12,244 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Parkhoo K, Schmitz LA, Fröb L et al. · 2026 · Dentistry journal
Objectives : Six dentin adhesives were tested in vitro regarding their cytotoxicity toward human fibroblasts. AdheSE, Clearfil SE Bond, Hybrid Bond, One-up Bond F Plus, Optibond Solo Plus, and Syntac were tested using a cell culture model.…
View details →Korodimos N, Wojtyś ME, Kostopanagiotou K et al. · 2026 · Journal of clinical medicine
Background: Non-small-cell lung cancer (NSCLC) is driven by distinct oncogenic alterations with important therapeutic and prognostic implications. Noninvasive biomarkers that predict molecular status in surgically resectable disease may…
View details →Mahajan A, Haideri S, Kumar VVH et al. · 2026 · Journal of education and health promotion
Background The oral health is an integral part of general well-being in children suffering from attention deficit hyperactivity disorder (ADHD). The present study aimed to analyze the impact of oral health education program on children…
View details →Abdi A, Abbasi E, Abazarlou A · 2026 · BMC neurology
Objectives Migraine is a common and disabling neurological disorder in children, often requiring preventive treatment. This study aimed to compare the efficacy and tolerability of cinnarizine and topiramate in the prophylaxis of migraine…
View details →Peker N, Yücetürk A, Tığlı E et al. · 2026 · Journal of ovarian research
Background We aimed to evaluate whether delayed initiation of gonadotropin hormone-releasing hormone (GnRH) antagonist treatment affects premature ovulation and the number of good-quality blastocysts. We retrospectively reviewed the…
View details →Yan Z, Jiang Q, Lu Z et al. · 2026 · International journal of general medicine
Background Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Observational studies suggest a link with gut microbiota (GM), possibly mediated by systemic inflammation, but causality remains unclear. Objective To…
View details →Conde-Disla E, González-Olmo MJ, Olmos-Valverde M et al. · 2026 · Dentistry journal
Background: Pain during orthodontic debonding is a common clinical concern. Although previous studies have mainly focused on mechanical approaches to reduce discomfort, the influence of emotional characteristics of patients on pain…
View details →Xu X, Zhang B, Wang X et al. · 2026 · Orthopaedic surgery
Objective There is no consensus on the age restriction for total ankle arthroplasty (TAA) patients. The aim of our study was to analyze the clinical function, radiographic outcomes, patient satisfaction, and complications between patients…
View details →Agarwal P, Kumar P, Chugh VK et al. · 2026 · Cureus
Background and aim Postoperative pain following root canal treatment (RCT) can be influenced by the obturation technique, as variations in apical sealing and material extrusion may affect periapical tissue response. The aim of this study…
View details →Lopresti AL, Smith SJ, Ferdinands FR · 2026 · Frontiers in reproductive health
Background Khaya senegalensis is a tree species that has traditional use for the alleviation of menstrual and hormonal symptoms in women. Moreover, supplementation with a Khaya senegalensis preparation (Khapregesic®) was associated with…
View details →Mousa N, Hasan AK · 2026 · Cureus
Background This study aimed to evaluate nasal morphological characteristics and their relationship with vertical facial growth patterns in a Syrian adult population using lateral cephalometric analysis. Methodology This retrospective…
View details →Atsuta S, Koizumi S, Takahashi SS et al. · 2026 · Dentistry journal
Background/Objectives : Acceleration of orthodontic tooth movement remains a major challenge in clinical orthodontics. Evidence suggests that increased local blood flow around the alveolar bone is key to bone remodeling and potentially…
View details →Yiğit N, Nazlıgül AS, Ülgen NK et al. · 2026 · Geriatric orthopaedic surgery & rehabilitation
Background Distal radius fractures are common among elderly patients and frequently pose management challenges due to advanced age, multiple comorbidities, and increased anesthesia-related risks. In high-risk individuals with limited…
View details →Rogalska E, Stenka W, Kupcewicz E et al. · 2026 · Frontiers in public health
Introduction Breast cancer is the most common malignancy among women worldwide. Mastectomy, often accompanied by breast reconstruction, plays a key role in treatment and prevention among high-risk patients; however, psychological outcomes…
View details →Nowell S, Fantini O, Roman A et al. · 2026 · Veterinary dermatology
Fluorescent light energy (FLE; Phovia, Vetoquinol) is a photobiomodulation therapy that promotes healing and reduces inflammation. Cutaneous epitheliotropic lymphoma (CTCL) is a neoplastic skin disease with limited treatment options.…
View details →Pei Y, Jones L, Minga J · 2026 · American journal of speech-language pathology
Purpose This study investigated patterns of question use in conversation among individuals with traumatic brain injury (TBI) by analyzing the frequency, types, and social actions of the questions. Method Questions from conversational…
View details →Ilbekova K, Ibrayeva D, Saifulina E et al. · 2026 · Journal of clinical medicine
Background/Objectives : Cancer incidence and mortality are key epidemiological indicators for evaluating the long-term biological effects of chronic low-dose radiation exposure. The aim of this study was to assess the incidence, structure,…
View details →Shan J, Yu J, Zhao L et al. · 2026 · BMC cancer
Background Dose reduction during concurrent chemoradiotherapy (cCRT) is frequently required in patients with limited-stage small-cell lung cancer (LS-SCLC) because of treatment-related toxicities or poor tolerance. However, the impact of…
View details →Alkhalifah OF, Ali Shah S, Tareen SUK et al. · 2026 · Cureus
Background Achieving a lifelike color match for anterior restorations is a persistent challenge because tooth appearance is heavily influenced by illumination and observer-dependent choices. While visual matching with VITA-type guides…
View details →Matsumoto T, Yamamoto Y, Kotaka M et al. · 2024 · Targeted oncology
Background Non-inferiority of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) to irinotecan/fluoropyrimidine plus BEV in metastatic colorectal cancer was investigated in the phase III TRUSTY study, and we conducted a phase II study…
View details →Webers C, Ortolan A, Sepriano A et al. · 2023 · Annals of the rheumatic diseases
Objective To update the evidence on efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in patients with axial spondyloarthritis (axSpA) to inform the 2022 update of the Assessment of SpondyloArthritis…
View details →Ma XT, Yao GY, Li JL et al. · 2025 · World journal of clinical oncology
Background Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) represents a distinct molecular cancer subtype that is often associated with a poor prognosis. While perioperative chemotherapy regimens are currently…
View details →Çam Ö, Ateş MO, Keleş A · 2026 · BMC oral health
BACKGROUND: The aim of this study was to evaluate the association of buccolingual width (BLW), age, and gender with the detection of a lingual canal in mandibular anterior teeth using cone-beam computed tomography (CBCT). METHODS: CBCT…
View details →Szablewska AW, Zając B · 2026 · Scientific reports
Gestational diabetes mellitus (GDM) is associated with various perinatal complications and may affect neonatal acid-base status. Umbilical cord arterial blood gas (ABG) analysis provides an objective measure of fetal well-being at birth,…
View details →Mohamed NS, Abdel Aziz NAS · 2026 · Cutaneous and ocular toxicology
Purpose To quantitatively assess the macular microvasculature after intravenous chemotherapy (IVC) for retinoblastoma (RB) using optical coherence tomography angiography (OCTA). Methods A case control study compared the OCT and OCTA…
View details →Das Gupta S, Kamishita K, Kondo M et al. · 2026 · Journal of functional morphology and kinesiology
Objectives : Treadmill walking is often employed for tightly controlled gait and energetics research, but growing evidence suggests that treadmill-based metabolic and biomechanical measurements may not directly reflect the ecologically…
View details →Soenarti S, Sitorus S, Nugroho MB et al. · 2026 · Rehabilitacion
Sarcopenia represents a leading cause of functional decline in older adults. This randomized controlled trial examined whether the addition of ankle weights to a Nordic walking protocol yields superior outcomes compared with standard…
View details →Bader S, Magnuson A, Brorsson C et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society
Background Haemorrhagic shock (HS) is frequently associated with secondary cerebral injury due to compromised cerebral perfusion. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an effective haemorrhage control…
View details →Iyiol AR · 2026 · Cureus
Background Intestinal ischemia-reperfusion (I/R) injury represents a critical clinical condition characterized by oxidative stress, inflammatory activation, and impairment of intestinal mucosal integrity. Although restoration of blood flow…
View details →Mizushima Y, Whaley C, Kaimal A et al. · 2026 · JAMA network open
Importance Noneconomic damage caps, a form of medical malpractice law, remain controversial, as several states have enacted such laws since 2010, whereas others have repealed them. The clinical consequences of repealing these caps are…
View details →