12,246 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Stitt GA, Hall MW, Diliberto MA et al. · 2025 · The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Objectives Primary objective: to quantify tocilizumab (TCZ) use in pediatric inpatients. Secondary objectives: to explore safety and clinical outcomes. Methods This retrospective cohort study took place in a free-standing, 564-bed…
View details →Kern DM, Bohn J, Maher MP et al. · 2026 · BMJ open
Objective To use best practices in pharmacoepidemiology to assess the association between new use of brain-penetrant calcium channel blockers (BP-CCBs) compared with use of non-brain-penetrant CCBs (NP-CCBs) and the incidence of…
View details →Deodato M, Melcher D · 2024 · Journal of cognitive neuroscience
The brain organizes the continuous flow of sensory input by parsing it into discrete events. In the case of two flashes separated by a brief ISI, for example, perception may be of a single flash or two distinct flashes, depending on the…
View details →Ambasta A, Grenet G, Otte J et al. · 2025 · African journal of primary health care & family medicine
Thyroid hormones regulate essential metabolic processes and development. The hypothalamic-pituitary-thyroid axis regulates hormone production, with thyroid-stimulating hormone (TSH) levels being a key indicator of thyroid function in…
View details →Neul JL · 2024 · The Journal of clinical investigation
Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and the single-gene cause of autism, is caused by decreased expression of the fragile X messenger ribonucleoprotein protein (FMRP), a ribosomal-associated…
View details →Sagadiev S, Hudson R Jr, Wang Y et al. · 2026 · Genetics
Integrin adhesion complexes (IACs) are a network of proteins that anchor cells to the extracellular matrix. In Caenorhabditis elegans muscle IACs exist at the bases of dense bodies and M-lines, and at the boundaries of adjacent muscle…
View details →Maeda Y, Akino S, Kondo N · 2026 · Microbes and environments
Fusarium crown and root rot (FCRR), caused by the fungus Fusarium oxysporum f. sp. asparagi, is one of the most destructive diseases affecting asparagus worldwide. Despite evidence of the suppression of FCRR by several nonpathogenic F.…
View details →Vicario-Feliciano R, Zil-E-Ali A, Aziz F · 2025 · Annals of vascular surgery
Introduction Predictors of sac behavior after endovascular aortic aneurysm repair (EVAR) and the impact of sac behavior on long-term survival are not well known. There are limited multicenter trials studying the impact of beta blockers…
View details →Maines E, Franceschi R, Candia FD et al. · 2025 · Diabetes/metabolism research and reviews
Definitive prevention for type 1 diabetes (T1D) is not yet available, but we are now entering a new era where disease-modifying therapies are becoming available in T1D to halt disease progression. In this review, we present up-to-date…
View details →Yang L, Zhuo S, Zhu X et al. · 2025 · Frontiers in endocrinology
Introduction Nonalcoholic steatohepatitis (NASH), characterized by progressive liver injury, inflammation, and fibrosis, is a leading chronic liver disease worldwide. Pharmacotherapy for NASH is thus urgently needed. Through a strategy of…
View details →Reboul A, Claidière N, Dautriche I et al. · 2025 · PloS one
This study investigates whether baboons are capable of semantic compositionality, specifically, whether they can apply compositional rules to new situations (generalization). In language, semantic compositionality is linked to…
View details →Zadrożniak M, Biskupski M, Szymański M et al. · 2025 · Antioxidants (Basel, Switzerland)
(1) Aminoglycosides remain indispensable in modern medicine but share a serious dose-limiting adverse effect: irreversible cochleovestibular ototoxicity. (2) This scoping review systematically maps experimental and clinical strategies…
View details →El Gazar SM, El Backly RN, Lotfy WA et al. · 2026 · BMC oral health
Aim To evaluate the antimicrobial effects of Nd: YAG laser irradiation, antimicrobial photodynamic therapy (aPDT), and passive ultrasonic irrigation (PUI) in comparison with conventional irrigation with Sodium hypochlorite (NaOCl) in root…
View details →Hatch-McChesney A, Whitney CC, Richardson M et al. · 2024 · Appetite
Consuming enough energy to meet high energy demands can be challenging for military personnel wherein logistical constraints limit food availability. Increasing dietary energy density (ED) and/or volume density (VD) of rations may be…
View details →Moubayed NMS, Alsabbagh R, Smiline GAS et al. · 2025 · Natural product research
Plants contain many bioactive compounds with potent antibacterial and efflux pump inhibitory activity (EPI). In this study, gallic acid extracted from pomegranate molasses by analytical HPLC holds promise as an EPI drug for Staphylococcus…
View details →Bi W, Li J, Xiong M et al. · 2024 · Genetic testing and molecular biomarkers
Objective: The purpose of this study was to evaluate the association between the single nucleotide polymorphisms (SNPs) ( EGR3 rs1996147; EGR4 rs3813226, rs6747506; ERBB3 rs2292238; and ERBB4 rs707284, rs7560730) and the risk of…
View details →Kong G, Aberkane C, Desoche C et al. · 2024 · Journal of experimental psychology. Human perception and performance
Intentional binding refers to the subjective temporal compression between a voluntary action and its subsequent sensory outcome. Despite some studies challenging the link between temporal compression and intentional action, intentional…
View details →Baker JF · 2026 · Hip & pelvis
Purpose Surgeons are both interested in the relationship between spinopelvic parameters and acetabular orientation since concomitant diseases of the spine and hip are common. Spondylolysis of L5 is common in 4% to 8% of the population. L5…
View details →Könemann H, Güler-Eren S, Ellermann C et al. · 2024 · Current heart failure reports
Purpose of review Arrhythmias are common in patients with heart failure (HF) and are associated with a significant risk of mortality and morbidity. Optimal antiarrhythmic treatment is therefore essential. Here, we review current approaches…
View details →Zafarani F, Soleimani Mehranjani M, Ghaffari F et al. · 2024 · International journal of fertility & sterility
Background This study aimed to determine the alteration of endometrial expression levels of HOXA9/HOXA10/ HOXA11/HOXD10 genes and HOX transcript antisense intergenic RNA (HOTAIR) in mid-luteal phase endometrium in patients with…
View details →Gandhi A, Parhizgar A · 2025 · Frontiers in endocrinology
Initially developed for type 2 diabetes and obesity, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are now emerging as promising candidates for modifying the course of neurodegenerative diseases. This potential stems from the…
View details →Aragón-Sánchez J, Víquez-Molina G, López-Valverde ME et al. · 2023 · Diabetic medicine : a journal of the British Diabetic Association
Aims We hypothesize that microbiology- and pathology-confirmed positive bone margins after the resection of diabetes-related foot osteomyelitis are associated with worse outcomes. Methods We conducted a prospective study consisting of a…
View details →Ahmed N, Russo L, Kuo YH · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives To compare levetiracetam and phenytoin as prophylaxis for the short-term development of status epilepticus (SE) during care of pediatric patients with acute severe traumatic brain injury (TBI). Design Nonprespecified secondary…
View details →Shefner JM, Cudkowicz ME, Genge A et al. · 2025 · JAMA neurology
Importance Treatment options for amyotrophic lateral sclerosis (ALS) remain suboptimal. Results from a phase 2 study of reldesemtiv in ALS suggested that it may slow disease progression. Objective To assess the effect of reldesemtiv vs…
View details →Apivatgaroon A, Sukkarnkosol S, Pukrittayakamee NC et al. · 2025 · JSES international
Background Suspension stabilization is a commonly used surgical method for acute acromioclavicular (AC) joint dislocation. However, a failure rate of around 26% caused various emerging surgical techniques and recommendations. We aimed to…
View details →Rannikko EH, Pajula S, Suominen SH et al. · 2025 · Plastic and reconstructive surgery
Background Breast cancer-related lymphedema is a common complication lacking medical treatment. Lymfactin is an adenovirus type 5-based gene therapy and prolymphangiogenic growth factor vector that induces vascular endothelial growth…
View details →Kim S, Shin MJ, Krauss RM · 2025 · Current atherosclerosis reports
Purpose of review This paper reviews the effects of major macronutrients and specific dietary interventions on atherogenic dyslipidemia, a common trait characterized by increased concentrations of triglyceride-rich and small, dense LDL…
View details →Cavalcante FP, Cardoso A, Antonini M et al. · 2025 · Translational breast cancer research : a journal focusing on translational research in breast cancer
Background Neoadjuvant chemotherapy (NAC) is widely accepted as standard treatment in breast cancer, particularly in cases of tumors with aggressive biology. NAC has increased the rates of breast-conserving surgery (BCS) and the conversion…
View details →Díaz de Terán T, Bolado J, Palomo P et al. · 2025 · Sleep & breathing = Schlaf & Atmung
Objective To assess the effectiveness of an intervention programme combining Oropharyngeal Myofunctional Therapy (OMT) and cervical spine exercises in the general population with mild to moderate Obstructive Sleep Apnoea (OSA), analysing…
View details →Shamsi F, Aligholi H, Karimi MT et al. · 2024 · Journal of motor behavior
The current study aimed to evaluate the effects of action observation on the walking ability and oscillatory brain activity of chronic stroke patients. Fourteen chronic stroke patients were allocated randomly to the action observation (AO)…
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