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Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Boric acid Attenuates premature ovarian insufficiency by Modulating oxidative stress in a Cyclophosphamide-Induced rat model.

Ozcakar TG, Kender Erturk N, Onguncan O et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Aim This study aimed to investigate whether boric acid (BA) exerts potential protective effects against cyclophosphamide (CYC)-induced premature ovarian insufficiency (POI) in rats through modulation of oxidative stress and preservation of…

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Negative / Null Result ReportMedicine

Effect of a goal-directed sedation nursing intervention bundle on comfort and compliance in children undergoing bronchoalveolar lavage under topical anesthesia with procedural sedation: a randomized controlled trial.

Luo X, Zhang H · 2026 · Frontiers in medicine

Objective To assess the impacts of goal-directed sedation nursing intervention on comfort and compliance in children undergoing bronchoalveolar lavage (BAL) under topical anesthesia with procedural sedation. Methods A total of 168 children…

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Negative / Null Result ReportMedicine

Comparison of Dacryoendoscopy-Aided Silicone Tube Intubation and Endoscopic Dacryocystorhinostomy for Complete Nasolacrimal Duct Obstruction.

Yoon Y, Yoon JS, Ko J · 2026 · Korean journal of ophthalmology : KJO

Purpose To compare the surgical outcomes of dacryoendoscopy-aided silicone tube intubation (STI) and endoscopic dacryocystorhinostomy (endo-DCR) for complete nasolacrimal duct obstruction (NLDO), and to identify factors associated with…

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Negative / Null Result ReportMedicine

Visual and refractive outcomes of small incision lenticule extraction planned with a VISULYZE-generated nomogram for myopia and astigmatism: a retrospective comparative study.

Lin Y, Wei X, Su H et al. · 2026 · BMC ophthalmology

Purpose Small-incision lenticule extraction (SMILE) is a widely used procedure for correcting myopia and myopic astigmatism. However, variability in refractive outcomes, particularly astigmatic correction, remains a concern. This study…

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Negative / Null Result ReportMedicine

Fibular allograft augmentation shows potential benefits in treating medial column comminuted proximal humeral fractures with osteoporosis: a secondary analysis of a randomized controlled trial.

Chai Y, Shi T, Jiang H et al. · 2026 · Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology

Background Fibular allograft (FA) augmentation is proposed to address the lack of medial column support in plate-fixed proximal humeral fractures; however, the role of FA augmentation in these fractures remains inadequately elucidated. Our…

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Negative / Null Result ReportMedicine

A community-based exercise intervention to reduce functional risk factors for injury among stroke survivors in South Korea: a pilot randomized controlled trial.

Kang D, Eun SD, Park J · 2026 · Scientific reports

Stroke survivors living in the community often experience persistent impairments in muscle strength, balance, mobility, and cardiorespiratory fitness after hospital discharge, which increase vulnerability during daily activities. This…

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Negative / Null Result ReportMedicine

Real-world predictors of severe chemotherapy-induced neutropenia in non-Hodgkin lymphoma: Evaluation of biosimilar and reference rituximab.

Andriyanto DB, Syafhan NF, Nurhayati F · 2026 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

BackgroundThe adoption of rituximab biosimilars offers a cost-effective alternative for treating Non-Hodgkin Lymphoma (NHL). However, real-world safety data regarding severe hematological toxicities in the Indonesian clinical setting…

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Negative / Null Result ReportMedicine

Three-year results of a prospective, controlled clinical study evaluating treatment of intra-bony defects with PRF or EMD- a randomized control trial.

Dőri F, Németh F, Arweiler N et al. · 2026 · BMC oral health

Background Periodontal regenerative surgery is a well-established treatment modality for intrabony periodontal defects. Enamel matrix derivative (EMD) is one of the most extensively documented biologic agents, whereas platelet-rich fibrin…

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Negative / Null Result ReportMedicine

Combined anterior cruciate ligament and anterolateral ligament reconstruction using an adjustable-loop device provides similar short-term clinical outcomes compared with isolated reconstruction.

Jaramillo Quiceno GA, Sarmiento Riveros PA, Arias Perez RD et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction/objectives Residual rotational laxity remains a relevant clinical concern after anterior cruciate ligament (ACL) reconstruction. Combined ACL and anterolateral ligament (ALL) reconstruction has been proposed to improve control…

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Negative / Null Result ReportMedicine

Avoiding the Umbilical Incision in Obese Patients Undergoing Laparoscopic Cholecystectomy: A Retrospective Cohort Study of Wound-Related Outcomes.

Uesato Y, Inamine S · 2026 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background The umbilical port is routinely used for camera insertion and specimen retrieval in laparoscopic cholecystectomy (LC). However, the umbilicus is anatomically vulnerable and may be associated with an increased risk of surgical…

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Negative / Null Result ReportMedicine

Comparative Efficacy of Subcutaneous and Sublingual Allergen Immunotherapy for Grass Pollen-Induced Allergic Rhinoconjunctivitis: Pairwise and Adjusted Indirect Treatment Comparison of Standardized ALK Products.

Di Lorenzo G, Melluso M, Rodolico A et al. · 2026 · The journal of allergy and clinical immunology. In practice

Background Allergen immunotherapy (AIT) is the only disease-modifying treatment for grass pollen-induced allergic rhinoconjunctivitis (ARC). Three delivery routes-subcutaneous (SCIT), sublingual drops (SLIT-D), and sublingual tablets…

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Negative / Null Result ReportMedicine

Documented Use of Piperacillin-Tazobactam and Increased 1-Month Mortality in Healthcare-Associated Intra-Abdominal Infections.

Baulier C, Zappella N, Grall N et al. · 2026 · Anaesthesia, critical care & pain medicine

Background Recent studies have increasingly questioned the efficacy and safety of piperacillin-tazobactam (TZP) in septic patients, particularly those with healthcare-associated intra-abdominal infections (hcIAI). This study assessed…

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Negative / Null Result ReportMedicine

Evaluation of Structural and Functional Outcomes After the Application of an Initial Single Dose of Faricimab.

Ariza-Torrado IP, Groman-Lupa S, Martínez-Córdoba CJ et al. · 2026 · Journal of vitreoretinal diseases

Purpose: To evaluate functional and structural outcomes after application of a single intravitreal dose of faricimab in patients with chronic retinal diseases. Methods: In this observational, longitudinal, prospective study, best-corrected…

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Negative / Null Result ReportOpen accessMedicine

Does Maternal Smoking Increase the Risk of Congenital Heart Disease? Insights from a Single-Center Fetal Echocardiography Study.

Kavgacı A, Kaya Ö, Örün UA et al. · 2026 · Journal of clinical medicine

Background : Congenital heart disease (CHD) represents a major cause of perinatal morbidity and mortality, and fetal echocardiography is essential for its early diagnosis and management. Maternal smoking has been suggested as a potential…

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