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Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

In relation to anxiety severity, puberty moderates functional connectivity between the amygdala and anterior cingulate cortex for negative relative to neutral stimuli during an emotional categorization task.

Suss SJ Jr, Kimbler A, Baker AE et al. · 2026 · Developmental cognitive neuroscience

Anxiety symptoms often escalate in peri-adolescence (ages 10-13 years), a sensitive period when puberty-related changes occur in neural systems implicated in psychopathology. Greater amygdala activation and altered functional connectivity…

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Negative / Null Result ReportMedicine

Impact of emergency medical services volume on outcomes and management in prehospital traumatic cardiac arrest: a retrospective cohort study.

Morcel B, Yordanov Y, Mercier E et al. · 2026 · Scandinavian journal of trauma, resuscitation and emergency medicine

Background While volume-outcome relationships for non-traumatic out-of-hospital cardiac arrest have been reported in hospital settings, the impact of prehospital exposure, particularly for the rare and clinically complex entity of…

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Negative / Null Result ReportOpen accessMedicine

Postoperative Consequences of Fear and Anxiety in Open Heart Surgery: A Comparative Analysis of Two Patient Groups.

Dizdar E, Kiliç A, Alkan Kayhan S et al. · 2026 · The journal of nursing research : JNR

Background Patients undergoing open heart surgery may experience negative emotions such as anxiety, fear, panic, and anger in the preoperative period that may negatively affect their postoperative recovery. Purpose This study was designed…

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Negative / Null Result ReportOpen accessMedicine

COVID-19 vaccination remains essential for healthcare professionals: clinical evidence from a Polish cross-sectional study.

Hoffmann K, Michalak M, Jarząb M et al. · 2026 · Frontiers in public health

Introduction Six years after the emergence of SARS-CoV-2, vaccination remains still central to preventing severe COVID-19. The aim was to determine the impact of the vaccine type and number of doses on the course of COVID-19 infection…

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Negative / Null Result ReportMedicine

A microplastic meal: A baseline assessment of microplastic polymer presence within manta-ray (Mobula alfredi) feeding grounds at D'Arros Island and the St. Joseph Atoll.

Choppy MT, Duncan MI, Gordon N et al. · 2026 · Marine pollution bulletin

Microplastic ingestion by reef manta rays (Mobula alfredi) is a threat to their health and population stability. Seychelles' outer islands are vital habitats for M. alfredi but nothing is known about marine microplastic pollution in the…

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Negative / Null Result ReportMedicine

The effect of physiological changes in estradiol hormone during the follicular phase of the menstrual cycle in healthy women on retinal ganglion cell function, retinal and optic nerve vascularization and structure.

Hamurcu M, Gültekin BP, Göçmen M et al. · 2026 · Documenta ophthalmologica. Advances in ophthalmology

Purpose This study aimed to investigate the effects of estradiol changes occurring during the early follicular phase of the menstrual cycle on retinal ganglion cell function, retinal and optic nerve vascularity and structure in healthy…

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Negative / Null Result ReportMedicine

No Association Between Anatomic Factors and Non-Contact ACL Injury Risk in 217 Female Team Sport Players: A Prospective 4.5-Year Study.

Leppänen M, Jarske H, Krosshaug T et al. · 2026 · Scandinavian journal of medicine & science in sports

The purpose of this explorative study was to investigate the association between anatomic factors and risk for non-contact anterior cruciate ligament (ACL) injuries among female team sport players. A total of 225 players from basketball,…

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Negative / Null Result ReportMedicine

Visual Outcomes and the Impact of Intermediate Segment Orientation on the Performance of an Asymmetric Multifocal Intraocular Lens.

McLintock C, Uprety S, McKelvie J et al. · 2026 · Journal of refractive surgery (Thorofare, N.J. : 1995)

Purpose To evaluate the visual outcomes and the impact of intermediate segment orientation on the performance of an asymmetric multifocal intraocular lens (IOL) in patients who have cataract. Methods In this retrospective single-center…

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Negative / Null Result ReportMedicine

Understanding AI adoption in medical education: Insights from students and faculty members in Indonesian medical schools.

Rujito L, Muhaimin A, Pergodi MA et al. · 2026 · Journal of education and health promotion

Background Artificial Intelligence (AI) implementation in medical education has changed the learning process, with new forms of diagnosis, treatment planning, and patient care. Biases in AI adoption among Indonesian medical schools'…

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Negative / Null Result ReportMedicine

Connectedness to Nature, Ceremonial Participation, and Mental and Physical Health Among Rural and Urban Wixárika in Jalisco, Mexico.

Shattuck EC, McKinnon L, Herrera IR et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Research in Western samples has repeatedly demonstrated a link between exposure to nature and natural stimuli and improved health. We sought to test these relationships in a sample of Indigenous Wixárika, whose traditional…

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Negative / Null Result ReportMedicine

Prognostic factors and outcome measures after BRAF-directed targeted therapy of unresectable metastatic BRAF<sup>V600E</sup> colorectal cancer: a study cohort-level analysis.

Colloca GA, Venturino A · 2026 · Investigational new drugs

BRAF V600E mutation in metastatic colorectal cancer (mCRC) is associated with a poor prognosis. BRAF V600E inhibitors (BRAFi) plus EGFR inhibitors + / - MEK inhibitors regimens prolonged overall survival (OS), but prognosis remains…

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Negative / Null Result ReportMedicine

The association of non-alcoholic fatty liver index, plasma metal levels, and genetic susceptibility using genome-wide type analysis.

Yu SH, Luo KH, Yang CC et al. · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Background & aims This study aimed to explore the relationship between heavy metal exposure and the occurrence of non-alcoholic fatty liver disease (NAFLD), an area with conflicting existing research and unexplored genetic implications.…

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Negative / Null Result ReportMedicine

The Relationship Between Neurofilament Light Chain and B Lymphocyte Chemoattractant and Cognition in Multiple Sclerosis.

Bakırcıoglu-Duman E, Petek-Balcı FB, Calıskan-Dolu N et al. · 2026 · Noro psikiyatri arsivi

Introduction Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, demyelinating disease of the central nervous system that is often associated with cognitive impairment. This study aims to investigate whether Neurofilament light…

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Negative / Null Result ReportMedicine

Investigating the effect of probiotics on seizure-related symptoms in children with medication-resistant epilepsy: a randomized clinical trial.

Mohammadi M, Zahiroddin H, Mohammadi MS et al. · 2026 · Clinical neurology and neurosurgery

Introduction Antiseizure Medications (ASMs) can be beneficial for many patients with epilepsy; however, some individuals with medication-resistant epilepsy (MRE) may not experience effective seizure control. Although effective alternative…

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Negative / Null Result ReportMedicine

Unmasking the Relationship Between Cyber Dating Abuse and Fear of Intimacy: Insights From a Cross-Sectional Study of Undergraduate Students.

Büyüktopaç Çakici H, Çiçek Gümüş E, Dişli E et al. · 2026 · Journal of interpersonal violence

The increasing digitalization of the world has led to a rise in cyber dating abuse among undergraduate students, who are transitioning into young adulthood and will be part of the future workforce. Additionally, identifying the…

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Negative / Null Result ReportOpen accessMedicine

Exploring how weight stigma relates to psychological distress, physical activity, and eating behaviors over time: a longitudinal study among young adults in Hong Kong.

Fung XCC, Siu AMH, Ye J et al. · 2026 · Journal of eating disorders

Background Many researchers have expressed concerns that weight stigma may cause adverse health effects and worsen weight issues in a vicious cycle. However, empirical evidence evaluating this cycle is scarce, especially among Eastern…

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