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WASTE Journal

Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Association of Driver Oncogenic Alterations with SUVmax, Preoperative Serum Calcium, and Smoking Status in Surgically Resected Non-Small-Cell Lung Cancer: A Retrospective Single-Center Study.

Korodimos N, Wojtyś ME, Kostopanagiotou K et al. · 2026 · Journal of clinical medicine

Background: Non-small-cell lung cancer (NSCLC) is driven by distinct oncogenic alterations with important therapeutic and prognostic implications. Noninvasive biomarkers that predict molecular status in surgically resectable disease may…

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Negative / Null Result ReportOpen accessMedicine

Impact of oral health education program in children suffering from attention deficit hyperactivity disorder: A cross-sectional study.

Mahajan A, Haideri S, Kumar VVH et al. · 2026 · Journal of education and health promotion

Background The oral health is an integral part of general well-being in children suffering from attention deficit hyperactivity disorder (ADHD). The present study aimed to analyze the impact of oral health education program on children…

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Negative / Null Result ReportMedicine

Delayed initiation of GnRH antagonist in PCOS patients undergoing IVF: a retrospective cohort study of premature ovulation and embryological outcomes.

Peker N, Yücetürk A, Tığlı E et al. · 2026 · Journal of ovarian research

Background We aimed to evaluate whether delayed initiation of gonadotropin hormone-releasing hormone (GnRH) antagonist treatment affects premature ovulation and the number of good-quality blastocysts. We retrospectively reviewed the…

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Negative / Null Result ReportOpen accessMedicine

The Gut-Disc Axis: Mendelian Randomization Study Reveals Causal Effects of Gut Microbiota on Intervertebral Disc Degeneration Not Mediated by Systemic Inflammation.

Yan Z, Jiang Q, Lu Z et al. · 2026 · International journal of general medicine

Background Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Observational studies suggest a link with gut microbiota (GM), possibly mediated by systemic inflammation, but causality remains unclear. Objective To…

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Negative / Null Result ReportOpen accessMedicine

Digestive Tract Cancer: A Retrospective Study of the Epidemiological Profile of Populations Exposed and Not Exposed to Uranium Contamination in North Kazakhstan (2014-2023).

Ilbekova K, Ibrayeva D, Saifulina E et al. · 2026 · Journal of clinical medicine

Background/Objectives : Cancer incidence and mortality are key epidemiological indicators for evaluating the long-term biological effects of chronic low-dose radiation exposure. The aim of this study was to assess the incidence, structure,…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of Interexaminer Reliability in Visual Shade Matching: A Comparative Analysis of Optilume Trueshade and Conventional Lighting for Permanent Anterior Teeth.

Alkhalifah OF, Ali Shah S, Tareen SUK et al. · 2026 · Cureus

Background Achieving a lifelike color match for anterior restorations is a persistent challenge because tooth appearance is heavily influenced by illumination and observer-dependent choices. While visual matching with VITA-type guides…

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Negative / Null Result ReportOpen accessMedicine

A Phase II Study of FOLFIRI Plus Ziv-Aflibercept After Trifluridine/Tipiracil Plus Bevacizumab in Patients with Metastatic Colorectal Cancer: WJOG 11018G.

Matsumoto T, Yamamoto Y, Kotaka M et al. · 2024 · Targeted oncology

Background Non-inferiority of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) to irinotecan/fluoropyrimidine plus BEV in metastatic colorectal cancer was investigated in the phase III TRUSTY study, and we conducted a phase II study…

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Negative / Null Result ReportMedicine

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.

Webers C, Ortolan A, Sepriano A et al. · 2023 · Annals of the rheumatic diseases

Objective To update the evidence on efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in patients with axial spondyloarthritis (axSpA) to inform the 2022 update of the Assessment of SpondyloArthritis…

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Negative / Null Result ReportOpen accessMedicine

Perioperative immunotherapy combined with standard therapy for human epidermal growth factor receptor 2-positive locally advanced gastric cancer: A case report.

Ma XT, Yao GY, Li JL et al. · 2025 · World journal of clinical oncology

Background Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) represents a distinct molecular cancer subtype that is often associated with a poor prognosis. While perioperative chemotherapy regimens are currently…

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Negative / Null Result ReportMedicine

Decreased evertor strength following peroneus longus tendon harvest for anterior cruciate ligament reconstruction : an isokinetic muscle strength testing study.

Kotian RN, Ajoy SM, Panduranga R et al. · 2026 · The bone & joint journal

Aims There are conflicting results in the literature regarding the safety of the peroneus longus tendon (PLT) as a potential graft for anterior cruciate ligament (ACL) reconstruction, and no long-term studies with objective assessment…

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Negative / Null Result ReportOpen accessMedicine

Predictive Factors of Functional Prognosis in Patients with Rhegmatogenous Retinal Detachment Treated by Pars Plana Vitrectomy-A Retrospective Study.

Chereji G, Chelaru VF, Nicoară SD · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Rhegmatogenous retinal detachment (RRD) is a surgical emergency that causes vision loss if not properly treated. Pars plana vitrectomy (PPV) is the preferred procedure for most complex RRD cases, with a high success…

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Negative / Null Result ReportOpen accessMedicine

Genetically predicted TTK inhibition and its association with reduced breast cancer risk: a two-step Mendelian randomization study of potential gut microbiome mediation.

Liu J, Liu M, Xu Y et al. · 2026 · Clinics (Sao Paulo, Brazil)

Background BOS172722, a selective TTK inhibitor, shows promise for Breast Cancer (BC) treatment. The role of gut microbiota as a potential mediator in this process has not been established. This Mendelian Randomization (MR) study…

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Negative / Null Result ReportMedicine

Effects of different hyrax maxillary expansion protocols compared with novel magnetic expansion on the pharyngeal airway and maxillary sinus spaces: A retrospective CBCT-based observational study.

Algahefi AL, Alhammadi MS, Li Z et al. · 2026 · American journal of otolaryngology

Purpose To evaluate three-dimensional changes in the maxillary sinus (MS) and pharyngeal airway space (PAS) following rapid (RME), slow (SME), and magnetic maxillary expansion (MME) using cone-beam computed tomography (CBCT). Methods This…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Lower Limb Muscle Strength Imbalances and Gait Performance in Postmenopausal Women with Healthy and Low Bone Mineral Density.

Svobodová L, Kasović M, Vodicka T et al. · 2026 · International journal of women's health

Introduction Osteoporosis and osteopenia increase the risk of fractures, impair physical function, and may lead to loss of independence in postmenopausal women. This study examined differences in muscle strength imbalances and gait…

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Negative / Null Result ReportOpen accessMedicine

Effect of Two Post-Curing Units on the Physico-Mechanical Properties of 3D-Printed Resins for Permanent Crown Fabrication.

Mujayridi M, Matinlinna J, Silikas N · 2026 · Materials (Basel, Switzerland)

Three-dimensional (3D) printing is increasingly used for the fabrication of definitive crowns; however, whether specific post-curing hardware is mandatory for clinical success remains a practical concern. This study provided a practical…

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Negative / Null Result ReportMedicine

Effect of oral health education by audio aids, braille, tactile models on the oral health status of visually impaired adults: a 6-month follow-up study.

Yıldırım D, Zorluoğlu SL, Navruz ES et al. · 2026 · BMC oral health

Background Oral and dental health education is typically delivered using visual methods on jaw models. However, these methods are insufficient for individuals with visual impairments. This study aims to contribute to the oral and dental…

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Negative / Null Result ReportOpen accessMedicine

Focus on comfort: the effect of focus language on postoperative hospital stay compared to the Numeric Rating Scale in children receiving postoperative care-a pre-post study.

Angenent A, Maaskant JM, Nieland L et al. · 2026 · European journal of pediatrics

This study evaluates the effect of a comfort assessment using focus language compared with pain assessment using the Numeric Rating Scale (NRS) on postoperative length of stay (LOS), analgesic use and patient and parental satisfaction.…

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