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WASTE Journal

Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Respiratory syncytial virus incidence and clinical outcomes in patients with inflammatory bowel disease: a National Veterans Affairs cohort study.

Khan N, Sundararajan R, Caldera F et al. · 2026 · Inflammatory bowel diseases

Background Data describing the incidence and clinical outcomes of respiratory syncytial virus (RSV) infection among patients with inflammatory bowel disease (IBD) are limited. Methods We conducted a nationwide retrospective cohort study…

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Negative / Null Result ReportMedicine

Evaluating the Quality of Artificial Intelligence-Generated Rubrics and Grading Reliability in Student-Written Reflection Assignments.

Dicken S, DeLeon N, Gutierrez EJ et al. · 2026 · American journal of pharmaceutical education

Objective To investigate whether generative artificial intelligence (genAI) can improve pharmacy assessment practices, specifically, rubric development, and the grading of student-written reflection assignments. Methods Sample…

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Negative / Null Result ReportMedicine

Purine Metabolism Alterations in Patients with Chronic Heart Failure: A Cross-Sectional Study of Associations with Iron Status, Oxidative Stress, and Anemia.

Konysbek Y, Turar A, Molotov-Luchanskiy VB et al. · 2026 · Metabolites

Background/Objectives : Anemia and iron dysregulation are common in chronic heart failure (CHF), but additional metabolic mechanisms may contribute to these alterations. This study aimed to evaluate purine metabolism and oxidative stress…

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Negative / Null Result ReportMedicine

Long-Term Outcomes After Percutaneous Coronary Intervention With the Polymer-Free Biolimus-Coated BioFreedom Stent Versus the Biodegradable-Polymer Sirolimus-Eluting Orsiro Stent in Patients With Acute Coronary Syndromes.

Noori M, Christiansen EH, Hougaard M et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background The polymer-free biolimus A9-coated BioFreedom stent (BF-BCS) releases a lipophilic drug that may provide a potent anti-inflammatory effect in patients with acute coronary syndromes (ACS). Five-year efficacy and safety of BF-BCS…

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Negative / Null Result ReportMedicine

Neural Correlates for Anticipating and Observing Goal-Directed Actions in Autism.

Krol MA, Skodova T, Jellema T · 2026 · Autism research : official journal of the International Society for Autism Research

We investigated possible atypicalities in activation of cortical motor-related circuits in young adults with Autism Spectrum Conditions (ASC) and typical-development (TD) when observing others' actions. Activation of these circuits is…

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Negative / Null Result ReportMedicine

Indoor discomfort from ground transportation traffic vibration and noise-Comparison between Vietnamese and Japanese young participants.

Tung NT, Matsumoto Y, Yokoshima S et al. · 2026 · The Journal of the Acoustical Society of America

This research investigated discomfort responses to combined whole-body vibration and noise in Vietnamese and Japanese participants. Twenty stimuli, comprising five vibration magnitudes and six noise levels induced by ground transportation…

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Negative / Null Result ReportMedicine

Comparison of obstetric, maternal, and neonatal outcomes between preterm prelabor rupture of membranes at 34 + 0-36 + 6 weeks and term prelabor rupture of membranes at ≥ 37 weeks.

Ay O, Bahçeci P, Taşkıran D et al. · 2026 · BMC pregnancy and childbirth

Background To compare preterm prelabor rupture of membranes (PPROM) at 34 + 0-36 + 6 weeks with term prelabor rupture of membranes at ≥ 37 weeks in terms of obstetric outcomes, maternal morbidity, and short-term neonatal outcomes. Methods…

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Negative / Null Result ReportMedicine

Comparative Investigation of Perceptions Between Adolescents with Idiopathic Scoliosis and Their Parents Regarding Body Image and Brace-Related Stress.

Xyda G, Bekas V, Kastrinis A et al. · 2026 · Studies in health technology and informatics

The conservative management of Adolescent Idiopathic Scoliosis (AIS) with rigid bracing imposes a significant psychological burden. This study investigated the convergence or divergence of views between female adolescents with AIS and…

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Negative / Null Result ReportMedicine

Ibandronate Use in Osteoporotic Vertebral Fractures: A Retrospective Clinical Study Integrated with Exploratory Network Pharmacology and Cross-Cohort Transcriptomic Analysis.

Albayrak M, Guner E, Ugur F et al. · 2026 · Biomedicines

Background: Ibandronate is a nitrogen-containing bisphosphonate used in osteoporosis; however, its relationship with vertebral-fracture-related outcomes, pain trajectories, and broader inflammatory-skeletal signaling remains incompletely…

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Negative / Null Result ReportMedicine

Assessment of fetal cardiac function using the modified myocardial performance index in fetuses with growth restriction: a prospective observational study.

Ates C, Karaaslan O · 2026 · BMC pregnancy and childbirth

Background Accurate differentiation between constitutionally small fetuses and those affected by true fetal growth restriction (FGR) remains a major clinical challenge, particularly in fetuses with estimated fetal weight between the 3rd…

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Negative / Null Result ReportMedicine

Interprofessional learning in diverse Middle Eastern maternity teams.

Mohan S, Reagu S, Lindow S et al. · 2026 · Journal of interprofessional care

This study aimed to assess a Middle Eastern maternity team's perceptions and attitudes toward interprofessional education (IPE), examine factors that may influence these perceptions, and consider their potential implications. Within…

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Negative / Null Result ReportMedicine

Complications following stock, customized, and extended total alloplastic temporomandibular joint replacement: a 10-year retrospective cohort study.

Rustemeyer J, Ponelis E, Sari-Rieger A · 2026 · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

Total alloplastic temporomandibular joint replacement (TMJ-AR) is an established treatment for end-stage temporomandibular joint disease; however, comparative data on different prosthesis designs remain limited. This retrospective 10-year…

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Negative / Null Result ReportMedicine

Rhythmic movements mimicking tremor under different metronome conditions.

Uzunçakmak-Uyanık H, Yıldız FG, Yalçın-Çakmaklı G et al. · 2026 · Scientific reports

Rhythmic movements mimicking tremor are commonly used as a control condition in tremor physiology studies, yet the influence of different metronome modalities on performance has not been systematically examined. We compared auditory,…

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Negative / Null Result ReportMedicine

MicroRNA Dysregulation and Hepatic Involvement in Alcohol-Related Macrocytic Anaemia: Links to Severity Without Predictive Value for Treatment Response.

Porr C, Vidrighin A, Ichim C et al. · 2026 · Life (Basel, Switzerland)

Background Alcohol-related macrocytic anemia remains insufficiently characterized, particularly regarding molecular correlates of disease severity and treatment response. We evaluated the hepatic, inflammatory and microRNA profile of…

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Negative / Null Result ReportMedicine

Epidural thickness of the dura sealants HEMOPATCH® and TACHOSIL® after elective supratentorial craniotomy: A comparative retrospective monocentric cohort study.

Rossmann J, Schicho A, Höhne J et al. · 2026 · Journal of biomaterials applications

This study compares the in vivo behavior (epidural thickness and complication rate including the development of cerebrospinal fluid fistula, CSF-fistula) of the newer dura sealant HEMOPATCH® (HP) with that of the well-established patch…

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Negative / Null Result ReportMedicine

Challenging the standard: comparison of outcomes between laparoscopically assisted anorectoplasty (LAARP) and posterior sagittal anorectoplasty (PSARP) in the correction of rectobulbar fistula in pediatric patients.

Carreño Sanchez MA, Ruiz J, Siffredi J et al. · 2026 · Pediatric surgery international

Background Posterior sagittal anorectoplasty (PSARP) remains the standard surgical approach for rectobulbar fistula in patients with anorectal malformations (ARM). Laparoscopically assisted anorectoplasty (LAARP) has emerged as an…

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Failed Experiment ReportOpen accessMedicine

Relationship Between the Size-Frequency Distribution of Nucleopolyhedrovirus Occlusion Bodies and Their Insecticidal Characteristics on <i>Spodoptera frugiperda</i> (Lepidoptera: Noctuidae).

Ángel-García C, Lasa R, López-Meza JE et al. · 2026 · Viruses

The Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV) is an important pathogen of the fall armyworm and is used as the basis for biological insecticides. In this study, we examined the relationship between the size-frequency…

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Negative / Null Result ReportMedicine

Effect of use of ambient listening technology on patient-reported communication and satisfaction ratings.

Taylor SL, Aizenberg D, Jost M et al. · 2026 · Journal of the American Medical Informatics Association : JAMIA

Objectives Evaluate the impact of ambient listening AI scribe technology for drafting notes on patient-reported communication and satisfaction ratings of their physician during ambulatory visits. Materials and methods We conducted a pilot…

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Negative / Null Result ReportMedicine

The Performance of Large Language Models on Antibiotic Prophylaxis for Endodontic Treatments.

Goker Kamali S, Imamoglu YT · 2026 · Australian endodontic journal : the journal of the Australian Society of Endodontology Inc

This study compared the accuracy and repeatability of responses generated by three advanced language models (ChatGPT-4, Gemini, and DeepSeek) in determining the necessity and appropriate regimen of antibiotic prophylaxis in endodontic…

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Negative / Null Result ReportMedicine

Masseter microvascular perfusion after minimally invasive sagittal split ramus osteotomy: A long-term split-mouth study.

Şahin M, Asan CY, Çukurluoğlu A et al. · 2026 · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

Sagittal split ramus osteotomy (SSRO), a widely used mandibular procedure in orthognathic surgery, may affect the masticatory muscles through subperiosteal dissection and soft-tissue manipulation. Although minimally invasive modifications…

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Negative / Null Result ReportMedicine

Clinical roles and workflow characteristics of the 3D 4K exoscope in brain tumor surgery: A single-center retrospective observational study.

Ogiwara T, Sato A, Wakabayashi M et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Background The three-dimensional (3D) 4K exoscope has emerged as a practical visualization platform in neurosurgery, offering high-resolution imaging together with ergonomic and workflow-related advantages. The aim of this study was to…

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