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WASTE Journal

Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Automated CT segmentation of kidneys successfully quantifies changes in total kidney volume in ICU patients, a retrospective cohort study.

Biersma AGW, van Leer B, Renes MH et al. · 2026 · BMC nephrology

BACKGROUND: Kidney function is associated with kidney volume. This study aims to explore automated segmentation for measuring total kidney volume (TKV) and to analyse the association between (changes in) TKV and acute kidney injury (AKI)…

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Negative / Null Result ReportOpen accessMedicine

Prediction of success in sports based on assumed individual genetic predisposition: lack of association with the C > T variant in the ACTN3 gene.

Godina E, Khromov-Borisov N, Bondareva E · 2025 · Journal of physiological anthropology

Background Prediction of sports success (sports talent) based on individual genetic characteristics is the main goal of sports genetics/genomics. Most often, markers of predisposition to speed-strength sports, or endurance, are…

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Negative / Null Result ReportOpen accessMedicine

The effect of serum lipase levels on clinical severity scores and mortality in acute pancreatitis: a retrospective cohort study.

Kilicaslan MB, Dikme O, Girgin MC et al. · 2026 · BMC gastroenterology

Aims This study aimed to investigate the relationship between admission serum lipase levels, prognostic clinical scoring systems, and in-hospital mortality in patients presenting to the emergency department with acute pancreatitis. Methods…

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Negative / Null Result ReportOpen accessMedicine

A Comprehensive Analysis of Predictors of Marginal Ulcers After Roux-en-Y Gastric Bypass: A Cohort Review of 2106 Patients.

Abedalqader T, Migliorini A, Cerecedo LG et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives: Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed metabolic and bariatric surgeries worldwide. Marginal ulcers (MU) are a common complication following RYGB, yet their pathophysiology and the…

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Negative / Null Result ReportOpen accessMedicine

Lack of Association of Serum MMP-9 Concentration and rs17576 Single Nucleotide Variant <i>MMP-9</i> Gene With the Degree of Coronary Atherosclerosis and Other Risk Factors in Ukrainian Patients With Coronary Artery Disease.

Pogorielova OS, Korniienko VV, Chumachenko YD et al. · 2025 · Cardiology research and practice

This study probes the relationship between serum matrix metalloproteinase-9 (MMP-9) levels, the genetic variant rs17576 in the MMP-9 gene, and the extent of coronary atherosclerosis among Ukrainian patients diagnosed with coronary artery…

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Negative / Null Result ReportMedicine

The acute effects of vaporized cannabis on drivers' hazard perception and risk-taking behaviors in medicinal patients: A within-subjects experiment.

Schiemer C, Horswill MS, Hill A et al. · 2025 · Journal of safety research

Introduction As the medically prescribed use of cannabis flower continues to increase, there is a need to understand how vaporized cannabis can acutely affect driving-related skills and risk-taking behaviors in medicinal populations.…

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Negative / Null Result ReportOpen accessMedicine

Lack of association between the -2549 insertion/deletion variant of vascular endothelial growth factor and coronary artery disease in the Turkish population.

Yigit S, Nursal AF, Celik A et al. · 2024 · Revista da Associacao Medica Brasileira (1992)

Objective Coronary artery disease is the leading cause of death worldwide. Vascular endothelial growth factor is known to induce endothelial cell migration and proliferation, increase vascular permeability, and modulate thrombogenicity.…

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Negative / Null Result ReportOpen accessMedicine

Cord blood DNA methylation and cell-type composition are not significantly associated with severe preeclampsia after cell-type and clinical covariate adjustment.

Yang X, Liu W, Mao Z et al. · 2026 · GigaScience

Background Preeclampsia is a severe pregnancy complication that threatens maternal and neonatal health and well-being. Previous studies on epigenome-wide association studies (EWAS) of preeclampsia produced inconsistent results in cord…

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Negative / Null Result ReportOpen accessMedicine

Relationships in anesthesia work areas between contamination measured as colony-forming units, <i>Staphylococcus aureus</i> detection<i>, and S. aureus</i> transmission.

Bhushan A, Dexter F, Brindeiro C et al. · 2026 · Anesthesiology and perioperative science

Purpose Earlier, patients developed surgical site infection for 2.0% of cases without Staphylococcus aureus transmission through anesthesia work areas, 11% with S. aureus transmitted susceptible to prophylactic antibiotic, and 18% with…

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Negative / Null Result ReportOpen accessMedicine

Are high residual chlorhexidine skin concentrations associated with improved clinical outcomes? Lessons from the CLEAR trial.

Khoja R, Catuna TD, Gussin GM et al. · 2026 · Infection control and hospital epidemiology

Residual chlorhexidine gluconate (CHG) skin concentrations are thought to improve disease prevention. In the Changing Lives by Eradicating Antibiotic Resistance (CLEAR) trial, posthospitalization decolonization of MRSA carriers reduced…

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Negative / Null Result ReportOpen accessMedicine

Cognitive Impairment and Quality of Life in AQP4-IgG Seropositive Neuromyelitis Optica Spectrum Disorder: A Cross-Sectional Study in Iranian Patients.

Ramazanzadeh S, Ashtari F · 2026 · Neurology research international

Background Cognitive impairment (CI) has been reported with wide variability in neuromyelitis optica spectrum disorder (NMOSD), but its impact on patients' quality of life (QoL) is not well understood. The aim of this study was to describe…

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Negative / Null Result ReportOpen accessMedicine

Plasmid diversity, antibiotic resistance and virulence genes associated with Staphylococcus aureus isolates from private hospitals in Gauteng, South Africa.

Ngoie K, Kingsburgh C, Hamiwe T et al. · 2026 · World journal of microbiology & biotechnology

This study investigated the association between plasmid diversity, antibiotic resistance and virulence genes of Staphylococcus aureus (S. aureus) isolates from private hospitals in Gauteng, South Africa. Automated antibiotic susceptibility…

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Negative / Null Result ReportMedicine

Understanding Platelet Activation in the Aeson Bioprosthetic Total Artificial Heart: Insights From Aspirin Treatment and Outcomes.

Smadja DM, Roux de Bezieux J, Peronino C et al. · 2025 · ASAIO journal (American Society for Artificial Internal Organs : 1992)

This study aimed to assess platelet activation following implantation of the Aeson bioprosthetic total artificial heart (A-TAH). We monitored plasma levels of platelet activation markers in patients receiving A-TAH support (n = 16)…

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Negative / Null Result ReportMedicine

Lack of association between Lp(a) and retinal vein occlusion in a single institution and US national database.

Russell MW, Maatouk CM, Kim S et al. · 2024 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Objective This study examines associations between lipoprotein(a) (Lp[a]), a low-density-like lipoprotein, and renal vein occlusion (RVO) in US cohorts to characterize its prognostic role in the setting of RVO. Design A two-phase…

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