e-ISSN: Pending

Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportOpen accessMedicine

Variation of rabbit serum IgA in relation to RHDV vaccination and infection: implications for serological diagnosis and epidemiological investigations.

Capucci L, Di Giovanni V, Schiavitto M et al. · 2026 · Veterinary research

Rabbit haemorrhagic disease (RHD) is a highly pathogenic and contagious disease caused by RHD virus (RHDV) and RHDV type 2 (RHDV2), two distinct Lagovirus europaeus belonging to the Caliciviridae family. Serological investigations have…

View details →
Failed Experiment ReportMedicine

Diagnostic challenges in cardiac amyloidosis: a case report of negative initial endomyocardial biopsy.

Mojahedi A, Goldschmidt M, Skopicki H et al. · 2025 · International journal of physiology, pathophysiology and pharmacology

Cardiac amyloidosis (CA) is a challenging acquired heart disease caused by the deposition of β-pleated amyloid proteins, often leading to nonspecific symptoms that complicate the diagnosis. This case report describes an 83-year-old male…

View details →
Negative / Null Result ReportOpen accessMedicine

Limits on transverse zero sound in Fermi liquid <sup>3</sup>He.

Nguyen MD, Park D, Scott JW et al. · 2026 · Science advances

Landau predicted that transverse sound propagates in a Fermi liquid with sufficiently strong interactions such as for liquid 3 He, unlike a classical fluid that cannot support shear oscillations. Previous attempts to observe this unique…

View details →
Negative / Null Result ReportOpen accessMedicine

Refining the role of presurgical PET/4D-CT in a large series of patients with primary hyperparathyroidism undergoing [ 18 F]Fluorocholine PET/CT.

Kaseb A, Benider H, Treglia G et al. · 2025 · European journal of clinical investigation

Background 4D-CT has garnered attention as complementary imaging for patients with primary hyperparathyroidism (pHPT). Herein we evaluated a diagnostic strategy using [ 18 F]Fluorocholine Positron Emission Tomography/Computed Tomography…

View details →
Negative / Null Result ReportOpen accessMedicine

Assessing the cardiovascular and potassium lowering effects of levalbuterol compared to albuterol: a randomized control trial.

Shebli B, Ghabally M, Shabouk MB et al. · 2025 · Frontiers in cardiovascular medicine

Background Beta-agonists like Levalbuterol and Albuterol are used in the treatment of Hyperkalemia. However, few studies in the medical literature have directly compared the cardiac effects and potassium-lowering efficacy of levalbuterol…

View details →
Negative / Null Result ReportMedicine

Impulse Oscillometry is Useful in Detecting Lung Function Abnormalities in Preschoolers with Primary Ciliary Dyskinesia but Not Cystic Fibrosis: A Cross-Sectional Study Results.

Sunman B, Yalcin E, Alboga D et al. · 2025 · Pediatric allergy, immunology, and pulmonology

Background: Although the forced oscillation technique has been used for many years in children, there is still inconclusive results about its efficiency in cystic fibrosis (CF). Moreover, no studies have been conducted on impulse…

View details →
Negative / Null Result ReportOpen accessMedicine

Efficacy of core biopsies for diagnosing inflammatory myofibroblastic tumors in pediatric patients: case series from a single tertiary referral center.

Pierucci UM, Paraboschi I, Ardenghi C et al. · 2024 · Translational pediatrics

Background Inflammatory myofibroblastic tumors (IMTs) are rare, often non-metastasizing neoplasms characterized by fibro/myofibroblastic spindle cells with varying infiltrates of plasma cells, lymphocytes, and/or eosinophils. Despite their…

View details →
Negative / Null Result ReportMedicine

A novel allele of B(A) blood group detected in a donor and a patient during a retrospective review of ABO group anomalies in a tertiary hospital.

Suksard K, Millard GM, Teravichitchainan U et al. · 2025 · Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

Background ABO discrepancies, inconclusive results between forward and reverse typing, are one of the significant challenges encountered in transfusion medicine. Their frequency and etiologies can vary among ethnicities. This study aimed…

View details →
Negative / Null Result ReportOpen accessMedicine

MRI findings of an incidental ectopic posterior pituitary gland in an adult: Case report and review of T1 hyperintense lesions in the literature.

Hashem S, Murhega RB, Migabo PA · 2026 · Radiology case reports

The ectopic posterior pituitary represents a rare congenital malformation attributable to aberrant embryogenesis of the neurohypophysis. Although it may occur as an isolated anomaly, it is frequently concomitant with other congenital…

View details →
Negative / Null Result ReportOpen accessMedicine

Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar.

Ramasindrazana B, Rahalison ZA, Gauthier P et al. · 2025 · PLoS neglected tropical diseases

Background The plague, caused by Yersinia pestis, remains a critical public health issue, particularly in endemic regions like Madagascar. Rapid and accurate detection of this pathogen is essential for effective outbreak management and…

View details →
Negative / Null Result ReportMedicine

Genetic counselling in the era of next generation sequencing.

Espada-Musitu D, Manero-Azua Á, Vado Y et al. · 2025 · Anales de pediatria

Advances in next-generation sequencing (NGS) technologies have made the detection of the molecular causes of paediatric diseases increasingly affordable, accessible and rapid. While exome sequencing and genome sequencing were until…

View details →
Negative / Null Result ReportOpen accessMedicine

Baseline radiological parameters associated with good neurological outcome following ventriculoperitoneal shunt in normal pressure hydrocephalus: A single-center study on 82 patients.

Paracino R, De Domenico P, Ricciuti RA et al. · 2025 · Surgical neurology international

Background Idiopathic normal pressure hydrocephalus (iNPH) is a benign neurologic condition with treatment response rates ranging only between 30 and 50%. Several studies have attempted to identify clinical or radiological predictive…

View details →
Negative / Null Result ReportMedicine

Cancer genetic profile and risk of thrombosis.

Pelegrín-Mateo FJ, Zambrano CB, Vázquez EB et al. · 2025 · European journal of internal medicine

Cancer-associated thrombosis (CAT) remains a leading cause of morbidity and mortality among oncology patients, with an incidence influenced by tumor type, stage, treatment, and molecular characteristics. This review explores the molecular…

View details →
Negative / Null Result ReportMedicine

Intraoperative electrophysiological balloon test occlusion (BTO): A novel Solution to an inconclusive conventional BTO.

Datta A, Katyayan I, Das KK et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Parent Artery Occlusion (PAO) is a valid treatment choice in giant internal carotid artery (ICA) aneurysms of the cavernous segment when the preoperative balloon test occlusion (BTO) demonstrates an adequate cross circulation from the…

View details →
Negative / Null Result ReportMedicine

Incidental Ovarian Uptake in Bone Scintigraphy.

Saber Tanha A, Hosseini S, Soltani E et al. · 2025 · Clinical nuclear medicine

Abstract A 47-year-old woman, recently diagnosed with breast cancer, underwent staging. A whole-body bone scan revealed an unexpected focal 99m Tc-MDP uptake in her right ovary. Extensive literature review suggested various malignant…

View details →
Negative / Null Result ReportOpen accessMedicine

A new multiplex molecular assay based on padlock probes and rolling circle amplification for MDR-TB detection in clinical specimens: a prospective diagnostic accuracy study.

Dudnyk A, Tytarenko N, Lytvyniuk O et al. · 2026 · Therapeutic advances in infectious disease

Background Patients with multidrug-resistant tuberculosis (MDR-TB) receive treatment that is at least 20% less effective than drug-susceptible cases globally. Objectives The study evaluated the diagnostic accuracy of mfloDx MDR-TB assay…

View details →
Negative / Null Result ReportMedicine

Assessment of blood serum stability with Raman spectroscopy and explanatory AI.

Mieites V, Fernández-Manteca MG, Santiuste Torcida I et al. · 2025 · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

This study explores the potential of conventional Raman spectroscopy and commonly used spectral analysis pipelines for rapid and straightforward assessment of degradation in serum samples resulting from storage delays. Serum samples from…

View details →
Negative / Null Result ReportOpen accessMedicine

Variations in transcranial doppler among pediatric patients with sickle cell disease in the Brazilian Northeast: a cross-sectional study.

de Oliveira Castro Marques TR, Vidal SA, da Costa HA et al. · 2026 · Hematology, transfusion and cell therapy

Background Stroke, the most severe neurological complication of sickle cell disease, can result in irreversible sequelae and death. Transcranial Doppler combined with periodic blood transfusions reduces the chances of stroke by 90 %. In…

View details →