12,379 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Autio KJ, Koivisto H, Schmitz W et al. · 2024 · The Journal of nutritional biochemistry
Mitochondrial fatty acids synthesis (mtFAS) is a conserved metabolic pathway essential for mitochondrial respiration. The best characterized mtFAS product is the medium-chain fatty acid octanoate (C8) used as a substrate in the synthesis…
View details →Chinitz L, Böhm M, Evonich R 3rd et al. · 2024 · JACC. Clinical electrophysiology
Background The autonomic nervous system plays an important role in atrial fibrillation (AF) and hypertension. Renal denervation (RDN) lowers blood pressure (BP), but its role in AF is poorly understood. Objectives The purpose of this study…
View details →Navaneetha Krishnan S, Jaiswal A, Mohan A et al. · 2026 · Gut microbes
Increasing evidence implicates mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease (IBD), with the IBD-associated pathobiont adherent-invasive E. coli -LF82 (AIEC) promoting epithelial mitochondrial depolarization…
View details →Flores Ramos S, Fogelson KA, Muti VB et al. · 2026 · Journal of biological rhythms
Time-restricted feeding (TRF), a dietary intervention that consolidates food intake to specific hours of the day, ameliorates key metabolic risk factors for metabolic-associated steatohepatitis (MASH), including adiposity, insulin…
View details →Nikolaev MV, Fedorova IM, Chistyakova OV et al. · 2025 · International journal of molecular sciences
The search for novel compounds with anticonvulsant properties remains a key focus in neuropharmacology. Recently, the diazepine-benzimidazole derivative, DAB-19, has emerged as a promising candidate due to its demonstrated anxiolytic and…
View details →Aung T, Cheah JX · 2025 · Cureus
Livedoid vasculopathy (LV) is a rare, chronic occlusive dermopathy causing recurrent painful ulcerations, impaired healing, and significant morbidity. Historically considered a thrombotic microangiopathy, emerging evidence suggests an…
View details →Ayusso LL, Girol AP, Ribeiro Souza H et al. · 2024 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
We assessed in vivo the protective effects and underlying antioxidant and anti-inflammatory properties of dry green tee extract (GTE) on glomerular and tubular kidney function and structure in an experimental model of gentamicin…
View details →Matta G, Edwards A, Roelands B et al. · 2026 · Research quarterly for exercise and sport
The physiological and placebo effects of beetroot juice remain unclear in settings outside traditional laboratory environments. Using a randomized, between-participant balanced placebo design, we asked 67 trained cyclists to complete…
View details →Pokhrel P, Phillips KT, Phillips MM et al. · 2026 · Addiction (Abingdon, England)
Background and aims Co-use of cannabis and e-cigarettes for nicotine is increasing among younger adults in the United States (US). This study aimed to determine (1) the patterns of cannabis and e-cigarette use and co-use over time and (2)…
View details →Fiebig N, Bartsch L, Klötzer C et al. · 2026 · Headache
Objective To evaluate the effects of a short, structured multimodal day-clinic program on health-related quality of life and disability in patients with primary headache disorders. Background Although monoclonal antibodies targeting the…
View details →Jean J, Klein JI, Karashchuk N et al. · 2026 · Headache
Objective To determine if there is increased headache burden and disability among women with and without migraine during an in vitro fertilization (IVF) cycle. Background Migraine and infertility commonly impact women of childbearing age.…
View details →Arko L, Nguyen TH, Stoffel M et al. · 2026 · AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
Documentation burden and cognitive load contribute to clinician burnout, and ambient AI scribes offer a promising solution, though real-world evaluations remain limited. This study evaluated the impact of an ambient AI scribe on…
View details →Gambale C, Faranda A, Ambrogio A et al. · 2026 · European journal of endocrinology
Objective Several patients with medullary thyroid carcinoma (MTC) are not cured after surgery. Disease persistence/recurrence is monitored by measuring calcitonin (CTN) and carcinoembryonic antigen (CEA) and by imaging. The role of…
View details →Zhang W, Guh DP, Tam ACT et al. · 2026 · Health affairs scholar
Introduction Evidence on the launch and diffusion of therapeutically important new medicines is limited. We examined the launch and diffusion of new patented medicines in 14 countries by therapeutic value. Methods We analyzed IQVIA MIDAS®…
View details →Xiao J, Choi HM, Yim G et al. · 2026 · American journal of epidemiology
Epidemiological evidence on whether cesarean delivery influences offspring neurodevelopment remains inconsistent. We evaluated the associations between maternal cesarean delivery and childhood autism spectrum disorder (ASD) and…
View details →Bilici N, Paruzel-Czachura M, Workman CI et al. · 2026 · BMC psychology
Facial anomalies, such as scars, are often linked to an "anomalous-is-bad" stereotype, in which people with visible differences are seen as less warm or less moral. We developed the "Normalizing Anomalies with Mobile Exposure" (NAME)…
View details →Akimoto Y, Itagaki T, Takashima T et al. · 2026 · Respiratory care
Background High-flow nasal cannula (HFNC) is commonly used for acute hypoxemic respiratory failure and for subjects at risk of postextubation failure. HFNC reduces inspiratory work, but its effects on expiratory muscle activity, including…
View details →Tschoner T, Mueller KR, Zablotski Y et al. · 2026 · The Veterinary record
Background Cattle only show subtle signs of pain, making pain assessment difficult. The approach to pain and the use of analgesics depend on the treating person's experience and opinions. Methods Bavarian veterinary students were asked to…
View details →Fiszdon JM, Wang K, Fulford D et al. · 2026 · Journal of the International Neuropsychological Society : JINS
Objectives Poor social function in people with psychosis has been linked to impairments in social cognition and neurocognition, which in turn have been identified as promising treatment targets. We developed a novel social cognitive…
View details →Liu N, Zhao J, Wu B et al. · 2026 · International ophthalmology
Purpose To evaluate the changes in corneal astigmatism, axial length and anterior chamber depth following vitrectomy versus phacovitrectomy in patients with rhegmatogenous retinal detachment (RRD) under more detail group.To discuss how to…
View details →Mitzner TL, Remillard ET, Mumma KT et al. · 2026 · Healthcare (Basel, Switzerland)
Background/Objectives : Telewellness programs can expand access to exercise and social opportunities for older adults, especially those with mobility disabilities. The TechSAge Tele Tai Chi clinical trial assessed whether the Tai Chi for…
View details →Terao R, Yashiro K, Kuriyama T et al. · 2026 · BMC ophthalmology
Background This study is aimed to evaluate retinal pigment epithelium (RPE) entropy in eyes with full-thickness macular hole (FTMH) using polarization-sensitive optical coherence tomography (PS-OCT). Methods Patients diagnosed with…
View details →Kerr S, Minatoguchi S, Dumitriu Carcoana AO et al. · 2026 · Cardiovascular intervention and therapeutics
This study evaluated the serial anatomical and morphological changes in de novo coronary lesions treated with a drug-coated balloon (DCB) using integrated-backscatter intravascular ultrasound (IB-IVUS). The aim of this study was to…
View details →Kotenko O, Kozlovskaya N, Emirova K et al. · 2026 · Nephron
Background The objective of a multicentre, prospective, observational study of an eculizumab biosimilar (Elizaria®) was to analyse the efficacy and safety of long-term complement inhibitor therapy in patients with atypical haemolytic…
View details →Joswig H, Oreizi-Esfahani S, Medack S et al. · 2026 · World neurosurgery
Background Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, resulting in motor and nonmotor symptoms including diminished sleep quality and altered dream…
View details →Raza GS, Jokelainen J, Stenbäck V et al. · 2026 · PloS one
Physical activity (PA) has numerous positive health effects, including improvements in cognitive function. PA stimulates the release of glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) from the liver, resulting in hippocampal…
View details →Esen Öksüzoğlu M, Kabukçu HO · 2026 · BMC psychiatry
Background Sleep terror (ST) is a common NREM parasomnia in early childhood and may be associated with broader emotional and behavioral dysregulation. However, its links with psychopathological symptoms and nutritional biomarkers remain…
View details →Tcherner S, Durom E, Peters J et al. · 2026 · COPD
In patients with moderate-to-severe COPD, airway mucus-occlusions correlate with airflow limitation, exacerbation and mortality-risk. However, the clinical relevance of mucus-plugs in milder COPD is not well-understood. We evaluated…
View details →Huang F, Chen K · 2026 · Human factors
ObjectiveThis study investigated how affective characteristics of interruptions (valence and arousal) influence task resumptions and post-interruption performance in younger and middle-aged/older adults under different task…
View details →Steen AV, Simmering JA, Perik M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology
Objective To determine the anatomical effect of pessaries in the upright position in women with pelvic organ prolapse (POP). Design Prospective observational cohort study. Setting Outpatient clinic of our gynaecology department. Population…
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