytochemical compounds have had some success in improving cognitive outcomes in preclinical studies. However, the evidence…

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Negative / Null Result ReportMedicine

Randomized clinical trial of duplex ultrasound surveillance after endovascular therapy for chronic limb-threatening ischemia.

Godoy MR, Brochado-Neto FC, Martins Cury MV et al. · 2025 · Journal of vascular surgery

Objective This study aimed to assess whether duplex ultrasound (DUS) surveillance yielded a better outcome compared with ankle-brachial index (ABI) surveillance after femoropopliteal endovascular therapy (EVT) in a cohort of patients…

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Negative / Null Result ReportMedicine

Cryotherapy following total knee replacement.

Aggarwal A, Adie S, Harris IA et al. · 2025 · The Cochrane database of systematic reviews

Background Total knee replacement (TKR) is a common intervention for people with end-stage symptomatic knee osteoarthritis, resulting in significant improvements in pain, function and quality of life within three to six months. It is,…

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