12,246 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Abdalla M · 2026 · Frontiers in medicine
Background Hormone replacement therapy (HRT) is widely prescribed for managing menopausal symptoms, yet its effects on the endometrium remain clinically important. While large-scale studies have established that estrogen-only HRT increases…
View details →O'Brien EA, Wypij D, Rofeberg V et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association
Objective Investigate the association between placental vascular abnormalities and regional brain volumes in congenital heart disease (CHD) fetuses with and without genetic abnormalities. Study design Secondary analysis of brain magnetic…
View details →Rosa R, Rosello G, Manzanillo K et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE
Following the implementation of in-house Candidozyma auris ( C. auris ) polymerase chain reaction as part of our surveillance strategy, we observed increasing incidence rates of colonization with C. auris already present at hospital…
View details →Carabas BA, Țǎpoi DA, Costache M · 2026 · Diagnostics (Basel, Switzerland)
Background: Neoadjuvant chemotherapy (NAC) is widely used in the management of stage I-III breast cancer, with tumor regression serving as an important surrogate for long-term outcome. Identifying reliable pathological biomarkers…
View details →Lee CC, Miller AA, Tallman PS et al. · 2025 · American journal of human biology : the official journal of the Human Biology Council
Helicobacter pylori (H. pylori) is a bacterium that infects the stomach and is associated with various gastrointestinal outcomes and increased cardiovascular disease risk. We examined the role of sex in and the social and ecological…
View details →Kozłowski K, Konończuk K, Muszyńska-Rosłan K et al. · 2024 · Journal of clinical medicine
Background/Objectives: The survival rate among pediatric cancer patients has reached 80%; however, these childhood cancer survivors (CCSs) are at a heightened risk of developing chronic conditions in adulthood, particularly kidney and…
View details →Ji S, Park SJ, Lee JY et al. · 2023 · Experimental gerontology
Myonectin is a muscle-secreted factor that helps maintain homeostasis in the body by regulating several functions, including lipid metabolism. Previous studies suggested that myonectin may play a role in muscle health in an autocrine…
View details →Agarwal Y, Metgudmath A, Metgudmath V · 2026 · Cureus
Aim To evaluate the association of mean platelet volume (MPV) and immature platelet fraction (IPF) with coronary angiographic severity, categorised by the number of significantly diseased epicardial vessels (single, double or triple vessel…
View details →Akbar Z, Fituri S, Shi Z et al. · 2025 · Diseases (Basel, Switzerland)
Background Evidence linking dietary fiber intake with cancer risk and mortality is equivocal. Objective We investigated the relationship between dietary fiber intake and all-cause, cancer, and cardiovascular disease (CVD) mortalities in US…
View details →Djordjevic N, Todorovic A, Sazdanovic P et al. · 2025 · Biomedicines
Objectives : Chlamydia trachomatis (CT) infection affects female fertility. The purpose of our study was to assess the association between serological and follicular fluid markers of CT infection and in vitro fertilization (IVF) success.…
View details →Kyriakidis I, Pelagiadis I, Martimianaki G et al. · 2026 · Cureus
Background Neuroblastoma (NB) is the most common extracranial solid tumor in children, but the inherited factors influencing susceptibility are not fully understood. Given the link between defective microRNA biogenesis and aggressive NB,…
View details →Bonardi CM, Nosadini M, Lorenzoni G et al. · 2024 · Clinical pediatrics
Appropriate status epilepticus (SE) management is key to minimize admission to the pediatric intensive care unit (PICU). We retrospectively describe 115 children admitted to the PICU of the tertiary-care referral hospital of Padova for…
View details →Errigo A, Dore MP, Mocci G et al. · 2024 · Scientific reports
More than two decades ago, in the central-eastern region of the Mediterranean island of Sardinia, a mountain area was identified where the population displays exceptional longevity, especially among men (the Longevity Blue Zone, LBZ). This…
View details →Feld RS, Ianiero MA, Goncharow MK et al. · 2026 · Current developments in nutrition
Background Menopause is associated with increases in visceral adipose tissue, reductions in lean mass, and a reduced energy expenditure. The ovariectomized (OVX) rat model can be used to model these changes and to test potential…
View details →van der Stouwe AMM · 2024 · Brain communications
This scientific commentary refers to 'Deep brain stimulation does not modulate resting-state functional connectivity in essential tremor', by Awad et al. (https://doi.org/10.1093/braincomms/fcae012).
View details →Fukuda R, Hashimoto R, Pak K et al. · 2026 · Health science reports
Background and aims Atopic dermatitis (AD) is characterized by impaired skin barrier function and reduced moisturizing factors. Moisturizers and emollients restore the barrier through distinct mechanisms, but their longitudinal molecular…
View details →Pimenta GF, Dourado TMH, de Souza KDB et al. · 2025 · Cell biochemistry and function
Increased oxidative stress and apoptosis are key mechanisms of thymic atrophy induced by cyclophosphamide (CYP). Atrophy leads to changes in the thymic microenvironment and disrupts T cell maturation. The hormone melatonin displays…
View details →Vasilev V, Georgieva K, Arabadzhiyska D et al. · 2025 · Naunyn-Schmiedeberg's archives of pharmacology
Selective androgen receptor modulators are currently not approved but are widely used in gyms. In the present study, the effects of ligandrol and its combination with endurance training on functional and clinically important parameters…
View details →Makhlin I, Demissei BG, D'Agostino R et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Preventing Anthracycline Cardiovascular Toxicity with Statins (PREVENT; NCT01988571) randomized patients with breast cancer or lymphoma receiving anthracyclines to atorvastatin 40 mg daily or placebo. We evaluated the effects of…
View details →Teipel S, Tang Y, Khachaturian A · 2025 · Alzheimer's & dementia (New York, N. Y.)
Introduction We aimed to determine the clinical efficacy of treating apolipoprotein E (ApoE) ε4 homozygotes with recently approved anti-amyloid antibodies. Methods Data were derived from supplementary analyses in the regulatory studies…
View details →Haggarty CJ, Glazer JE, Nusslock R et al. · 2024 · Psychopharmacology
Introduction Stimulant drugs are thought to alter processing of rewarding stimuli. However, the mechanisms by which they do this are not fully understood. Method In this study we used EEG to assess effects of single doses of…
View details →Girişgen İ, Altıncık SA, Avcı E et al. · 2025 · Journal of clinical research in pediatric endocrinology
Objective To compare serum mitochondrial open reading frame of 12S rRNA-c (MOTS-c) levels, a new potential biomarker for oxidative stress, in children with type 1 diabetes mellitus (T1DM) and healthy children. A further aim was to…
View details →Tristani-Firouzi B, Pappas L, Joseph M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology
Objective Maternal genotypes may be useful to customise foetal growth assessment, but generalisability across diverse racial and ancestral groups remains uncertain. We assessed the generalisability of a genetic risk score for birth weight…
View details →Posada-López A, Duque JD, Pineda-Tamayo RA et al. · 2023 · Reumatologia clinica
Background and objective Periodontitis and rheumatoid arthritis (RA) have been associated in a bidirectional way. The objective of this study was to determine the association between clinical parameters of periodontitis and RA. Materials…
View details →Zhang X, Goldberg SB, Baldwin SA et al. · 2025 · Journal of consulting and clinical psychology
Objective This study applied a machine-learning-based skill assessment system to investigate the association between supportive counseling skills (empathy, open questions, and reflections) and treatment outcomes. We hypothesized that…
View details →Sznitman S, Mabouk C, Said Z et al. · 2023 · BMJ supportive & palliative care
Background Various jurisdictions have legalised medical cannabis (MC) for use in chronic pain treatment. The objective of this study was to determine if the use of MC is related to a reduction in the use of prescription opioids and other…
View details →Ellenardóttir V, Coronel R, Folke F et al. · 2024 · Open heart
Aim Conflicting results have been reported regarding the association between fluoroquinolones (FQs) and the risk of out-of-hospital cardiac arrest (OHCA). In particular, it has not become clear whether OHCA in FQ users is related to the…
View details →Nacar MC, Yigit S · 2023 · Nucleosides, nucleotides & nucleic acids
Background Osteoporosis (OP) is a common systemic, metabolic bone disease that affects 40% of postmenopausal women. Oxidative stress (OS) ìs caused by reactive oxygen species (ROS), inhibits osteoblast differentiation and causes apoptosis…
View details →Sato K, Arasaki N, Agena S et al. · 2025 · JMA journal
Introduction Increased muscle mass may positively influence the recovery of balance function. In this study, we aimed to investigate the relationship between changes in muscle mass and improved balance in patients with cerebral infarction.…
View details →Lozano-Meca JA, Gacto-Sánchez M, Montilla-Herrador J · 2024 · European journal of pain (London, England)
Introduction Knee Osteoarthritis (KOA) is mainly characterized by pain. The assessment of KOA-related pain frequently focuses on different constructs subject to sources of bias or drawbacks, as the classical Pain at Rest (PAR).…
View details →