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WASTE Journal

Browse the failure-mode index

12,244 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The effect of astaxanthin supplementation on inflammatory markers, lipid profile, and anthropometric indices in patients with heart failure: a randomized controlled trial.

Ghotboddin Mohammadi S, Shafie D, Feizi A et al. · 2026 · Scientific reports

Chronic inflammation and dyslipidemia are common pathophysiological features of heart failure (HF). Astaxanthin, a potent marine-derived antioxidant, has shown anti-inflammatory and lipid-lowering properties. This study conducted to…

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Negative / Null Result ReportMedicine

Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial.

Corbett A, Taylor R, Llewellyn D et al. · 2025 · Journal of the American Medical Directors Association

Objectives Preserved cognitive health with ageing is a public health imperative. Vitamin D deficiency is associated with poor cognition, but it is unclear whether supplementation would provide benefit, particularly in individuals with…

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Negative / Null Result ReportMedicine

Tadalafil Use in Cardiovascular Disease.

Kallash M, Frishman WH · 2025 · Cardiology in review

Tadalafil is a phosphodiesterase inhibitor currently approved for use in erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). While tadalafil's benefits in ED and BPH have been…

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Negative / Null Result ReportMedicine

Immediate versus staged complete revascularization in patients presenting with multivessel disease and ST- or non-ST-segment elevation acute coronary syndrome.

Elscot JJ, Kakar H, den Dekker WK et al. · 2025 · International journal of cardiology

Background Recent randomized trials have suggested that immediate complete revascularization (ICR) is a viable alternative to staged complete revascularization (SCR) in patients with acute coronary syndrome (ACS) and multivessel disease.…

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Negative / Null Result ReportOpen accessMedicine

Quality of Recovery after Intraoral Surgery: Total Intravenous Anaesthesia versus Sevoflurane: A Randomised Controlled Trial.

Šitum I, Mihaljević S, Blivajs I et al. · 2026 · Acta stomatologica Croatica

Objectives To compare the quality of recovery between total intravenous anaesthesia (TIVA) with propofol and balanced inhalational anaesthesia with sevoflurane in patients undergoing intraoral surgical procedures. Materials and methods We…

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Negative / Null Result ReportMedicine

Extended pelvic lymphadenectomy and rectal cancer: An umbrella review.

Villanova V, Martinino A, Stanzani E et al. · 2025 · Surgical oncology

Extended pelvic lymph node dissection (EPLND) for rectal cancer is common in Asian countries to reduce local recurrence and improve survival. This umbrella review investigates the benefit of adding extended lymphadenectomy to the standard…

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Negative / Null Result ReportOpen accessMedicine

Will DANCAVAS be the most important screening trial in the last 50 years?

Dixit NM, Chau E, Schaefer S · 2024 · American journal of preventive cardiology

Screening trials for cardiovascular disease have not demonstrated a reduction in all-cause mortality. The Danish Cardiovascular Screening trial (DANCAVAS) involved men aged 65-74 years old who were randomized to an invitation to undergo…

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Negative / Null Result ReportMedicine

Real-time qPCR evaluation of amino acids buffered sodium hypochlorite gel as an adjunct to non-surgical periodontal treatment: a randomized clinical trial.

Dolińska E, Starosz A, Grubczak K et al. · 2026 · Scientific reports

This study aimed to evaluate the effects of non-surgical periodontal therapy (SRP) and SRP with an amino acid-buffered hypochlorite solution (NaOCl/AA + SRP) on subgingival plaque bacteria. Quantitative changes in Porphyromonas gingivalis,…

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Negative / Null Result ReportMedicine

Mandibular Response in Class II Division 1 Growing Subjects: Clear Aligners vs. Rapid Maxillary Expansion Therapy. A Controlled Pilot Study.

Chiara RF, Letizia L, Francesca G et al. · 2026 · Orthodontics & craniofacial research

Objectives The present study aimed to evaluate the skeletal and dental changes in two different groups of mixed dentition Class II division 1 patients treated with Clear Aligners and with Rapid Maxillary Expansion and to assess the…

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Negative / Null Result ReportOpen accessMedicine

Randomized Controlled Pilot Study of Transcutaneous Electrical Nerve Stimulation for Acute Back Pain in Emergency Department Patients.

Moor-Smith M, Kozak N, McCue M et al. · 2026 · The western journal of emergency medicine

Background Musculoskeletal back pain is a common presenting complaint to emergency departments (ED) worldwide. In this study we aimed to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) as an adjunct to…

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Negative / Null Result ReportMedicine

Comparative effects of metformin and lifestyle therapy on bone metabolism markers: A 6-month pilot, open-label randomized-clinical trial.

Almosfer M, Sabico S, Wani K et al. · 2026 · Aging clinical and experimental research

Background The metabolic effects of Metformin (Met) and lifestyle modification in early type 2 diabetes mellitus (T2DM) management are well established, but their influence on bone remodeling remains uncertain in under-investigated…

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Negative / Null Result ReportMedicine

Twelve-month outcomes after open bleb revision for Preserflo<sup>®</sup> microshunt bleb failure in refractory glaucoma patients.

Darmon J, Bastelica P, Huard M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Purpose To evaluate the 12-month efficacy and safety of open bleb revision (OBR) for Preserflo ® MicroShunt (PMS) (Santen, Osaka, Japan) bleb failure. Patients and methods All consecutive patients who underwent PMS OBR for primary bleb…

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Negative / Null Result ReportOpen accessMedicine

Use of vericiguat in the VICTOR trial: a study that is difficult to interpret.

Orso F, Basile C · 2026 · European heart journal supplements : journal of the European Society of Cardiology

Vericiguat is a soluble guanylate cyclase stimulator that acts by restoring the nitric oxide-cyclic guanosine monophosphate pathway, which is markedly impaired in heart failure with reduced ejection fraction (HFrEF). The VICTORIA trial…

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Negative / Null Result ReportOpen accessMedicine

Impact of red propolis addition on the color stability and surface roughness of glass ionomer cements.

Sampaio GKML, Sette-de-Souza PH, Vieira BR et al. · 2026 · Biomaterial investigations in dentistry

Objective The present study aimed to evaluate the surface roughness (SR) and color stability of conventional restorative glass ionomer cements (GICs) modified with the addition of red propolis ethanolic extract (RPEE) as an antimicrobial…

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Negative / Null Result ReportMedicine

Phthalocyanine-based mouth gel as an adjunct to non-surgical periodontal treatment: a randomized controlled trial.

Neto SOP, Rosalen PL, da Cruz Pegoraro JV et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology

This study aimed to evaluate the effect of topical application of a mouth gel formulation containing iron tetracarboxyphthalocyanine (FeTcPc) during non-surgical periodontal treatment. Forty-seven individuals with periodontitis underwent a…

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Negative / Null Result ReportMedicine

Effects of Live and Heat-Treated Bifidobacterium longum CECT 7347 in Adults With Allergic Rhinitis: A Randomised, Double-Blind, Placebo-Controlled Trial.

Cardoso A, Naghibi M, Climent E et al. · 2026 · Allergy

Background Allergic rhinitis (AR) is an increasingly common chronic inflammatory condition of the nasal mucosa. While conventional anti-allergy treatments are widely used, they can come with side effects and are not always effective. As a…

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Negative / Null Result ReportMedicine

Effects of Extended-Release Liposomal Bupivacaine on Postoperative Mechanical and Thermal Hypersensitivity in C57BL/6 Mice (Mus musculus).

Wang AI, Duong MP, Frohlich JR et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS

Systemic analgesics, such as opioids and nonsteroidal anti-inflammatory drugs, may be contraindicated in certain studies due to their mechanisms of action and risk for systemic effects. Local anesthetics (LAs) are therefore crucial in…

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Negative / Null Result ReportMedicine

Hemidesmosomal Proteins in Oral Cancer Progression: An Immunohistochemical Study of Human and Mouse.

Mongia N, Mohammed AI, McCullough M et al. · 2026 · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Background Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease…

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Negative / Null Result ReportOpen accessMedicine

AIDS patients with Talaromycosis Marneffei exhibit inflammatory activation and depletion in their peripheral blood monocytes.

Guo P, Yang Y, Chen X et al. · 2026 · PLoS neglected tropical diseases

Objectives This study seeks to investigate the characteristics, dynamics, and association with disease progression of monocyte inflammation in patients with AIDS/Talaromycosis Marneffei (TSM). The findings are expected to contribute to a…

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Negative / Null Result ReportMedicine

In Silico Morphometric Analysis of the Tibia Following Four Virtual Proximal Levelling Osteotomies for the Treatment of Canine Cranial Cruciate Ligament Rupture.

de Marcos Carpio I, de Vicente F, Vallefuoco R · 2026 · Veterinary and comparative orthopaedics and traumatology : V.C.O.T

Objectives (1) To describe and compare the morphometric changes of the tibia following four virtual proximal tibial osteotomies for treatment of canine cranial cruciate ligament deficiency and (2) to determine how these changes are…

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Negative / Null Result ReportMedicine

Mindful-Compassion Art-Based Therapy for Dementia Care (MCAT-DC): A multicomponent approach to enhancing resilience in dementia family caregivers.

Tan-Ho G, Choo PY, Ma SHXY et al. · 2026 · Psychological trauma : theory, research, practice and policy

Objective Caring for a loved one with dementia imposes significant physical strain, emotional burden, and psychological trauma on family caregivers. Singaporean caregivers face added pressures under cultural norms that emphasize familial…

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Negative / Null Result ReportMedicine

Topical lidocaine spray for reducing pain during paracervical block administration in postmenopausal women undergoing manual vacuum aspiration: A randomized trial.

Ortíz Aguirre MJ, Barrientos Chinchilla AC, León-Velásquez M et al. · 2026 · Journal of gynecology obstetrics and human reproduction

Objective To assess the efficacy of topical lidocaine versus placebo in reducing pain during manual vacuum aspiration (MVA) for endometrial sampling in patients with endometrial thickening, as measured by the visual analog scale (VAS).…

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Negative / Null Result ReportOpen accessMedicine

Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptations.

Camargo A, Kaya I, Sturchio A et al. · 2026 · Translational psychiatry

Lipid systems play a substantial role in the pathophysiological mechanisms underlying several brain disorders. However, the mechanisms underlying the lipid profile in stress-induced maladaptations and how these changes can impact distinct…

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Negative / Null Result ReportMedicine

Impact of aromatherapy neck massage on resting cardiovascular parameters in patients with chronic kidney disease and secondary hypertension: A self-controlled study.

Deepa Y, Vijay A, Padmavathi K et al. · 2026 · Journal of bodywork and movement therapies

Objective Chronic kidney disease (CKD) is characterized by kidney damage persisting for 3 months or more. Hypertension (HTN) is a common cause of CKD progression. Previous studies had shown that aroma massage can effectively reduce…

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